Serum Human Epididymis Protein 4 is Associated with Renal Function and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus.

Abstract:

:Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients with type 2 diabetes mellitus (T2DM). We enrolled 236 patients with T2DM and 82 healthy individuals. Serum HE4 was detected by ARCHITECT i2000 and compared between T2DM patients and healthy controls. The relationships between various variables and HE4 were analyzed by univariate or multivariate linear regression analyses. The receiver operating characteristic (ROC) curve was constructed to assess the diagnostic performance of HE4 for DKD. The association between HE4 and DKD was analyzed by logistic regression analysis. The serum HE4 level was significantly increased in T2DM patients (median, interquartile range (IQR), 69.7, 46.5-153.9, pM) compared with healthy control (median, IQR, 40.3 33.2-46.3, pM) (P < 0.001). Furthermore, it was higher in those with DKD (median, IQR, 211.1, 141.6-367.4, pM) than those without DKD (median, IQR, 55.5, 42.7-79.6, pM) (P < 0.001). The multivariable analysis showed that age, eGFR, HDL, CRP, and urea significantly independently correlated with HE4 level, while other variables did not. The ROC curve showed that the diagnostic performance of serum HE4 for DKD with 82.9 pM as the optimal cutoff value was good (AUC = 0.917, 95% CI: 0.872-0.961, P < 0.001, with a sensitivity and specificity of 92.1% and 76.9%, respectively) in T2DM patients. Multivariable logistic regression analysis showed that increased HE4 level was a significant, independent risk factor for DKD (OR, 95% CI, 57.7, 3.0-1112.9, P < 0.001) after adjusting for factors associated with HE4. Increased serum HE4 level is associated with decreased renal function and increased risks of DKD in patients with DM. It displays a good diagnostic value for DKD.

journal_name

Biomed Res Int

authors

Zhang M,Zhao B,Xie J,Liang Y,Yang Z

doi

10.1155/2019/4831459

subject

Has Abstract

pub_date

2019-11-11 00:00:00

pages

4831459

eissn

2314-6133

issn

2314-6141

journal_volume

2019

pub_type

杂志文章
  • Prosexual Effect of Chrysactinia mexicana A. Gray (Asteraceae), False Damiana, in a Model of Male Sexual Behavior.

    abstract::Chrysactinia mexicana A. Gray (Asteraceae) and Turnera diffusa Willd (Turneraceae) are employed in traditional medicine as aphrodisiacs; however, there is no scientific evidence supporting the prosexual properties of C. mexicana. The aim of this study was to determine whether an aqueous extract of C. mexicana (Cm) sti...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2987917

    authors: Estrada-Reyes R,Ferreyra-Cruz OA,Jiménez-Rubio G,Hernández-Hernández OT,Martínez-Mota L

    更新日期:2016-01-01 00:00:00

  • Development of bioadhesive chitosan superporous hydrogel composite particles based intestinal drug delivery system.

    abstract::Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full fact...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/563651

    authors: Chavda H,Modhia I,Mehta A,Patel R,Patel C

    更新日期:2013-01-01 00:00:00

  • RF-Phos: A Novel General Phosphorylation Site Prediction Tool Based on Random Forest.

    abstract::Protein phosphorylation is one of the most widespread regulatory mechanisms in eukaryotes. Over the past decade, phosphorylation site prediction has emerged as an important problem in the field of bioinformatics. Here, we report a new method, termed Random Forest-based Phosphosite predictor 2.0 (RF-Phos 2.0), to predi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3281590

    authors: Ismail HD,Jones A,Kim JH,Newman RH,Kc DB

    更新日期:2016-01-01 00:00:00

  • Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota.

    abstract::Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent stu...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/8102589

    authors: Gong D,Yu X,Wang L,Kong L,Gong X,Dong Q

    更新日期:2017-01-01 00:00:00

  • Inverse Kinematics for Upper Limb Compound Movement Estimation in Exoskeleton-Assisted Rehabilitation.

    abstract::Robot-Assisted Rehabilitation (RAR) is relevant for treating patients affected by nervous system injuries (e.g., stroke and spinal cord injury). The accurate estimation of the joint angles of the patient limbs in RAR is critical to assess the patient improvement. The economical prevalent method to estimate the patient...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2581924

    authors: Cortés C,de Los Reyes-Guzmán A,Scorza D,Bertelsen Á,Carrasco E,Gil-Agudo Á,Ruiz-Salguero O,Flórez J

    更新日期:2016-01-01 00:00:00

  • Postoperative Renal Outcomes of Patients Receiving Percutaneous Nephrolithotomy versus Pyelolithotomy: A Population-Based Cohort Study.

    abstract::The aim of this population-based cohort study was to explore postoperative renal outcomes of patients receiving pyelolithotomy versus percutaneous nephrolithotomy (PCNL). Data were retrieved from the Taiwan National Health Insurance Research Database. During the period from Jan 1, 1998, to Dec 31, 2012, there were 254...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8582901

    authors: Chen FT,Liu FC,Cheng CW,Lin JR,Yu HP

    更新日期:2018-05-02 00:00:00

  • The domain landscape of virus-host interactomes.

    abstract::Viral infections result in millions of deaths in the world today. A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies. In this study, we presented a landscape of virus-host interactomes based on protein domain interaction. Compared to the analysis at protei...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/867235

    authors: Zheng LL,Li C,Ping J,Zhou Y,Li Y,Hao P

    更新日期:2014-01-01 00:00:00

  • Effects of Nitric Oxide on Renal Proximal Tubular Na+ Transport.

    abstract::Nitric oxide (NO) has a wide variety of physiological functions in the kidney. Besides the regulatory effects in intrarenal haemodynamics and glomerular microcirculation, in vivo studies reported the diuretic and natriuretic effects of NO. However, opposite results showing the stimulatory effect of NO on Na+ reabsorpt...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/6871081

    authors: Satoh N,Nakamura M,Suzuki A,Tsukada H,Horita S,Suzuki M,Moriya K,Seki G

    更新日期:2017-01-01 00:00:00

  • Effect of Bacillus megaterium-Coated Diets on the Growth, Digestive Enzyme Activity, and Intestinal Microbial Diversity of Songpu Mirror Carp Cyprinus specularis Songpu.

    abstract::The present study was conducted to evaluate the effect of a Bacillus megaterium-coated diet on growth performance, digestive enzymes, and intestinal microbial diversity in Songpu mirror carp (Cyprinus specularis Songpu). The fish were manually fed two diets (a control diet and a B. megaterium-coated diet) three times ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8863737

    authors: Luo L,Xu Q,Xu W,Li J,Wang C,Wang L,Zhao Z

    更新日期:2020-11-13 00:00:00

  • Andrographolide Inhibits Proliferation and Metastasis of SGC7901 Gastric Cancer Cells.

    abstract::To explore the mechanisms by which andrographolide inhibits gastric cancer cell proliferation and metastasis, we employed the gastric cell line SGC7901 to investigate the anticancer effects of andrographolide. The cell survival ratio, cell migration and invasion, cell cycle, apoptosis, and matrix metalloproteinase act...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6242103

    authors: Dai L,Wang G,Pan W

    更新日期:2017-01-01 00:00:00

  • Balloon-Occluded Trans-Arterial Chemo-Embolization Technique with Repeated Alternate Infusion of Cisplatin Solution and Sparse Gelatin Slurry (RAIB-TACE) for Large Hepatocellular Carcinoma Nodules More than 7 cm in Diameter.

    abstract:Objective:It is sometimes difficult to obtain complete/partial response of large hepatocellular carcinoma (HCC) nodules by trans-arterial chemoembolization/embolization (TACE/TAE). The aim is retrospective investigation of tumor response of large HCC nodules (>7 cm) treated by the new TACE technique, repeated alternate...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9289321

    authors: Irie T,Takahashi N,Kamoshida T,Kashimura J,Ariga H

    更新日期:2020-01-19 00:00:00

  • Corrigendum to "Cytotoxic Effect of Ethanol Extract of Microalga, Chaetoceros calcitrans, and Its Mechanisms in Inducing Apoptosis in Human Breast Cancer Cell Line".

    abstract::[This corrects the article DOI: 10.1155/2013/783690.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2016/8693826

    authors: Ebrahimi Nigjeh S,Yusoff FM,Alitheen NB,Pirozyan MR,Keong YS,Omar AR

    更新日期:2016-01-01 00:00:00

  • Gear Shifting of Quadriceps during Isometric Knee Extension Disclosed Using Ultrasonography.

    abstract::Ultrasonography has been widely employed to estimate the morphological changes of muscle during contraction. To further investigate the motion pattern of quadriceps during isometric knee extensions, we studied the relative motion pattern between femur and quadriceps under ultrasonography. An interesting observation is...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6385315

    authors: Zhang S,Huang W,Zeng Y,Shi W,Diao X,Wei X,Ling S

    更新日期:2018-03-18 00:00:00

  • Skin delivery of kojic acid-loaded nanotechnology-based drug delivery systems for the treatment of skin aging.

    abstract::The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can mod...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/271276

    authors: Gonçalez ML,Corrêa MA,Chorilli M

    更新日期:2013-01-01 00:00:00

  • Safety of Natural Insecticides: Toxic Effects on Experimental Animals.

    abstract::Long-term application and extensive use of synthetic insecticides have resulted in accumulating their residues in food, milk, water, and soil and cause adverse health effects to human and ecosystems. Therefore, application of natural insecticides in agriculture and public health sectors has been increased as alternati...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/4308054

    authors: Mossa AH,Mohafrash SMM,Chandrasekaran N

    更新日期:2018-10-16 00:00:00

  • Effects of Arteriovenous Thrombolysis Combined with Mechanical Thrombectomy on Efficacy and Neurological Function of Acute Cerebral Infarct Patients.

    abstract:Objective:To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients. Methods:A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9743075

    authors: Ding T,Tang L,Hu B,Yuan J,Li X,Wen J

    更新日期:2020-10-09 00:00:00

  • Automatic Segmentation of Ultrasound Tomography Image.

    abstract::Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2059036

    authors: Wu S,Yu S,Zhuang L,Wei X,Sak M,Duric N,Hu J,Xie Y

    更新日期:2017-01-01 00:00:00

  • Craniofacial Reconstruction Method Based on Region Fusion Strategy.

    abstract::Craniofacial reconstruction is to estimate a person's face model from the skull. It can be applied in many fields such as forensic medicine, archaeology, and face animation. Craniofacial reconstruction is based on the relationship between the skull and the face to reconstruct the facial appearance from the skull. Howe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8835179

    authors: Wen Y,Mingquan Z,Pengyue L,Guohua G,Xiaoning L,Kang L

    更新日期:2020-12-04 00:00:00

  • Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients.

    abstract::(i) Purpose. The fluid challenge (FC) is a well-established test of preload reserve. Only limited data exist in regard to the FC efficacy based on infusion time. Slow administration may be associated with lack of effect based on fluid redistribution and external conditions changes. On the contrary, fast administration...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/8925345

    authors: Pouska J,Tegl V,Astapenko D,Cerny V,Lehmann C,Benes J

    更新日期:2018-11-01 00:00:00

  • Correlations of Expression Levels of a Panel of Genes (IRF5, STAT4, TNFSF4, MECP2, and TLR7) and Cytokine Levels (IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α) with Systemic Lupus Erythematosus Outcomes in Jordanian Patients.

    abstract::Systemic lupus erythematosus (SLE) is characterized by systemic end-organ damage. We investigated the involvement of IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes and TNF-α, IFN-γ, IL-2, IL-12, IL-6, and IL-10 cytokines in SLE pathogenesis and in organ damage in Jordanian patients. Blood was collected from 51 patients a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1703842

    authors: Uzrail AH,Assaf AM,Abdalla SS

    更新日期:2019-11-29 00:00:00

  • Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma.

    abstract::This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2015/617143

    authors: Tang M,Ou N,Li C,Lu A,Li J,Ma L,Zhong W,Gao J,Zheng Y,Cai Y

    更新日期:2015-01-01 00:00:00

  • Ablative therapy for esophageal dysplasia and early malignancy: focus on RFA.

    abstract::Ablative therapies have been utilized with increasing frequency for the treatment of Barrett's esophagus with and without dysplasia. Multiple modalities are available for topical ablation of the esophagus, but radiofrequency ablation (RFA) remains the most commonly used. There have been significant advances in techniq...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/642063

    authors: Tuttle R,Nurkin SJ,Hochwald SN

    更新日期:2014-01-01 00:00:00

  • Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members.

    abstract::Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions. The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns. 63...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/613910

    authors: Zhou T,Yan X,Wang G,Liu H,Gan X,Zhang T,Wang J,Li L

    更新日期:2015-01-01 00:00:00

  • Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.

    abstract::Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, inclu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/916136

    authors: Mennan C,Wright K,Bhattacharjee A,Balain B,Richardson J,Roberts S

    更新日期:2013-01-01 00:00:00

  • Discovery of Potential Inhibitors of Aldosterone Synthase from Chinese Herbs Using Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Studies.

    abstract::Aldosterone synthase (CYP11B2) is a key enzyme for the biosynthesis of aldosterone, which plays a significant role for the regulation of blood pressure. Excess aldosterone can cause the dysregulation of the renin-angiotensin-aldosterone system (RAAS) and lead to hypertension. Therefore, research and development of CYP...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/4182595

    authors: Luo G,Lu F,Qiao L,Chen X,Li G,Zhang Y

    更新日期:2016-01-01 00:00:00

  • Identification of Key Genes and Long Noncoding RNA-Associated Competing Endogenous RNA (ceRNA) Networks in Early-Onset Preeclampsia.

    abstract:Background:Preeclampsia (PE) is a pregnancy-specific hypertension syndrome and is one of the leading causes of maternal and perinatal morbidity and mortality. Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in many diseases, including preeclampsia. The present study is aimed at identifying t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1673486

    authors: Zhang Z,Wang P,Zhang L,Huang C,Gao J,Li Y,Yang B

    更新日期:2020-06-05 00:00:00

  • No evidence for an association of vitamin D deficiency and migraine: a systematic review of the literature.

    abstract::Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the key...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/827635

    authors: Lippi G,Cervellin G,Mattiuzzi C

    更新日期:2014-01-01 00:00:00

  • The influence of hypoxia during different pregnancy stages on cardiac collagen accumulation in the adult offspring.

    abstract::We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/419805

    authors: Wang L,Li M,Huang Z,Wang Z

    更新日期:2014-01-01 00:00:00

  • Identification and Progression of Heart Disease Risk Factors in Diabetic Patients from Longitudinal Electronic Health Records.

    abstract::Heart disease is the leading cause of death worldwide. Therefore, assessing the risk of its occurrence is a crucial step in predicting serious cardiac events. Identifying heart disease risk factors and tracking their progression is a preliminary step in heart disease risk assessment. A large number of studies have rep...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/636371

    authors: Jonnagaddala J,Liaw ST,Ray P,Kumar M,Dai HJ,Hsu CY

    更新日期:2015-01-01 00:00:00

  • Lung cancer stem cell lose their stemness default state after exposure to microgravity.

    abstract::Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when canc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/470253

    authors: Pisanu ME,Noto A,De Vitis C,Masiello MG,Coluccia P,Proietti S,Giovagnoli MR,Ricci A,Giarnieri E,Cucina A,Ciliberto G,Bizzarri M,Mancini R

    更新日期:2014-01-01 00:00:00