Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota.

Abstract:

:Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent studies have demonstrated that modulation of the gut microbiota plays a major role in EEN-induced remission. Variations of microbial components, which directly influence the diversity and metabolic functions of the gut microbiota, are closely associated with the immunological conditions of the gut and the susceptibility to diseases. The reduction of proinflammatory microbial components and harmful microbial metabolites after EEN treatment greatly decreases the inflammatory injuries of the gut.

journal_name

Biomed Res Int

authors

Gong D,Yu X,Wang L,Kong L,Gong X,Dong Q

doi

10.1155/2017/8102589

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

8102589

eissn

2314-6133

issn

2314-6141

journal_volume

2017

pub_type

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