Potential of RAS inhibition to improve metabolic bone disorders.

Abstract:

:Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic disorders. Based on in vitro, in vivo, and clinical studies, this review explains the roles of RAS in bone metabolism and also covers the potential approaches and beneficial effects of RAS inhibition on bone health. Differential strategies for inhibiting RAS can be employed to maintain bone health, which are attributed primarily to the reduced level of angiotensin II (AngII) and suppressed stimulation of the AngII signaling pathway. The use of renin inhibitors, angiotensin-converting enzyme inhibitors, and AngII receptor blockers either individually or in combination with each other could have promising results in fighting bone metabolic disorders associated with other cardiovascular diseases as well as independent bone injuries.

journal_name

Biomed Res Int

authors

Gebru Y,Diao TY,Pan H,Mukwaya E,Zhang Y

doi

10.1155/2013/932691

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

932691

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

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