Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Gα16/gust44/pcDNA3.1 (+) Cells.

abstract：:A search for novel and more efficient therapeutic modalities of inflammatory bowel disease (IBD) is one of the most important tasks of contemporary medicine. The anti-inflammatory action of nicotine in IBD might be therapeutic, but its toxicity due to off-target and nonreceptor effects limited its use and prompted a s...

journal_title：BioMed research international

authors： Chernyavsky AI,Galitovskiy V,Shchepotin IB,Grando SA

更新日期：2014-01-01 00:00:00

abstract：:Contamination of heavy metals would threaten the water and soil resources; phytoremediation can be potentially used to remediate metal contaminated sites. We constructed the Phragmites australis artificial floating wetlands outside the Qingcaosha Reservoir in the Yangtze Estuary. Water characteristic variables were me...

journal_title：BioMed research international

authors： Huang X,Zhao F,Yu G,Song C,Geng Z,Zhuang P

更新日期：2017-01-01 00:00:00

abstract：:We review the recent literature concerning the efficiency of antimicrobial photodynamic inactivation toward various microbial species in planktonic and biofilm cultures. The review is mainly focused on biofilm-growing microrganisms because this form of growth poses a threat to chronically infected or immunocompromised...

journal_title：BioMed research international

authors： Taraszkiewicz A,Fila G,Grinholc M,Nakonieczna J

更新日期：2013-01-01 00:00:00

abstract：:Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-β (TGF-β). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts...

journal_title：BioMed research international

authors： Rodrigues-Diez R,Rodrigues-Diez RR,Lavoz C,Carvajal G,Droguett A,Garcia-Redondo AB,Rodriguez I,Ortiz A,Egido J,Mezzano S,Ruiz-Ortega M

更新日期：2014-01-01 00:00:00

abstract：:The use of endotamponade agents has gained a major role in the management of macular complications of high myopia. Myopic foveoschisis and macular hole are the main macular complication of pathologic myopia, this growing condition that is a main cause of visual loss, especially in patients at a younger age. We discuss...

journal_title：BioMed research international

authors： Valldeperas X,Lorenzo-Carrero J

更新日期：2014-01-01 00:00:00

abstract：:Accurate definition and better understanding of the mechanisms of stroke are crucial as this will guide the effective care and therapy. In this paper, we review the previous basic and clinical researches on the causes or mechanisms of ischemic cerebrovascular diseases (ICVD) and interpret the correlation between embol...

journal_title：BioMed research international

authors： Yu YP,Tan L

更新日期：2016-01-01 00:00:00

abstract：:The success rate of oral implants is lower in type 2 diabetes mellitus (T2DM) patients than in nondiabetic subjects; functional impairment of bone marrow-derived mesenchymal stem cells (BMSCs) is an important underlying cause. Many factors in the blood can act on BMSCs to regulate their biological functions and influe...

journal_title：BioMed research international

authors： Liang C,Sun R,Xu Y,Geng W,Li J

更新日期：2020-06-07 00:00:00

abstract：:Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be an important in microRNA let-7 expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (...

journal_title：BioMed research international

authors： Nagai T,Kanasaki M,Srivastava SP,Nakamura Y,Ishigaki Y,Kitada M,Shi S,Kanasaki K,Koya D

更新日期：2014-01-01 00:00:00

abstract：:Patients with clinical suspicion of large-vessel vasculitis (LVV) may present with nonspecific signs and symptoms and increased inflammatory parameters and may remain without diagnosis after routine diagnostic procedures. Both the nonspecificity of the radiopharmaceutical (18)F-FDG and the synergy of integrating funct...

journal_title：BioMed research international

authors： Balink H,Bennink RJ,van Eck-Smit BL,Verberne HJ

更新日期：2014-01-01 00:00:00

abstract：Purpose:Osteosarcoma is one of the most common primary malignant, aggressive bone neoplasms. However, the mechanisms of osteosarcoma proliferation, migration, and invasion are not well understood. To explore the possible mechanism of osteosarcoma progression, we used a public database for gene analysis to identify the ...

journal_title：BioMed research international

authors： Xu J,Xu G,Zhang T,Chen T,Zhao W,Wang G

更新日期：2019-11-30 00:00:00

abstract：:Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...

journal_title：BioMed research international

authors： Lee H,Kong SY,Sohn JY,Shim H,Youn HS,Lee S,Kim HJ,Eom HS

更新日期：2014-01-01 00:00:00

abstract：:Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease, which manifests as a succession of outbreaks. OLP was associated with salivary oxidative stress. Randomized, double blind, parallel-group study was performed. The sample consisted of 55 clinically and histopathologically diagnosed OLP patients. ...

journal_title：BioMed research international

authors： Tvarijonaviciute A,Aznar-Cayuela C,Rubio CP,Tecles F,Ceron JJ,López-Jornet P

更新日期：2018-05-27 00:00:00

abstract：:Melanoma is a human skin malignant tumor with high invasion and poor prognosis. The limited understanding of genomic alterations in melanomas in China impedes the diagnosis and therapeutic strategy selection. We conducted comprehensive genomic profiling of melanomas from 39 primary and metastatic formalin-fixed paraff...

journal_title：BioMed research international

authors： Luo Y,Zhang Z,Liu J,Li L,Xu X,Yao X,Dai Z,Wang X,Yang S,Wu H,Bu J,Wu Y,Xiang T,Li X

更新日期：2020-01-30 00:00:00

abstract：Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...

journal_title：BioMed research international

authors： Cannella V,Altomare R,Leonardi V,Russotto L,Di Bella S,Mira F,Guercio A

更新日期：2020-05-21 00:00:00

abstract：:D-Ribose is a five-carbon sugar and generally used as an energy source to improve athletic performance and the ability. The culture conditions for maximum D-ribose production performance from cheap raw material corn starch hydrolysate were improved by using one-factor-at-a-time experiments and a three-level Box-Behnke...

journal_title：BioMed research international

authors： Wei Z,Zhou J,Sun W,Cui F,Xu Q,Liu C

更新日期：2015-01-01 00:00:00

abstract：:Blood compatibility of metallocene polyethylene (mPE) was investigated after modifying the surface using hydrochloric acid. Contact angle of the mPE exposed to HCl poses a decrease in its value which indicates increasing wettability and better blood compatibility. Surface of mPE analyzed by using FTIR revealed no sign...

journal_title：BioMed research international

authors： Jaganathan SK,Mohandas H,Sivakumar G,Kasi P,Sudheer T,Avineri Veetil S,Murugesan S,Supriyanto E

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:This paper presents the final results of a cross-sectional study started in 2010. It compares the perceived efficacy of different types of tobacco health warning (texts versus shocking pictures) to quit or reduce tobacco use. METHODS:The study conducted between 2010 and 2012 in Italy enrolled adults smoke...

journal_title：BioMed research international

authors： Mannocci A,Colamesta V,Conti V,Cattaruzza MS,Paone G,Cafolla M,Saulle R,Bulzomì V,Antici D,Cuccurullo P,Boccia A,La Torre G,Terzano C

更新日期：2014-01-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects of emodin against SAP with SIRS. However, the exact mechanism unde...

journal_title：BioMed research international

authors： Wang GJ,Wang Y,Teng YS,Sun FL,Xiang H,Liu JJ,Xia SL,Zhang GX,Chen HL,Shang D

更新日期：2016-01-01 00:00:00

abstract：:Guanosine is an important building block for supramolecular gels owing to the unique self-assembly property that results from the unique hydrogen bond acceptors and donor groups. Guanosine-derived supramolecular hydrogels have promise in the fields of drug delivery, targeted release, tissue engineering applications, e...

journal_title：BioMed research international

authors： Chen M,Lin W,Hong L,Ji N,Zhao H

更新日期：2019-06-13 00:00:00

abstract：Background:Neighborhood destinations play important roles in daily activity levels of older adults. However, little is known about how specific destinations are associated with these activities and/or sedentary behaviors, especially in Asia. This study investigated how neighborhood destinations were associated with phy...

journal_title：BioMed research international

authors： Park JH,Park JH,Song S,Lai TF,Liao Y

更新日期：2020-07-30 00:00:00

abstract：:Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with ...

journal_title：BioMed research international

authors： Gaur PK,Mishra S,Bajpai M,Mishra A

更新日期：2014-01-01 00:00:00

abstract：:Detection of single based genetic mutation by using oligonucleotide probes is one of the common methods of detecting single nucleotide polymorphisms at known loci. In this paper, we demonstrated a hybridization system which included a buffer solution that produced selective salt-induced effect and a locked nucleic aci...

journal_title：BioMed research international

authors： Zhang J,Wu H,Chen Q,Zhao P,Zhao H,Yao W,Wei M

更新日期：2015-01-01 00:00:00

abstract：:Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...

journal_title：BioMed research international

authors： Amaya-Amaya J,Montoya-Sánchez L,Rojas-Villarraga A

更新日期：2014-01-01 00:00:00

abstract：:In this study dairy sludge was evaluated as an alternative cultivation medium for Rhizobium. Growth of bacterial strains at different concentrations of Dairy sludge was monitored. Maximum growth of all strains was observed at 60% Dairy sludge concentration. At 60% optical density (OD) values are 0.804 for Rhizobium tr...

journal_title：BioMed research international

authors： Singh AK,Singh G,Gautam D,Bedi MK

更新日期：2013-01-01 00:00:00

abstract：Introduction:Retinol Binding Protein 4 (RBP4) is mainly excreted by the kidney and plays a pivotal role in insulin resistance (IR). In our study, we evaluated the association between RBP4 and IR in hemodialysis subjects (HD). We also assessed how circulating RBP4 could be influenced by kidney transplant or different di...

journal_title：BioMed research international

authors： Grosjean F,Esposito P,Maccarrone R,Libetta C,Dal Canton A,Rampino T

更新日期：2017-01-01 00:00:00

abstract：:Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...

journal_title：BioMed research international

authors： de Souza Fernandez T,Fonseca Alvarenga T,Almeida Antônio de Kós E,Lamim Lovatel V,Tavares RC,da Costa ES,de Souza Fernandez C,Abdelhay E

更新日期：2019-12-10 00:00:00

abstract：OBJECTIVE:Radiopharmaceutical production process must adhere to current good manufacturing process (CGMP) compliance to ensure the quality of precursor, prodrug (active pharmaceutical ingredient, API), and the final drug product that meet acceptance criteria. We aimed to develop an automated system for production of CG...

journal_title：BioMed research international

authors： Chi YT,Chu PC,Chao HY,Shieh WC,Chen CC

更新日期：2014-01-01 00:00:00

abstract：:Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the...

journal_title：BioMed research international

authors： Malyshev I,Malyshev Y

更新日期：2015-01-01 00:00:00

abstract：:Keratinases are proteolytic enzymes predominantly active when keratin substrates are available that attack disulfide bridges in the keratin to convert them from complex to simplified forms. Keratinases are essential in preparation of animal nutrients, protein supplements, leather manufacture, textile processing, deter...

journal_title：BioMed research international

authors： Gopinath SC,Anbu P,Lakshmipriya T,Tang TH,Chen Y,Hashim U,Ruslinda AR,Arshad MK

更新日期：2015-01-01 00:00:00

abstract：Objective:The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature ...

journal_title：BioMed research international

authors： Yu X,Li X,Wang L,Liu R,Xie Y,Li S,Li J

更新日期：2019-03-21 00:00:00