A Genomewide Integrative Analysis of GWAS and eQTLs Data Identifies Multiple Genes and Gene Sets Associated with Obesity.

abstract：:The aim of the study is to investigate the relationship between physical activity as assessed by accelerometers and cognitive development across the human age ranges (from children and adolescents to adults). Additionally, this study seeks to explore whether physical activity contributes to cognitive development via m...

journal_title：BioMed research international

authors： Zhao G,Quan M,Su L,Zhang H,Zhang J,Zhang J,Fang H,Cao ZB,Zhu Z,Niu Z,Wang R,Chen P

更新日期：2017-01-01 00:00:00

abstract：:Bacteria are a source of a large number of secondary metabolites with several biomedical and biotechnological applications. In recent years, there has been tremendous progress in the development of novel synthetic biology approaches both to increase the production rate of secondary metabolites of interest in native pr...

journal_title：BioMed research international

authors： de Frias UA,Pereira GKB,Guazzaroni ME,Silva-Rocha R

更新日期：2018-07-09 00:00:00

abstract：:This study evaluated the efficacy and safety of pulmonary rehabilitation (PR) for pneumoconiosis. We systematically searched PubMed, Embase, The Cochrane Library, Web of Science, SinoMed, CNKI, VIP databases and Wanfang Data from their inception to June 1, 2019. A systematic review and meta-analysis of randomized cont...

journal_title：BioMed research international

authors： Zhao H,Xie Y,Wang J,Li X,Li J

更新日期：2020-07-28 00:00:00

abstract：:Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and pre...

journal_title：BioMed research international

authors： Lin WC,Tsai NW,Huang YC,Cheng KY,Chen HL,Li SH,Kung CT,Su YJ,Lin WM,Chen MH,Chiu TM,Yang IH,Lu CH

更新日期：2014-01-01 00:00:00

abstract：:Calcium phosphate cement (CPC) has good release efficiency and has therefore been used as a drug delivery system for postoperative infection. The release profile of CPC has mainly been evaluated by in vitro studies, which are carried out by immersing test specimens in a relatively large amount of solvent. However, it ...

journal_title：BioMed research international

authors： Uchida K,Sugo K,Nakajima T,Nakawaki M,Takano S,Nagura N,Takaso M,Urabe K

更新日期：2018-05-15 00:00:00

abstract：:Vitamin B6 is one of the most versatile cofactors in plants and an essential phytonutrient in the human diet that benefits a variety of human health aspects. Although biosynthesis of the vitamin has been well resolved in recent years, the main research is currently based on Arabidopsis thaliana with very little work d...

journal_title：BioMed research international

authors： Mooney S,Chen L,Kühn C,Navarre R,Knowles NR,Hellmann H

更新日期：2013-01-01 00:00:00

abstract：:According to the Ministry of Labor, Health and Social Affairs of Georgia a new health management system has to be introduced in the nearest future. In this context arises the problem of structuring and classifying documents containing all the history of medical services provided. The present work introduces the instru...

journal_title：BioMed research international

authors： Khachidze M,Tsintsadze M,Archuadze M

更新日期：2016-01-01 00:00:00

abstract：:Secretory leukoprotease inhibitor (SLPI) is an anti-inflammatory protein present in respiratory secretions. Whilst epithelial cell SLPI is extensively studied, neutrophil associated SLPI is poorly characterised. Neutrophil function including chemotaxis and degranulation of proteolytic enzymes involves changes in cytos...

journal_title：BioMed research international

authors： Reeves EP,Banville N,Ryan DM,O'Reilly N,Bergin DA,Pohl K,Molloy K,McElvaney OJ,Alsaleh K,Aljorfi A,Kandalaft O,O'Flynn E,Geraghty P,O'Neill SJ,McElvaney NG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Inflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache...

journal_title：BioMed research international

authors： Motaghi M,Haghjooy Javanmard S,Haghdoost F,Tajadini M,Saadatnia M,Rafiee L,Zandifar A

更新日期：2013-01-01 00:00:00

abstract：:Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses. Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases an...

journal_title：BioMed research international

authors： Ponomarenko P,Rasskazov D,Suslov V,Sharypova E,Savinkova L,Podkolodnaya O,Podkolodny NL,Tverdokhleb NN,Chadaeva I,Ponomarenko M,Kolchanov N

更新日期：2016-01-01 00:00:00

abstract：:Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties....

journal_title：BioMed research international

authors： Landová H,Vetchý D,Gajdziok J,Doležel P,Muselík J,Dvořáčková K,Jekl V,Hauptman K,Knotek Z

更新日期：2014-01-01 00:00:00

abstract：:Early Infantile Epileptic Encephalopathy (known as Ohtahara Syndrome) is one of the most severe and earliest forms of epilepsy, characterized by early seizures onset. It affects newborns and children between two and six years old. Among the genes that have been associated with early infantile epileptic encephalopathy,...

journal_title：BioMed research international

authors： Al Mehdi K,Fouad B,Zouhair E,Boutaina B,Yassine N,Chaimaa AEC,Najat S,Hassan R,Rachida R,Abdelhamid B,Halima N

更新日期：2019-12-17 00:00:00

abstract：:This study was conducted to evaluate the effect of mesenchymal stem cells (MSCs) and a novel curcumin derivative (NCD) on HepG2 cells (hepatoma cell line) and to investigate their effect on Notch1 signaling pathway target genes. HepG2 cells were divided into HepG2 control group, HepG2 cells treated with MSC conditione...

journal_title：BioMed research international

authors： Abdel Aziz MT,Khaled HM,El Hindawi A,Roshdy NK,Rashed LA,Sabry D,Hassouna AA,Taha F,Ali WI

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Tuberculosis is still one of the most important health problems in developing countries and increasing drug resistance is the main concern for its treatment. This study was designed to characterize the drug resistant Mycobacterium tuberculosis isolated from patients suffering from pulmonary tuberculosis in...

journal_title：BioMed research international

authors： Tavanaee Sani A,Shakiba A,Salehi M,Bahrami Taghanaki HR,Ayati Fard SF,Ghazvini K

更新日期：2015-01-01 00:00:00

abstract：:The endoscopic and histopathological findings detected in Sparus aurata experimentally infected with third-stage Anisakis larvae without intermediate host are evaluated and discussed. In six fish, live nematode larvae were introduced by gastroscopy into the stomach. The first observation by endoscope, 15 days after ch...

journal_title：BioMed research international

authors： Marino F,Lanteri G,Passantino A,De Stefano C,Costa A,Gaglio G,Macrì F

更新日期：2013-01-01 00:00:00

abstract：:Objective. Duodenal atresia (DA) routinely has been corrected by laparotomy and duodenoduodenostomy with excellent long-term results. We revisited the patients with DA treated in the last 12 years (2004-2016) comparing the open and the minimally invasive surgical (MIS) approach. Methods. We divided our cohort of patie...

journal_title：BioMed research international

authors： Chiarenza SF,Bucci V,Conighi ML,Zolpi E,Costa L,Fasoli L,Bleve C

更新日期：2017-01-01 00:00:00

abstract：:Among the different signaling molecules released during reactive gliosis occurring in Alzheimer's disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. The use of pharmacological tools targeting S100B may be crucial to embank its effects and some ...

journal_title：BioMed research international

authors： Cirillo C,Capoccia E,Iuvone T,Cuomo R,Sarnelli G,Steardo L,Esposito G

更新日期：2015-01-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are an abundant cell source and provide an easy way to harvest mesenchymal stem cells, which are the focus of considerable attention in regenerative medicine. Electric fields (EF) play roles in many biological events and have been reported to promote cell proliferation, migration, an...

journal_title：BioMed research international

authors： Jin M,Zhang Y,Bian Y,Qi R,Gao X

更新日期：2020-11-06 00:00:00

abstract：:This study is to investigate multiple chemotherapeutic agent- and radiation-related genetic biomarkers in locally advanced rectal cancer (LARC) patients following fluoropyrimidine-based concurrent chemoradiotherapy (CCRT) for response prediction. We initially selected 6 fluoropyrimidine metabolism-related genes (DPYD,...

journal_title：BioMed research international

authors： Huang MY,Wu CH,Huang CM,Chung FY,Huang CW,Tsai HL,Chen CF,Lin SR,Wang JY

更新日期：2013-01-01 00:00:00

abstract：:This paper presents different applications, in various foodstuffs, by a novel electronic nose (EN) based on a mixed metal oxide sensors array composed of thin films as well as nanowires. The electronic nose used for this work has been done, starting from the commercial model EOS835 produced by SACMI Scarl. The SENSOR ...

journal_title：BioMed research international

authors： Sberveglieri V,Carmona EN,Comini E,Ponzoni A,Zappa D,Pirrotta O,Pulvirenti A

更新日期：2014-01-01 00:00:00

abstract：:Schistosomiasis is the most prevalent tropical disease in the world after malaria. According to the World Health Organization, the disease afflicts more than 240 million people in about 80 countries. Recently, an epidemiological surveillance study performed between 1997 and 2010 by the European Network for Tropical Me...

journal_title：BioMed research international

authors： Brindicci G,Santoro CR,De Laurentiis V,Capolongo C,Solarino ME,Papagni R,Ciracì E,Gatti P,Loconsole D,Monno R,Monno L,Miragliotta G,Angarano G

更新日期：2017-01-01 00:00:00

abstract：:Tsetse flies (Glossina spp.) are the primary vectors of trypanosomes, which can cause human and animal African trypanosomiasis in Sub-Saharan African countries. The objective of this study was to explore the genome of Glossina morsitans morsitans for evidence of horizontal gene transfer (HGT) from microorganisms. We e...

journal_title：BioMed research international

authors： Nakao R,Abe T,Funayama S,Sugimoto C

更新日期：2016-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a very aggressive malignant type of tumor that currently lacks effective targeted therapies. In hematological malignancies, chimeric antigen receptor T (CAR-T) cells have shown very significant antitumor ability; however, in solid tumors, the efficacy is poor. In order to apply ...

journal_title：BioMed research international

authors： Zhao Z,Li Y,Liu W,Li X

更新日期：2020-01-02 00:00:00

abstract：:Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...

journal_title：BioMed research international

authors： Fulciniti M,Munshi NC,Martinez-Lopez J

更新日期：2015-01-01 00:00:00

abstract：:In this paper, differences between multichannel EEG signals of artists and nonartists were analyzed during visual perception and mental imagery of some paintings and at resting condition using approximate entropy (ApEn). It was found that ApEn is significantly higher for artists during the visual perception and the me...

journal_title：BioMed research international

authors： Shourie N,Firoozabadi M,Badie K

更新日期：2014-01-01 00:00:00

abstract：:Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophyla...

journal_title：BioMed research international

authors： Kane SC,Costa Fda S,Brennecke S

更新日期：2014-01-01 00:00:00

abstract：:The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds o...

journal_title：BioMed research international

authors： Li C,Xiao ZX

更新日期：2014-01-01 00:00:00

abstract：:Finding an optimal set of discriminative features is still a crucial but challenging task in biomedical science. The complexity of the task is intensified when any of the two scenarios arise: a highly dimensioned dataset and a small sample-sized dataset. The first scenario poses a big challenge to existing machine lea...

journal_title：BioMed research international

authors： Segera D,Mbuthia M,Nyete A

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:Wear-related failures and instabilities are frequent failure mechanisms of total knee replacements. High-conforming designs may provide additional stability for the joint. This study analyzes the effects of a ligamentous insufficiency on the stability and the wear behavior of a high-conforming knee design. ...

journal_title：BioMed research international

authors： Reinders J,Sonntag R,Kretzer JP

更新日期：2014-01-01 00:00:00

abstract：:For the induction of robust humoral and cellular immune responses, a strong rationale exists to use vaccine-adjuvant combinations possessing both immune modulatory and enhanced delivery capabilities. Herein, we evaluated the combination of 2 different adjuvants, a TLR9 agonist, composed of synthetic oligodeoxynucleoti...

journal_title：BioMed research international

authors： McCluskie MJ,Weeratna RD,Evans DM,Makinen S,Drane D,Davis HL

更新日期：2013-01-01 00:00:00