Prevalence of Extended Spectrum β-Lactamase and Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas from Patients of Khyber Pakhtunkhwa, Pakistan.

Abstract:

:Majority of gram negative pathogenic bacteria are responsible for extended spectrum β-lactamases (ESBLs) production, which show resistance to some newer generation of antibiotics. The study was aimed at evaluating the prevalence of ESBL and antibiotic susceptibility pattern of Pseudomonas isolates collected during 2010 to 2014 from tertiary care hospitals of Peshawar, Pakistan. Out of 3450 samples, 334 Pseudomonas spp. isolates comprised of 232 indoor and 102 outdoor patients were obtained from different specimens and their susceptibility pattern was determined against 20 antibiotics. Antimicrobial susceptibility testing was carried out using the Kirby-Bauer agar diffusion method and ESBL production was detected by Synergy Disc Diffusion technique. The mean age group of the patients was 29.9 + 9.15 years. Meronem showed best activity (91.02%) from class carbapenem, β-lactam and β-lactamase inhibitors exhibited 69.16% activity, and doxycycline had a diminished activity (10.18%) to Pseudomonas spp. Outdoor isolates were more resistant than the indoor and during the course of the study the sensitivity rate of antibiotics was gradually reducing. ESBL production was observed in 44.32% while the remaining was non-ESBL. The moderate active antibiotics were amikacin (50.7%), SCF (51.4%), TZP (52.7%), and MXF (54.1%) among ESBL producing isolates. Lack of antibiotic policy, irrational uses (3GCs particularly), and the emergence of antibiotic resistant organisms in hospitals may be causes of high antibiotic resistance.

journal_name

Biomed Res Int

authors

Ahmad M,Hassan M,Khalid A,Tariq I,Asad MH,Samad A,Mahmood Q,Murtaza G

doi

10.1155/2016/6068429

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

6068429

eissn

2314-6133

issn

2314-6141

journal_volume

2016

pub_type

杂志文章
  • Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion.

    abstract::CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4093435

    authors: Garay-Canales CA,Licona-Limón I,Ortega E

    更新日期:2018-03-29 00:00:00

  • Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells.

    abstract:Background:Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formatio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6069390

    authors: Li T,Huang Y,Zhou W,Yan Q

    更新日期:2020-03-16 00:00:00

  • Identification and Verification of Core Genes in Colorectal Cancer.

    abstract::Colorectal cancer, a malignant neoplasm that occurs in the colorectal mucosa, is one of the most common types of gastrointestinal cancer. Colorectal cancer has been studied extensively, but the molecular mechanisms of this malignancy have not been characterized. This study identified and verified core genes associated...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8082697

    authors: Xu H,Ma Y,Zhang J,Gu J,Jing X,Lu S,Fu S,Huo J

    更新日期:2020-05-08 00:00:00

  • Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis.

    abstract::Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC. Brain-derived neurotrophic factor (BDNF), b...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4193541

    authors: Lombardi M,D'Ascanio M,Scarpino S,Scozzi D,Giordano M,Costarelli L,Raj ER,Mancini R,Cardillo G,Cardaci V,Innammorato M,Vecchione A,Ricci A

    更新日期:2020-11-17 00:00:00

  • EEG-Based Computer Aided Diagnosis of Autism Spectrum Disorder Using Wavelet, Entropy, and ANN.

    abstract::Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder with core impairments in the social relationships, communication, imagination, or flexibility of thought and restricted repertoire of activity and interest. In this work, a new computer aided diagnosis (CAD) of autism ‎based on electroencephalogra...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/9816591

    authors: Djemal R,AlSharabi K,Ibrahim S,Alsuwailem A

    更新日期:2017-01-01 00:00:00

  • Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging.

    abstract::The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/632570

    authors: Oliveira MB,do Prado AH,Bernegossi J,Sato CS,Lourenço Brunetti I,Scarpa MV,Leonardi GR,Friberg SE,Chorilli M

    更新日期:2014-01-01 00:00:00

  • A Bibliometric Analysis of Publications on Oxycodone from 1998 to 2017.

    abstract:Background:Oxycodone is a widely used opioid analgesic, which is involved in cancer pain and non-cancer pain. This study is intended to understand the publication characteristics of oxycodone research field and assess the quality of pertinent articles from 1998 to 2017. Methods:Oxycodone-related publications from 1998...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9096201

    authors: Lei F,Ye J,Wang J,Xia Z

    更新日期:2019-10-31 00:00:00

  • Inflammation-related effects of diesel engine exhaust particles: studies on lung cells in vitro.

    abstract::Diesel exhaust and its particles (DEP) have been under scrutiny for health effects in humans. In the development of these effects inflammation is regarded as a key process. Overall, in vitro studies report similar DEP-induced changes in markers of inflammation, including cytokines and chemokines, as studies in vivo. I...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/685142

    authors: Schwarze PE,Totlandsdal AI,Låg M,Refsnes M,Holme JA,Øvrevik J

    更新日期:2013-01-01 00:00:00

  • Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms.

    abstract::The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different conce...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/941318

    authors: Fabri RL,Aragão DM,Florêncio JR,Pinto Nde C,Mattos AC,Coelho PM,Castañon MC,Vasconcelos EG,Pinto Pde F,Scio E

    更新日期:2014-01-01 00:00:00

  • A Computer-Aided Analysis Method of SPECT Brain Images for Quantitative Treatment Monitoring: Performance Evaluations and Clinical Applications.

    abstract::The objective and quantitative analysis of longitudinal single photon emission computed tomography (SPECT) images are significant for the treatment monitoring of brain disorders. Therefore, a computer aided analysis (CAA) method is introduced to extract a change-rate map (CRM) as a parametric image for quantifying the...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/1962181

    authors: Zheng X,Wei W,Huang Q,Song S,Wan J,Huang G

    更新日期:2017-01-01 00:00:00

  • Circulating Tumour Cells, Circulating Tumour DNA and Circulating Tumour miRNA in Blood Assays in the Different Steps of Colorectal Cancer Management, a Review of the Evidence in 2019.

    abstract::Despite many advances in the diagnosis and treatment of colorectal cancer (CRC), its incidence and mortality rates continue to make an impact worldwide and in some countries rates are mounting. Over the past decade, liquid biopsies have been the object of fundamental and clinical research with regard to the different ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/5953036

    authors: Christou N,Meyer J,Popeskou S,David V,Toso C,Buchs N,Liot E,Robert J,Ris F,Mathonnet M

    更新日期:2019-12-04 00:00:00

  • Potentiated Osteoinductivity via Cotransfection with BMP-2 and VEGF Genes in Microencapsulated C2C12 Cells.

    abstract::Microcapsules with entrapped cells hold great promise for repairing bone defects. Unfortunately, the osteoinductivity of microcapsules has been restricted by many factors, among which the deficiency of functional proteins is a significant priority. We potentiated the osteoinductivity of microencapsulated cells via cot...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/435253

    authors: Shen Y,Qiao H,Fan Q,Zhang S,Tang T

    更新日期:2015-01-01 00:00:00

  • Andrographolide Inhibits Proliferation and Metastasis of SGC7901 Gastric Cancer Cells.

    abstract::To explore the mechanisms by which andrographolide inhibits gastric cancer cell proliferation and metastasis, we employed the gastric cell line SGC7901 to investigate the anticancer effects of andrographolide. The cell survival ratio, cell migration and invasion, cell cycle, apoptosis, and matrix metalloproteinase act...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6242103

    authors: Dai L,Wang G,Pan W

    更新日期:2017-01-01 00:00:00

  • Tranexamic Acid Combined with Compression Bandage Following Total Knee Arthroplasty Promotes Blood Coagulation: A Retrospective Analysis.

    abstract:Objective:This paper included a retrospective review of the effect of tranexamic acid (TXA) combined with pressure bandaging on hemostasis of patients who received a unilateral total knee arthroplasty (TKA) from 2017 to 2019. Methods:A total of 197 patients undergoing TKA were chosen to be classified into 2 groups, th...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/2739560

    authors: Li GH,Ding LM,Sun L,Wang F

    更新日期:2020-11-02 00:00:00

  • miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1.

    abstract::MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistanc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/373574

    authors: Long J,Ji Z,Jiang K,Wang Z,Meng G

    更新日期:2015-01-01 00:00:00

  • Performance study of chromium (VI) removal in presence of phenol in a continuous packed bed reactor by Escherichia coli isolated from East Calcutta Wetlands.

    abstract::Organic pollutants, like phenol, along with heavy metals, like chromium, are present in various industrial effluents that pose serious health hazard to humans. The present study looked at removal of chromium (VI) in presence of phenol in a counter-current continuous packed bed reactor packed with E. coli cells immobil...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/373412

    authors: Chakraborty B,Indra S,Hazra D,Betai R,Ray L,Basu S

    更新日期:2013-01-01 00:00:00

  • The Physical Activity Type Most Related to Cognitive Function and Quality of Life.

    abstract:Background:Physical activity has been found to maintain and improve cognitive function and consequently improve health-related quality of life (HRQoL). The relationships between different types of physical activities, cognitive function, and HRQoL have not been studied sufficiently and compared in different age and gen...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8856284

    authors: Alsubaie SF,Alkathiry AA,Abdelbasset WK,Nambi G

    更新日期:2020-12-18 00:00:00

  • The relationship between Helicobacter pylori and beta-2 microglobulin in humans.

    abstract:UNLABELLED:H. pylori is related to various gastrointestinal diseases. β₂ Microglobulin (β 2M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β₂M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β₂M and H. pylori bearing CagA strains....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/615089

    authors: Yeniova AÖ,Kucukazman M,Ata N,Dal K,Kefeli A,Başyiğit S,Aktaş B,Akın KO,Nazlıgül Y

    更新日期:2014-01-01 00:00:00

  • The differential effects of a selective kappa-opioid receptor agonist, U50488, in guinea pig heart tissues.

    abstract::The differential effects of a selective kappa- (κ-) opioid receptor agonist, U50488, were elucidated by monitoring the contraction of isolated guinea pig atrial and ventricular muscles. In electrically driven left atria, U50488 in nanomolar concentration range decreased the contractile force. Norbinaltorphimine (norBN...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/906039

    authors: Hung CF,Li HJ,Chang HH,Lee GA,Su MJ

    更新日期:2015-01-01 00:00:00

  • The Clinical Characteristics and Treatment of Cerebral Microarteriovenous Malformation Presenting with Intracerebral Hemorrhage: A Series of 13 Cases.

    abstract:OBJECT:The aim of this report was to explore the clinical presentation, radiological features, treatment methods, and outcome of micro-AVMs presenting with intracerebral hemorrhage. METHODS:The clinical data, radiological features, treatment, and follow-up results for a consecutive series of 13 cases with micro-AVMs w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/257153

    authors: Hong JF,Song YF,Liu HB,Liu Z,Wang SS

    更新日期:2015-01-01 00:00:00

  • Recombinant dense granular protein (GRA5) for detection of human toxoplasmosis by Western blot.

    abstract::Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/690529

    authors: Ching XT,Lau YL,Fong MY,Nissapatorn V,Andiappan H

    更新日期:2014-01-01 00:00:00

  • A Meta-Analysis of Different Types of Cardiac Adipose Tissue in HIV Patients.

    abstract:Background:Antiretroviral therapy transformed HIV infection into a chronic disease but accelerated cardiovascular disease (CVD). Both of epicardial adipose tissue (EAT) and pericardial fat (PCF) have close relationships with CVD. The associations between these two cardiac adipose tissue and HIV are unclear. Methods:El...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/8234618

    authors: Song G,Qiao W,Sun L,Yu X

    更新日期:2020-12-09 00:00:00

  • Comparison of two reconstructive techniques in the surgical management of four-level cervical spondylotic myelopathy.

    abstract::To compare the clinical efficacy and radiological outcome of treating 4-level cervical spondylotic myelopathy (CSM) with either anterior cervical discectomy and fusion (ACDF) or "skip" corpectomy and fusion, 48 patients with 4-level CSM who had undergone ACDF or SCF at our hospital were analyzed retrospectively betwee...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/513906

    authors: Li F,Li Z,Huang X,Chen Z,Zhang F,Shen H,Kang Y,Zhang Y,Cai B,Hou T

    更新日期:2015-01-01 00:00:00

  • Hepatoprotective and antioxidant effect of Bauhinia hookeri extract against carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive compounds by HPLC-PDA-ESI-MS/MS.

    abstract::The hepatoprotective and antioxidant activity of Bauhinia hookeri ethanol extract (BHE) against CCl4-induced liver injury was investigated in mice. BHE was administered (500 and 1000 mg/kg/day) along with CCl4 for 6 weeks. The hepatic marker enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), an...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/245171

    authors: Al-Sayed E,Martiskainen O,Seif el-Din SH,Sabra AN,Hammam OA,El-Lakkany NM,Abdel-Daim MM

    更新日期:2014-01-01 00:00:00

  • Factors affecting graft survival among patients receiving kidneys from live donors: a single-center experience.

    abstract:INTRODUCTION:The aim of this report is to study the graft and patient survival in a large cohort of recipients with an analysis of factors that may affect the final outcomes. METHODS:Between March 1976 and March 2008, 1967 consecutive live-donor renal transplants were carried out. Various variables that may have an im...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/912413

    authors: Ghoneim MA,Bakr MA,Refaie AF,Akl AI,Shokeir AA,Shehab El-Dein AB,Ammar HM,Ismail AM,Sheashaa HA,El-Baz MA

    更新日期:2013-01-01 00:00:00

  • 3D Culture of MIN-6 Cells on Decellularized Pancreatic Scaffold: In Vitro and In Vivo Study.

    abstract::Type 1 diabetes is an autoimmune disease which is due to the lack of β cells. The ideal therapy to cure the disease is pancreas transplantation, but its application is confined to a limited number of people due to the shortage of organ and the need for life-long immunosuppression. Regenerative medicine methods such as...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/432645

    authors: Wu D,Wan J,Huang Y,Guo Y,Xu T,Zhu M,Fan X,Zhu S,Ling C,Li X,Lu J,Zhu H,Zhou P,Lu Y,Wang Z

    更新日期:2015-01-01 00:00:00

  • Antimania-Like Effect of Panax ginseng Regulating the Glutamatergic Neurotransmission in REM-Sleep Deprivation Rats.

    abstract::Previous studies have shown the therapeutic properties of ginseng and ginsenosides on hyperactive and impulsive behaviors in several psychiatric diseases. Herein, we investigated the effect of Panax ginseng Meyer (PG) on hyperactive/impulsive behaviors in a manic-like animal model, sleep deprivation (SD) rats. Male ra...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3636874

    authors: Leem KH,Kim SA,Park HJ

    更新日期:2020-10-17 00:00:00

  • Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer.

    abstract:Background:Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectab...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6278403

    authors: D'Ascanio M,Pezzuto A,Fiorentino C,Sposato B,Bruno P,Grieco A,Mancini R,Ricci A

    更新日期:2018-08-27 00:00:00

  • Aesthetic evaluation of the nasolabial region in children with unilateral cleft lip and palate comparing expert versus nonexperience health professionals.

    abstract::Esthetic evaluation of cleft lip and palate rehabilitation outcomes may assist in the determination of new surgical interventions and aid in reevaluation of treatment protocols. Our objective was to compare esthetics assessments of the nasolabial region in children with a unilateral cleft lip and palate between health...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/460106

    authors: Paiva TS,Andre M,Paiva WS,Mattos BS

    更新日期:2014-01-01 00:00:00

  • Current Approach in the Diagnosis and Management of Uveitic Glaucoma.

    abstract::Uveitic glaucoma (UG) typically is associated with very high intraocular pressure (IOP) and more intense optic nerve damage than other glaucoma types. This secondary glaucoma requires an early diagnosis and adequate management of both uveitis and glaucoma. It is mandatory to identify the mechanisms of IOP elevation th...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/742792

    authors: Muñoz-Negrete FJ,Moreno-Montañés J,Hernández-Martínez P,Rebolleda G

    更新日期:2015-01-01 00:00:00