Abstract:
:Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be an important in microRNA let-7 expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is a substrate of angiotensin-converting enzyme (ACE). Here, we found that AcSDKP inhibited the EndMT and exhibited fibrotic effects that were associated with FGF receptor-mediated anti-fibrotic program. Conventional ACE inhibitor plus AcSDKP ameliorated kidney fibrosis and inhibited EndMT compared to therapy with the ACE inhibitor alone in diabetic CD-1 mice. The endogenous AcSDKP levels were suppressed in diabetic animals. Cytokines induced cultured endothelial cells into EndMT; coincubation with AcSDKP inhibited EndMT. Expression of microRNA let-7 family was suppressed in the diabetic kidney; antifibrotic and anti-EndMT effects of AcSDKP were associated with the restoration of microRNA let-7 levels. AcSDKP restored diabetes- or cytokines-suppressed FGF receptor expression/phosphorylation into normal levels both in vivo and in vitro. These results suggest that AcSDKP is an endogenous antifibrotic molecule that has the potential to cure diabetic kidney fibrosis via an inhibition of the EndMT associated with the restoration of FGF receptor and microRNA let-7.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Nagai T,Kanasaki M,Srivastava SP,Nakamura Y,Ishigaki Y,Kitada M,Shi S,Kanasaki K,Koya Ddoi
10.1155/2014/696475subject
Has Abstractpub_date
2014-01-01 00:00:00pages
696475eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::The 3'-end processing (3'P) of each viral long terminal repeat (LTR) during human immunodeficiency virus type-1 (HIV-1) integration is a vital step in the HIV life cycle. Blocking the 3'P using 3'P inhibitor has recently become an attractive strategy for HIV-1 therapeutic intervention. Recently, we have developed a no...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/853891
更新日期:2015-01-01 00:00:00
abstract::Curcumin is a bright yellow compound found in Curcuma longa L., a member of the family Zingiberaceae. In the present study, we determined whether curcumin protects against oxidative stress in liver and brain in mice fed excessive alcohol. BALB/c mice were administered 20% alcohol (16 g/kg body weight) with or without ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/242671
更新日期:2013-01-01 00:00:00
abstract::Due to alarming increase in population and rapid industrialization, drinking water quality is being deteriorated day by day in Pakistan. This review sums up the outcomes of various research studies conducted for drinking water quality status of different areas of Pakistan by taking into account the physicochemical pro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7908183
更新日期:2017-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2014/479180.]. ...
journal_title:BioMed research international
pub_type: 撤回出版物
doi:10.1155/2016/4938464
更新日期:2016-01-01 00:00:00
abstract::Black stain is characterized as a dark line or an incomplete coalescence of dark dots localized on the cervical third of the tooth. Over the last century, the etiology of black stain has been the subject of much debate. Most of the studies concerning this issue were conducted in pediatric population. According to the ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/469392
更新日期:2015-01-01 00:00:00
abstract:Objective:Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods:In this retrospe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052143
更新日期:2020-08-13 00:00:00
abstract::The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly. We detected the expression level of SNHG12 in PCa tissues and matched adjacent normal tissues that were collected ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812923
更新日期:2020-12-22 00:00:00
abstract::One of the most important tasks of a living organism is to maintain its genetic integrity with respect to stress. Endoplasmic reticulum (ER) has a crucial role in sensing cellular homeostasis by controlling metabolism, proteostasis, and several signaling processes. ER stressors can induce autophagy-dependent survival;...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/319589
更新日期:2015-01-01 00:00:00
abstract::The laser speckle contrast imaging (LSCI) is proved to be a reliable tool in flap monitoring in general surgery; however, it has not been evaluated in oral surgery yet. We applied the LSCI to compare the effect of a xenogeneic collagen matrix (Geistlich Mucograft®) to connective tissue grafts (CTG) on the microcircula...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4042902
更新日期:2017-01-01 00:00:00
abstract::Craniofacial reconstruction is to estimate a person's face model from the skull. It can be applied in many fields such as forensic medicine, archaeology, and face animation. Craniofacial reconstruction is based on the relationship between the skull and the face to reconstruct the facial appearance from the skull. Howe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8835179
更新日期:2020-12-04 00:00:00
abstract::Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltrati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1267038
更新日期:2018-10-08 00:00:00
abstract:Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7146028
更新日期:2020-03-07 00:00:00
abstract::Majority of gram negative pathogenic bacteria are responsible for extended spectrum β-lactamases (ESBLs) production, which show resistance to some newer generation of antibiotics. The study was aimed at evaluating the prevalence of ESBL and antibiotic susceptibility pattern of Pseudomonas isolates collected during 201...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6068429
更新日期:2016-01-01 00:00:00
abstract::Type 1 diabetes (T1D), a chronic autoimmune disease, is often preceded by a preclinical phase of islet autoimmunity (IA) where the insulin-producing beta cells of the pancreas are destroyed and circulating autoantibodies can be detected. The goal of this study was to demonstrate methods for identifying exposures that ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2015/708289
更新日期:2015-01-01 00:00:00
abstract:Background:Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clinical characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. Methods:A retrospec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9742754
更新日期:2020-09-14 00:00:00
abstract::VEGF-NO axis uncoupling is an important pathogenesis for DN. Reduced β2GPI could play a part in VEGF signaling pathway and has a protective effect on diabetic vascular disease. This study investigates the effect of reduced β2GPI on glomerular mesangial cells VEGF-NO axis uncoupling induced by high glucose. Compared to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5484731
更新日期:2018-07-18 00:00:00
abstract::It is widely reported that miR-381 is dysregulated in various tumors. However, the specific role of miR-381 in respiratory infections has not been reported. To probe this role, A549 cells were pretreated with 1 μg/mL LPS for 24 h. The level of miR-381 was detected using RT-qPCR. The expression of proinflammatory cytok...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/849475
更新日期:2015-01-01 00:00:00
abstract::The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections, are reported to have low bioavailability pertaining to high first-pass metabolism, high protein binding, and enzymatic metabolism. They also show low permeability across blood brain barrier. The CNS is reported to be the most...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5984014
更新日期:2017-01-01 00:00:00
abstract::Until now, the chemical bonding between titanium and bone has been examined only through a few mechanical detachment tests. Therefore, in this study, a sandblasted and acid-etched titanium mini-implant was removed from a human patient after 2 months of placement in order to identify the chemical integration mechanism ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/960410
更新日期:2015-01-01 00:00:00
abstract:Background:The predictive values of monocytes in the prognosis of patients with acute paraquat (PQ) poisoning are unclear. This retrospective study investigated the predictive values of monocytes in the prognosis of patients with acute PQ poisoning. Methods:Adult patients who suffered from acute PQ poisoning in the em...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/6360459
更新日期:2019-07-15 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation has been identified as an important initiator of skeletal damage in RA. Iguratimod (T-614) is an anti-inflammatory agent which has been reported to show the inhibitory effect of bone destruction in RA. Ho...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4901591
更新日期:2018-02-19 00:00:00
abstract::The purpose of this paper is to review some of the psychological and neural mechanisms behind mindfulness practice in order to explore the unique factors that account for its positive impact on emotional regulation and health. After reviewing the mechanisms of mindfulness and its effects on clinical populations we wil...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/670724
更新日期:2015-01-01 00:00:00
abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2607928
更新日期:2018-06-14 00:00:00
abstract::The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE in villous 3A first trimester trophoblast cells expos...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/257090
更新日期:2015-01-01 00:00:00
abstract::The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/261745
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Abnormal expression of ABCA1 and ABCG1 in the placenta can elicit lipid metabolism disorder and adverse pregnancy outcomes. However, whether it is associated with preterm delivery remains unclear. Our present study aimed to evaluate the relationship between abnormal expression of ABCA1 or ABCG1 and preterm de...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/8248094
更新日期:2017-01-01 00:00:00
abstract::Introduction. The triangular fibrocartilage complex (TFCC) provides both mobility and stability of the radiocarpal joint. TFCC lesions are difficult to diagnose due to the complex anatomy. The standard treatment for TFCC lesions is arthroscopy, posing surgery-related risks onto the patients. This feasibility study aim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5870875
更新日期:2017-01-01 00:00:00
abstract::The proper functioning of a hospital computer system is an arduous work for managers and staff. However, inconsistent policies are frequent and can produce enormous problems, such as stolen information, frequent failures, and loss of the entire or part of the hospital data. This paper presents a new method named EMRlo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/542016
更新日期:2015-01-01 00:00:00
abstract::Application of enzymes in biotechnological process has expanded considerably in recent years. In food and related industry, major importance was being attached to the use of enzymes in upgrading quality, increasing yields of extractive processes, product stabilization, and improvement of flavor and byproduct utilizati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2961767
更新日期:2018-04-03 00:00:00
abstract::We performed a retrospective review of 40 consecutive modern cementless THAs with 65-month mean followup in 34 patients under the age of 30 primarily for diagnoses other than inflammatory arthritis. We found acceptable functional improvement and radiographic outcomes at mean 5-year followup. We found a high transfusio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/649506
更新日期:2013-01-01 00:00:00