Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression.

abstract：:In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Se...

journal_title：BioMed research international

authors： Wattanathorn J,Prabsattroo T,Somsapt P,Sritragool O,Thukham-Mee W,Muchimapura S

更新日期：2018-10-25 00:00:00

abstract：Background:The aims of this study were to explore the characteristics of left ventricular (LV) functional changes in subjects with or without acute mountain sickness (AMS) and their associations with AMS incidence. Methods:A total of 589 healthy men were enrolled and took a trip from Chengdu (500 m, above sea level (a...

journal_title：BioMed research international

authors： Ke J,Liu C,Yu S,Bian S,Zhang C,Yang J,Zhang J,Jin J,Rao R,Zeng Y,Huang L

更新日期：2020-11-10 00:00:00

abstract：:Diverse high energy diets have been utilized to precipitate obesity and related metabolic disorders in rodent models, though the dietary intervention has not absolutely been standardized. The present study established usage of a customized semipurified normal control diet (NCD) and high fat diet (HFD), for research st...

journal_title：BioMed research international

authors： Sasidharan SR,Joseph JA,Anandakumar S,Venkatesan V,Ariyattu Madhavan CN,Agarwal A

更新日期：2013-01-01 00:00:00

abstract：:A standard protocol of dosimetric measurements is used by the organizations responsible for verifying that the doses delivered in radiation-therapy institutions are within authorized limits. This study evaluated a self-designed simple auditing phantom for use in verifying the dose of radiation therapy; the phantom des...

journal_title：BioMed research international

authors： Lee JH,Chang LT,Shiau AC,Chen CW,Liao YJ,Li WJ,Lee MS,Hsu SM

更新日期：2015-01-01 00:00:00

abstract：:Functional connectivity has been correlated with a patient's level of consciousness and has been found to be altered in several neuropsychiatric disorders. Absence epilepsy patients, who experience a loss of consciousness, are assumed to suffer from alterations in thalamocortical networks; however, previous studies ha...

journal_title：BioMed research international

authors： Xu CP,Zhang SW,Fang T,Manxiu M,Chencan Q,Huafu C,Zhu HW,Li YJ,Zuxiang L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Anaemia with an estimated prevalence of 35-75% among pregnant women is a major cause of maternal deaths in Nigeria. objective: To determine the prevalence of anaemia, associated sociodemographic factors and red cell morphological pattern among pregnant women during booking at the University Teaching Hospital...

journal_title：BioMed research international

authors： Olatunbosun OA,Abasiattai AM,Bassey EA,James RS,Ibanga G,Morgan A

更新日期：2014-01-01 00:00:00

abstract：:Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...

journal_title：BioMed research international

authors： Liu L,Yang K,Wang X,Shi Z,Yang Y,Yuan Y,Guo T,Xiao X,Luo H

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:The aim of our work was to investigate the causal connection between M1 and M2 macrophage phenotypes occurrence and prostate cancer, their correlation with tumor extension (ECE), and biochemical recurrence (BR). PATIENT AND METHODS:Clinical and pathological data were prospectively gathered from 93 patient...

journal_title：BioMed research international

authors： Lanciotti M,Masieri L,Raspollini MR,Minervini A,Mari A,Comito G,Giannoni E,Carini M,Chiarugi P,Serni S

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistanc...

journal_title：BioMed research international

authors： Long J,Ji Z,Jiang K,Wang Z,Meng G

更新日期：2015-01-01 00:00:00

abstract：:This study investigates the mechanism underlying the improving effect of zinc on fertility in obese rats using proteomics. The effects of three different doses of ZnSO4 on spermatogenesis and hormone levels were studied. Testicular spermatogenesis was observed by HE staining. Serum estrogen and testosterone levels wer...

journal_title：BioMed research international

authors： Ma J,Han R,Li Y,Cui T,Wang S

更新日期：2020-05-04 00:00:00

abstract：:Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients' characteristics. The functional experiments and mechanism studies...

journal_title：BioMed research international

authors： Wang A,Jiang A,Gan X,Wang Z,Huang J,Dong K,Liu B,Wang L,Chen M

更新日期：2020-12-22 00:00:00

abstract：:Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...

journal_title：BioMed research international

authors： Miao YY,Liu J,Zhu J,Tao YL,Zhang JA,Luo D,Zhou BR

更新日期：2017-01-01 00:00:00

abstract：:The influence of biomimetic calcium phosphate coating on osteoblasts behavior in vitro is not well established yet. In this study, we investigated the behavior of osteoblastic rat osteosarcoma 17/2.8 cells (ROS17/2.8) on two groups of biomaterial surfaces: alkaline-treated titanium surface (ATT) and biomimetic calcium...

journal_title：BioMed research international

authors： Yu X,Wei M

更新日期：2013-01-01 00:00:00

abstract：:Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...

journal_title：BioMed research international

authors： de Souza Fernandez T,Fonseca Alvarenga T,Almeida Antônio de Kós E,Lamim Lovatel V,Tavares RC,da Costa ES,de Souza Fernandez C,Abdelhay E

更新日期：2019-12-10 00:00:00

abstract：:Over the years, studies have demonstrated morphological changes in the brain of fibromyalgia (FMS). We aimed to conduct a coordinate-based meta-analytic research through systemic review on voxel-based morphometry (VBM) imaging results to identify consistent gray matter (GM) difference between FMS patients and healthy ...

journal_title：BioMed research international

authors： Lin C,Lee SH,Weng HH

更新日期：2016-01-01 00:00:00

abstract：:Chromosome rearrangements and fusion genes present major portion of leukemogenesis and contribute to leukemic subtypes. It is practical and helpful to detect the fusion genes in clinic diagnosis of leukemia. Present application of reverse transcription polymerase chain reaction (RT-PCR) method to detect the fusion gen...

journal_title：BioMed research international

authors： Xiong FF,Li BS,Zhang CX,Xiong H,Shen SH,Zhang QH

更新日期：2013-01-01 00:00:00

abstract：:Astragalus membranaceus polysaccharide (APS) components are main ingredients of TCM and have proven efficacy to activate T cells and B cells, enhancing immunity in humans. In this study, elevated cytokine and anti-PD-1 antibody titers were found in mice after immunization with APS. Therefore, phage-display technology ...

journal_title：BioMed research international

authors： Chang FL,Tsai KC,Lin TY,Yang TW,Lo YN,Chen WC,Chang JH,Lu MK,Chiou CT,Chen PH,Yen Y,Pan SL,Lee YC

更新日期：2020-03-03 00:00:00

abstract：:Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism impairment. MicroRNAs are implicated in the development of heart failure. However, the mitochondria enriched microRNA during heart failure remains elusive. Here, we generated a pressure overload-induced early and late stage heart fai...

journal_title：BioMed research international

authors： Wang X,Song C,Zhou X,Han X,Li J,Wang Z,Shang H,Liu Y,Cao H

更新日期：2017-01-01 00:00:00

abstract：:Preoperative 5-fluorouracil- (5-FU-) based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, the effect of 5-FU-based chemoradiotherapy on CRC is limited due to the development of chemoradiation resistance (CRR), and the molecular mechanisms underlying this resistance are...

journal_title：BioMed research international

authors： Xiong W,Ai YQ,Li YF,Ye Q,Chen ZT,Qin JY,Liu QY,Wang H,Ju YH,Li WH,Li YF

更新日期：2017-01-01 00:00:00

abstract：Objectives:To estimate the prevalence of craniofacial anomalies among Iraqi people and its association with other congenital malformations. Methods:A hospital-based cohort study. It was conducted in Iraq, Fallujah city from Jan 2019-April 2019. The pediatric age group below 16 years attending the consultation clinic. ...

journal_title：BioMed research international

authors： Farhan TM,Al-Abdely BA,Abdullateef AN,Jubair AS

更新日期：2020-08-18 00:00:00

abstract：:Brachial plexus injury often involves traumatic root avulsion resulting in permanent paralysis of the innervated muscles. The lack of sufficient regeneration from spinal motoneurons to the peripheral nerve (PN) is considered to be one of the major causes of the unsatisfactory outcome of various surgical interventions ...

journal_title：BioMed research international

authors： Su H,Yuan Q,Qin D,Yang X,Wong WM,So KF,Wu W

更新日期：2014-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...

journal_title：BioMed research international

authors： Vianna VF,Bonfim DC,Cavalcanti Ados S,Fernandes MC,Kahn SA,Casado PL,Lima IC,Murray SS,Murray EJ,Duarte ME

更新日期：2013-01-01 00:00:00

abstract：:Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase sub...

journal_title：BioMed research international

authors： Gilinsky MA,Polityko YK,Markel AL,Latysheva TV,Samson AO,Polis B,Naumenko SE

更新日期：2020-02-12 00:00:00

abstract：:Cardiac computed tomography angiography (CCTA) is widely used as a diagnostic tool for evaluation of coronary artery disease (CAD). Despite the excellent capability to rule-out CAD, CCTA may overestimate the degree of stenosis; furthermore, CCTA analysis can be time consuming, often requiring advanced postprocessing t...

journal_title：BioMed research international

authors： Muscogiuri G,Van Assen M,Tesche C,De Cecco CN,Chiesa M,Scafuri S,Guglielmo M,Baggiano A,Fusini L,Guaricci AI,Rabbat MG,Pontone G

更新日期：2020-12-16 00:00:00

abstract：:Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL...

journal_title：BioMed research international

authors： Li XJ,Mishra SK,Wu M,Zhang F,Zheng J

更新日期：2014-01-01 00:00:00

abstract：:The use of supplemental oxygen in uncomplicated cesarean deliveries under spinal anesthesia has been thoroughly investigated during recent decades. The aim of this study was to determine the benefits for both mother and infant of administering supplemental, low-dose oxygen via a nasal cannula versus having no suppleme...

journal_title：BioMed research international

authors： Siriussawakul A,Triyasunant N,Nimmannit A,Ngerncham S,Hirunkanokpan P,Luang-Aram S,Pechpaisit N,Wangdee A,Ruangvutilert P

更新日期：2014-01-01 00:00:00

abstract：Background:In addition to the widely known effect of vitamin D3 (vitD3) on the skeleton, its role in the regulation of the immune response was also confirmed. Aim:The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosi...

journal_title：BioMed research international

authors： Niedziela N,Pierzchała K,Zalejska-Fiolka J,Niedziela JT,Romuk E,Torbus-Paluszczak M,Adamczyk-Sowa M

更新日期：2018-08-23 00:00:00

abstract：:Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is a complex multifactorial process. Animal models are essential to furthering understanding of the degenerative process and testing pot...

journal_title：BioMed research international

authors： Daly C,Ghosh P,Jenkin G,Oehme D,Goldschlager T

更新日期：2016-01-01 00:00:00

abstract：:Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract su...

journal_title：BioMed research international

authors： Liu G,Guan G,Fang J,Martínez Y,Chen S,Bin P,Duraipandiyan V,Gong T,Tossou MC,Al-Dhabi NA,Yin Y

更新日期：2016-01-01 00:00:00

abstract：Background:The aim of our study was to investigate the impact of abdominal wall reconstruction surgery on tissue anatomy and to explore how flap surgery influences the patient's immune status. Methods:Experimental abdominal wall defects were created in 8 Sus scrofa (swine) animal models. The animals were divided into ...

journal_title：BioMed research international

authors： Popa F,Georgescu AV

更新日期：2017-01-01 00:00:00