ID1 As a Prognostic Biomarker and Promising Drug Target Plays a Pivotal Role in Deterioration of Clear Cell Renal Cell Carcinoma.

abstract：:[This corrects the article DOI: 10.1155/2016/6935123.]. ...

journal_title：BioMed research international

authors： Pruimboom L,Ruiz-Núñez B,Raison CL,Muskiet FAJ,Freese J

更新日期：2017-01-01 00:00:00

abstract：:The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certa...

journal_title：BioMed research international

authors： Gopalai AA,Lim SY,Chua JY,Tey S,Lim TT,Mohamed Ibrahim N,Tan AH,Eow GB,Abdul Aziz Z,Puvanarajah SD,Viswanathan S,Looi I,Lim SK,Tan LP,Chong YB,Tan CT,Zhao Y,Tan EK,Ahmad-Annuar A

更新日期：2014-01-01 00:00:00

abstract：:Taenia solium thioredoxin-1 gene (TsTrx-1) has a length of 771 bp with three exons and two introns. The core promoter gene presents two putative stress transcription factor binding sites, one putative TATA box, and a transcription start site (TSS). TsTrx-1 mRNA is expressed higher in larvae than in adult. This gene en...

journal_title：BioMed research international

authors： Jiménez L,Rodríguez-Lima O,Ochoa-Sánchez A,Landa A

更新日期：2015-01-01 00:00:00

abstract：:The 3'-end processing (3'P) of each viral long terminal repeat (LTR) during human immunodeficiency virus type-1 (HIV-1) integration is a vital step in the HIV life cycle. Blocking the 3'P using 3'P inhibitor has recently become an attractive strategy for HIV-1 therapeutic intervention. Recently, we have developed a no...

journal_title：BioMed research international

authors： Sakkhachornphop S,Thongkum W,Tayapiwatana C

更新日期：2015-01-01 00:00:00

abstract：:Abnormal metabolism is another cancer hallmark. The two most characterized altered metabolic pathways are high rates of glycolysis and glutaminolysis, which are natural targets for cancer therapy. Currently, a number of newer compounds to block glycolysis and glutaminolysis are being developed; nevertheless, lonidamin...

journal_title：BioMed research international

authors： Cervantes-Madrid D,Romero Y,Dueñas-González A

更新日期：2015-01-01 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is defined as a disease characterized by persistent, progressive airflow limitation. Recent studies have underlined that COPD is correlated to many systemic manifestations, probably due to an underlying pattern of systemic inflammation. In COPD fractional exhaled Nitric Oxi...

journal_title：BioMed research international

authors： Malerba M,Radaeli A,Olivini A,Damiani G,Ragnoli B,Montuschi P,Ricciardolo FL

更新日期：2014-01-01 00:00:00

abstract：OBJECT:The aim of this report was to explore the clinical presentation, radiological features, treatment methods, and outcome of micro-AVMs presenting with intracerebral hemorrhage. METHODS:The clinical data, radiological features, treatment, and follow-up results for a consecutive series of 13 cases with micro-AVMs w...

journal_title：BioMed research international

authors： Hong JF,Song YF,Liu HB,Liu Z,Wang SS

更新日期：2015-01-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is characterized by muscular wasting caused by dystrophin deficiency that ultimately ends in force reduction and premature death. In addition to primary genetic defect, several mechanisms contribute to DMD pathogenesis. Recently, antioxidan...

journal_title：BioMed research international

authors： Sitzia C,Farini A,Colleoni F,Fortunato F,Razini P,Erratico S,Tavelli A,Fabrizi F,Belicchi M,Meregalli M,Comi G,Torrente Y

更新日期：2015-01-01 00:00:00

abstract：:Increasing consumption of tobacco and alcohol has led to a steady increase in the incidence of head and neck cancers in Asia. The drawbacks associated with the existing chemotherapeutic and surgical interventions have necessitated the development of a safer alternative for therapy of head and neck cancers. In this stu...

journal_title：BioMed research international

authors： Mohan A,Narayanan S,Sethuraman S,Krishnan UM

更新日期：2014-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation has been identified as an important initiator of skeletal damage in RA. Iguratimod (T-614) is an anti-inflammatory agent which has been reported to show the inhibitory effect of bone destruction in RA. Ho...

journal_title：BioMed research international

authors： Song J,Liu H,Zhu Q,Miao Y,Wang F,Yang F,Cheng W,Xi Y,Niu X,He D,Chen G

更新日期：2018-02-19 00:00:00

abstract：:Brain injury such as traumatic brain injury (TBI) and stroke is the major cause of long-term disabilities in many countries. The increasing rate of brain damaged victims and the heterogeneity of impairments decrease rehabilitation effectiveness and competence resulting in higher cost of rehabilitation treatment. On th...

journal_title：BioMed research international

authors： Shapi'i A,Mat Zin NA,Elaklouk AM

更新日期：2015-01-01 00:00:00

abstract：:Studies have investigated the association between age-related macular degeneration (AMD) and subsequent risks of mortality, but results have been equivocal. We conducted a comprehensive analysis of prospective cohort studies to assess the association of AMD and the risk of mortality in the general population. We searc...

journal_title：BioMed research international

authors： Wang P,Wang J,Ma J,Jin G,Guan X

更新日期：2017-01-01 00:00:00

abstract：:Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs are bound to conforma...

journal_title：BioMed research international

authors： Hu WG,Yin J,Chau D,Hu CC,Lillico D,Yu J,Negrych LM,Cherwonogrodzky JW

更新日期：2013-01-01 00:00:00

abstract：:We previously reported that Runx2/miR-3960/miR-2861 regulatory feedback loop stimulates osteoblast differentiation. However, the effect of this feedback loop on the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) remains unclear. Our recent study showed that miR-2861 and miR-3960 expression inc...

journal_title：BioMed research international

authors： Xia ZY,Hu Y,Xie PL,Tang SY,Luo XH,Liao EY,Chen F,Xie H

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy. METHODS:In this cross-sectional study UC patients were interviewed, ...

journal_title：BioMed research international

authors： da Silva BC,Lyra AC,Mendes CM,Ribeiro CP,Lisboa SR,de Souza MT,Portela RC,Santana GO

更新日期：2015-01-01 00:00:00

abstract：:Myosin VI (MVI) is a unique motor protein moving towards the minus end of actin filaments unlike other known myosins. Its important role has recently been postulated for striated muscle and myogenic cells. Since MVI functions through interactions of C-terminal globular tail (GT) domain with tissue specific partners, w...

journal_title：BioMed research international

authors： Karolczak J,Sobczak M,Skowronek K,Rędowicz MJ

更新日期：2015-01-01 00:00:00

abstract：:Microcystins (MCs) are hepatotoxins harmful for animal and human health. The most toxic type between them is MC-LR whose presence has been investigated in different reservoirs all around the world. In this work microcystins were monitored in spring and summer in water and mussels (Mytilus galloprovincialis) of two Sar...

journal_title：BioMed research international

authors： Baralla E,Varoni MV,Sedda T,Pasciu V,Floris A,Demontis MP

更新日期：2017-01-01 00:00:00

abstract：Purpose:3D nonfluoroscopic mapping systems (NMSs) are generally used in the catheter ablation (CA) of complex ventricular and atrial arrhythmias. The aim of this study was to evaluate the efficacy, safety, and long-term effect of the extended, routine use of NMSs for CA. Methods:Our study involved 1028 patients who un...

journal_title：BioMed research international

authors： Marini M,Martin M,Ravanelli D,Del Greco M,Quintarelli S,Guarracini F,Coser A,Valentini A,Bonmassari R

更新日期：2019-03-10 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disorder of the synovial membrane that results in the destruction of bone and cartilage in affected joints. Tocilizumab is a biological agent and an anti-interleukin-6 (IL-6) receptor monoclonal antibody that blocks IL-6-mediated inflammatory processes in RA patients...

journal_title：BioMed research international

authors： Yanagida M,Kawasaki M,Fujishiro M,Miura M,Ikeda K,Nozawa K,Kaneko H,Morimoto S,Takasaki Y,Ogawa H,Takamori K,Sekigawa I

更新日期：2013-01-01 00:00:00

abstract：:Blood pressure is the most important, modifiable risk factor for cardiovascular diseases. Lifestyle factors and also workload are the main, potential risk factors for the development of hypertension. This study focused on the early detection of unknown hypertension by screening employees in the hotel and restaurant in...

journal_title：BioMed research international

authors： Seibt R,Hunger B,Stieler L,Stoll R,Kreuzfeld S

更新日期：2018-04-08 00:00:00

abstract：:T. reesei is an efficient cellulase producer and biomass degrader. To improve xylitol production in Trichoderma reesei strains by genetic engineering, two approaches were used in this study. First, the presumptive D-xylulokinase gene in T. reesei (xyiH), which has high homology to known fungi D-xylulokinase genes, was...

journal_title：BioMed research international

authors： Hong Y,Dashtban M,Kepka G,Chen S,Qin W

更新日期：2014-01-01 00:00:00

abstract：:The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis t...

journal_title：BioMed research international

authors： Flávia Nardy A,Santos L,Freire-de-Lima CG,Morrot A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based 18F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs. MATERIALS AND METHODS:We retrospectively...

journal_title：BioMed research international

authors： Matsumoto Y,Baba S,Endo M,Setsu N,Iida K,Fukushi JI,Kawaguchi K,Okada S,Bekki H,Isoda T,Kitamura Y,Honda H,Nakashima Y

更新日期：2017-01-01 00:00:00

abstract：:The intra- and extracellular accumulation of misfolded and aggregated amyloid proteins is a common feature in several neurodegenerative diseases, which is thought to play a major role in disease severity and progression. The principal machineries maintaining proteostasis are the ubiquitin proteasomal and lysosomal aut...

journal_title：BioMed research international

authors： Maiti P,Manna J,Veleri S,Frautschy S

更新日期：2014-01-01 00:00:00

abstract：Objective:To assess the application value of perfusion-weighted imaging (PWI) in early diagnosis, quantitation, and hepatic fibrosis staging by analyzing the related parameters in hepatic fibrosis. Methods:A total of 60 rats were randomly divided into the hepatic fibrosis and control groups, and carbon tetrachloride (...

journal_title：BioMed research international

authors： Fan G,Ya Y,Ni X,Hou J,Yu R

更新日期：2019-12-28 00:00:00

abstract：:In order to understand disease pathogenesis, improve medical diagnosis, or discover effective drug targets, it is important to identify significant genes deeply involved in human disease. For this purpose, many earlier approaches attempted to prioritize candidate genes using gene expression profiles or SNP genotype da...

journal_title：BioMed research international

authors： Che J,Shin M

更新日期：2015-01-01 00:00:00

abstract：Background:The aim of our study was to investigate the impact of abdominal wall reconstruction surgery on tissue anatomy and to explore how flap surgery influences the patient's immune status. Methods:Experimental abdominal wall defects were created in 8 Sus scrofa (swine) animal models. The animals were divided into ...

journal_title：BioMed research international

authors： Popa F,Georgescu AV

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologou...

journal_title：BioMed research international

authors： Jiménez-Hernández E,Dueñas-González MT,Arellano-Galindo J,Medrano-Ortíz-De-Zárate ME,Bekker-Méndez VC,Berges-García A,Solís-Labastida K,Sánchez-Jara B,Tiznado-García HM,Jaimes-Reyes EZ,García-Jiménez X,Espinoza-Hernández L,Núñez-

更新日期：2015-01-01 00:00:00

abstract：Introduction:Retinol Binding Protein 4 (RBP4) is mainly excreted by the kidney and plays a pivotal role in insulin resistance (IR). In our study, we evaluated the association between RBP4 and IR in hemodialysis subjects (HD). We also assessed how circulating RBP4 could be influenced by kidney transplant or different di...

journal_title：BioMed research international

authors： Grosjean F,Esposito P,Maccarrone R,Libetta C,Dal Canton A,Rampino T

更新日期：2017-01-01 00:00:00

abstract：:The incidence and rates of diagnosis of drug-induced liver injury (DILI) have been increasing in recent years as findings from basic research and the examination of clinical databases reveal information about the clinical course, etiology, and prognosis of this complex disease. The prevalence of metabolic comorbiditie...

journal_title：BioMed research international

authors： Li X,Gao P,Niu J

更新日期：2019-08-18 00:00:00