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The Demographic and Clinical Characteristics of Ulcerative Colitis in a Northeast Brazilian Population.

Abstract：

INTRODUCTION:The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy. METHODS:In this cross-sectional study UC patients were interviewed, and additional information was collected from the medical records. Descriptive statistics and multivariate Poisson regression analysis were used. RESULTS:This study included 267 individuals, the mean age of whom was 39.4 years at diagnosis. There was a predominance of females and left-side colitis. Extensive colitis was positively associated with male gender, diarrhea, weight loss, and a younger age at diagnosis. In contrast, active smoking and a family history of IBD were negatively associated with extensive colitis. Positive associations were observed between steroid therapy and diarrhea, weight loss, urban patients, extraintestinal manifestations (EIMs), and hospitalization. Younger age and weight loss at diagnosis, a family history of IBD, extensive colitis, EIMs, hospitalization, and steroid therapy were all positively associated with immunosuppression. In contrast, Caucasian individuals, smokers, patients with rectal bleeding, and rural patients areas were all observed to have a decreased likelihood of immunosuppression. CONCLUSIONS:Our results corroborate the association between higher prevalence of extensive colitis and younger age at diagnosis. An association between steroid therapy and clinical presentation at diagnosis was observed. The observation that white individuals and rural patients use less immunosuppressive drugs highlights the need to study the influence of environmental and genetic factors on the behavior of UC in this population.

journal_name

Biomed Res Int

journal_title

BioMed research international

authors

da Silva BC,Lyra AC,Mendes CM,Ribeiro CP,Lisboa SR,de Souza MT,Portela RC,Santana GO

doi

10.1155/2015/359130

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

359130

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

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The Demographic and Clinical Characteristics of Ulcerative Colitis in a Northeast Brazilian Population.