Abstract:
:Type 1 diabetes (T1D), a chronic autoimmune disease, is often preceded by a preclinical phase of islet autoimmunity (IA) where the insulin-producing beta cells of the pancreas are destroyed and circulating autoantibodies can be detected. The goal of this study was to demonstrate methods for identifying exposures that differentially influence the disease process at certain ages by assessing age-related heterogeneity. The Diabetes Autoimmunity Study in the Young (DAISY) has followed 2,547 children at increased genetic risk for T1D from birth since 1993 in Denver, Colorado, 188 of whom developed IA. Using the DAISY population, we evaluated putative determinants of IA, including non-Hispanic white (NHW) ethnicity, maternal age at birth, and erythrocyte membrane n-3 fatty acid (FA) levels, for age-related heterogeneity. A supremum test, weighted Schoenfeld residuals, and restricted cubic splines were used to assess nonproportional hazards, that is, an age-related association of the exposure with IA risk. NHW ethnicity, maternal age, and erythrocyte membrane n-3 FA levels demonstrated a significant age-related association with IA risk. Assessing heterogeneity in disease etiology enables researchers to identify associations that may lead to better understanding of complex chronic diseases.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Frederiksen BN,Kroehl M,Barón A,Lamb MM,Crume TL,Sontag MK,Rewers M,Norris JMdoi
10.1155/2015/708289subject
Has Abstractpub_date
2015-01-01 00:00:00pages
708289eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
临床试验,杂志文章,多中心研究abstract:Aims:The purpose of this study was to describe the challenge of cross-cultural care encounters from perspective of imported nurses in Lhasa, Tibet, as well as investigate the relationship of cross-cultural care encounters and its influencing factors. Methods:A cross-sectional survey was designed among 300 imported nur...
journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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doi:10.1155/2013/630803
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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