Abstract:
:Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall survival 106 glioblastoma patients were analysed. IDH1 mutations were detected in 13 and IDH2 mutation in one patient. Two homozygous samples with R132H mutation in IDH1 gene and a novel aberration K129R in IDH2 gene were found. Sixty-four percent of IDH1/IDH2 mutated tumours harboured also a mutation in TP53 gene. Genetic aberrations in TP53 were present in 37 patients. Statistical analysis of the impact of the studied factors on the overall survival showed that the mutations in IDH1/IDH2, but not the ones in TP53, were associated with longer survival. Also, the impact of age on prognosis was confirmed. This is the first comprehensive study on glioblastomas in Bulgaria. Our results suggest that IDH1/IDH2 but not TP53 mutations together with other prognostic factors such as age might be applied in clinical practice for prediction of outcome in patients with glioblastomas.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Stancheva G,Goranova T,Laleva M,Kamenova M,Mitkova A,Velinov N,Poptodorov G,Mitev V,Kaneva R,Gabrovsky Ndoi
10.1155/2014/654727subject
Has Abstractpub_date
2014-01-01 00:00:00pages
654727eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract:Objective:Epidemiological studies have shown a correlation between periodontal disease (PD) and age-related macular degeneration (AMD). However, the results have been inconsistent, and no relevant meta-analysis has been performed on this topic. Hence, we performed a meta-analysis to evaluate whether the two diseases ar...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4753645
更新日期:2020-09-28 00:00:00
abstract:OBJECTIVE:In the process of care for disorders of sex development (DSD), clinical decisions should focus on the long-term quality of life (QOL). We sought to investigate the QOL of patients with DSD in China. DESIGN:Case-control study was carried out. PATIENTS:90 patients of DSD participated in the study. Finally, 87...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/342420
更新日期:2015-01-01 00:00:00
abstract::We study the interaction of 3T3 Swiss albino mouse fibroblasts with polymeric nanoparticles (NPs) and investigate cellular behaviour in terms of viability/cytotoxicity, cell cycle, NPs uptake, MAP kinase (ERK1/2), and focal adhesion kinase (FAK) activation. After incubation of NPs with cell culture media, western blot...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/539348
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy. METHODS:In this cross-sectional study UC patients were interviewed, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/359130
更新日期:2015-01-01 00:00:00
abstract::Otitis media (OM) is a common inflammatory disease of the middle ear cavity and mainly occurs in children. As a critical regulator of inflammation response, the nuclear factor kappa B (NF-κB) pathway has been found to play an essential role in the pathogenesis of various human diseases. The aim of this study was to ex...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/8844119
更新日期:2021-01-06 00:00:00
abstract::This study compares the effects of team-sport training, for sedentary men with lifestyle diseases, with fitness training in a pragmatic set-up in a community health centre (CHC). Thirty-two men in the fitness group (FiG) and 36 men in the team-sport group (TsG) completed the training and trained for 60-90 min, two tim...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1571807
更新日期:2018-05-15 00:00:00
abstract::Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effect...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/801214
更新日期:2013-01-01 00:00:00
abstract::The objective of this study is to introduce a method using a percutaneous full-endoscopic interlaminar approach via a surrounding nerve root discectomy (SNRD) operative route that involves removing the protrusive disc via both the shoulder and the axilla of the corresponding nerve root for the treatment of ventral-typ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/9157089
更新日期:2018-02-12 00:00:00
abstract:Background:The apolipoprotein E knockout (ApoE -/-) mouse model is well established for the study of terpenoids in the prevention of atherosclerosis. Studies investigating the clinical benefit of terpenoids in humans are scarce. This systematic review and meta-analysis evaluated the effects of terpenoid administration ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2019/2931831
更新日期:2019-07-17 00:00:00
abstract::The purpose of the present study was to examine the convergent and divergent validity of the Biber Cognitive Estimation Test (BCET) in individuals with ABI undergoing postacute rehabilitation and to assess the measure's ability to account for unique variance in community integration following rehabilitation. Participa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2874819
更新日期:2017-01-01 00:00:00
abstract:Background and Aim:ROHHADNET (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor) syndrome is a rare disease with grave outcome. Although early recognition is essential, prompt diagnosis may be challenging due to its extreme rarity. This study aimed to systematically r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1250721
更新日期:2018-11-21 00:00:00
abstract::Autoimmunity remains a complex physiologic deviation, enabled and perpetuated by a variety of interplayers and pathways. Simplistic approaches, targeting either isolated end-effectors of more centrally placed interactors of these mechanisms, are continuously tried in an effort to comprehend and halt cascades with pote...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/973609
更新日期:2014-01-01 00:00:00
abstract::Two fullerene derivatives (fullerenes 1 and 2), bearing a hydrophilic chain on the pyrrolidinic nitrogen, were developed with the aim to deliver anticancer agents to solid tumors. These two compounds showed a significantly different behaviour on human neoplastic cell lines in vitro in respect to healthy leukocytes. In...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/915130
更新日期:2015-01-01 00:00:00
abstract::Chlamydophila psittaci (C. psittaci) is a human zoonotic pathogen, which could result in severe respiratory disease. In the present study, we investigated the role and mechanism of the type III secretion system (T3SS) of C. psittaci in regulating the inflammatory response in host cells. C. psittaci-infected THP-1 cell...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/652416
更新日期:2015-01-01 00:00:00
abstract::Professional phagocytic cells, such as dendritic cells, are mainly responsible for phagocytosis, antigen presentation, and cytokine secretion, which induce subsequent activation of T cell-mediated immunity. Thus, strategies that deliver antigens and stimulatory signals to the cells have significant implications for va...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/562924
更新日期:2013-01-01 00:00:00
abstract::There is an emerging body of evidence that chemoresistance and minimal residual disease result from selective resistance of a cell subpopulation from the original tumor that is molecularly and phenotypically distinct. These cells are called "cancer stem cells" (CSCs). In this review, we analyze the potential targeting...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/859871
更新日期:2014-01-01 00:00:00
abstract::Hydrogel injection has been recently proposed as a novel therapy for disc degenerative diseases, with the potential to restore the spine motion and the intervertebral disc height. However, it remains unknown whether the new technique could also maintain the shock absorbing property of the treated intervertebral disc. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/461724
更新日期:2014-01-01 00:00:00
abstract::Influenza virus contains two highly variable envelope glycoproteins, hemagglutinin (HA) and neuraminidase (NA). Here we show that, while HA evolution is much more complex than NA evolution, it still shows abrupt punctuation changes linked to punctuation changes of NA. HA exhibits proteinquakes, which resemble earthqua...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243162
更新日期:2015-01-01 00:00:00
abstract::Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries. Actually, only few models of cardiac cache...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9549036
更新日期:2016-01-01 00:00:00
abstract::We compared the performances of 3 Multiple Allergen Simultaneous Test (MAST) assays: RIDA Allergy Screen (R-Biopharm, Darmstadt, Germany), MAST Optigen allergy system (Hitachi Chemical Diagnostics, Mountain View, CA), and Polycheck Allergy (Biocheck GmbH, Munster, Germany). Forty sera that tested positive with the RID...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/340513
更新日期:2013-01-01 00:00:00
abstract::Although a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of subsequent pregnancy outcome is not clearly elucidated. Here, a retrospective analysis was performed on the clinical data of 492 singleton pregnant women. 164 of them with t...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4359424
更新日期:2017-01-01 00:00:00
abstract::Hilar cholangiocarcinoma (HCC) remains one of the most difficult tumors to stage and treat. The aim of the study was to assess the diagnostic efficiency of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computer tomography (PET/CT) in evaluating the resectability of HCC. A...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/497942
更新日期:2015-01-01 00:00:00
abstract::In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/814984
更新日期:2014-01-01 00:00:00
abstract::Big data bioinformatics aims at drawing biological conclusions from huge and complex biological datasets. Added value from the analysis of big data, however, is only possible if the data is accompanied by accurate metadata annotation. Particularly in high-throughput experiments intelligent approaches are needed to kee...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/958302
更新日期:2015-01-01 00:00:00
abstract::Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase sub...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4935386
更新日期:2020-02-12 00:00:00
abstract::Contrast-induced acute kidney injury (CI-AKI) is commonly defined as a decline in kidney function occurring in a narrow time window after administration of iodinated contrast material. The incidence of AKI after contrast material administration greatly depends on the specific definition and cutoff values used. Althoug...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/859328
更新日期:2014-01-01 00:00:00
abstract:Background:Currently, effective genetic markers are limited to predict the clinical outcome of melanoma. High-throughput multiomics sequencing data have provided a valuable approach for the identification of genes associated with cancer prognosis. Method:The multidimensional data of melanoma patients, including clinic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5323614
更新日期:2020-05-08 00:00:00
abstract::The aim of this study was to investigate the anticancer and antioxidant activities as well as the safety of the brown algae Dictyota dichotoma of the Western seacoast of Yemen. Cytotoxicity of methanol extract of D. dichotoma and several of its fractions, petroleum ether, chloroform, ethyl acetate, n-butanol, and aque...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2425693
更新日期:2020-02-17 00:00:00
abstract::Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ. We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/197183
更新日期:2015-01-01 00:00:00
abstract::Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the secretome from the following informative cervical cell lines: SiHa (HPV16+), HeLa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4180703
更新日期:2017-01-01 00:00:00