Pharmacokinetics and Bioavailability Study of Monocrotaline in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry.

abstract：PURPOSE:Electrical Bioimpedance Cerebral Monitoring is assessment in real time of health of brain tissue through study of passive dielectric properties of brain. During the last two decades theory and technology have been developed in parallel with animal experiments aiming to confirm feasibility of using bioimpedance-...

journal_title：BioMed research international

authors： Seoane F,Reza Atefi S,Tomner J,Kostulas K,Lindecrantz K

更新日期：2015-01-01 00:00:00

abstract：Background:Uveitis is a known ophthalmologic manifestation of seronegative spondyloarthropathy, including psoriatic arthritis. However, the data is less clear among patients with psoriasis due to the limited number of published studies. Aims:To investigate whether the risk of incident and prevalent uveitis is elevated...

journal_title：BioMed research international

authors： Chaiyabutr C,Ungprasert P,Silpa-Archa N,Wongpraparut C,Chularojanamontri L

更新日期：2020-07-15 00:00:00

abstract：:[This retracts the article DOI: 10.1155/2019/5879089.]. ...

journal_title：BioMed research international

authors： BioMed Research International .

更新日期：2020-08-26 00:00:00

abstract：:Increasing age negatively affects different phases of bone fracture healing. The present study aimed to explore underlying mechanisms related to bone fracture repair in the elderly. GSE17825 public transcriptome data from the Gene Expression Omnibus database were used for analysis. First, raw data were normalized and ...

journal_title：BioMed research international

authors： Zhao SJ,Kong FQ,Fan J,Chen Y,Zhou S,Xue MX,Yin GY

更新日期：2018-12-16 00:00:00

abstract：:Subtle perturbations in intraglomerular VEGF/VEGFR-2 signaling or in the influencing microenvironment can profoundly affect renal function, resulting in the apparently paradoxical observation that VEGF blockade attenuates proteinuria development in experimental diabetes despite exerting the opposite effect under other...

journal_title：BioMed research international

authors： Advani A,Connelly KA,Advani SL,Thai K,Zhang Y,Kelly DJ,Gilbert RE

更新日期：2013-01-01 00:00:00

abstract：:Excessive ethanol consumption is one of the main causes of liver fibrosis. However, direct effects of ethanol exposure on endothelial cells and their contribution to fibrogenesis and metastasis were not investigated. Therefore we analysed whether ethanol directly affects endothelial cells and if this plays a role duri...

journal_title：BioMed research international

authors： Raskopf E,Gonzalez Carmona MA,Van Cayzeele CJ,Strassburg C,Sauerbruch T,Schmitz V

更新日期：2014-01-01 00:00:00

abstract：:This paper presents a rapid label-free method for the identification of morphological characteristics of biological cells. Based on quantitative phase microscopy as well as the connotation of phase value, the gradient operator of phase and the associated analytic processing are employed to determine the edge of differ...

journal_title：BioMed research international

authors： Tang WB,Ji Y,Zhang MM,Chen ZY,Xu YY,Wang YW

更新日期：2018-04-11 00:00:00

abstract：:Purpose. To evaluate correlation between tomographic gradation of keratoconus (KC) and its corresponding air-puff induced biomechanical response. Methods. Corneal tomography and biomechanics were measured with Scheimpflug imaging in 44 normal and 92 KC corneas. Deformation waveform was also analyzed with Fourier serie...

journal_title：BioMed research international

authors： Shetty R,Nuijts RM,Srivatsa P,Jayadev C,Pahuja N,Akkali MC,Sinha Roy A

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To evaluate the role of nutritional factors, serum lipids, and lipoproteins in late age-related macular degeneration (late AMD). METHODS:Intake of red meat, fruit, fish, vegetables, and alcohol, smoking status, and body mass index (BMI) were ascertained questionnaire-based in 1147 late AMD cases and 1773 contr...

journal_title：BioMed research international

authors： Ersoy L,Ristau T,Lechanteur YT,Hahn M,Hoyng CB,Kirchhof B,den Hollander AI,Fauser S

更新日期：2014-01-01 00:00:00

abstract：:Aspergillus species originating from Greece were examined by morphological and molecular criteria to explore the diversity of this genus. The phylogenetic relationships of these species were determined using sequences from the ITS and IGS region of the nuclear rRNA gene complex, two nuclear genes ( β -tubulin (benA) a...

journal_title：BioMed research international

authors： Krimitzas A,Pyrri I,Kouvelis VN,Kapsanaki-Gotsi E,Typas MA

更新日期：2013-01-01 00:00:00

abstract：:The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects o...

journal_title：BioMed research international

authors： Pei K,Gui T,Kan D,Feng H,Jin Y,Yang Y,Zhang Q,Du Z,Gai Z,Wu J,Li Y

更新日期：2020-07-18 00:00:00

abstract：:Background. Findings on the association between posttransplant anemia (PTA) and mortality in posttransplant patients are scarce. This study explored whether PTA shortly after kidney transplantation (KT) predicts mortality at up to 10 years' follow-up, stratified for chronic kidney disease (CKD) stages. Methods. PTA wa...

journal_title：BioMed research international

authors： Majernikova M,Rosenberger J,Prihodova L,Jarcuskova M,Roland R,Groothoff JW,van Dijk JP

更新日期：2017-01-01 00:00:00

abstract：:Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis o...

journal_title：BioMed research international

authors： Yuan X,Wang S,Liu M,Lu Z,Zhan Y,Wang W,Xu AM

更新日期：2017-01-01 00:00:00

abstract：Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...

journal_title：BioMed research international

authors： Nie H,Hu Y,Guo W,Wang W,Yang Q,Dong Q,Tang Y,Li Q,Tang Z

更新日期：2020-06-07 00:00:00

abstract：:This study introduced a combined computational fluid dynamics (CFD) and echocardiography methodology to simulate blood flow in the single right ventricle (SRV) and normal ventricles to study the intraventricular flow. Derived from echocardiographic image loops, CFD-based three-dimensional (3D) flow models of normal su...

journal_title：BioMed research international

authors： Chen LJ,Tong ZR,Wang Q,Zhang YQ,Liu JL

更新日期：2018-01-16 00:00:00

abstract：Background and Aims:Contrast-induced nephropathy (CIN) is a relatively infrequent complication after percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). However, little is known about the association between cytochrome c (cyt c) and increased risk of CIN. We conducted t...

journal_title：BioMed research international

authors： Tang C,Hou J,Yan G,Qiao Y,Wang D,Zhu B,Liu B,Luo E,Nawabi AQ,Chen L

更新日期：2019-01-23 00:00:00

abstract：:Nutrient overload leads to impaired muscle oxidative capacity and insulin sensitivity. However, comparative analyses of the effects of dietary manipulation on skeletal muscles with different fiber composition are lacking. This study aimed to investigate the selective adaptations in the soleus and tibialis anterior mus...

journal_title：BioMed research international

authors： Collino M,Mastrocola R,Nigro D,Chiazza F,Aragno M,D'Antona G,Minetto MA

更新日期：2014-01-01 00:00:00

abstract：:Secretory leukoprotease inhibitor (SLPI) is an anti-inflammatory protein present in respiratory secretions. Whilst epithelial cell SLPI is extensively studied, neutrophil associated SLPI is poorly characterised. Neutrophil function including chemotaxis and degranulation of proteolytic enzymes involves changes in cytos...

journal_title：BioMed research international

authors： Reeves EP,Banville N,Ryan DM,O'Reilly N,Bergin DA,Pohl K,Molloy K,McElvaney OJ,Alsaleh K,Aljorfi A,Kandalaft O,O'Flynn E,Geraghty P,O'Neill SJ,McElvaney NG

更新日期：2013-01-01 00:00:00

abstract：Background and Aim:ROHHADNET (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor) syndrome is a rare disease with grave outcome. Although early recognition is essential, prompt diagnosis may be challenging due to its extreme rarity. This study aimed to systematically r...

journal_title：BioMed research international

authors： Lee JM,Shin J,Kim S,Gee HY,Lee JS,Cha DH,Rim JH,Park SJ,Kim JH,Uçar A,Kronbichler A,Lee KH,Shin JI

更新日期：2018-11-21 00:00:00

abstract：:Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with ...

journal_title：BioMed research international

authors： Gaur PK,Mishra S,Bajpai M,Mishra A

更新日期：2014-01-01 00:00:00

abstract：:We aimed to predict the ten-year cardiovascular disease (CVD) risk among low-income urban dwellers of metropolitan Malaysia. Participants were selected from a cross-sectional survey conducted in Kuala Lumpur. To assess the 10-year CVD risk, we employed the Framingham risk scoring (FRS) models. Significant determinants...

journal_title：BioMed research international

authors： Su TT,Amiri M,Mohd Hairi F,Thangiah N,Bulgiba A,Majid HA

更新日期：2015-01-01 00:00:00

abstract：:The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and immunomodulation. Here we identified PROK2 as a critical mediator of neuropathic pain in the chronic constriction injury (CCI) of the sciatic nerve in mice and demonstrated that blocking the prokineticin rec...

journal_title：BioMed research international

authors： Lattanzi R,Maftei D,Marconi V,Florenzano F,Franchi S,Borsani E,Rodella LF,Balboni G,Salvadori S,Sacerdote P,Negri L

更新日期：2015-01-01 00:00:00

abstract：:Over the years, studies have demonstrated morphological changes in the brain of fibromyalgia (FMS). We aimed to conduct a coordinate-based meta-analytic research through systemic review on voxel-based morphometry (VBM) imaging results to identify consistent gray matter (GM) difference between FMS patients and healthy ...

journal_title：BioMed research international

authors： Lin C,Lee SH,Weng HH

更新日期：2016-01-01 00:00:00

abstract：:Long-term application and extensive use of synthetic insecticides have resulted in accumulating their residues in food, milk, water, and soil and cause adverse health effects to human and ecosystems. Therefore, application of natural insecticides in agriculture and public health sectors has been increased as alternati...

journal_title：BioMed research international

authors： Mossa AH,Mohafrash SMM,Chandrasekaran N

更新日期：2018-10-16 00:00:00

abstract：:It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...

journal_title：BioMed research international

authors： Chen MF,Tsai JT,Chen LJ,Wu TP,Yang JJ,Yin LT,Yang YL,Chiang TA,Lu HL,Wu MC

更新日期：2014-01-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world. Our aim is to identify prognostic biomarkers that contribute to the progression of early stage ccRCC and clarify the mechanism. Here, the mRNA microarray expression profile of ccRCC samples was obtained from Gene Expression Omnibus...

journal_title：BioMed research international

authors： Qiu X,Gu Y,Ni Y,Li Q

更新日期：2020-10-29 00:00:00

abstract：:In the past decade, much emphasis has been put on the transcriptional activation of HIV-1, which is proposed as a promised strategy for eradicating latent HIV-1 provirus. Two drugs, prostratin and hexamethylene bisacetamide (HMBA), have shown potent effects as inducers for releasing HIV-1 latency when used alone or in...

journal_title：BioMed research international

authors： Chen D,Wang H,Aweya JJ,Chen Y,Chen M,Wu X,Chen X,Lu J,Chen R,Liu M

更新日期：2016-01-01 00:00:00

abstract：:Preoperative 5-fluorouracil- (5-FU-) based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, the effect of 5-FU-based chemoradiotherapy on CRC is limited due to the development of chemoradiation resistance (CRR), and the molecular mechanisms underlying this resistance are...

journal_title：BioMed research international

authors： Xiong W,Ai YQ,Li YF,Ye Q,Chen ZT,Qin JY,Liu QY,Wang H,Ju YH,Li WH,Li YF

更新日期：2017-01-01 00:00:00

abstract：Purpose:To detect the responsiveness and predictive ability of the Chinese version Action Research Arm Test (C-ARAT) in participants within the first 3 months after cerebral infarction. Methods:Ninety-seven individuals (75 men, mean age 59.87 ± 10.94 years) with a first cerebral infarction were enrolled in this study....

journal_title：BioMed research international

authors： Zhao JL,Zhang T,Xu ZQ,Ding MH,Leng Y,Bian RH,Mao YR,Huang DF

更新日期：2019-10-07 00:00:00

abstract：:Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the...

journal_title：BioMed research international

authors： Malyshev I,Malyshev Y

更新日期：2015-01-01 00:00:00