Abstract:
Purpose:To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods:A retrospective analysis was conducted in 34 eyes from 24 progressive KC patients who have underwent CXL from 2015 to 2017. Area with K-value more than 47D shown in the corneal topography was marked and identified as KEA. Keratometry (K1, K2, and Kmax), KEA, thinnest corneal thickness (TCT), and endothelial cell density (ECD) were evaluated preoperatively or at months 3, 6, and 12 postoperatively. The changes of KEA before and after operation were evaluated. The relation of KEA and other parameters, including Kmax and TCT, was analyzed. Results:Linear regression model revealed the KEA, Kmax, K1, and K2 decreased after CXL in model y = 0.9622 -0.02408 x (P<0.05), y = 0.9982 -0.003469 x(P<0.05), y = 0.9977 + -0.001347 x(P<0.05), y = 0.9992 + -0.001779 x(P<0.05) (y represents KEA, Kmax, K1, or K2; x represents time (month)). The KEA is significantly decreased in early stage (before month 3) (P<0.05); however, the Kmax, K1, and K2 have no significant decrease in early stage (P= 0.09, 0.19, 0.32). Conclusions:The KEA is more sensitive than K-value in describing the morphological changes of cornea after CXL, especially in early stage after treatment.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wang J,Li Z,Zhang H,Gao N,Mu Gdoi
10.1155/2019/1762537subject
Has Abstractpub_date
2019-04-03 00:00:00pages
1762537eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract::The framework of graph theory provides useful tools for investigating the neural substrates of neuropsychiatric disorders. Graph description measures may be useful as predictor variables in classification procedures. Here, we consider several centrality measures as predictor features in a classification algorithm to i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/380531
更新日期:2014-01-01 00:00:00
abstract::A wide range of molecular techniques have been developed for genotyping Candida species. Among them, multilocus sequence typing (MLST) and microsatellite length polymorphisms (MLP) analysis have recently emerged. MLST relies on DNA sequences of internal regions of various independent housekeeping genes, while MLP iden...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/923742
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2020/9175369
更新日期:2020-09-07 00:00:00
abstract::The crude ethanolic extract from aerial parts of Pothomorphe umbellata L. (Piperaceae) and fractions obtained by partitions sequentially among water-methanol, methylene chloride, and ethyl acetate, as well as the major constituent, 4-nerolidylcatechol, were, respectively, evaluated and evidenced for antioxidant and cy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/206581
更新日期:2013-01-01 00:00:00
abstract::Upper-limb movement analysis is important to monitor objectively rehabilitation interventions, contributing to improving the overall treatments outcomes. Simple, fast, easy-to-use, and applicable methods are required to allow routinely functional evaluation of patients with different pathologies and clinical condition...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/484131
更新日期:2015-01-01 00:00:00
abstract::There has been a remarkable interest in finding lipid inhibitors from natural products to replace synthetic compounds, and a variety of oriental medicinal herbs are reported to have biological activity with regard to lipid inhibition. Buginawa (Bugi) is a novel combined formula that contains twelve medicinal herbs wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3101987
更新日期:2019-07-30 00:00:00
abstract::Panax ginseng Meyer, a valuable medicinal plant, is severely threatened by rusty root, a condition that greatly affects its yield and quality. Studies investigating the relationship between soil microbial community composition and rusty roots are vital for the production of high-quality ginseng. Here, high-throughput ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8018525
更新日期:2020-01-15 00:00:00
abstract:Background:Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods:Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2953068
更新日期:2020-03-18 00:00:00
abstract::Hydrocephalus is a common neurological condition that can have traumatic ramifications and can be lethal without treatment. Nowadays, during therapy radiologists have to spend a vast amount of time assessing the volume of cerebrospinal fluid (CSF) by manual segmentation on Computed Tomography (CT) images. Further, som...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3059170
更新日期:2019-07-07 00:00:00
abstract::Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7902760
更新日期:2018-10-14 00:00:00
abstract:Background:Haemonchus contortus, the causative agent of Haemonchosis, is the most economically important parasite in small ruminant production. Control with chemotherapy has not been successful due to rapid emergence of drug-resistant strains. There is a continuous search for alternative leads particularly from plants....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1905987
更新日期:2017-01-01 00:00:00
abstract::Picobirnavirus (PBV) which has been included in the list of viruses causing enteric infection in animals is highly versatile because of its broad host range and genetic diversity. PBVs are among the most recent and emerging small, nonenveloped viruses with a bisegmented double-stranded RNA genome, classified under a n...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/780752
更新日期:2014-01-01 00:00:00
abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1843142
更新日期:2018-02-06 00:00:00
abstract:Objective:The objective of this study is to evaluate the effect of simvastatin on the jaw bone microstructural defect and autophagy in rats with high cholesterol diet (HCD). Methods:Male Sprague-Dawley rats were fed a standard rodent chow (NC group) or a high cholesterol diet for 32 weeks and the HCD-fed rats were tre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4147932
更新日期:2018-06-27 00:00:00
abstract::Metabolomics is the sophisticated and high-throughput technology based on the entire set of metabolites which is known as the connector between genotypes and phenotypes. For any phenotypic changes, potential metabolite (biomarker) identification is very important because it provides diagnostic as well as prognostic ma...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2437608
更新日期:2017-01-01 00:00:00
abstract::Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities. Our knowledge about how platelets modulate inflammatory and immunity has greatly improved in recent years. In this revi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/9060143
更新日期:2016-01-01 00:00:00
abstract::In vivo confocal microscopy (IVCM) of the living human cornea offers the ability to perform repeated imaging without tissue damage. Studies using corneal IVCM have led to significant contributions to scientific and clinical knowledge of the living cornea in health and pathological states. Recently the application of c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/951081
更新日期:2015-01-01 00:00:00
abstract::In esophageal squamous cell carcinoma, an elevated preoperative absolute monocyte count (Pre-AMC) is reported to be a predictor of survival, but the clinical application of postoperative absolute monocyte count change (AMCc) remains unknown. The present study was designed to investigate the prognostic value of AMCc in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2702719
更新日期:2019-08-14 00:00:00
abstract::Objectives. To construct a frailty index from next-of-kin information of the last year of life of community-dwelling 50 years old or older adults and test its association with health services utilization. Methods. Cross-sectional analysis from next-of-kin data available from the last wave of the Mexican Health and Agi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6069374
更新日期:2017-01-01 00:00:00
abstract::Densitometry data generated for Western blots are commonly used to compare protein abundance between samples. In the last decade, it has become apparent that assumptions underpinning these comparisons are often violated in studies reporting Western blot data in the literature. These violations can lead to erroneous in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5214821
更新日期:2019-01-21 00:00:00
abstract::The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6492183
更新日期:2016-01-01 00:00:00
abstract::Heavy metals have the potential to interact and induce several stress responses in the plants; thus, effects of heavy metal stress on DNA damages and total antioxidants level in Urtica dioica leaves and stems were investigated. The samples are sampled from areas with different metal exposition. Metal content was analy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276417
更新日期:2013-01-01 00:00:00
abstract::As the fifth most common cancer in men and the eighth most common cancer in women, hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, with standard chemotherapy and radiation being minimally effective in prolonging survival. Virus hepatitis, particularly HBV and HCV infection is th...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/735672
更新日期:2014-01-01 00:00:00
abstract::In our study, we evaluated the feasibility of a new sampling method for splenic stiffness (SS) measurement by Quantitative Acoustic Radiation Force Impulse Elastography (Virtual Touch Tissue Quantification (VTTQ)).We measured SS in 54 patients with HCV-related cirrhosis of whom 28 with esophageal varices (EV), 27 with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/365982
更新日期:2014-01-01 00:00:00
abstract::Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries. Actually, only few models of cardiac cache...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9549036
更新日期:2016-01-01 00:00:00
abstract::Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes. It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases. Within the various craniofacial abnormalities, orofacial clefting is one of the mos...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/901041
更新日期:2015-01-01 00:00:00
abstract::Primary cilia are organelles protruding from cell surface into environment that function in regulating cell cycle and modulating cilia-related signal. Primary ciliogenesis and autophagy play important roles in tumorigenesis. However, the functions and interactions between primary cilia and autophagy in hepatocellular ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5202750
更新日期:2019-10-02 00:00:00
abstract::There has been no previous study using three-dimensional (3D) measurement on femoral tunnel characteristics according to the combined influence of various flexion angles of knee and transverse drill angles in single-bundle ACL reconstruction with transportal technique. The purpose of this study was to determine optima...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2643247
更新日期:2018-07-17 00:00:00
abstract::Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown. This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4375075
更新日期:2020-11-14 00:00:00
abstract::Cabbages (Brassica oleracea L.) are an important vegetable crop around world, and cold temperature is among the most significant abiotic stresses causing agricultural losses, especially in cabbage crops. Plant bZIP transcription factors play diverse roles in biotic/abiotic stress responses. In this study, 119 putative...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4376598
更新日期:2016-01-01 00:00:00