Abstract:
:The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC significantly suppressed DSS-induced disease activity index (DAI) as well as histopathological scores, compared to control or CM-treated group. To elucidate the anti-IBD activity of GSC, we checked the level of matrix metalloproteinases (MMPs) and inflammatory mediators. GSC extract decreased the level of MMP-3 and -9 mRNAs and p53 proteins. The level and activity of LPS-induced MMP-9 were reduced in GSC-treated RAW264.7 cells. It also attenuated the level of inducible nitric oxide synthase (iNOS) and tumor necrosis factor- (TNF-) α mRNAs both in colon tissue and in macrophage cells. These results suggest that GSC can be applied as a protective agent against IBDs.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Park DK,Park HJdoi
10.1155/2013/102918subject
Has Abstractpub_date
2013-01-01 00:00:00pages
102918eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::Brachial plexus injury often involves traumatic root avulsion resulting in permanent paralysis of the innervated muscles. The lack of sufficient regeneration from spinal motoneurons to the peripheral nerve (PN) is considered to be one of the major causes of the unsatisfactory outcome of various surgical interventions ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/658753
更新日期:2014-01-01 00:00:00
abstract:Purpose:To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods:A retrospective analysis was conducted in 34 eyes from 24 progressive...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1762537
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:The prognosis of patients with advanced oropharyngeal carcinoma (OPSCC) is generally poor. The aim of this study is to investigate the different therapeutic approaches and identify prognostic factors associated with a worse outcome for patients treated for T4a OPSCC, in order to improve treatment selection f...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/390825
更新日期:2014-01-01 00:00:00
abstract::Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs are bound to conforma...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/471346
更新日期:2013-01-01 00:00:00
abstract::Introduction. The aim of this study was to examine the incidence and risk factors of catheterization-related CI in the contemporary era, using diffusion-weighted magnetic resonance imaging. Methods. We retrospectively analyzed consecutive 84 patients who underwent MRI (magnetic resonance imaging) after 2.81 ± 2.4 days...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6052125
更新日期:2016-01-01 00:00:00
abstract::Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients' characteristics. The functional experiments and mechanism studies...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6665974
更新日期:2020-12-22 00:00:00
abstract::Using the dual-process model of assimilative-tenacity (TGP) and accommodative-flexibility (FGA), the study aims to identify trajectories of TGP and FGA over five time points within a 9-year period, explore the relationships between the trajectories of TGP and FGA, and explore if participants from distinct TGP and FGA ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8017541
更新日期:2017-01-01 00:00:00
abstract:Objective:To investigate the effects of electroacupuncture (EA) at "Zusanli" (ST36) and "Shangjuxu"(ST37) on reducing inflammatory reaction and improving intestinal dysfunction in patients with sepsis-induced intestinal dysfunction with syndrome of obstruction of the bowels Qi. Methods:A total of 71 patients with seps...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/8293594
更新日期:2018-06-26 00:00:00
abstract::Interactions between proteins and drugs, which can lead to formation of stable drug-protein complexes, have important implications on several processes related to human health. These interactions can affect, for instance, free concentration, biological activity, and metabolism of the drugs in the blood stream. Here, w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/872701
更新日期:2014-01-01 00:00:00
abstract:Objective:To analyse the short-term adverse effects (AEs) of propranolol in the treatment of infantile hemangiomas (IHs) and their relevant factors, as well as the relationship between child growth and propranolol. Methods:A total of 506 patients with confirmed or suspected IHs were enrolled, and a total of 439 cases ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2728952
更新日期:2019-11-25 00:00:00
abstract::The aim of the study is to investigate the relationship between physical activity as assessed by accelerometers and cognitive development across the human age ranges (from children and adolescents to adults). Additionally, this study seeks to explore whether physical activity contributes to cognitive development via m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8568459
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to investigate whether osteopontin (OPN) variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. Polymorphisms at the 9175th position in exon 7 of OPN and rs17524488 were genotyped using direct sequencing in 186 unrelated AS patients and 188 ethnica...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3458439
更新日期:2018-01-18 00:00:00
abstract::Background. Surgical treatment of proximal humeral fractures (PHF) in osteoporotic bone of elderly patients is challenging. The aim of this retrospective study was to evaluate the clinical and radiological outcome after percutaneous reduction and internal fixation of osteoporotic PHF in geriatric patients using the se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6451849
更新日期:2016-01-01 00:00:00
abstract::Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
abstract::Introduction. This study aimed to evaluate the effects of resorbable blasting media (RBM) treatment on early stability of orthodontic mini-implants by mechanical, histomorphometric, and histological analyses. Methods. Ninety-six (64 for mechanical study and 32 for histological study and histomorphometric analysis) tit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7520959
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Obesity has become a global epidemic due to an increase in the number of obese individuals worldwide. There is little research in the field of obesity genetics in Pakistan. The aim of the current study was to analyze the association of common variants in Fat Mass and Obesity associated (FTO) gene w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/852920
更新日期:2015-01-01 00:00:00
abstract:Background:Hypertrophic pachymeningitis (HP) is generally regarded as a rare inflammatory disease, which results in a diffuse thickening of the dura mater. We retrospectively collected data from patients with HP. Methods:A total of 16 patients with HP were included in our study. The clinical features, laboratory evalu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2926419
更新日期:2020-08-14 00:00:00
abstract::The similarity-based retrieval of lung nodule computed tomography (CT) images is an important task in the computer-aided diagnosis of lung lesions. It can provide similar clinical cases for physicians and help them make reliable clinical diagnostic decisions. However, when handling large-scale lung images with a gener...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3162649
更新日期:2016-01-01 00:00:00
abstract::Schistosomiasis is the most prevalent tropical disease in the world after malaria. According to the World Health Organization, the disease afflicts more than 240 million people in about 80 countries. Recently, an epidemiological surveillance study performed between 1997 and 2010 by the European Network for Tropical Me...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8257310
更新日期:2017-01-01 00:00:00
abstract::Polyketide belongs to a family of abundant natural products typically produced by the filamentous soil bacteria Streptomyces. Similar to the biosynthesis of most secondary metabolites produced in the Streptomyces species, polyketide compounds are synthesized through tight regulatory networks in the cell, and thus extr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/549737
更新日期:2013-01-01 00:00:00
abstract:Objectives:Patients with stage 3 medication-related osteonecrosis of the jaw (MRONJ) suffer from severe complications. Chemotherapeutic agents and targeted drugs are considered to be associated with the development of MRONJ. However, little is known regarding the association of those agents with stage 3 MRONJ. The purp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5847429
更新日期:2020-10-15 00:00:00
abstract:AIM:To evaluate the impact of SPARC on female sexual function. METHODS:151 women with a mean age of 60 ± 11.90 and SUI had a complete urodynamic investigation and underwent SPARC operation. 98 women completed the validated female sexual function index questionnaire (FSFI) at baseline and 94 women at follow-up. A minim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/957547
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/4671349.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2020/7638969
更新日期:2020-06-30 00:00:00
abstract::The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4923640
更新日期:2017-01-01 00:00:00
abstract::Graphene is the first 2-dimensional material and possesses a plethora of original properties. Graphene and its derivatives have exhibited a great potential in a number of fields, both medical and nonmedical. The aim of this review is to set the theoretical basis for further research in developing graphene-based endova...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3180954
更新日期:2016-01-01 00:00:00
abstract::Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/839761
更新日期:2013-01-01 00:00:00
abstract::Sericin is a natural protein component of silks of silkworm and has potential utility in multiple areas such as pharmacological, cosmetics, and biotechnological industries. However, the understanding of its toxicological safety is still limited. This study evaluated the safety of water-extract sericin from silkworm (B...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9689386
更新日期:2020-11-05 00:00:00
abstract::In the past decade, much emphasis has been put on the transcriptional activation of HIV-1, which is proposed as a promised strategy for eradicating latent HIV-1 provirus. Two drugs, prostratin and hexamethylene bisacetamide (HMBA), have shown potent effects as inducers for releasing HIV-1 latency when used alone or in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5173205
更新日期:2016-01-01 00:00:00
abstract::The objective of this study is to introduce a method using a percutaneous full-endoscopic interlaminar approach via a surrounding nerve root discectomy (SNRD) operative route that involves removing the protrusive disc via both the shoulder and the axilla of the corresponding nerve root for the treatment of ventral-typ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/9157089
更新日期:2018-02-12 00:00:00
abstract::Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostruct...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/815981
更新日期:2014-01-01 00:00:00