A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic.

abstract：Background:As a newly discovered lncRNA, bladder cancer-associated transcript 1 (BLACAT1) has been reported to correlate with poor clinical outcomes in several different cancers. This study aimed to evaluate its generalized predictive value for cancer prognosis. Materials and Methods:We thoroughly searched PubMed, Emb...

journal_title：BioMed research international

authors： Lu H,Liu H,Yang X,Ye T,Lv P,Wu X,Ye Z

更新日期：2019-04-02 00:00:00

abstract：:Astrocytic impairment is a pathologic feature of neuromyelitis optica spectrum disorder (NMOSD). S100B and glial fibrillary acidic protein (GFAP) are the two most commonly used astrocytic markers. The aim of this study was to evaluate whether CSF-S100B could serve as a marker of NMOSD. We enrolled 49 NMOSD patients [2...

journal_title：BioMed research international

authors： Wei Y,Chang H,Li X,Du L,Xu W,Cong H,Yao Y,Zhang X,Yin L

更新日期：2018-10-22 00:00:00

abstract：:Cabbages (Brassica oleracea L.) are an important vegetable crop around world, and cold temperature is among the most significant abiotic stresses causing agricultural losses, especially in cabbage crops. Plant bZIP transcription factors play diverse roles in biotic/abiotic stress responses. In this study, 119 putative...

journal_title：BioMed research international

authors： Hwang I,Manoharan RK,Kang JG,Chung MY,Kim YW,Nou IS

更新日期：2016-01-01 00:00:00

abstract：:Activity-dependent plasticity as a result of reorganization of neural circuits is a fundamental characteristic of the central nervous system that occurs simultaneously in multiple sites. In this study, we established the effects of subthreshold transcranial magnetic stimulation (TMS) over the primary motor cortex regi...

journal_title：BioMed research international

authors： Hajela N,Mummidisetty CK,Smith AC,Knikou M

更新日期：2013-01-01 00:00:00

abstract：:This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-14...

journal_title：BioMed research international

authors： Zhang ZY,Li YC,Geng CY,Wang HJ,Chen WM

更新日期：2019-12-14 00:00:00

abstract：:Introduction. The triangular fibrocartilage complex (TFCC) provides both mobility and stability of the radiocarpal joint. TFCC lesions are difficult to diagnose due to the complex anatomy. The standard treatment for TFCC lesions is arthroscopy, posing surgery-related risks onto the patients. This feasibility study aim...

journal_title：BioMed research international

authors： Hammer N,Hirschfeld U,Strunz H,Werner M,Wolfskämpf T,Löffler S

更新日期：2017-01-01 00:00:00

abstract：:Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract su...

journal_title：BioMed research international

authors： Liu G,Guan G,Fang J,Martínez Y,Chen S,Bin P,Duraipandiyan V,Gong T,Tossou MC,Al-Dhabi NA,Yin Y

更新日期：2016-01-01 00:00:00

abstract：:Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that s...

journal_title：BioMed research international

authors： Nikitovic D,Kouvidi K,Karamanos NK,Tzanakakis GN

更新日期：2013-01-01 00:00:00

abstract：:Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route ...

journal_title：BioMed research international

authors： Kundu SK,Sharma AR,Lee SS,Sharma G,Doss CG,Yagihara S,Kim DY,Nam JS,Chakraborty C

更新日期：2014-01-01 00:00:00

abstract：Objective:To investigate the effects of electroacupuncture (EA) at "Zusanli" (ST36) and "Shangjuxu"(ST37) on reducing inflammatory reaction and improving intestinal dysfunction in patients with sepsis-induced intestinal dysfunction with syndrome of obstruction of the bowels Qi. Methods:A total of 71 patients with seps...

journal_title：BioMed research international

authors： Meng JB,Jiao YN,Zhang G,Xu XJ,Ji CL,Hu MH,Lai ZZ,Zhang M

更新日期：2018-06-26 00:00:00

abstract：:Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing t...

journal_title：BioMed research international

authors： Farini A,Sitzia C,Erratico S,Meregalli M,Torrente Y

更新日期：2014-01-01 00:00:00

abstract：:Introduction. Given its efficacy and safety, NexoBrid™ (NXB) has become part of our therapeutic options in burns treatment with satisfactory results. However, no cost analysis comparing NXB to the standard of care (SOC) has been carried out as of today. Aim. To assess the cost of treatment with NXB and compare it to t...

journal_title：BioMed research international

authors： Giudice G,Filoni A,Maggio G,Bonamonte D,Vestita M

更新日期：2017-01-01 00:00:00

abstract：:Upon allergen challenge, DC subsets are recruited to target sites under the influence of chemotactic agents; however, details pertinent to their trafficking remain largely unknown. We investigated the kinetic profiles of blood and skin-infiltrating DC subsets in twelve atopic subjects receiving six weekly intradermal ...

journal_title：BioMed research international

authors： Vittorakis S,Samitas K,Tousa S,Zervas E,Aggelakopoulou M,Semitekolou M,Panoutsakopoulou V,Xanthou G,Gaga M

更新日期：2014-01-01 00:00:00

abstract：:Persistent catecholamine-resistant shock in children causes severe morbidity and mortality. We aimed to analyze the association between hemodynamics and serum lactate at different time points and 28-day mortality in children with persistent catecholamine-resistant shock. Methods. Twenty-six children with persistent ca...

journal_title：BioMed research international

authors： Lee EP,Chu SC,Hsia SH,Chen KF,Chan OW,Lin CY,Su YT,Lin JJ,Wu HP

更新日期：2020-06-19 00:00:00

abstract：:The 3'-end processing (3'P) of each viral long terminal repeat (LTR) during human immunodeficiency virus type-1 (HIV-1) integration is a vital step in the HIV life cycle. Blocking the 3'P using 3'P inhibitor has recently become an attractive strategy for HIV-1 therapeutic intervention. Recently, we have developed a no...

journal_title：BioMed research international

authors： Sakkhachornphop S,Thongkum W,Tayapiwatana C

更新日期：2015-01-01 00:00:00

abstract：Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...

journal_title：BioMed research international

authors： Mulatu T,Sintayehu Y,Dessie Y,Deressa M

更新日期：2020-12-29 00:00:00

abstract：Background and Aims:Concordance between transient elastography (TE) and ultrasonography (US) in assessing liver fibrosis in patients with chronic hepatitis B (CHB) and concurrent nonalcoholic fatty liver disease (NAFLD) has been rarely studied. This study aimed to evaluate the individual and combined performances of TE...

journal_title：BioMed research international

authors： Zhang GL,Zhao QY,Lin CS,Hu ZX,Zhang T,Gao ZL

更新日期：2019-01-23 00:00:00

abstract：:The aim of this study was to investigate the anticancer and antioxidant activities as well as the safety of the brown algae Dictyota dichotoma of the Western seacoast of Yemen. Cytotoxicity of methanol extract of D. dichotoma and several of its fractions, petroleum ether, chloroform, ethyl acetate, n-butanol, and aque...

journal_title：BioMed research international

authors： El-Shaibany A,Al-Habori M,Al-Maqtari T,Al-Mahbashi H

更新日期：2020-02-17 00:00:00

abstract：Objective:It is sometimes difficult to obtain complete/partial response of large hepatocellular carcinoma (HCC) nodules by trans-arterial chemoembolization/embolization (TACE/TAE). The aim is retrospective investigation of tumor response of large HCC nodules (>7 cm) treated by the new TACE technique, repeated alternate...

journal_title：BioMed research international

authors： Irie T,Takahashi N,Kamoshida T,Kashimura J,Ariga H

更新日期：2020-01-19 00:00:00

abstract：:Diabetes-triggered apoptosis of Schwann cells (SC) contributes to the degradation of diabetic peripheral neuropathy (DNP). In recent years, mesenchymal stem cells (MSC) were applied to DPN repair and it was demonstrated that paracrine secretion played a key role in neuroprotection exerted by MSC. Erythropoietin (EPO) ...

journal_title：BioMed research international

authors： Zhang S,Shi B

更新日期：2017-01-01 00:00:00

abstract：:The plant cytoskeleton, including microtubules and microfilaments, is one of the important factors in determining the polarity of cell division and growth, as well as the interaction of plants with invading pathogens. In defense responses of wheat against the stripe rust (Puccinia striiformis f. sp. tritici) infection...

journal_title：BioMed research international

authors： Wang J,Wang Y,Liu X,Xu Y,Ma Q

更新日期：2016-01-01 00:00:00

abstract：:Background. Neuroinflammation which presents as a possible mechanism of delirium is associated with MCP-1, an important proinflammatory factor which is expressed on astrocytes. It is known that dexmedetomidine (DEX) possesses potent anti-inflammatory properties. This study aimed to investigate the potential effects of...

journal_title：BioMed research international

authors： Liu H,Davis JR,Wu ZL,Faez Abdelgawad A

更新日期：2017-01-01 00:00:00

abstract：:Extra-intestinal E. coli are emerging as a global threat due to their diffusion as opportunistic pathogens and, above all, to their wide set of antibiotic resistance determinants. There are still many gaps in our knowledge of their origin and spread pathways, although food animals have been adjudicated vehicles for pa...

journal_title：BioMed research international

authors： Caruso G,Giammanco A,Cardamone C,Oliveri G,Mascarella C,Capra G,Fasciana T

更新日期：2018-11-18 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) using warmed and nonwarmed miriplatin for hepatocellular carcinoma. Eighty patients (117 nodules), treated between January 2010 and June 2013, were evaluated. Thirty-two and 85 nodules were treated with non...

journal_title：BioMed research international

authors： Yasui D,Murata S,Onozawa S,Mine T,Ueda T,Sugihara F,Kawamoto C,Uchida E,Kumita S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Although expression of miR-200s is aberrant in liver fibrosis, its role in liver fibrogenesis still remains unknown. Here, we investigated the role of miR-200c in the activation of human hepatic stellate cells (HSCs) and induction of liver fibrosis. METHODS:We engineered human HSCs (LX2 cell line) to stably...

journal_title：BioMed research international

authors： Ma T,Cai X,Wang Z,Huang L,Wang C,Jiang S,Hua Y,Liu Q

更新日期：2017-01-01 00:00:00

abstract：:For more than 30 years, heart transplantation has been a successful therapy for patients with terminal heart failure. Mechanical circulatory support (MCS) was developed as a therapy for end-stage heart failure at a time when cardiac transplantation was not yet a useful treatment modality. With the more successful outc...

journal_title：BioMed research international

authors： Anand J,Singh SK,Antoun DG,Cohn WE,Frazier OH,Mallidi HR

更新日期：2015-01-01 00:00:00

abstract：:One of the most common complications of diabetes mellitus is diabetic neuropathy. It may be provoked by metabolic and/or vascular factors, and depending on duration of disease, various layers of nerve may be affected. Our aim was to investigate influence of diabetes on the epineurial, perineurial, and endoneurial conn...

journal_title：BioMed research international

authors： Kundalić B,Ugrenović S,Jovanović I,Stefanović N,Petrović V,Kundalić J,Stojanović V,Živković V,Antić V

更新日期：2014-01-01 00:00:00

abstract：:Background and Purposes. The 320-detector row CT scanner enables visualization of whole-brain hemodynamic information (dynamic CT angiography (CTA) derived from CT perfusion scans). However, arterial image quality in dynamic CTA (dCTA) is inferior to arterial image quality in standard CTA. This study evaluates whether...

journal_title：BioMed research international

authors： Ghariq E,Mendrik AM,Willems PW,Joemai RM,Ghariq E,Vonken EJ,van Osch MJ,van Walderveen MA

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. MATERIALS AND METHODS:A comparison of the outcomes of randomized controlled trials (RCTs) included ...

journal_title：BioMed research international

authors： Milants C,Bruyère O,Kaux JF

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:This paper presents the final results of a cross-sectional study started in 2010. It compares the perceived efficacy of different types of tobacco health warning (texts versus shocking pictures) to quit or reduce tobacco use. METHODS:The study conducted between 2010 and 2012 in Italy enrolled adults smoke...

journal_title：BioMed research international

authors： Mannocci A,Colamesta V,Conti V,Cattaruzza MS,Paone G,Cafolla M,Saulle R,Bulzomì V,Antici D,Cuccurullo P,Boccia A,La Torre G,Terzano C

更新日期：2014-01-01 00:00:00