IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation.

Abstract:

Background:Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods:Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosis and the inflammatory response were detected. The effect of IL-4 treatment on Kupffer cells (KCs) polarization and expression of the STAT6-JMJD3 pathway was evaluated in vivo and in vitro. KCs in donor livers were depleted by clodronate liposome treatment or JMJD3 was inhibited by GSK-J4 before liver transplantation to determine whether the protective effect of IL-4 treatment was dependent on KCs. Results:IL-4 treatment decreased sALT and sAST levels and alleviated hepatocellular apoptosis and inflammation at 6 h after liver transplantation. IL-4 treatment induced KCs alternatively activated (M2) polarization in vitro. KCs in donor livers were depleted by clodronate liposome treatment or JMJD3 was inhibited by GSK-J4 before liver transplantation to determine whether the protective effect of IL-4 treatment was dependent on KCs. in vivo and in vitro. KCs in donor livers were depleted by clodronate liposome treatment or JMJD3 was inhibited by GSK-J4 before liver transplantation to determine whether the protective effect of IL-4 treatment was dependent on KCs. Conclusions:IL-4 treatment-induced KCs M2 polarization was dependent on the STAT6-JMJD3 pathway and protected liver grafts from IRI after liver transplantation.

journal_name

Biomed Res Int

authors

Deng M,Wang J,Wu H,Wang M,Cao D,Li J,Wu Y,Gong J

doi

10.1155/2020/2953068

subject

Has Abstract

pub_date

2020-03-18 00:00:00

pages

2953068

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • Dragging human mesenchymal stem cells with the aid of supramolecular assemblies of single-walled carbon nanotubes, molecular magnets, and peptides in a magnetic field.

    abstract::Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/143504

    authors: de Paula AC,Sáfar GA,Góes AM,Bemquerer MP,Ribeiro MA,Stumpf HO

    更新日期:2015-01-01 00:00:00

  • Functional development of the circadian clock in the zebrafish pineal gland.

    abstract::The zebrafish constitutes a powerful model organism with unique advantages for investigating the vertebrate circadian timing system and its regulation by light. In particular, the remarkably early and rapid development of the zebrafish circadian system has facilitated exploring the factors that control the onset of ci...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/235781

    authors: Ben-Moshe Z,Foulkes NS,Gothilf Y

    更新日期:2014-01-01 00:00:00

  • The Effect of Muscle Direction on the Predictions of Finite Element Model of Human Lumbar Spine.

    abstract::The normal physiological loads from muscles experienced by the spine are largely unknown due to a lack of data. The aim of this study is to investigate the effects of varying muscle directions on the outcomes predicted from finite element models of human lumbar spine. A nonlinear finite element model of L3-L5 was empl...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4517471

    authors: Zhu R,Niu WX,Wang ZP,Pei XL,He B,Zeng ZL,Cheng LM

    更新日期:2018-01-03 00:00:00

  • Plant growth promotion potential is equally represented in diverse grapevine root-associated bacterial communities from different biopedoclimatic environments.

    abstract::Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/491091

    authors: Marasco R,Rolli E,Fusi M,Cherif A,Abou-Hadid A,El-Bahairy U,Borin S,Sorlini C,Daffonchio D

    更新日期:2013-01-01 00:00:00

  • Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis.

    abstract:Background:According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body's internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2020/3105248

    authors: Xiong J,Long J,Chen X,Li Y,Song H

    更新日期:2020-02-15 00:00:00

  • Corrigendum to "Effect of Short-Term Stimulation with Interleukin-1β and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts".

    abstract::[This corrects the article DOI: 10.1155/2015/714230.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2016/9325260

    authors: Voss JO,Loebel C,Bara JJ,Fuessinger MA,Duttenhoefer F,Alini M,Stoddart MJ

    更新日期:2016-01-01 00:00:00

  • The Preoperative CT-Scan Can Help to Predict Postoperative Complications after Pancreatoduodenectomy.

    abstract::After pancreatoduodenectomy, complication rates are up to 40%. To predict the risk of developing postoperative pancreatic fistula or severe complications, various factors were evaluated. 110 consecutive patients undergoing pancreatoduodenectomy at our institute between January 2012 and September 2014 with complete CT ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/824525

    authors: Schröder FF,de Graaff F,Bouman DE,Brusse-Keizer M,Slump KH,Klaase JM

    更新日期:2015-01-01 00:00:00

  • ACE-I/ARB therapy prior to contrast exposure: what should the clinician do?

    abstract::Contrast-induced nephropathy (CIN) is now one of the three leading causes of acute kidney injury in the world. A lot is known about the risk factors of CIN, yet it remains a major cause of morbidity, end stage renal disease, prolonged hospital stay, and increased costs as well as a high mortality. Many patients underg...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/423848

    authors: Kalyesubula R,Bagasha P,Perazella MA

    更新日期:2014-01-01 00:00:00

  • Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-κB Pathways.

    abstract::Malignant melanoma is characterized by its bad prognosis for aggressiveness, drug resistance, and early metastasis. Isorhamnetin (3'-methoxy-3,4',5,7-tetrahydroxyflavone; IH) is a natural flavonoid that has been investigated for its antitumor effects in breast cancer, colon cancer, and gastric cancer through inducing ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1057943

    authors: Duan R,Liang X,Chai B,Zhou Y,Du H,Suo Y,Chen Z,Li Q,Huang X

    更新日期:2020-05-05 00:00:00

  • Demethylation of cancer/testis antigens and CpG ODN stimulation enhance dendritic cell and cytotoxic T lymphocyte function in a mouse mammary model.

    abstract:BACKGROUND:Cancer/testis antigens (CTAs) are ideal targets for cancer immunotherapy in virtue of their restricted expression profile in normal tissues. However, CTA-targeted immunotherapy has been rather disappointing clinical setting for CTAs are downregulated by cytosine-phosphate-guanosine (CpG) methylation in their...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/196894

    authors: Sun JZ,Gao L,Gao L,Wang W,Du N,Yang J,Wan L,Liu F,Wang LL,Yu L

    更新日期:2013-01-01 00:00:00

  • The Effect of Altitude on Intraocular Pressure in Vitrectomized Eyes with Sulfur Hexafluoride Tamponade by the Friedenwald Method: Rabbit Animal Model.

    abstract::The aim of this study is to assess the change in intraocular pressure after a road trip, in eyes with different levels of filling with gas tamponade. Five rabbit eyes were subject to pars plana vitrectomy and gas tamponade (filling percentage: 25%, 50%, and 100% of nonexpansile SF6, 100% saline solution, and 100% room...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7326160

    authors: Fromow-Guerra J,Solís-Vivanco A,Velez-Montoya R,Perez-Reguera A,Quiroz-Mercado H,Meza-de Regil A,Papa-Oliva G,Morales-Cantón V

    更新日期:2016-01-01 00:00:00

  • The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression.

    abstract::Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that s...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/929531

    authors: Nikitovic D,Kouvidi K,Karamanos NK,Tzanakakis GN

    更新日期:2013-01-01 00:00:00

  • Gypenoside Inhibits Endothelial Cell Apoptosis in Atherosclerosis by Modulating Mitochondria through PI3K/Akt/Bad Pathway.

    abstract::Atherosclerosis remains the most common cause of deaths worldwide. Endothelial cell apoptosis is an important process in the progress of atherosclerosis, as it can cause the endothelium to lose their capability in regulating the lipid homeostasis, inflammation, and immunity. Endothelial cell injury can disrupt the int...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2819658

    authors: Song N,Jia L,Cao H,Ma Y,Chen N,Chen S,Lv X,Yang G

    更新日期:2020-06-20 00:00:00

  • Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis.

    abstract::Osteoarthritis (OA) is a chronic degenerative joint disease, where chondrocyte apoptosis is responsible for cartilage degeneration. Bax is a well-known proapoptotic protein of the Bcl-2 family, involved in a large number of physiological and pathological processes. However, the regulation mechanisms of Bax underlying ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1434538

    authors: Miao G,Zang X,Hou H,Sun H,Wang L,Zhang T,Tan Y,Liu W,Ye P,Gao L,Zha Z

    更新日期:2019-03-12 00:00:00

  • Modulation of the rat hepatic cytochrome P4501A subfamily using biotin supplementation.

    abstract::Studies have found that biotin favors glucose and lipid metabolism, and medications containing biotin have been developed. Despite the use of biotin as a pharmacological agent, few studies have addressed toxicity aspects including the possible interaction with cytochrome P450 enzyme family. This study analyzed the eff...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/627907

    authors: Ronquillo-Sánchez MD,Camacho-Carranza R,Fernandez-Mejia C,Hernández-Ojeda S,Elinos-Baez M,Espinosa-Aguirre JJ

    更新日期:2013-01-01 00:00:00

  • Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension.

    abstract::ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria. However, no evidence show that circulating ELA is deficient in early placental develo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2051701

    authors: Ma S,Guo C,Zhang J,Long S,Tan H,You Y

    更新日期:2020-09-28 00:00:00

  • Comparison of Immune Checkpoint Inhibitors between Older and Younger Patients with Advanced or Metastatic Lung Cancer: A Systematic Review and Meta-Analysis.

    abstract:Objectives:Despite the fact that it is widely acknowledged that immune checkpoint inhibitors (ICIs) rely on the presence of immune response to take their antitumor effect, little is known whether there is an influence exerted on the efficacy of ICIs based on patients' age. We performed a systematic review and meta-anal...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2019/9853701

    authors: Zhang L,Sun L,Yu J,Shan F,Zhang K,Pang X,Ma C,Zhang Y,Shen M,Ma S,Ruan S

    更新日期:2019-05-13 00:00:00

  • Incidence and Risk Factors for Postoperative Delirium in Patients Undergoing Spine Surgery: A Systematic Review and Meta-Analysis.

    abstract:Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2019/2139834

    authors: Wu X,Sun W,Tan M

    更新日期:2019-11-26 00:00:00

  • Genetic polymorphisms of ORAI1 and chronic kidney disease in Taiwanese population.

    abstract::Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involve...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/290863

    authors: Hwang DY,Chien SC,Hsu YW,Kao CC,Cheng SY,Lu HC,Wu MS,Chang JM

    更新日期:2014-01-01 00:00:00

  • The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection.

    abstract::C-type lectins are multifunctional sugar-binding molecules expressed on dendritic cells (DCs) and macrophages that internalize antigens for processing and presentation. Macrophage galactose-type lectin 1 (MGL1) recognizes glycoconjugates expressing Lewis X structures which contain galactose residues, and it is selecti...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/615865

    authors: Montero-Barrera D,Valderrama-Carvajal H,Terrazas CA,Rojas-Hernández S,Ledesma-Soto Y,Vera-Arias L,Carrasco-Yépez M,Gómez-García L,Martínez-Saucedo D,Becerra-Díaz M,Terrazas LI

    更新日期:2015-01-01 00:00:00

  • The Antiobesity Effects of Buginawa in 3T3-L1 Preadipocytes and in a Mouse Model of High-Fat Diet-Induced Obesity.

    abstract::There has been a remarkable interest in finding lipid inhibitors from natural products to replace synthetic compounds, and a variety of oriental medicinal herbs are reported to have biological activity with regard to lipid inhibition. Buginawa (Bugi) is a novel combined formula that contains twelve medicinal herbs wit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3101987

    authors: Park YJ,Seo DW,Ju JY,Cha YY,An HJ

    更新日期:2019-07-30 00:00:00

  • Design and user evaluation of a wheelchair mounted robotic assisted transfer device.

    abstract:PURPOSE:The aim of this study is to describe the robotic assisted transfer device (RATD) and an initial focus group evaluation by end users. The purpose of the device is to aid in the transfers of people with disabilities to and from their electric powered wheelchair (EPW) onto other surfaces. The device can be used fo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/198476

    authors: Grindle GG,Wang H,Jeannis H,Teodorski E,Cooper RA

    更新日期:2015-01-01 00:00:00

  • Detecting Genetic Interactions for Quantitative Traits Using m-Spacing Entropy Measure.

    abstract::A number of statistical methods for detecting gene-gene interactions have been developed in genetic association studies with binary traits. However, many phenotype measures are intrinsically quantitative and categorizing continuous traits may not always be straightforward and meaningful. Association of gene-gene inter...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/523641

    authors: Yee J,Kwon MS,Jin S,Park T,Park M

    更新日期:2015-01-01 00:00:00

  • Expression of genes encoding enzymes involved in the one carbon cycle in rat placenta is determined by maternal micronutrients (folic acid, vitamin B12) and omega-3 fatty acids.

    abstract::We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming. Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in r...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/613078

    authors: Khot V,Kale A,Joshi A,Chavan-Gautam P,Joshi S

    更新日期:2014-01-01 00:00:00

  • Effects of Habitat Types on Macroinvertebrates Assemblages Structure: Case Study of Sun Island Bund Wetland.

    abstract::Sun Island Bund Wetland (SIBW) is a river floodplain wetland located at the south part of Heilongjiang Province in Northeast China. An investigation of the influence of habitat type on macroinvertebrates assemblages structure was conducted in July 2016. Nine (9) sampling sites were selected based on sediment type, wat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2650678

    authors: Khudhair N,Yan C,Liu M,Yu H

    更新日期:2019-02-13 00:00:00

  • Population Diversity of Campylobacter jejuni in Poultry and Its Dynamic of Contamination in Chicken Meat.

    abstract::This study aimed to analyse the diversity of the Campylobacter jejuni population in broilers and to evaluate the major source of contamination in poultry meat. Eight rearing cycles over one year provided samples from three different broiler farms processed at the same slaughterhouse. A total of 707 C. jejuni were isol...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/859845

    authors: Marotta F,Garofolo G,Di Donato G,Aprea G,Platone I,Cianciavicchia S,Alessiani A,Di Giannatale E

    更新日期:2015-01-01 00:00:00

  • The Influence of Recognition and Social Support on European Health Professionals' Occupational Stress: A Demands-Control-Social Support-Recognition Bayesian Network Model.

    abstract::Healthcare professionals undergo high levels of occupational stress as a result of their working conditions. Thus, the aim of this study is to develop a model that focuses on healthcare professionals so as to analyze the influence that job demands, control, social support, and recognition have on the likelihood that a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4673047

    authors: García-Herrero S,Lopez-Garcia JR,Herrera S,Fontaneda I,Báscones SM,Mariscal MA

    更新日期:2017-01-01 00:00:00

  • Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation.

    abstract:Background:The pathogenesis of abdominal aortic aneurysm (AAA) is characterized by atherosclerosis with chronic inflammation in the aortic wall. Montelukast is a selective cys-LT 1 receptor antagonist that can suppress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9104680

    authors: Kawai Y,Narita Y,Yamawaki-Ogata A,Usui A,Komori K

    更新日期:2019-05-27 00:00:00

  • Pregnancy after acute coronary syndrome: a proposal for patients' management and a literature review.

    abstract::Coronary artery disease complicates only 0.01% of all pregnancies. For this reason, more exhaustive data on the management of such cases is lacking. Even guidelines on management of cardiovascular disease in pregnant women are scarce focusing mainly on acute myocardial infarction. This is a complex issue involving tho...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/957027

    authors: Janion-Sadowska A,Sadowski M,Kurzawski J,Zandecki L,Janion M

    更新日期:2013-01-01 00:00:00

  • An Anatomical Basis for the Myofascial Trigger Points of the Abductor Hallucis Muscle.

    abstract::Myofascial pain syndrome is characterized by pain and a limited range of joint motion caused by muscle contracture related to motor-end-plate dysfunction and the presence of myofascial trigger points (MTrPs). It is the most frequent cause of musculoskeletal pain, with a worldwide prevalence varying between 13.7% and 4...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9240581

    authors: Wada JT,Akamatsu F,Hojaij F,Itezerote A,Scarpa JC,Andrade M,Jacomo A

    更新日期:2020-01-22 00:00:00