Gremlin activates the Smad pathway linked to epithelial mesenchymal transdifferentiation in cultured tubular epithelial cells.

abstract：:With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compar...

journal_title：BioMed research international

authors： Čapková M,Šáchová J,Strnad H,Kolář M,Hroudová M,Chovanec M,Čada Z,Šteffl M,Valach J,Kastner J,Vlček Č,Smetana K Jr,Plzák J

更新日期：2014-01-01 00:00:00

abstract：Objectives:The purpose of the study was to evaluate the correlation between dynamic test results obtained on a stabilometric platform and the results achieved on the Y-balance test (Y-BT). Method:The study group consisted of 52 adolescent athletes, aged 14 to 17 years. Each participant was evaluated in the scope of th...

journal_title：BioMed research international

authors： Sikora D,Pałac M,Myśliwiec A,Wolny T,Linek P

更新日期：2020-11-12 00:00:00

abstract：Background:With the continuous improvement of the modernization of the Chinese military and the major adjustments made by the state to the recruitment policy, the newly recruited military undergone multiple pressures such as targeted high-intensity military training and environmental changes. The mental health of milit...

journal_title：BioMed research international

authors： Tao N,An H,Zhang J,Zhang Y,Jin L,Xu L,Liu J,Xu X

更新日期：2020-04-02 00:00:00

abstract：:Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of muscle mass and strength. The more rationale approach to delay the progression of sarcopenia is based on the combination of proper nutrition, possibly associated with the use of dietary supplements and a regular exercise program. ...

journal_title：BioMed research international

authors： Rondanelli M,Faliva M,Monteferrario F,Peroni G,Repaci E,Allieri F,Perna S

更新日期：2015-01-01 00:00:00

abstract：:It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...

journal_title：BioMed research international

authors： Czarzasta K,Cudnoch-Jedrzejewska A,Niemczyk L,Wrzesien R,Tkaczyk M,Puchalska L,Saracyn M,Zmudzki W,Niemczyk S

更新日期：2018-06-14 00:00:00

abstract：:The most frequently seen types of tremor are essential (ET) and parkinsonian tremor (PT) and in some patients clinical characteristics of these tremor types overlap. It is vital to distinguish between these two types of tremor in order to reach the right diagnosis and select the appropriate treatment. One of the widel...

journal_title：BioMed research international

authors： Kragelj V,Georgiev D,Pirtošek Z,Ribarič S

更新日期：2014-01-01 00:00:00

abstract：:A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/m...

journal_title：BioMed research international

authors： Osińska-Jaroszuk M,Jaszek M,Mizerska-Dudka M,Błachowicz A,Rejczak TP,Janusz G,Wydrych J,Polak J,Jarosz-Wilkołazka A,Kandefer-Szerszeń M

更新日期：2014-01-01 00:00:00

abstract：:Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...

journal_title：BioMed research international

authors： He Y,Yang J,Lv Y,Chen J,Yin F,Huang J,Zheng Q

更新日期：2018-02-06 00:00:00

abstract：:The purpose of this study was to establish an acid-etching procedure for altering the Ca/P ratio of the nanostructured surface of hydroxyapatite (HAP) by using surface chemical and morphological analyses (XPS, XRD, SEM, surface roughness, and wettability) and to evaluate the in vitro response of osteoblast-like cells ...

journal_title：BioMed research international

authors： Abe Y,Okazaki Y,Hiasa K,Yasuda K,Nogami K,Mizumachi W,Hirata I

更新日期：2013-01-01 00:00:00

abstract：:Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltrati...

journal_title：BioMed research international

authors： Correa MA,Borrego A,Jensen JR,Cabrera WHK,Barros M,Katz ISS,Canhamero T,Spadafora-Ferreira M,Fernandes JG,Starobinas N,Ribeiro OG,Ibañez OM,De Franco M

更新日期：2018-10-08 00:00:00

abstract：Objective:To investigate the clinicopathological characteristics and risk factors in patients with lung cancer and COPD. Materials and Methods:We retrospectively reviewed the clinical data of 282 patients with lung cancer, including 174 and 108 patients with and without COPD, respectively. Information on age, sex, smo...

journal_title：BioMed research international

authors： Miao JL,Cai JJ,Qin XF,Liu RJ

更新日期：2018-02-14 00:00:00

abstract：:In the past decade, much emphasis has been put on the transcriptional activation of HIV-1, which is proposed as a promised strategy for eradicating latent HIV-1 provirus. Two drugs, prostratin and hexamethylene bisacetamide (HMBA), have shown potent effects as inducers for releasing HIV-1 latency when used alone or in...

journal_title：BioMed research international

authors： Chen D,Wang H,Aweya JJ,Chen Y,Chen M,Wu X,Chen X,Lu J,Chen R,Liu M

更新日期：2016-01-01 00:00:00

abstract：:We evaluated the effects of mechanical stimulation on the osteogenic differentiation of human intraoral mesenchymal stem and progenitor cells (MSPCs) using the Flexcell FX5K Tension System that mediated cyclic tensile stretch on the cells. MSPCs were isolated from human mandibular retromolar bones and characterized us...

journal_title：BioMed research international

authors： Lohberger B,Kaltenegger H,Stuendl N,Payer M,Rinner B,Leithner A

更新日期：2014-01-01 00:00:00

abstract：:This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The interventi...

journal_title：BioMed research international

authors： Moss J,Tew GA,Copeland RJ,Stout M,Billings CG,Saxton JM,Winter EM,Bianchi SM

更新日期：2014-01-01 00:00:00

abstract：:Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged o...

journal_title：BioMed research international

authors： Song Y,Zhao Y,Wang F,Tao L,Xiao J,Yang C

更新日期：2014-01-01 00:00:00

abstract：:Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...

journal_title：BioMed research international

authors： Coyle KM,Boudreau JE,Marcato P

更新日期：2017-01-01 00:00:00

abstract：:Different batches of atorvastatin, represented by two immediate release formulation designs, were studied using a novel dynamic dissolution apparatus, simulating stomach and small intestine. A universal dissolution method was employed which simulated the physiology of human gastrointestinal tract, including the precis...

journal_title：BioMed research international

authors： Čulen M,Tuszyński PK,Polak S,Jachowicz R,Mendyk A,Dohnal J

更新日期：2015-01-01 00:00:00

abstract：:Recent reports of retinal stem cells being present in several locations of the adult eye have sparked great hopes that they may be used to treat the millions of people worldwide who suffer from blindness as a result of retinal disease or injury. A population of proliferative cells derived from the ciliary body epithel...

journal_title：BioMed research international

authors： Frøen R,Johnsen EO,Nicolaissen B,Facskó A,Petrovski G,Moe MC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. METHODS:Young children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital...

journal_title：BioMed research international

authors： Jain SK,Ordonez A,Kinikar A,Gupte N,Thakar M,Mave V,Jubulis J,Dharmshale S,Desai S,Hatolkar S,Kagal A,Lalvani A,Gupta A,Bharadwaj R

更新日期：2013-01-01 00:00:00

abstract：Background:Glucagon-like peptide 1 (GLP-1) hormone is an incretin hormone that is secreted in the ileum and plays a role in the pancreas to increase insulin secretion, stimulate proliferation, and prevent pancreatic β-cell apoptosis. Currently, diabetes mellitus (DM) treatment based on GLP-1 work is being developed, fo...

journal_title：BioMed research international

authors： Kartinah NT,Fadilah F,Ibrahim EI,Suryati Y

更新日期：2019-11-11 00:00:00

abstract：BACKGROUND:Macrosomia has become a worldwide problem with the rapid economic growth in the past few years. However, the detailed mechanism of how the macrosomia happened remains unknown. Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis. We hypothesized that serum miRNAs are poten...

journal_title：BioMed research international

authors： Hu L,Han J,Zheng F,Ma H,Chen J,Jiang Y,Jiang H

更新日期：2014-01-01 00:00:00

abstract：:Alpha-linolenic acid (ALA) is plant-based essential omega-3 polyunsaturated fatty acids that must be obtained through the diet. This could explain in part why the severe deficiency in omega-3 intake pointed by numerous epidemiologic studies may increase the brain's vulnerability representing an important risk factor i...

journal_title：BioMed research international

authors： Blondeau N,Lipsky RH,Bourourou M,Duncan MW,Gorelick PB,Marini AM

更新日期：2015-01-01 00:00:00

abstract：:Purpose. Kawasaki disease (KD) is a systemic vasculitis and is a leading cause of coronary artery lesions (CALs) in childhood. Our previous study has shown higher levels of serum Resistin in KD patients with coronary aneurysm. This study aimed at examining the association of Resistin with inflammatory cytokine express...

journal_title：BioMed research international

authors： Gao F,Si F,Feng S,Yi Q,Liu R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. METHODS:Dat...

journal_title：BioMed research international

authors： Su YJ,Huang CR,Chang WN,Tsai NW,Kung CT,Lin WC,Huang CC,Su CM,Cheng BC,Chang YT,Lu CH

更新日期：2014-01-01 00:00:00

abstract：:Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...

journal_title：BioMed research international

authors： Fanos V,Atzori L,Makarenko K,Melis GB,Ferrazzi E

更新日期：2013-01-01 00:00:00

abstract：:L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases ex...

journal_title：BioMed research international

authors： Izidoro LF,Sobrinho JC,Mendes MM,Costa TR,Grabner AN,Rodrigues VM,da Silva SL,Zanchi FB,Zuliani JP,Fernandes CF,Calderon LA,Stábeli RG,Soares AM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The serotonin (5-HT) pathway was shown to play a role in pulmonary hypertension (PH), but its functions in right ventricular failure (RVF) remain poorly understood. The aim of the current study was to investigate the effects of Terguride (5-HT2A and 2B receptor antagonist) or SB204741 (5-HT2B receptor antagon...

journal_title：BioMed research international

authors： Janssen W,Schymura Y,Novoyatleva T,Kojonazarov B,Boehm M,Wietelmann A,Luitel H,Murmann K,Krompiec DR,Tretyn A,Pullamsetti SS,Weissmann N,Seeger W,Ghofrani HA,Schermuly RT

更新日期：2015-01-01 00:00:00

abstract：:A surface plasmon resonance- (SPR-) based recognition method applying H-2 Ld:Ig/peptides complexes for ex vivo monitoring cellular immune responses during murine infection with Leishmania (Leishmania) amazonensis is described. Lymphocytes from lesion-draining popliteal lymph nodes were captured on a carboxylated senso...

journal_title：BioMed research international

authors： da Silveira-Júnior LS,Souza-Silva F,Pereira BA,Cysne-Finkelstein L,Cavalcanti Júnior GB,Alves CR

更新日期：2017-01-01 00:00:00

abstract：:The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n = 57) and healthy controls (n = 19) and if their expression levels are related to selected clinical p...

journal_title：BioMed research international

authors： Gackowska L,Litwin M,Trojanek J,Eljaszewicz A,Kubiszewska I,Niemirska A,Wierzbicka A,Michalkiewicz J

更新日期：2015-01-01 00:00:00

abstract：Background:Acute heart failure (AHF) is associated with disturbances of the peripheral perfusion leading to the dysfunction of many organs. Consequently, an episode of AHF constitutes a "multiple organ failure" which may also affect the skeletal muscles. However, the abnormalities within skeletal muscles during AHF hav...

journal_title：BioMed research international

authors： Węgrzynowska-Teodorczyk K,Siennicka A,Josiak K,Zymliński R,Kasztura M,Banasiak W,Ponikowski P,Woźniewski M

更新日期：2018-03-12 00:00:00