当前位置： SCI文献检索 > Biomed Research International期刊下所有文献 > Primary Cilia Blockage Promotes the Malignant Behaviors of Hepatocellular Carcinoma via Induction of Autophagy.

Primary Cilia Blockage Promotes the Malignant Behaviors of Hepatocellular Carcinoma via Induction of Autophagy.

Abstract：

:Primary cilia are organelles protruding from cell surface into environment that function in regulating cell cycle and modulating cilia-related signal. Primary ciliogenesis and autophagy play important roles in tumorigenesis. However, the functions and interactions between primary cilia and autophagy in hepatocellular carcinoma (HCC) have not been reported yet. Here, we aimed to investigate the relationship and function of primary cilia and autophagy in HCC. In vitro, we showed that serum starvation stimuli could trigger primary ciliogenesis in HCC cells. Blockage of primary ciliogenesis by IFT88 silencing enhanced the proliferation, migration, and invasion ability of HCC cells. In addition, inhibition of primary cilia could positively regulate autophagy. However, the proliferation, migration, and invasion ability which were promoted by IFT88 silencing could be partly reversed by inhibition of autophagy. In vivo, interference of primary cilia led to acceleration of tumor growth and increase of autophagic flux in xenograft HCC mouse models. Moreover, IFT88 high expression or ATG7 low expression in HCC tissues was correlated with longer survival time indicated by the Cancer Genome Atlas (TCGA) analysis. In conclusion, our study demonstrated that blockage of primary ciliogenesis by IFT88 silencing had protumor effects through induction of autophagy in HCC. These findings define a newly recognized role of primary cilia and autophagy in HCC.

journal_name

Biomed Res Int

journal_title

BioMed research international

authors

Liu L,Sheng JQ,Wang MR,Gan Y,Wu XL,Liao JZ,Tian DA,He XX,Li PY

doi

10.1155/2019/5202750

subject

Has Abstract

pub_date

2019-10-02 00:00:00

pages

5202750

eissn

2314-6133

issn

2314-6141

journal_volume

2019

pub_type

杂志文章

相关文献

Biomed Research International文献大全
  • The Vulnerability of Vessels Involved in the Role of Embolism and Hypoperfusion in the Mechanisms of Ischemic Cerebrovascular Diseases.

    abstract：:Accurate definition and better understanding of the mechanisms of stroke are crucial as this will guide the effective care and therapy. In this paper, we review the previous basic and clinical researches on the causes or mechanisms of ischemic cerebrovascular diseases (ICVD) and interpret the correlation between embol...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2016/8531958

    authors： Yu YP,Tan L

    更新日期：2016-01-01 00:00:00

  • Performance of glutamate dehydrogenase and triose phosphate isomerase genes in the analysis of genotypic variability of isolates of Giardia duodenalis from livestocks.

    abstract：:Giardia duodenalis is a small intestinal protozoan parasite of several terrestrial vertebrates. This work aims to assess the genotypic variability of Giardia duodenalis isolates from cattle, sheep and pigs in the Southeast of Brazil, by comparing the standard characterization between glutamate dehydrogenase (gdh) and ...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2013/875048

    authors： Fava NM,Soares RM,Scalia LA,Kalapothakis E,Pena IF,Vieira CU,Faria ES,Cunha MJ,Couto TR,Cury MC

    更新日期：2013-01-01 00:00:00

  • Identification and Expression Pattern of EZH2 in Pig Developing Fetuses.

    abstract：:The proper methylation status of histones is essential for appropriate cell lineage and organogenesis. EZH2, a methyltransferase catalyzing H3K27me3, has been abundantly studied in human and mouse embryonic development. The pig is an increasing important animal model for molecular study and pharmaceutical research. Ho...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2020/5315930

    authors： Tan B,Hong L,Qiao J,Zhou J,Xing P,Yan G,Zheng E,Cai G,Huang S,Wu Z,Gu T

    更新日期：2020-10-05 00:00:00

  • Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats.

    abstract：:This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as normal control, hepatic control, and ...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2015/356729

    authors： Akhter S,Rahman MA,Aklima J,Hasan MR,Chowdhury JM

    更新日期：2015-01-01 00:00:00

  • Minimally Invasive Surgical Treatment of Acute Epidural Hematoma: Case Series.

    abstract：:Background and Objective. Although minimally invasive surgical treatment of acute epidural hematoma attracts increasing attention, no generalized indications for the surgery have been adopted. This study aimed to evaluate the effects of minimally invasive surgery in acute epidural hematoma with various hematoma volume...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2016/6507350

    authors： Wang W

    更新日期：2016-01-01 00:00:00

  • Fbxw7 and Skp2 Regulate Stem Cell Switch between Quiescence and Mitotic Division in Lung Adenocarcinoma.

    abstract：Background/Aims:The molecular mechanism of dormancy initiation of cancer stem cells (CSCs) is not clear. This study was to explore the molecular mechanism by which CSCs switch from mitotic division to quiescence. Methods:MTT assays, flow cytometry, Western blotting, qRT-PCR, and immunofluorescence staining were used t...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/9648269

    authors： Zhang W,Ren Z,Jia L,Li X,Jia X,Han Y

    更新日期：2019-08-25 00:00:00

  • Reconstruction of cochlea based on micro-CT and histological images of the human inner ear.

    abstract：:The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly at...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2014/485783

    authors： Bellos C,Rigas G,Spiridon IF,Bibas A,Iliopoulou D,Böhnke F,Koutsouris D,Fotiadis DI

    更新日期：2014-01-01 00:00:00

  • Creating Well-Being: Increased Creativity and proNGF Decrease following Quadrato Motor Training.

    abstract：:Mind-body practices (MBP) are known to induce electrophysiological and morphological changes, whereas reports related to changes of neurotrophins are surprisingly scarce. Consequently, in the current paper, we focused on the Quadrato motor training (QMT), a newly developed whole-body movement-based MBP, which has been...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2015/275062

    authors： Venditti S,Verdone L,Pesce C,Tocci N,Caserta M,Ben-Soussan TD

    更新日期：2015-01-01 00:00:00

  • Prognostic Significance of Blood Transfusion in Newly Diagnosed Multiple Myeloma Patients without Autologous Hematopoietic Stem Cell Transplantation.

    abstract：:The aim of this study was to evaluate whether blood transfusions affect overall survival (OS) and progression-free survival (PFS) in newly diagnosed multiple myeloma (MM) patients without hematopoietic stem cell transplantation. A total of 181 patients were enrolled and divided into two groups: 68 patients in the tran...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2017/5462087

    authors： Fan L,Fu D,Zhang J,Huang H,Wang Q,Ye Y,Xie Q

    更新日期：2017-01-01 00:00:00

  • The investigation of quality of life in 87 Chinese patients with disorders of sex development.

    abstract：OBJECTIVE:In the process of care for disorders of sex development (DSD), clinical decisions should focus on the long-term quality of life (QOL). We sought to investigate the QOL of patients with DSD in China. DESIGN:Case-control study was carried out. PATIENTS:90 patients of DSD participated in the study. Finally, 87...

    journal_title：BioMed research international

    pub_type： 临床试验,杂志文章

    doi：10.1155/2015/342420

    authors： Wang C,Tian Q

    更新日期：2015-01-01 00:00:00

  • Long non-coding RNA deregulation in tongue squamous cell carcinoma.

    abstract：BACKGROUND:The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC). METHODS:Functional reannotation for the human lncRNA was carried out by ncFANs. Real-time quantitative PCR was used to v...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2014/405860

    authors： Gao W,Chan JY,Wong TS

    更新日期：2014-01-01 00:00:00

  • Knowledge, Awareness, and Health-Seeking Behaviour regarding Tuberculosis in a Rural District of Khyber Pakhtunkhwa, Pakistan.

    abstract：Background:Pakistan is a country with one of the highest burden of tuberculosis (TB) in the world, and therefore, it is imperative to revisit the design of behaviour change interventions in the program. This study was designed to understand and assess the knowledge, awareness, perceptions, and health-seeking behaviour ...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2020/1850541

    authors： Khan A,Shaikh BT,Baig MA

    更新日期：2020-04-21 00:00:00

  • Machine Learning in Ultrasound Computer-Aided Diagnostic Systems: A Survey.

    abstract：:The ultrasound imaging is one of the most common schemes to detect diseases in the clinical practice. There are many advantages of ultrasound imaging such as safety, convenience, and low cost. However, reading ultrasound imaging is not easy. To support the diagnosis of clinicians and reduce the load of doctors, many u...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2018/5137904

    authors： Huang Q,Zhang F,Li X

    更新日期：2018-03-04 00:00:00

  • Characterization of Positional Distribution of Fatty Acids and Triacylglycerol Molecular Compositions of Marine Fish Oils Rich in Omega-3 Polyunsaturated Fatty Acids.

    abstract：:The regiospecific characteristics of n-3 polyunsaturated fatty acids (PUFAs) in triacylglycerol (TAG) significantly affect the physicochemical and physiological properties of marine fish oils. In this study, the TAG molecular species composition and positional distributions of fatty acids were investigated in three ma...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2018/3529682

    authors： Zhang H,Zhao H,Zhang Y,Shen Y,Su H,Jin J,Jin Q,Wang X

    更新日期：2018-07-10 00:00:00

  • Peripheral leukocyte apoptosis in patients with Parkinsonism: correlation with clinical characteristics and neuroimaging findings.

    abstract：:Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and pre...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2014/635923

    authors： Lin WC,Tsai NW,Huang YC,Cheng KY,Chen HL,Li SH,Kung CT,Su YJ,Lin WM,Chen MH,Chiu TM,Yang IH,Lu CH

    更新日期：2014-01-01 00:00:00

  • Liver autophagy in anorexia nervosa and acute liver injury.

    abstract：:Autophagy, a lysosomal catabolic pathway for long-lived proteins and damaged organelles, is crucial for cell homeostasis, and survival under stressful conditions. During starvation, autophagy is induced in numerous organisms ranging from yeast to mammals, and promotes survival by supplying nutrients and energy. In the...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2014/701064

    authors： Kheloufi M,Boulanger CM,Durand F,Rautou PE

    更新日期：2014-01-01 00:00:00

  • Assessment of Corneal Pachymetry Distribution and Morphologic Changes in Subclinical Keratoconus with Normal Biomechanics.

    abstract：Purpose:To investigate the pachymetry distribution of central cornea and morphologic changes in subclinical keratoconus with normal biomechanics and determine their potential benefit for the screening of very early keratoconus. Methods:This retrospective comparative study was performed in 33 clinically unaffected eyes...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/1748579

    authors： Song P,Yang K,Li P,Liu Y,Liang D,Ren S,Zeng Q

    更新日期：2019-11-19 00:00:00

  • Black stain and dental caries: a review of the literature.

    abstract：:Black stain is characterized as a dark line or an incomplete coalescence of dark dots localized on the cervical third of the tooth. Over the last century, the etiology of black stain has been the subject of much debate. Most of the studies concerning this issue were conducted in pediatric population. According to the ...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2015/469392

    authors： Żyła T,Kawala B,Antoszewska-Smith J,Kawala M

    更新日期：2015-01-01 00:00:00

  • Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Gα16/gust44/pcDNA3.1 (+) Cells.

    abstract：:Bitterness is an important taste sensation for chickens, which provides useful sensory information for acquisition and selection of diet, and warns them against ingestion of potentially harmful and noxious substances in nature. Bitter taste receptors (T2Rs) mediate the recognition of bitter compounds belonging to a fa...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/6301915

    authors： Su Y,Jie H,Zhu Q,Zhao X,Wang Y,Yin H,Kumar Mishra S,Li D

    更新日期：2019-10-31 00:00:00

  • Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis.

    abstract：Background:According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body's internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association...

    journal_title：BioMed research international

    pub_type： 杂志文章,meta分析

    doi：10.1155/2020/3105248

    authors： Xiong J,Long J,Chen X,Li Y,Song H

    更新日期：2020-02-15 00:00:00

  • Preformulation studies for generic omeprazole magnesium enteric coated tablets.

    abstract：:Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr's index), Hauser's ratio (H), and sieve analysis were performed in order to determine the best excipients to be ...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2015/307032

    authors： Migoha CO,Ratansi M,Kaale E,Kagashe G

    更新日期：2015-01-01 00:00:00

  • Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters.

    abstract：:Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular c...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/8579619

    authors： Kim J,Choi SE,Lee KH,Jeong HJ,Shin JI,Lim BJ

    更新日期：2019-01-20 00:00:00

  • Links between Vitamin D Deficiency and Cardiovascular Diseases.

    abstract：:The aim of the present paper was to review the most important mechanisms explaining the possible association of vitamin D deficiency and cardiovascular diseases, focusing on recent experimental and clinical data. Low vitamin D levels favor atherosclerosis enabling vascular inflammation, endothelial dysfunction, format...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2015/109275

    authors： Mozos I,Marginean O

    更新日期：2015-01-01 00:00:00

  • Automatic Segmentation of Ultrasound Tomography Image.

    abstract：:Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2017/2059036

    authors： Wu S,Yu S,Zhuang L,Wei X,Sak M,Duric N,Hu J,Xie Y

    更新日期：2017-01-01 00:00:00

  • Increasing hematopoietic stem cell yield to develop mice with human immune systems.

    abstract：:Hematopoietic stem cells (HSCs) are unique in their capacity to give rise to all mature cells of the immune system. For years, HSC transplantation has been used for treatment of genetic and neoplastic diseases of the hematopoietic and immune systems. The sourcing of HSCs from human umbilical cord blood has salient adv...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2013/740892

    authors： Biancotti JC,Town T

    更新日期：2013-01-01 00:00:00

  • Odontogenic Abscess-Related Emergency Hospital Admissions: A Retrospective Data Analysis of 120 Children and Young People Requiring Surgical Drainage.

    abstract：Introduction:Even today, despite medical progress and intensive health education, odontogenic infections leading to surgical intervention and hospitalization are common in children and young people. The aim of this study was to give a detailed overview of clinical and economic data on children and young people treated ...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2018/3504727

    authors： Doll C,Carl F,Neumann K,Voss JO,Hartwig S,Waluga R,Heiland M,Raguse JD

    更新日期：2018-08-26 00:00:00

  • Removal of Cu, Zn, Pb, and Cr from Yangtze Estuary Using the Phragmites australis Artificial Floating Wetlands.

    abstract：:Contamination of heavy metals would threaten the water and soil resources; phytoremediation can be potentially used to remediate metal contaminated sites. We constructed the Phragmites australis artificial floating wetlands outside the Qingcaosha Reservoir in the Yangtze Estuary. Water characteristic variables were me...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2017/6201048

    authors： Huang X,Zhao F,Yu G,Song C,Geng Z,Zhuang P

    更新日期：2017-01-01 00:00:00

  • Serum CCL21 as a Potential Biomarker for Cognitive Impairment in Spinal Cord Injury.

    abstract：Objective:Cognitive impairment is considered to be an important complication of spinal cord injury (SCI), but its underlying mechanism remains unclear. The purpose of this study is to explore whether serum CCL21 can be used as a potential biomarker of cognitive impairment in SCI. Methods:In Neck-Shoulder and Lumbocrur...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2020/6692802

    authors： Chen Y,Liang L,Cao S,Hou G,Zhang Q,Ma H,Shi B

    更新日期：2020-12-09 00:00:00

  • Prediction of cardiovascular disease risk among low-income urban dwellers in metropolitan Kuala Lumpur, Malaysia.

    abstract：:We aimed to predict the ten-year cardiovascular disease (CVD) risk among low-income urban dwellers of metropolitan Malaysia. Participants were selected from a cross-sectional survey conducted in Kuala Lumpur. To assess the 10-year CVD risk, we employed the Framingham risk scoring (FRS) models. Significant determinants...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2015/516984

    authors： Su TT,Amiri M,Mohd Hairi F,Thangiah N,Bulgiba A,Majid HA

    更新日期：2015-01-01 00:00:00

  • The Use of Ropivacaine in Therapeutic Treatment of Oral Aphthosis.

    abstract：:The use of anaesthetic drugs in the treatment of oral aphthosis is one of the pharmaceutical possibilities that a doctor can use for the most painful forms. Normally, Lidocaine or Diclofenac is used to treat this disease, but they can be used for a very limited time and so they are of little practical use. In this stu...

    journal_title：BioMed research international

    pub_type： 临床试验,杂志文章

    doi：10.1155/2018/1868254

    authors： Gasparini G,Saponaro G,Gasparini D,Foresta E,Azzuni C,Adduci A,Boniello R,Moro A,De Angelis P,Di Nardo F,Damato G,Doneddu P,Todaro M,Garagiola U,Pelo S

    更新日期：2018-03-11 00:00:00