Abstract:
:Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the proinflammatory M1 phenotype or toward the anti-inflammatory M2 phenotype. Macrophage reprogramming involves well-coordinated changes in activities of signalling and posttranslational mechanisms. Macrophage reprogramming is provided by JNK-, PI3K/Akt-, Notch-, JAK/STAT-, TGF-β-, TLR/NF-κB-, and hypoxia-dependent pathways. Posttranscriptional regulation is based on micro-mRNA. We have hypothesized that, in addition to the M1 and M2 phenotypes, an M3 switch phenotype exists. This switch phenotype responds to proinflammatory stimuli with reprogramming towards the anti-inflammatory M2 phenotype or, contrarily, it responds to anti-inflammatory stimuli with reprogramming towards the proinflammatory M1 phenotype. We have found signs of such a switch phenotype in lung diseases. Understanding the mechanisms of macrophage reprogramming will assist in the selection of new therapeutic targets for correction of impaired immunity.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Malyshev I,Malyshev Ydoi
10.1155/2015/341308subject
Has Abstractpub_date
2015-01-01 00:00:00pages
341308eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract:Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6096280
更新日期:2020-12-29 00:00:00
abstract::Objective. This study aims to extract motor ingredients through data mining from wearable sensors in a virtual reality goal-directed shoulder rehabilitation (GDSR) system and to examine their effects toward clinical assessment. Design. A single-group before/after comparison. Setting. Outpatient research hospital. Subj...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7075464
更新日期:2016-01-01 00:00:00
abstract::Significant positive effects, particularly on psychological state in patients who completed the follow-up pulmonary rehabilitation programs, are indicated by a large number of studies. Yet, a remarkable proportion of selected patients drop out from these programs. In this study, we investigated existing differences on...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/401326
更新日期:2014-01-01 00:00:00
abstract::Type 1 diabetes (T1D), a chronic autoimmune disease, is often preceded by a preclinical phase of islet autoimmunity (IA) where the insulin-producing beta cells of the pancreas are destroyed and circulating autoantibodies can be detected. The goal of this study was to demonstrate methods for identifying exposures that ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2015/708289
更新日期:2015-01-01 00:00:00
abstract::The present study deals with the enzymatic synthesis of biodiesel by transesterification of Jatropha oil (Jatropha curcas L.) with ethanol in a solvent-free system. Seven commercial lipase preparations immobilized by covalent attachment on epoxy-polysiloxane-polyvinyl alcohol composite (epoxy-SiO2-PVA) were tested as ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1404567
更新日期:2016-01-01 00:00:00
abstract::This paper presents an ultrasound simulation model for pulsatile blood flow, modulated by the motion of a stenosed vessel wall. It aims at generating more realistic ultrasonic signals to provide an environment for evaluating ultrasound signal processing and imaging and a framework for investigating the behaviors of bl...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8502873
更新日期:2016-01-01 00:00:00
abstract:Objective:The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/8498603
更新日期:2019-03-21 00:00:00
abstract::Introduction. This study aimed to evaluate the effects of resorbable blasting media (RBM) treatment on early stability of orthodontic mini-implants by mechanical, histomorphometric, and histological analyses. Methods. Ninety-six (64 for mechanical study and 32 for histological study and histomorphometric analysis) tit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7520959
更新日期:2016-01-01 00:00:00
abstract::The laser speckle contrast imaging (LSCI) is proved to be a reliable tool in flap monitoring in general surgery; however, it has not been evaluated in oral surgery yet. We applied the LSCI to compare the effect of a xenogeneic collagen matrix (Geistlich Mucograft®) to connective tissue grafts (CTG) on the microcircula...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4042902
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To distinguish between normal (SV-HUC-1) and cancerous (TCCSUP) human urothelial cell lines using microelectrical impedance spectroscopy (μEIS). MATERIALS AND METHODS:Two types of μEIS devices were designed and used in combination to measure the impedance of SV-HUC-1 and TCCSUP cells flowing through the channe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8748023
更新日期:2016-01-01 00:00:00
abstract::Nonlinear contrast-enhanced ultrasound imaging schemes strive to suppress tissue signals in order to better visualize nonlinear signals from blood-pooling ultrasound contrast agents. Because tissue does not generate a subharmonic response (i.e., signal at half the transmit frequency), subharmonic imaging has been prop...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/640397
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:While studies using various materials to overcome ischemia-reperfusion (IR) injury are becoming increasingly common, studies on the effects of botulinum toxin A (BoTA) on IR injury in musculocutaneous flaps are still limited. The purpose of this study was to examine our hypotheses that BoTA provide protect...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1074178
更新日期:2017-01-01 00:00:00
abstract::Trichoderma spp. are important biocontrol filamentous fungi, which are widely used for their adaptability, broad antimicrobial spectrum, and various antagonistic mechanisms. In our previous studies, we cloned thga1 gene encoding GαI protein from Trichoderma harzianum Th-33. Its knockout mutant showed that the growth r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8329513
更新日期:2016-01-01 00:00:00
abstract::In esophageal squamous cell carcinoma, an elevated preoperative absolute monocyte count (Pre-AMC) is reported to be a predictor of survival, but the clinical application of postoperative absolute monocyte count change (AMCc) remains unknown. The present study was designed to investigate the prognostic value of AMCc in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2702719
更新日期:2019-08-14 00:00:00
abstract::One common negative side effect of orthodontic treatment with fixed appliances is the development of white spot lesions (WSLs) around brackets. This study is aimed at comparing the efficacy of various oral hygiene practices in preventing enamel demineralization around orthodontic brackets under similar in vitro condit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1989817
更新日期:2020-03-30 00:00:00
abstract::Trichoderma spp. are important biocontrol filamentous fungi and have tremendous potential in soil bioremediation. In our previous studies, a C2H2 type transcription factor coding gene (thmea1) was cloned from a biocontrol agent T. harzianum Th-33; the encoded sequence of thmea1 contained 3 conserved C2H2 domains with ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8149682
更新日期:2018-07-18 00:00:00
abstract::Microcapsules with entrapped cells hold great promise for repairing bone defects. Unfortunately, the osteoinductivity of microcapsules has been restricted by many factors, among which the deficiency of functional proteins is a significant priority. We potentiated the osteoinductivity of microencapsulated cells via cot...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/435253
更新日期:2015-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract::A large number of occupational exposure limit values (OELs) are based on avoiding of sensory irritation of the eyes and the upper respiratory tract. In order to investigate the chemosensory effect range of a chemical, odor and sensory irritation thresholds (lateralization thresholds, LTs) can be assessed. Humidity aff...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/6015761
更新日期:2016-01-01 00:00:00
abstract::The purpose of the study is to evaluate the relationship between NIH-CPSI and IIEF-5 in Chinese men with CP/CPPS. A large cross-sectional and multicenter survey was conducted from July 2012 to January 2014. Men were recruited from urology clinics which were located at the five cities in China. All men participated in ...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/560239
更新日期:2015-01-01 00:00:00
abstract::The aim of the present study was to evaluate the antitumor potential of iminoflavones in in vitro and in vivo anticancer models. Preliminary screening in various cancer cell lines revealed four potential iminoflavones out of which IMF-8 was taken based on its activity against colon cancer cells. This was further confi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569130
更新日期:2014-01-01 00:00:00
abstract::A prospective nonrandomized controlled study was conducted to explore the association between ocular dominance and degree of myopia in patients with anisometropia and to investigate the character of visual evoked potential (VEP) in high anisometropias. 1771 young myopia cases including 790 anisometropias were recruite...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5064892
更新日期:2016-01-01 00:00:00
abstract:Purpose:To investigate the pachymetry distribution of central cornea and morphologic changes in subclinical keratoconus with normal biomechanics and determine their potential benefit for the screening of very early keratoconus. Methods:This retrospective comparative study was performed in 33 clinically unaffected eyes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1748579
更新日期:2019-11-19 00:00:00
abstract::External focus of attention (EFA) and internal focus of attention (IFA) represent commonly used strategies to instruct subjects during exercise. Several studies showed EFA to be more effective than IFA to improve motor performance and learning. To date the role of these strategies on motor performance during finger mo...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/2946465
更新日期:2017-01-01 00:00:00
abstract::Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 (EZR-AS1) is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6840234
更新日期:2020-05-22 00:00:00
abstract::Contamination of heavy metals would threaten the water and soil resources; phytoremediation can be potentially used to remediate metal contaminated sites. We constructed the Phragmites australis artificial floating wetlands outside the Qingcaosha Reservoir in the Yangtze Estuary. Water characteristic variables were me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6201048
更新日期:2017-01-01 00:00:00
abstract:Introduction:Rapid eye movement sleep behavior disorder (RBD) is characterized by dream-enacting behavior (shouting, punching, and falling out of bed) related to unpleasant dreams and loss of normal rapid eye movement (REM) sleep muscle atonia. Rapid eye movement sleep enhances learning and memory by regulating neurona...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1810836
更新日期:2020-05-15 00:00:00
abstract::Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6875968
更新日期:2017-01-01 00:00:00
abstract::Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown. This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4375075
更新日期:2020-11-14 00:00:00
abstract::Adult orthodontics may confront problems related to the bonding performance of orthodontic brackets to new generation restorative materials used for crown or laminate restorations. The aim of the present study was to investigate the shear bond strength of ceramic brackets to two new generation CAD/CAM interpenetrating...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1871598
更新日期:2018-05-30 00:00:00