Abstract:
:MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistance is a common and critical limitation to cancer therapy. The aim of this study was to investigate whether miR-193b mediated the resistance of breast cancer cells to doxorubicin by targeting myeloid cell leukemia-1 (MCL-1). In this study, we found that miR-193b levels were significantly lower in doxorubicin-resistant MCF-7 (MCF-7/DOXR) cells than in the parental MCF-7 cells. We observed that exogenous miR-193b significantly suppressed the ability of MCF-7/DOXR cells to resist doxorubicin. It demonstrated that miR-193b directly targeted MCL-1 3'-UTR (3'-Untranslated Regions). Further studies indicated that miR-193b sensitized MCF-7/DOXR cells to doxorubicin through a mechanism involving the downregulation of MCL-1. Together, our findings provide evidence that the modulation of miR-193b may represent a novel therapeutic target for the treatment of breast cancer.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Long J,Ji Z,Jiang K,Wang Z,Meng Gdoi
10.1155/2015/373574subject
Has Abstractpub_date
2015-01-01 00:00:00pages
373574eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Cognitive decline impacts older adults, particularly their independence. The goal of this project was to increase understanding of how short-term, everyday lifestyle options, including physical activity, help an older adult sustain cognitive independence. Using a secondary analysis of lifestyle choices, we drew on a d...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2016/7405748
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/576528
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2874819
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5147156
更新日期:2018-02-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/549785
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/151503
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2926419
更新日期:2020-08-14 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9209676
更新日期:2019-04-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/872701
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4658024
更新日期:2018-05-30 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1630890
更新日期:2020-01-08 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/741309
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3698742
更新日期:2019-04-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/845041
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7279036
更新日期:2018-07-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4759060
更新日期:2019-07-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8421614
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/401341
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/190629
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3462363
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243681
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/187989
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/4816527
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/493019
更新日期:2013-01-01 00:00:00
abstract::Several intestinal parasites of baboons are of zoonotic importance, especially where there is considerable interaction between the baboons and humans. The identification of gastrointestinal parasite infections of baboons (Papio anubis) was undertaken at the Shai Hills Reserve Resort, Ghana. A total of 51 faecal sample...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1083251
更新日期:2020-03-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/351942
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/615312
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/273936
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/231474
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/913235
更新日期:2014-01-01 00:00:00