Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches.

Abstract:

:Sericin is a natural protein component of silks of silkworm and has potential utility in multiple areas such as pharmacological, cosmetics, and biotechnological industries. However, the understanding of its toxicological safety is still limited. This study evaluated the safety of water-extract sericin from silkworm (Bombyx mori) cocoons using different model approaches, including three genotoxicity studies (the bacterial reverse mutation test, the mammalian erythrocyte micronucleus test, and the mouse spermatogonia chromosomal aberration test) and a 90-day subchronic toxicity study in Sprague-Dawley (SD) rats. The results of this study showed that water-extract sericin was nonmutagenic and nongenotoxic both in vitro and in vivo. Sericin did not induce significant changes in the body and organ weight, food intake, blood hematology and serum biochemistry, urine index, and histopathology in rats. The NOAEL of sericin was determined to be 1 g/kg/day for male and female rats. These results indicated that water-extract sericin was of low toxicity in the experimental conditions of the current study and had the potential for application in food-related products.

journal_name

Biomed Res Int

authors

Qin H,Zhang J,Yang H,Yao S,He L,Liang H,Wang Y,Chen H,Zhao P,Qin G

doi

10.1155/2020/9689386

subject

Has Abstract

pub_date

2020-11-05 00:00:00

pages

9689386

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • The Use and Effectiveness of Triple Multiplex System for Coding Region Single Nucleotide Polymorphism in Mitochondrial DNA Typing of Archaeologically Obtained Human Skeletons from Premodern Joseon Tombs of Korea.

    abstract::Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions SNPs could be also...

    journal_title:BioMed research international

    pub_type: 历史文章,杂志文章

    doi:10.1155/2015/850648

    authors: Oh CS,Lee SD,Kim YS,Shin DH

    更新日期:2015-01-01 00:00:00

  • Long-term effects of postearthquake distress on brain microstructural changes.

    abstract::Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability fac...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/180468

    authors: Sekiguchi A,Kotozaki Y,Sugiura M,Nouchi R,Takeuchi H,Hanawa S,Nakagawa S,Miyauchi CM,Araki T,Sakuma A,Taki Y,Kawashima R

    更新日期:2014-01-01 00:00:00

  • A Decision for Predicting Successful Extubation of Patients in Intensive Care Unit.

    abstract::Approximately 40% of patients admitted to the medical intensive care unit (ICU) require mechanical ventilation. An accurate prediction of successful extubation in patients is a key clinical problem in ICU due to the fact that the successful extubation is highly associated with prolonged ICU stay. The prolonged ICU sta...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6820975

    authors: Tu CS,Chang CH,Chang SC,Lee CS,Chang CT

    更新日期:2018-01-04 00:00:00

  • Identification of age-related macular degeneration related genes by applying shortest path algorithm in protein-protein interaction network.

    abstract::This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The gene...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/523415

    authors: Zhang J,Jiang M,Yuan F,Feng KY,Cai YD,Xu X,Chen L

    更新日期:2013-01-01 00:00:00

  • A Rapid Detection Method for Morphological Characteristics of Biological Cells Based on Phase Imaging.

    abstract::This paper presents a rapid label-free method for the identification of morphological characteristics of biological cells. Based on quantitative phase microscopy as well as the connotation of phase value, the gradient operator of phase and the associated analytic processing are employed to determine the edge of differ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4651639

    authors: Tang WB,Ji Y,Zhang MM,Chen ZY,Xu YY,Wang YW

    更新日期:2018-04-11 00:00:00

  • Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.

    abstract::It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/182846

    authors: Chen MF,Tsai JT,Chen LJ,Wu TP,Yang JJ,Yin LT,Yang YL,Chiang TA,Lu HL,Wu MC

    更新日期:2014-01-01 00:00:00

  • Disease modifying therapies for Alzheimer's disease targeting Aβ oligomers: implications for therapeutic mechanisms.

    abstract::Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO antibody (monoclonal 72D9)...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/984041

    authors: Matsubara E,Takamura A,Okamoto Y,Oono H,Nakata T,Wakasaya Y,Kawarabayashi T,Shoji M

    更新日期:2013-01-01 00:00:00

  • Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells.

    abstract::Heteronemin is a bioactive marine sesterterpene isolated from the sponge Hyrtios sp. Previous reports have shown that heteronemin possesses anticancer activity. Here, heteronemin displayed cytotoxic effects against three human cancer cell lines (A549, ACHN, and A498) and exhibited potent activity in A498 human renal c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/738241

    authors: Wu SY,Sung PJ,Chang YL,Pan SL,Teng CM

    更新日期:2015-01-01 00:00:00

  • Long Noncoding RNA EZR-AS1 Regulates the Proliferation, Migration, and Apoptosis of Human Venous Endothelial Cells via SMYD3.

    abstract::Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 (EZR-AS1) is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6840234

    authors: You G,Long X,Song F,Huang J,Tian M,Xiao Y,Deng S,Wu Q

    更新日期:2020-05-22 00:00:00

  • Sex steroid metabolism in benign and malignant intact prostate biopsies: individual profiling of prostate intracrinology.

    abstract::In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in prostate homeostasis. Most of the studies evaluated intraprostatic hormone metabolism using cell lines or preprocessed specimens. Using an ex vivo model of intact tissue cultures with preserved architecture, we characteriz...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/464869

    authors: Gianfrilli D,Pierotti S,Pofi R,Leonardo C,Ciccariello M,Barbagallo F

    更新日期:2014-01-01 00:00:00

  • The use of infrared thermography as a rapid, quantitative, and noninvasive method for evaluation of inflammation response in different anatomical regions of rats.

    abstract:PURPOSE:Thermographic assessment of temperature distribution within the examined tissues allows a quick, noncontact, noninvasive measurement of their temperature. The aim of the study was to evaluate the usefulness of digital infrared imaging in monitoring experimental inflammation of pleura (PL), lower lip (LL), and l...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/972535

    authors: Całkosiński I,Dobrzyński M,Rosińczuk J,Dudek K,Chrószcz A,Fita K,Dymarek R

    更新日期:2015-01-01 00:00:00

  • Mediterranean spotted fever in southeastern Romania.

    abstract::Although cases of Mediterranean spotted fever (MSF) have been reported for decades in southeastern Romania, there are few published data. We retrospectively studied 339 patients, diagnosed with MSF at the National Institute of Infectious Diseases "Prof. Dr. Matei Bals" between 2000 and 2011, in order to raise awarenes...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/395806

    authors: Pitigoi D,Olaru ID,Badescu D,Rafila A,Arama V,Hristea A

    更新日期:2013-01-01 00:00:00

  • The Effect of Botulinum Toxin Type A on Expression Profiling of Long Noncoding RNAs in Human Dermal Fibroblasts.

    abstract::Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2957941

    authors: Miao YY,Liu J,Zhu J,Tao YL,Zhang JA,Luo D,Zhou BR

    更新日期:2017-01-01 00:00:00

  • 124 Iodine: a longer-life positron emitter isotope-new opportunities in molecular imaging.

    abstract::(124)Iodine ((124)I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of (124)I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecul...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/672094

    authors: Cascini GL,Niccoli Asabella A,Notaristefano A,Restuccia A,Ferrari C,Rubini D,Altini C,Rubini G

    更新日期:2014-01-01 00:00:00

  • Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts.

    abstract::The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE in villous 3A first trimester trophoblast cells expos...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/257090

    authors: Cross CE,Tolba MF,Rondelli CM,Xu M,Abdel-Rahman SZ

    更新日期:2015-01-01 00:00:00

  • Screening and Molecular Identification of Pectinase Producing Microbes from Coffee Pulp.

    abstract::Application of enzymes in biotechnological process has expanded considerably in recent years. In food and related industry, major importance was being attached to the use of enzymes in upgrading quality, increasing yields of extractive processes, product stabilization, and improvement of flavor and byproduct utilizati...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2961767

    authors: Oumer OJ,Abate D

    更新日期:2018-04-03 00:00:00

  • Deep Response in Multiple Myeloma: A Critical Review.

    abstract::Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/832049

    authors: Fulciniti M,Munshi NC,Martinez-Lopez J

    更新日期:2015-01-01 00:00:00

  • Sera from Visceral Leishmaniasis Patients Display Oxidative Activity and Affect the TNF-α Production by Macrophages In Vitro.

    abstract::Mammalian protection against leishmanial infection depends on the development of an effective immune response. Zoonotic visceral leishmaniasis (ZVL) patients are usually unable to mount an effective immune response against the parasite and indeed appear to be severely immunosuppressed. This suppression has strong nons...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/5861453

    authors: Soares NM,de Souza JN,Leal TF,Reis EAG,Miranda MS,Dos Santos WLC,Teixeira MCA

    更新日期:2017-01-01 00:00:00

  • Accuracy and repeatability of the gait analysis by the WalkinSense system.

    abstract::WalkinSense is a new device designed to monitor walking. The aim of this study was to measure the accuracy and repeatability of the gait analysis performed by the WalkinSense system. Descriptions of values recorded by WalkinSense depicting typical gait in adults are also presented. A bench experiment using the Trublu ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/348659

    authors: de Castro MP,Meucci M,Soares DP,Fonseca P,Borgonovo-Santos M,Sousa F,Machado L,Vilas-Boas JP

    更新日期:2014-01-01 00:00:00

  • IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice.

    abstract::The aim of the present study was to determine the anti-inflammatory effect of IFN-τ on endometritis using a mouse model of S. aureus-induced endometritis and to elucidate the mechanism of action underlying these effects. In the present study, the effect of IFN-τ on S. aureus growth was monitored by turbidimeter at 600...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2350482

    authors: Zhang Z,Guo Y,Liu Y,Li C,Guo M,Deng G

    更新日期:2017-01-01 00:00:00

  • Predictive contribution of neutrophil/lymphocyte ratio in diagnosis of brucellosis.

    abstract::Here we wanted to investigate predictive value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in the diagnosis of brucellosis. Thirty-two brucellosis patients diagnosed with positive serum agglutination test and thirty-two randomized healthy subjects were enrolled in this study retrospectivel...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/210502

    authors: Olt S,Ergenç H,Açıkgöz SB

    更新日期:2015-01-01 00:00:00

  • Clinical and Prognostic Significance of Positive Hepatojugular Reflux on Discharge in Acute Heart Failure: Insights from the ESCAPE Trial.

    abstract::Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF. Methods. Using the ESCAP...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/5734749

    authors: Omar HR,Guglin M

    更新日期:2017-01-01 00:00:00

  • Circular RNA cir-ITCH Is a Potential Therapeutic Target for the Treatment of Castration-Resistant Prostate Cancer.

    abstract::cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. However, its expression and functional role in prostate cancer (PCa) are unclear. Herein, we explored the potential mechanism and tumor-inhibiting role of cir-ITCH in PCa. Using reverse transcriptase polymerase chain rea...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7586521

    authors: Li S,Yu C,Zhang Y,Liu J,Jia Y,Sun F,Zhang P,Li J,Guo L,Xiao H,Gao F,Deng X,Cai Z,Cai J

    更新日期:2020-08-20 00:00:00

  • Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats.

    abstract::Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and lo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/169841

    authors: Brito J,Siques P,Arribas SM,López de Pablo AL,González MC,Naveas N,Arriaza K,Flores K,León-Velarde F,Pulido R,Ordenes S,López MR

    更新日期:2015-01-01 00:00:00

  • Corrigendum to "Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly".

    abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2020/9175369

    authors: Arosio B,D'Addario C,Gussago C,Casati M,Tedone E,Ferri E,Nicolini P,Rossi PD,Maccarrone M,Mari D

    更新日期:2020-09-07 00:00:00

  • Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine.

    abstract::Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9620870

    authors: Coyle KM,Boudreau JE,Marcato P

    更新日期:2017-01-01 00:00:00

  • Automatic detection and quantification of acute cerebral infarct by fuzzy clustering and histographic characterization on diffusion weighted MR imaging and apparent diffusion coefficient map.

    abstract::Determination of the volumes of acute cerebral infarct in the magnetic resonance imaging harbors prognostic values. However, semiautomatic method of segmentation is time-consuming and with high interrater variability. Using diffusion weighted imaging and apparent diffusion coefficient map from patients with acute infa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/963032

    authors: Tsai JZ,Peng SJ,Chen YW,Wang KW,Wu HK,Lin YY,Lee YY,Chen CJ,Lin HJ,Smith EE,Yeh PS,Hsin YL

    更新日期:2014-01-01 00:00:00

  • An experimental approach for selecting appropriate rodent diets for research studies on metabolic disorders.

    abstract::Diverse high energy diets have been utilized to precipitate obesity and related metabolic disorders in rodent models, though the dietary intervention has not absolutely been standardized. The present study established usage of a customized semipurified normal control diet (NCD) and high fat diet (HFD), for research st...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/752870

    authors: Sasidharan SR,Joseph JA,Anandakumar S,Venkatesan V,Ariyattu Madhavan CN,Agarwal A

    更新日期:2013-01-01 00:00:00

  • Knockdown of PHF5A Inhibits Migration and Invasion of HCC Cells via Downregulating NF-κB Signaling.

    abstract:Background:Inflammation is the major risk factor for the progression of hepatocellular carcinoma (HCC), and the nuclear factor-κB (NF-κB) signaling plays the central role in the inflammation process. However, the activated mechanism of NF-κB signaling in HCC is unclear. Methods:The expression of PHF5A is examined by q...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1621854

    authors: Yang Q,Zhang J,Xu S,Jia C,Meng W,Tang H,Zhang X,Zhang Y,Fu B

    更新日期:2019-01-15 00:00:00

  • Formulation and evaluation of chitosan-chondroitin sulphate based nasal inserts for zolmitriptan.

    abstract::Bioadhesive nasal dosage forms are an attractive method for overcoming rapid mucociliary clearance transport in the nose and for delivering the drug directly to brain. The present study was designed to formulate chondroitin sulphate (CS) and chitosan (CH) nasal inserts employing zolmitriptan, an antimigraine drug. The...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/958465

    authors: Kaur K,Kaur G

    更新日期:2013-01-01 00:00:00