Abstract:
:Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes. It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases. Within the various craniofacial abnormalities, orofacial clefting is one of the most common phenotypic outcomes associated with retarded facial growth or fusion. Cleft lip is one of the representative and frequently encountered conditions in the spectrum of orofacial clefting. Despite various mechanisms or signaling pathways that have been proposed to be the cause of cleft lip, a detailed mechanism that bridges individual signaling pathways to the cleft lip is still elusive. Shh signaling is indispensable for normal embryonic development, and disruption can result in a wide spectrum of craniofacial disorders, including cleft lip. This review focuses on the current knowledge about the mechanisms of facial development and the etiology of cleft lip that are related to Shh signaling.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kurosaka Hdoi
10.1155/2015/901041subject
Has Abstractpub_date
2015-01-01 00:00:00pages
901041eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::Systemic lupus erythematosus (SLE) is characterized by systemic end-organ damage. We investigated the involvement of IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes and TNF-α, IFN-γ, IL-2, IL-12, IL-6, and IL-10 cytokines in SLE pathogenesis and in organ damage in Jordanian patients. Blood was collected from 51 patients a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1703842
更新日期:2019-11-29 00:00:00
abstract:Background:As a newly discovered lncRNA, bladder cancer-associated transcript 1 (BLACAT1) has been reported to correlate with poor clinical outcomes in several different cancers. This study aimed to evaluate its generalized predictive value for cancer prognosis. Materials and Methods:We thoroughly searched PubMed, Emb...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/1275491
更新日期:2019-04-02 00:00:00
abstract::The large-scale production of cardiomyocytes is a key step in the development of cell therapy and tissue engineering to treat cardiovascular diseases, particularly those caused by ischemia. The main objective of this study was to establish a procedure for the efficient production of cardiomyocytes by reprogramming mes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/390789
更新日期:2013-01-01 00:00:00
abstract::Eccentric exercise is characterized by initial unfavorable effects such as subcellular muscle damage, pain, reduced fiber excitability, and initial muscle weakness. However, stretch combined with overload, as in eccentric contractions, is an effective stimulus for inducing physiological and neural adaptations to train...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/193741
更新日期:2015-01-01 00:00:00
abstract::Legumes have developed a unique way to interact with bacteria: in addition to preventing infection from pathogenic bacteria like any other plant, legumes also developed a mutualistic symbiotic relationship with one gender of soil bacteria: rhizobium. This interaction leads to the development of a new root organ, the n...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/507946
更新日期:2014-01-01 00:00:00
abstract::Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8798546
更新日期:2017-01-01 00:00:00
abstract::There is minimal research of upper extremity joint dynamics during pediatric wheelchair mobility despite the large number of children using manual wheelchairs. Special concern arises with the pediatric population, particularly in regard to the longer duration of wheelchair use, joint integrity, participation and commu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/634768
更新日期:2015-01-01 00:00:00
abstract::A reliable in vivo imaging method to localize transplanted cells and monitor their viability would enable a systematic investigation of cell therapy. Most stem cell transplantation studies have used immunohistological staining, which does not provide information about the migration of transplanted cells in vivo in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/231805
更新日期:2015-01-01 00:00:00
abstract::Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/261813
更新日期:2015-01-01 00:00:00
abstract::Antibiotics are among the most counterfeited anti-infectious medicines in developing countries. Amoxicillin is one of the commonly prescribed, affordable, and easily accessible antibiotic in Kenya. It is a broad-spectrum antibiotic hence commonly used in chemotherapy. This study sought to determine the quality and ide...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7091278
更新日期:2020-06-12 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease. NAFLD encompasses a wide range of pathologies, from simple steatosis to steatosis with inflammation to fibrosis. The pathogenesis of NAFLD progression has not been completely elucidated, and different liver cells could be imp...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/768071
更新日期:2015-01-01 00:00:00
abstract::Single-sided deafness (SSD) induces cortical neural plastic changes according to duration of deafness. However, it is still unclear how the auditory cortical changes accompany the subcortical neural changes. The present study aimed to find the neural plastic changes in the cortical and subcortical auditory system foll...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8624745
更新日期:2018-11-26 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldeh...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/2025636
更新日期:2019-06-24 00:00:00
abstract::Optical molecular imaging, a new medical imaging technique, is developed based on genomics, proteomics and modern optical imaging technique, characterized by non-invasiveness, non-radiativity, high cost-effectiveness, high resolution, high sensitivity and simple operation in comparison with conventional imaging modali...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/429198
更新日期:2014-01-01 00:00:00
abstract::Heart disease is the leading cause of death worldwide. Therefore, assessing the risk of its occurrence is a crucial step in predicting serious cardiac events. Identifying heart disease risk factors and tracking their progression is a preliminary step in heart disease risk assessment. A large number of studies have rep...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/636371
更新日期:2015-01-01 00:00:00
abstract::Both strict blood pressure (BP) control and improvements in BP profile such as BP variability are important for suppression of renal deterioration and cardiovascular complication in hypertension and chronic kidney disease (CKD). In the present study, we examined the beneficial effects of the single pill-based combinat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/437087
更新日期:2014-01-01 00:00:00
abstract::This study aimed to analyse the diversity of the Campylobacter jejuni population in broilers and to evaluate the major source of contamination in poultry meat. Eight rearing cycles over one year provided samples from three different broiler farms processed at the same slaughterhouse. A total of 707 C. jejuni were isol...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/859845
更新日期:2015-01-01 00:00:00
abstract::Cabbages (Brassica oleracea L.) are an important vegetable crop around world, and cold temperature is among the most significant abiotic stresses causing agricultural losses, especially in cabbage crops. Plant bZIP transcription factors play diverse roles in biotic/abiotic stress responses. In this study, 119 putative...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4376598
更新日期:2016-01-01 00:00:00
abstract::Schistosomiasis is the most prevalent tropical disease in the world after malaria. According to the World Health Organization, the disease afflicts more than 240 million people in about 80 countries. Recently, an epidemiological surveillance study performed between 1997 and 2010 by the European Network for Tropical Me...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8257310
更新日期:2017-01-01 00:00:00
abstract::In clinical endodontics, preoperative estimation of root canal curvature is crucial regarding the prevention of iatrogenic errors. Reproduction of the two-dimensional radiographic images causes certain proximal view curvatures not seen. Therefore, the present study is aimed at investigating the degree of root canal cu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/6699635
更新日期:2021-01-13 00:00:00
abstract::The total knee arthroplasty (TKA) is the gold standard for patients with an advanced symptomatic gonarthrosis. However, there are very few publications dealing with the primary TKA for patients with a proximal tibia fracture. In our retrospective study we evaluated 30 patients treated with a TKA for a proximal tibia f...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6047876
更新日期:2016-01-01 00:00:00
abstract:Introduction:Baseline neutrophil-to-lymphocyte ratio (NLR) has been repeatedly reported as a significant prognostic factor in advanced cancer patients. We explored whether changes in NLR may predict outcome of advanced cancer patients enrolled into phase 1 trials and treated with PD-1/PD-L1 inhibitors. Patients and Me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1506824
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:There is an unmet need for a specific cardiovascular risk (CV) algorithm for rheumatoid arthritis (RA) patients. Lipoprotein data are often not available in RA cohorts but could be obtained from frozen blood samples. The objective of this study was to estimate the storage effect on lipoproteins in long-term (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/930925
更新日期:2014-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is a critical public health and socioeconomic problem worldwide. The herb pair Astragali Radix (AR)-Radix Angelica Sinensis (RAS) is a common prescribed herbal formula or is added to other Chinese medicine prescriptions for traumatic brain injury (TBI) treatment. However, the underlying me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3951783
更新日期:2018-11-25 00:00:00
abstract::Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and exist as an important cause of pulmonary infections in humans. Pulmonary involvement is the most common disease manifestation of NTM and the incidence of NTM is growing in North America. Susceptibility to NTM infection is incompletely understood; ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/919474
更新日期:2014-01-01 00:00:00
abstract::Following cerebral ischemia/reperfusion (I/R) injury, a series of pathophysiological processes are stimulated in both the central nervous system (CNS) and the periphery, including, but not limited to, the peripheral immune and endocrine systems and underregulation of the neuroendocrine-immune network. Glutamate (Glu) ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6316059
更新日期:2018-07-19 00:00:00
abstract:OBJECTIVE:To investigate the relationship of delivery type, maternal anesthesia, feeding modalities, and first feeding and meconium passage times with early bilirubin levels of healthy infants. METHODS:Cord, 24 hours' and 48 hours' total bilirubin levels were measured in 388 study infants. RESULTS:Infants born with c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/316430
更新日期:2013-01-01 00:00:00
abstract::The similarity-based retrieval of lung nodule computed tomography (CT) images is an important task in the computer-aided diagnosis of lung lesions. It can provide similar clinical cases for physicians and help them make reliable clinical diagnostic decisions. However, when handling large-scale lung images with a gener...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3162649
更新日期:2016-01-01 00:00:00
abstract::The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867321
更新日期:2014-01-01 00:00:00
abstract::CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4093435
更新日期:2018-03-29 00:00:00