Abstract:
:Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent studies have demonstrated that modulation of the gut microbiota plays a major role in EEN-induced remission. Variations of microbial components, which directly influence the diversity and metabolic functions of the gut microbiota, are closely associated with the immunological conditions of the gut and the susceptibility to diseases. The reduction of proinflammatory microbial components and harmful microbial metabolites after EEN treatment greatly decreases the inflammatory injuries of the gut.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Gong D,Yu X,Wang L,Kong L,Gong X,Dong Qdoi
10.1155/2017/8102589subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8102589eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章,评审abstract::Lung cancer is a leading cause of death worldwide. Currently, in differential diagnosis of lung cancer, accurate classification of cancer types (adenocarcinoma, squamous cell carcinoma, and small cell carcinoma) is required. However, improving the accuracy and stability of diagnosis is challenging. In this study, we d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4067832
更新日期:2017-01-01 00:00:00
abstract::Xiaoxuming decoction (XXMD), a classic traditional Chinese medicine (TCM) prescription, has been used as a therapeutic in the treatment of stroke in clinical practice for over 1200 years. However, the pharmacological mechanisms of XXMD have not yet been elucidated. The purpose of this study was to develop neuroprotect...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6847685
更新日期:2019-07-10 00:00:00
abstract:Background:Acute heart failure (AHF) is associated with disturbances of the peripheral perfusion leading to the dysfunction of many organs. Consequently, an episode of AHF constitutes a "multiple organ failure" which may also affect the skeletal muscles. However, the abnormalities within skeletal muscles during AHF hav...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/6982897
更新日期:2018-03-12 00:00:00
abstract::Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleosomes and/or chromos...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/5959721
更新日期:2016-01-01 00:00:00
abstract::Although extensive studies have identified large number of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in ischemic stroke, the RNA regulation network response to focal ischemia remains poorly understood. In this study, we simultaneously interrogate the expression profiles of lncRNAs, miRNAs, and mRNAs changes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8354350
更新日期:2018-01-08 00:00:00
abstract:Objective:To retrospectively investigate computed tomographic (CT) quantitative analysis of ground-glass opacity (GGO) volume percentage and morphologic features of resected lung adenocarcinomas according to epidermal growth factor receptor (EGFR) mutation status and subtypes. Methods:Amplification refractory mutation...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9643836
更新日期:2019-03-06 00:00:00
abstract::The aim of this study was to develop a freeze-drying protocol facilitating successful processing of plant material containing the small surface antigen of hepatitis B virus (S-HBsAg) while preserving its VLP structure and immunogenicity. Freeze-drying of the antigen in lettuce leaf tissue, without any isolation or pur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/485689
更新日期:2014-01-01 00:00:00
abstract::Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based therapy for skin regeneration. Aiming to establish human iPSCs as a potential cell source for skin tissue engineering, we expect to obtain an epidermal-like cell line with angiogenic and keratinogenic differentiation potential ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8459503
更新日期:2018-09-13 00:00:00
abstract::In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staph...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1067413
更新日期:2018-10-22 00:00:00
abstract:Objective:This study aimed to investigate the effects of Ang-1 on neovascularization of diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 diabetic rats. Methods:Ang-1 adenoviral vector was constructed. The rat model was established by STZ and divided into four group. The Matrigel was i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2016972
更新日期:2019-01-09 00:00:00
abstract::Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic diso...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/932691
更新日期:2013-01-01 00:00:00
abstract:Background:Physical activity has been found to maintain and improve cognitive function and consequently improve health-related quality of life (HRQoL). The relationships between different types of physical activities, cognitive function, and HRQoL have not been studied sufficiently and compared in different age and gen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8856284
更新日期:2020-12-18 00:00:00
abstract::We applied a metabolomic approach to monitor the modifications occurring in goat vitreous humor (VH) metabolite composition at different times (0, 6, 12, 18, and 24 hours) after death. The (1)H-NMR analysis of the VH samples was performed for the simultaneous determination of several metabolites (i.e., the metabolite ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/627201
更新日期:2015-01-01 00:00:00
abstract::Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostruct...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/815981
更新日期:2014-01-01 00:00:00
abstract::Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be an important in microRNA let-7 expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/696475
更新日期:2014-01-01 00:00:00
abstract::Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3019410
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/4370258.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2020/2049759
更新日期:2020-07-16 00:00:00
abstract::Chromosome/DNA instability could be one of the primary causes of malignant cell transformation. The objective of the present study was to evaluate the spontaneous genetic damages in exfoliated cells of buccal mucosa of head and neck cancer (HNC) by counting micronucleus (MN) and binucleated (BN) cells frequencies. MN ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/905252
更新日期:2013-01-01 00:00:00
abstract:Purpose:Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9765162
更新日期:2020-02-22 00:00:00
abstract::Lung cancer consists of two main subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) that are classified according to their physiological phenotypes. In this study, we have developed a network-based approach to identify molecular biomarkers that can distinguish SCLC from NSCLC. By identifyin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/685303
更新日期:2015-01-01 00:00:00
abstract::Aim. The aim of this study was to describe PCa characteristics and long-term outcomes in young men aged ≤55 years after radical prostatectomy (RP) and to compare them with older men cohort. Methods. Among 2,200 patients who underwent RP for clinically localized PCa at our centre between 2001 and 2015, 277 (10.3%) men ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9858923
更新日期:2017-01-01 00:00:00
abstract::The relationship between socioeconomic position (SEP) and population health is contextual. This study identifies the determinants of SEP producing health inequalities in the Latvian population. We also estimate the proportional contribution of different socioeconomic strata- (SES-) related determinants in Latvian heal...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7541416
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Our study aims to determine the prevalence of nicotine dependence and investigate the effect of nicotine dependence on psychopathology among schizophrenia patients. METHODS:A cross-sectional study was carried out in an outpatient psychiatric clinic at a general hospital in Malaysia. 180 recruited subjects...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/730291
更新日期:2015-01-01 00:00:00
abstract::Epidemiological studies have proven an association between consumption of polyphenols and prevention of Alzheimer's disease, the most common form of dementia characterized by extracellular deposition of amyloid beta plaques. The aim of this study is pharmacological screening of the aqueous alcohol extract of Markhamia...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/843263
更新日期:2014-01-01 00:00:00
abstract:Background:The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). Abundant evidence indicates that abnormal expression of Pc proteins is associated with a variety of tumors, but their role in the pathogen...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/6436825
更新日期:2019-05-09 00:00:00
abstract:Objective:To analyze the ten-year surgical outcomes and postoperative complications of French-Door laminoplasty (FDL) in the management of multilevel cervical spondylotic myelopathy (MCSM) and analyze the prognostic factors for FDL in treating MCSM. Methods:64 patients with MCSM, who were operated by FDL, were include...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3627071
更新日期:2020-05-06 00:00:00
abstract::Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular function...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/413708
更新日期:2014-01-01 00:00:00
abstract::Purpose. The aim of the present study was to elucidate the metabolic mechanisms associated with chronic fatigue syndrome (CFS) via an analysis of urine metabolites prior to and following exercise in a rat model. Methods. A rat model of CFS was established using restraint-stress, forced exercise, and crowded and noisy ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8182020
更新日期:2017-01-01 00:00:00
abstract::Tracking individual-cell/object over time is important in understanding drug treatment effects on cancer cells and video surveillance. A fundamental problem of individual-cell/object tracking is to simultaneously address the cell/object appearance variations caused by intrinsic and extrinsic factors. In this paper, in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8182416
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Although expression of miR-200s is aberrant in liver fibrosis, its role in liver fibrogenesis still remains unknown. Here, we investigated the role of miR-200c in the activation of human hepatic stellate cells (HSCs) and induction of liver fibrosis. METHODS:We engineered human HSCs (LX2 cell line) to stably...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2670658
更新日期:2017-01-01 00:00:00