Abstract:
:Emergence and spread of pandemic strains of Vibrio parahaemolyticus have drawn attention to make detailed study on their genomes. The pathogenicity of V. parahaemolyticus has been associated with thermostable-direct hemolysin (TDH) and/or TDH-related hemolysin (TRH). The present study evaluated characteristics of tdh and trh genes, considering the phylogenetic and in silico functional features of V. parahaemolyticus and other bacteria. Fifty-two tdh and trh genes submitted to the GenBank were analyzed for sequence similarity. The promoter sequences of these genes were also analyzed from transcription start point to -35 regions and correlated with amino acid substitution within the coding regions. The phylogenetic analysis revealed that tdh and trh are highly distinct and also differ within the V. parahaemolyticus strains that were isolated from different geographical regions. Promoter sequence analysis revealed nucleotide substitutions and deletions at -18 and -19 positions among the pandemic, prepandemic, and nonpandemic tdh sequences. Many amino acid substitutions were also found within the signal peptide and also in the matured protein region of several TDH proteins as compared to TDH-S protein of pandemic V. parahaemolyticus. Experimental evidences are needed to recognize the importance of substitutions and deletions in the tdh and trh genes.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Bhowmik SK,Pazhani GP,Ramamurthy Tdoi
10.1155/2014/576528subject
Has Abstractpub_date
2014-01-01 00:00:00pages
576528eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Quantitative magnetic resonance imaging (qMRI) is a promising approach to detect early cartilage degeneration. However, there is no consensus on which cartilage component contributes to the tissue's qMRI signal properties. T1, T1ρ, and T2⁎ maps of cartilage samples (n = 8) were generated on a clinical 3.0-T MRI system...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9460456
更新日期:2018-05-15 00:00:00
abstract::The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failu...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/137287
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6109497
更新日期:2020-06-11 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2013/168438
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5202750
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/563756
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2020/5843874
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/964365
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/5953036
更新日期:2019-12-04 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2016/1893474
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/4179617
更新日期:2019-05-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/421746
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/325806
更新日期:2013-01-01 00:00:00
abstract::Malaria is one of the life-threatening diseases in the world. The spread of resistance to antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in the Southeast Asian region. In the previous study, the active compound of Streptomyces hygroscopicus subsp. Hygroscopicus (S. hygroscopic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6135696
更新日期:2020-01-09 00:00:00
abstract::Hydrogel injection has been recently proposed as a novel therapy for disc degenerative diseases, with the potential to restore the spine motion and the intervertebral disc height. However, it remains unknown whether the new technique could also maintain the shock absorbing property of the treated intervertebral disc. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/461724
更新日期:2014-01-01 00:00:00
abstract::Functional connectivity has been correlated with a patient's level of consciousness and has been found to be altered in several neuropsychiatric disorders. Absence epilepsy patients, who experience a loss of consciousness, are assumed to suffer from alterations in thalamocortical networks; however, previous studies ha...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/734893
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4309161
更新日期:2020-01-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/307032
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/654727
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1061979
更新日期:2019-05-15 00:00:00
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pub_type: 杂志文章
doi:10.1155/2017/4637621
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9530963
更新日期:2019-10-20 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569130
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3281590
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5046934
更新日期:2019-06-23 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2905987
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/8193821.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5089270
更新日期:2018-05-08 00:00:00