Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients.

Abstract:

:Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis of gastric cancer AGS cells. miR-204 directly targeted SOX4. In clinical tissue research, we determined that miR-204 was expressed much lower and SOX4 expressed much higher in gastric cancer tissues compared with normal gastric tissues. Associated analysis with clinicopathological parameters in gastric cancer patients showed miR-204 was associated with no lymph node metastasis and early tumor stages whereas SOX4 was associated with lymph node metastasis and advanced tumor stages. In addition, miR-204 and SOX4 were negatively correlated in tissues from gastric cancer patients. Our findings examined the important role of miR-204 and SOX4 played in gastric cancer, and they could be used as candidate therapeutic targets for gastric cancer therapy.

journal_name

Biomed Res Int

authors

Yuan X,Wang S,Liu M,Lu Z,Zhan Y,Wang W,Xu AM

doi

10.1155/2017/6894675

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

6894675

eissn

2314-6133

issn

2314-6141

journal_volume

2017

pub_type

杂志文章
  • Genetic polymorphisms of ORAI1 and chronic kidney disease in Taiwanese population.

    abstract::Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involve...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/290863

    authors: Hwang DY,Chien SC,Hsu YW,Kao CC,Cheng SY,Lu HC,Wu MS,Chang JM

    更新日期:2014-01-01 00:00:00

  • Donor and Recipient Outcomes following Robotic-Assisted Laparoscopic Living Donor Nephrectomy: A Systematic Review.

    abstract:Aims:We aimed to summarize available lines of evidence about intraoperative and postoperative donor outcomes following robotic-assisted laparoscopic donor nephrectomy (RALDN) as well as outcomes of graft and recipients. Methods:A systematic review of PubMed/Medline, ISI Web of Knowledge, and Scopus databases was perfo...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2019/1729138

    authors: Creta M,Calogero A,Sagnelli C,Peluso G,Incollingo P,Candida M,Minieri G,Longo N,Fusco F,Tammaro V,Dodaro CA,Mangiapia F,Carlomagno N

    更新日期:2019-04-22 00:00:00

  • Improved efficacy of transcatheter arterial chemoembolization using warmed miriplatin for hepatocellular carcinoma.

    abstract::The aim of this study was to evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) using warmed and nonwarmed miriplatin for hepatocellular carcinoma. Eighty patients (117 nodules), treated between January 2010 and June 2013, were evaluated. Thirty-two and 85 nodules were treated with non...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/359296

    authors: Yasui D,Murata S,Onozawa S,Mine T,Ueda T,Sugihara F,Kawamoto C,Uchida E,Kumita S

    更新日期:2014-01-01 00:00:00

  • The Role of Tc-99m DTPA Renal Dynamic Scintigraphy in Retroperitoneal Liposarcoma.

    abstract:Purpose:Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9765162

    authors: Wang Y,Li M,Dai S,Li Y

    更新日期:2020-02-22 00:00:00

  • Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer.

    abstract::The aim of the present study was to evaluate the antitumor potential of iminoflavones in in vitro and in vivo anticancer models. Preliminary screening in various cancer cell lines revealed four potential iminoflavones out of which IMF-8 was taken based on its activity against colon cancer cells. This was further confi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/569130

    authors: Prasad VG,Kawade S,Jayashree BS,Reddy ND,Francis A,Nayak PG,Kishore A,Nandakumar K,Rao CM,Shenoy RR

    更新日期:2014-01-01 00:00:00

  • Analysis of Transcription Factor-Related Regulatory Networks Based on Bioinformatics Analysis and Validation in Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinoma (HCC) accounts for a significant proportion of liver cancer, which has become the second most common cause of cancer-related mortality worldwide. To investigate the potential mechanisms of invasion and progression of HCC, bioinformatics analysis and validation by qRT-PCR were performed. We fou...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1431396

    authors: Liu S,Yao X,Zhang D,Sheng J,Wen X,Wang Q,Chen G,Li Z,Du Z,Zhang X

    更新日期:2018-08-29 00:00:00

  • Does the Length of Elbow Flexors and Visual Feedback Have Effect on Accuracy of Isometric Muscle Contraction in Men after Stroke?

    abstract:UNLABELLED:The aim of the study was to determine the effect of different muscle length and visual feedback information (VFI) on accuracy of isometric contraction of elbow flexors in men after an ischemic stroke (IS). MATERIALS AND METHODS:Maximum voluntary muscle contraction force (MVMCF) and accurate determinate musc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7641705

    authors: Juodzbaliene V,Darbutas T,Skurvydas A,Brazaitis M

    更新日期:2016-01-01 00:00:00

  • Characterization of a Thioredoxin-1 Gene from Taenia solium and Its Encoding Product.

    abstract::Taenia solium thioredoxin-1 gene (TsTrx-1) has a length of 771 bp with three exons and two introns. The core promoter gene presents two putative stress transcription factor binding sites, one putative TATA box, and a transcription start site (TSS). TsTrx-1 mRNA is expressed higher in larvae than in adult. This gene en...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/453469

    authors: Jiménez L,Rodríguez-Lima O,Ochoa-Sánchez A,Landa A

    更新日期:2015-01-01 00:00:00

  • Chair-based exercises for frail older people: a systematic review.

    abstract:INTRODUCTION:Frail older people are often unable to undertake high-intensity exercise programmes. Chair-based exercises (CBEs) are used as an alternative, for which health benefits are uncertain. OBJECTIVE:To examine the effects of CBE programmes for frail older people through a systematic review of existing literatur...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/309506

    authors: Anthony K,Robinson K,Logan P,Gordon AL,Harwood RH,Masud T

    更新日期:2013-01-01 00:00:00

  • Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds.

    abstract::Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine. However, little is known regarding the sedative and hypnotic effects of PRPCA. In the present study, we examined th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6198067

    authors: Lin S,Nie B,Song K,Ye R,Yuan Z

    更新日期:2019-04-28 00:00:00

  • Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy.

    abstract:Purpose:Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/4756313

    authors: Bienert M,Plange N,Remky A,Arend KO,Kuerten D

    更新日期:2018-02-06 00:00:00

  • Effect of modulated alternating and direct current iontophoresis on transdermal delivery of lidocaine hydrochloride.

    abstract::The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/537941

    authors: Bhatia G,Banga AK

    更新日期:2014-01-01 00:00:00

  • Elevated miRNA Inversely Correlates with E-cadherin Gene Expression in Tissue Biopsies from Crohn Disease Patients in contrast to Ulcerative Colitis Patients.

    abstract::Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn disease (CD). Similar symptoms, but different treatment procedures for both diseases require precise diagnosis. MicroRNAs (miRNAs) are major posttranscriptional players that regulate the expression of genes during the inflammation and thus co...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4250329

    authors: Guz M,Dworzański T,Jeleniewicz W,Cybulski M,Kozicka J,Stepulak A,Celiński K

    更新日期:2020-07-22 00:00:00

  • Recent trends of polymer mediated liposomal gene delivery system.

    abstract::Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route ...

    journal_title:BioMed research international

    pub_type: 杂志文章,收录出版,评审

    doi:10.1155/2014/934605

    authors: Kundu SK,Sharma AR,Lee SS,Sharma G,Doss CG,Yagihara S,Kim DY,Nam JS,Chakraborty C

    更新日期:2014-01-01 00:00:00

  • Clinical Usefulness of Immunohistochemical Staining of p57 kip2 for the Differential Diagnosis of Complete Mole.

    abstract:OBJECTIVE:Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? METHODS AND MATERIALS:Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and exami...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/905648

    authors: Sasaki S,Sasaki Y,Kunimura T,Sekizawa A,Kojima Y,Iino K

    更新日期:2015-01-01 00:00:00

  • The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study.

    abstract::The incidence of postoperative nausea and vomiting (PONV) is 30-50% after surgery. PONV occurs frequently, especially after craniotomy. In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant, a neurokinin-1 (NK1) receptor antago...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/307025

    authors: Tsutsumi YM,Kakuta N,Soga T,Kume K,Hamaguchi E,Tsutsumi R,Tanaka K

    更新日期:2014-01-01 00:00:00

  • An Artificial Intelligence Model for Predicting 1-Year Survival of Bone Metastases in Non-Small-Cell Lung Cancer Patients Based on XGBoost Algorithm.

    abstract::Non-small-cell lung cancer (NSCLC) patients often develop bone metastases (BM), and the overall survival for these patients is usually perishing. However, a model with high accuracy for predicting the survival of NSCLC with BM is still lacking. Here, we aimed to establish a model based on artificial intelligence for p...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3462363

    authors: Huang Z,Hu C,Chi C,Jiang Z,Tong Y,Zhao C

    更新日期:2020-06-27 00:00:00

  • Shaped 3D singular spectrum analysis for quantifying gene expression, with application to the early zebrafish embryo.

    abstract::Recent progress in microscopy technologies, biological markers, and automated processing methods is making possible the development of gene expression atlases at cellular-level resolution over whole embryos. Raw data on gene expression is usually very noisy. This noise comes from both experimental (technical/methodolo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/986436

    authors: Shlemov A,Golyandina N,Holloway D,Spirov A

    更新日期:2015-01-01 00:00:00

  • Impact of Iodinated Contrast on Renal Function and Hemodynamics in Rats with Chronic Hyperglycemia and Chronic Kidney Disease.

    abstract::Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3019410

    authors: Fernandes SM,Martins DM,da Fonseca CD,Watanabe M,Vattimo Mde F

    更新日期:2016-01-01 00:00:00

  • Newborn first feed and prelacteal feeds in Mansoura, Egypt.

    abstract:BACKGROUND:Prelacteal feed (feeding any other substance before first breastfeeding) appears to be common despite its harmful effects. By definition a child provided with prelacteal feed (PLF) is not exclusively breastfed and PLF has many implications for the success and early initiation of breastfeeding. Objectives. To...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/258470

    authors: El-Gilany AH,Abdel-Hady DM

    更新日期:2014-01-01 00:00:00

  • Tumor and endothelial cell hybrids participate in glioblastoma vasculature.

    abstract:BACKGROUND:Recently antiangiogenic therapy with bevacizumab has shown a high but transient efficacy in glioblastoma (GBM). Indeed, GBM is one of the most angiogenic human tumors and endothelial proliferation is a hallmark of the disease. We therefore hypothesized that tumor cells may participate in endothelial prolifer...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/827327

    authors: El Hallani S,Colin C,El Houfi Y,Idbaih A,Boisselier B,Marie Y,Ravassard P,Labussière M,Mokhtari K,Thomas JL,Delattre JY,Eichmann A,Sanson M

    更新日期:2014-01-01 00:00:00

  • Molecular fingerprints to identify Candida species.

    abstract::A wide range of molecular techniques have been developed for genotyping Candida species. Among them, multilocus sequence typing (MLST) and microsatellite length polymorphisms (MLP) analysis have recently emerged. MLST relies on DNA sequences of internal regions of various independent housekeeping genes, while MLP iden...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/923742

    authors: Spampinato C,Leonardi D

    更新日期:2013-01-01 00:00:00

  • Removal of white mineral trioxide aggregate cement: a promising approach.

    abstract::Removal of MTA from dentin by applying 37% hydrochloric acid (HCl) to reduce microhardness and push-out bond strength. Forty dentin slices were filled with WMTA and divided into two groups (n = 20). Ten slices remained untreated while others were exposed to either HCl or phosphate buffer saline (PBS) and all samples w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/469164

    authors: Saghiri MA,Garcia-Godoy F,Gutmann JL,Sheibani N,Asatourian A,Lotfi M,Elyasi M

    更新日期:2013-01-01 00:00:00

  • miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1.

    abstract::MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistanc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/373574

    authors: Long J,Ji Z,Jiang K,Wang Z,Meng G

    更新日期:2015-01-01 00:00:00

  • The Effect of Botulinum Toxin Type A on Expression Profiling of Long Noncoding RNAs in Human Dermal Fibroblasts.

    abstract::Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2957941

    authors: Miao YY,Liu J,Zhu J,Tao YL,Zhang JA,Luo D,Zhou BR

    更新日期:2017-01-01 00:00:00

  • Quantitative Changes in Cerebral Perfusion during Urinary Urgency in Women with Overactive Bladder.

    abstract:PURPOSE:To quantitatively measure changes in cerebral perfusion in select regions of interest in the brain during urinary urgency in women with overactive bladder (OAB) using arterial spin labeling (ASL). METHODS:Twelve women with OAB and 10 controls underwent bladder filling and rated urinary urgency (scale 0-10). AS...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2759035

    authors: Arya NG,Weissbart SJ,Xu S,Bhavsar R,Rao H

    更新日期:2017-01-01 00:00:00

  • Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes.

    abstract::Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during meiotic maturation of mouse oocytes and higher expression of Txndc9 mRNA and protein ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6265890

    authors: Ma F,Hou L,Yang L

    更新日期:2017-01-01 00:00:00

  • The Relationship of Motor Coordination, Visual Perception, and Executive Function to the Development of 4-6-Year-Old Chinese Preschoolers' Visual Motor Integration Skills.

    abstract::Visual motor integration (VMI) is a vital ability in childhood development, which is associated with the performance of many functional skills. By using the Beery Developmental Test Package and Executive Function Tasks, the present study explored the VMI development and its factors (visual perception, motor coordinati...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6264254

    authors: Fang Y,Wang J,Zhang Y,Qin J

    更新日期:2017-01-01 00:00:00

  • Novel Model to Predict the Prognosis of Patients with Stage II-III Colon Cancer.

    abstract::Different opinions exist on the relationship between the C-reactive protein-to-albumin ratio (CAR) and the prognosis of colon cancer. This study is aimed at evaluating the relationship between CAR and prognosis of stage II-III colon cancer and establishing a clinical prognosis model. Patients were randomised to a trai...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8812974

    authors: Xu Y,Liang F,Chen Y,Wang Z,Zhong H,Tang W

    更新日期:2020-11-22 00:00:00

  • Expression and complex formation of MMP9, MMP2, NGAL, and TIMP1 in porcine myocardium but not in skeletal muscles in male pigs with tachycardia-induced systolic heart failure.

    abstract::Matrix metalloproteinases (MMPs) are involved in the remodeling of extracellular matrix in various tissues. Their functioning could be related to the formation of complexes, containing MMP9, MMP2, tissue inhibitor of metalloproteinases type 1 (TIMP1), and neutrophil gelatinase-associated lipocalin (NGAL). Such complex...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/283856

    authors: Kiczak L,Tomaszek A,Bania J,Paslawska U,Zacharski M,Noszczyk-Nowak A,Janiszewski A,Skrzypczak P,Ardehali H,Jankowska EA,Ponikowski P

    更新日期:2013-01-01 00:00:00