Does the adult human ciliary body epithelium contain "true" retinal stem cells?

abstract：:We evaluated the effects of mechanical stimulation on the osteogenic differentiation of human intraoral mesenchymal stem and progenitor cells (MSPCs) using the Flexcell FX5K Tension System that mediated cyclic tensile stretch on the cells. MSPCs were isolated from human mandibular retromolar bones and characterized us...

journal_title：BioMed research international

authors： Lohberger B,Kaltenegger H,Stuendl N,Payer M,Rinner B,Leithner A

更新日期：2014-01-01 00:00:00

abstract：:Diarrhea is a major clinical problem affecting foals up to 3 months of age. The aim of this study was to identify enteric microorganisms involved in monoinfections and coinfections and the associated virulence factors in healthy and diarrheic foals. Diarrheic (D) (n = 56) and nondiarrheic (ND) foals (n = 60) up to thr...

journal_title：BioMed research international

authors： Olivo G,Lucas TM,Borges AS,Silva RO,Lobato FC,Siqueira AK,da Silva Leite D,Brandão PE,Gregori F,de Oliveira-Filho JP,Takai S,Ribeiro MG

更新日期：2016-01-01 00:00:00

abstract：:VEGF-NO axis uncoupling is an important pathogenesis for DN. Reduced β2GPI could play a part in VEGF signaling pathway and has a protective effect on diabetic vascular disease. This study investigates the effect of reduced β2GPI on glomerular mesangial cells VEGF-NO axis uncoupling induced by high glucose. Compared to...

journal_title：BioMed research international

authors： Saijun Z,Xin L,Jie W,Shumin X,Shuaihui L,Pei Y

更新日期：2018-07-18 00:00:00

abstract：:Libidibia ferrea (LF) is a medicinal plant that holds many pharmacological properties. We evaluated the antinociceptive effect in the LF aqueous seed extract and Lipidic Portion of Libidibia ferrea (LPLF), partially elucidating their mechanisms. Histochemical tests and Gas chromatography of the LPLF were performed to ...

journal_title：BioMed research international

authors： Sawada LA,Monteiro VS,Rabelo GR,Dias GB,Da Cunha M,do Nascimento JL,Bastos Gde N

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase Cγ-1 (PLCγ-1), a key downstream mediator of the hepatocyte growth factor (HGF)/C-MET axis. Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast c...

journal_title：BioMed research international

authors： Sasi W,Ye L,Jiang WG,Sharma AK,Mokbel K

更新日期：2014-01-01 00:00:00

abstract：:Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...

journal_title：BioMed research international

authors： Chen S,Meng XF,Zhang C

更新日期：2013-01-01 00:00:00

abstract：:Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...

journal_title：BioMed research international

authors： Mellor LF,Huebner P,Cai S,Mohiti-Asli M,Taylor MA,Spang J,Shirwaiker RA,Loboa EG

更新日期：2017-01-01 00:00:00

abstract：:A search for novel and more efficient therapeutic modalities of inflammatory bowel disease (IBD) is one of the most important tasks of contemporary medicine. The anti-inflammatory action of nicotine in IBD might be therapeutic, but its toxicity due to off-target and nonreceptor effects limited its use and prompted a s...

journal_title：BioMed research international

authors： Chernyavsky AI,Galitovskiy V,Shchepotin IB,Grando SA

更新日期：2014-01-01 00:00:00

abstract：:This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tiss...

journal_title：BioMed research international

authors： Nahm KY,Heo JS,Lee JH,Lee DY,Chung KR,Ahn HW,Kim SH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cost sharing between beneficiaries and government is critical to attain universal health coverage. The government of Ethiopia introduced social health insurance to improve access to quality health services. Hence, HCP are the ultimate frontline service provider; their WTP for health insurance could influence...

journal_title：BioMed research international

authors： Mekonne A,Seifu B,Hailu C,Atomsa A

更新日期：2020-04-14 00:00:00

abstract：:Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions. The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns. 63...

journal_title：BioMed research international

authors： Zhou T,Yan X,Wang G,Liu H,Gan X,Zhang T,Wang J,Li L

更新日期：2015-01-01 00:00:00

abstract：:Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the key...

journal_title：BioMed research international

authors： Lippi G,Cervellin G,Mattiuzzi C

更新日期：2014-01-01 00:00:00

abstract：:Polyketide belongs to a family of abundant natural products typically produced by the filamentous soil bacteria Streptomyces. Similar to the biosynthesis of most secondary metabolites produced in the Streptomyces species, polyketide compounds are synthesized through tight regulatory networks in the cell, and thus extr...

journal_title：BioMed research international

authors： Nah JH,Kim HJ,Lee HN,Lee MJ,Choi SS,Kim ES

更新日期：2013-01-01 00:00:00

abstract：:Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent stu...

journal_title：BioMed research international

authors： Gong D,Yu X,Wang L,Kong L,Gong X,Dong Q

更新日期：2017-01-01 00:00:00

abstract：:Stem cells have been proposed as a promising therapy for treating stroke. While several studies have demonstrated the therapeutic benefits of stem cells, the exact mechanism remains elusive. Molecular imaging provides the possibility of the visual representation of biological processes at the cellular and molecular le...

journal_title：BioMed research international

authors： Chao F,Shen Y,Zhang H,Tian M

更新日期：2013-01-01 00:00:00

abstract：Objectives:To evaluate the effects of pentobarbital dosages on lower urinary tract function and to define an appropriate dosage of sodium pentobarbital that would be suitable for urodynamic studies in which recovery from anesthesia and long term survive were needed for subsequent experiment. Methods:Twenty-four 8-week...

journal_title：BioMed research international

authors： Xu SF,Du GH,Abulikim K,Cao P,Tan HB

更新日期：2020-06-11 00:00:00

abstract：:In patients with sepsis and septic shock, the hemodynamic management in both early and later phases of these "organ dysfunction syndromes" is a key therapeutic component. It needs, however, to be differentiated between "early goal-directed therapy" (EGDT) as proposed for the first 6 hours of emergency department treat...

journal_title：BioMed research international

authors： Saugel B,Huber W,Nierhaus A,Kluge S,Reuter DA,Wagner JY

更新日期：2016-01-01 00:00:00

abstract：:Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is...

journal_title：BioMed research international

authors： Zhou X,Gao C,Huang W,Yang M,Chen G,Jiang L,Gou F,Feng H,Ai N,Xu Y

更新日期：2014-01-01 00:00:00

abstract：:Introduction. Patients with head and neck cancer suffer from various impairments due to the primary illness, as well as secondary consequences of the oncological treatment. This systematic review describes the effects of radiotherapy and/or chemotherapy on the functions of the upper aerodigestive tract in patients wit...

journal_title：BioMed research international

authors： Heijnen BJ,Speyer R,Kertscher B,Cordier R,Koetsenruijter KW,Swan K,Bogaardt H

更新日期：2016-01-01 00:00:00

abstract：:Puffer fishes were collected from the central sea in Vietnam from spring to summer season. The eggs were incubated in MRS broth that was used to test the toxicity in mice and isolate the lactic acid bacteria community that could produce tetrodotoxin (TTX). Thin layer chromatography (TLC) and high performance lipid chr...

journal_title：BioMed research international

authors： Nguyen TH,Nguyen HN,Nghe DV,Nguyen KH

更新日期：2015-01-01 00:00:00

abstract：:In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The ex...

journal_title：BioMed research international

authors： Yao S,Hu K,Tang G,Gao S,Tang C,Yao B,Nie D,Sun T,Jiang S

更新日期：2015-01-01 00:00:00

abstract：Background:Pakistan is a country with one of the highest burden of tuberculosis (TB) in the world, and therefore, it is imperative to revisit the design of behaviour change interventions in the program. This study was designed to understand and assess the knowledge, awareness, perceptions, and health-seeking behaviour ...

journal_title：BioMed research international

authors： Khan A,Shaikh BT,Baig MA

更新日期：2020-04-21 00:00:00

abstract：:Visual motor integration (VMI) is a vital ability in childhood development, which is associated with the performance of many functional skills. By using the Beery Developmental Test Package and Executive Function Tasks, the present study explored the VMI development and its factors (visual perception, motor coordinati...

journal_title：BioMed research international

authors： Fang Y,Wang J,Zhang Y,Qin J

更新日期：2017-01-01 00:00:00

abstract：:The use of endotamponade agents has gained a major role in the management of macular complications of high myopia. Myopic foveoschisis and macular hole are the main macular complication of pathologic myopia, this growing condition that is a main cause of visual loss, especially in patients at a younger age. We discuss...

journal_title：BioMed research international

authors： Valldeperas X,Lorenzo-Carrero J

更新日期：2014-01-01 00:00:00

abstract：:Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentratio...

journal_title：BioMed research international

authors： Maurer-Ertl W,Pranckh-Matzke D,Friesenbichler J,Bratschitsch G,Holzer LA,Maier M,Leithner A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-M...

journal_title：BioMed research international

authors： Sklavos MM,Spracklen CN,Saftlas AF,Pinto LA

更新日期：2014-01-01 00:00:00

abstract：:Dental modeling resins have been developed for use in areas where highly precise resin structures are needed. The manufacturers claim that these polymethyl methacrylate/methyl methacrylate (PMMA/MMA) resins show little or no shrinkage after polymerization. This study examined the polymerization shrinkage of five denta...

journal_title：BioMed research international

authors： Kwon TY,Ha JY,Chun JN,Son JS,Kim KH

更新日期：2014-01-01 00:00:00

abstract：:Hypertrophic Scars (HTSs) are a complex fibroproliferative disorder, and their exact mechanism is still not fully understood. In this study, we first found that cystic fibrosis transmembrane conductance regulator (CFTR) expression was downregulated in human hypertrophic scars at the RNA and protein levels by microarra...

journal_title：BioMed research international

authors： Zhou Y,Zhao Y,Du H,Suo Y,Chen H,Li H,Liang X,Li Q,Huang X

更新日期：2020-01-02 00:00:00

abstract：:Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world. DM is seen associated with obesity and diabetic retinopathy (DR). In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking t...

journal_title：BioMed research international

authors： Rampogu S,Rampogu Lemuel M

更新日期：2016-01-01 00:00:00

abstract：:Recently, cardiovascular disease, also known as loop circulatory system diseases or disorders, is one of the serious diseases including heart disease, stroke, atherosclerosis, myocardial infarction, hypertension, hypotension, and thrombosis. Human pregnane X receptor, PXR, plays a crucial role in exogenous and endobio...

journal_title：BioMed research international

authors： Chen KB,Chen HY,Chen KC,Chen CY

更新日期：2014-01-01 00:00:00