S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease.

abstract：:It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...

journal_title：BioMed research international

authors： Chen MF,Tsai JT,Chen LJ,Wu TP,Yang JJ,Yin LT,Yang YL,Chiang TA,Lu HL,Wu MC

更新日期：2014-01-01 00:00:00

abstract：:Alveolar bone resorption is one of the most important facts in denture construction. Porphyromonas gingivalis (Pg) causes alveolar bone resorption, and morphologic measurements are the most frequent methods to identify bone resorption in periodontal studies. This study has aimed at evaluating the effect of Andrographo...

journal_title：BioMed research international

authors： Al Batran R,Al-Bayaty FH,Al-Obaidi MM

更新日期：2013-01-01 00:00:00

abstract：:We aimed to explore the effects of raloxifene (RAL) on the proliferation and apoptosis of human aortic valve interstitial cells (AVICs). Different concentrations of RAL were used to act on AVICs. MTS kit is used to test the effects of different concentrations of RAL on the proliferation of AVICs. Cell cycle and apopto...

journal_title：BioMed research international

authors： Fu Z,Luo B,Li M,Peng B,Wang Z

更新日期：2016-01-01 00:00:00

abstract：:J-proteins are molecular chaperones and present in a wide variety of organisms from prokaryote to eukaryote. Based on their domain organizations, J-proteins can be classified into 4 types, that is, Type I, Type II, Type III, and Type IV. Different types of J-proteins play distinct roles in influencing cancer propertie...

journal_title：BioMed research international

authors： Feng P,Lin H,Chen W,Zuo Y

更新日期：2014-01-01 00:00:00

abstract：:Growing evidence indicates that immune-related biomarkers play an important role in tumor processes. This study investigates immune-related gene expression and its prognostic value in lung squamous cell carcinoma (LUSC). A cohort of 493 samples of patients with LUSC was collected and analyzed from data generated by th...

journal_title：BioMed research international

authors： Yan Y,Zhang M,Xu S,Xu S

更新日期：2020-06-27 00:00:00

abstract：:Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn disease (CD). Similar symptoms, but different treatment procedures for both diseases require precise diagnosis. MicroRNAs (miRNAs) are major posttranscriptional players that regulate the expression of genes during the inflammation and thus co...

journal_title：BioMed research international

authors： Guz M,Dworzański T,Jeleniewicz W,Cybulski M,Kozicka J,Stepulak A,Celiński K

更新日期：2020-07-22 00:00:00

abstract：:Primary cilia are organelles protruding from cell surface into environment that function in regulating cell cycle and modulating cilia-related signal. Primary ciliogenesis and autophagy play important roles in tumorigenesis. However, the functions and interactions between primary cilia and autophagy in hepatocellular ...

journal_title：BioMed research international

authors： Liu L,Sheng JQ,Wang MR,Gan Y,Wu XL,Liao JZ,Tian DA,He XX,Li PY

更新日期：2019-10-02 00:00:00

abstract：Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...

journal_title：BioMed research international

authors： Ding L,Yang J,Li L,Yang Y

更新日期：2020-09-23 00:00:00

abstract：Background:Pyroptosis, a novel form of inflammatory programmed cell death, was recently found to be a cause of mucosal barrier defect. In our pervious study, CD147 expression was documented to increase in intestinal tissue of inflammatory bowel disease (IBD). Objective:The aim of this study was to determine the functi...

journal_title：BioMed research international

authors： Xu Z,Liu R,Huang L,Xu Y,Su M,Chen J,Geng L,Xu W,Gong S

更新日期：2020-06-30 00:00:00

abstract：:Vascular aging, a specific type of organic aging, is related to age-dependent changes in the vasculature, including atherosclerotic plaques, arterial stiffness, fibrosis, and increased intimal thickening. Vascular aging could influence the threshold, process, and severity of various cardiovascular diseases, thus makin...

journal_title：BioMed research international

authors： Lin X,Zhan JK,Wang YJ,Tan P,Chen YY,Deng HQ,Liu YS

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to analyze periprocedural and mid-term effect of clopidogrel on platelet function using the VerifyNow P2Y12 point-of-care assay in patients undergoing TAVI. Platelet reactivity was measured at the beginning of the procedure after 300 mg clopidogrel bolus administration and during the follow-u...

journal_title：BioMed research international

authors： Tousek P,Kocka V,Sulzenko J,Bednar F,Linkova H,Widimsky P

更新日期：2013-01-01 00:00:00

abstract：:Previous studies have shown the therapeutic properties of ginseng and ginsenosides on hyperactive and impulsive behaviors in several psychiatric diseases. Herein, we investigated the effect of Panax ginseng Meyer (PG) on hyperactive/impulsive behaviors in a manic-like animal model, sleep deprivation (SD) rats. Male ra...

journal_title：BioMed research international

authors： Leem KH,Kim SA,Park HJ

更新日期：2020-10-17 00:00:00

abstract：BACKGROUND:The aim of this study is to investigate the effectiveness of preemptive thoracic epidural analgesia (TEA) comparing conventional postoperative epidural analgesia on thoracotomy. MATERIAL AND METHODS:Forty-four patients were randomized in to two groups (preemptive: Group P, control: Group C). Epidural cathet...

journal_title：BioMed research international

authors： Erturk E,Aydogdu Kaya F,Kutanis D,Besir A,Akdogan A,Geze S,Tugcugil E

更新日期：2014-01-01 00:00:00

abstract：:Progression of idiopathic dilated cardiomyopathy (IDCM) is marked with extensive left ventricular remodeling whose clinical manifestations and molecular basis are poorly understood. We aimed to evaluate the clinical potential of titin ligands in monitoring progression of cardiac remodeling associated with end-stage ID...

journal_title：BioMed research international

authors： Bogomolovas J,Brohm K,Čelutkienė J,Balčiūnaitė G,Bironaitė D,Bukelskienė V,Daunoravičus D,Witt CC,Fielitz J,Grabauskienė V,Labeit S

更新日期：2015-01-01 00:00:00

abstract：:A dentin-cement-prosthesis complex restored with either all-porcelain, cured resin-composite, or cast base metal alloy and cemented with either of the different resin cements was trimmed into a mini-dumbbell shape for tensile testing. The fractured surfaces and characterization of the dentin-cement interface of bonded...

journal_title：BioMed research international

authors： Piemjai M,Nakabayashi N

更新日期：2015-01-01 00:00:00

abstract：Background:This study explored the therapeutic efficacy of standard triple therapy combined with sucralfate suspension gel as well as the mechanisms of action in mouse models of H. pylori infection. Materials and Methods:C57BL/6J mice were randomly divided into 5 groups: NC (natural control), HP (H. pylori infection),...

journal_title：BioMed research international

authors： Teng G,Liu Y,Wu T,Wang W,Wang H,Hu F

更新日期：2020-08-31 00:00:00

abstract：:In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-international prognostic index (CLL-IPI), and the Barcelona-Brno biomarke...

journal_title：BioMed research international

authors： Muñoz-Novas C,Poza-Santaella M,González-Gascón Y Marín I,Hernández-Sánchez M,Rodríguez-Vicente AE,Infante MS,Heras C,Foncillas MÁ,Marín K,Hernández-Rivas JM,Hernández JÁ

更新日期：2018-03-15 00:00:00

abstract：Background:Shedding of the endothelial glycocalyx layer (EGL) is known to occur during major surgery, but its degradation associated with minimally invasive video-assisted thoracoscopy (VATS) remains unclear. We investigated if serum biomarkers of EGL disruption were elevated during VATS lobectomy, and whether the urin...

journal_title：BioMed research international

authors： Wang J,Wu A,Wu Y

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Parents' birth weight acts as a predictor for the descendant birth weight, with the correlation more strongly transmitted through maternal line. The present research aims to study the correlation between the child's low or increased birth weight, the mother's birth weight, and maternal conditi...

journal_title：BioMed research international

authors： Costa e Silva LI,Gomes FM,Valente MH,Escobar AM,Brentani AV,Grisi SJ

更新日期：2015-01-01 00:00:00

abstract：:This study is to investigate multiple chemotherapeutic agent- and radiation-related genetic biomarkers in locally advanced rectal cancer (LARC) patients following fluoropyrimidine-based concurrent chemoradiotherapy (CCRT) for response prediction. We initially selected 6 fluoropyrimidine metabolism-related genes (DPYD,...

journal_title：BioMed research international

authors： Huang MY,Wu CH,Huang CM,Chung FY,Huang CW,Tsai HL,Chen CF,Lin SR,Wang JY

更新日期：2013-01-01 00:00:00

abstract：:Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dr...

journal_title：BioMed research international

authors： Mohd Ali N,Mohd Yusof H,Long K,Yeap SK,Ho WY,Beh BK,Koh SP,Abdullah MP,Alitheen NB

更新日期：2013-01-01 00:00:00

abstract：:The role of nitric oxide and its reactive derivatives (NO x ) is well known in the pathogenesis of multiple sclerosis, which is an inflammatory disease while NO x seems to be important in coordinating inflammatory response. The...

journal_title：BioMed research international

authors： Niedziela N,Adamczyk-Sowa M,Niedziela JT,Mazur B,Kluczewska E,Sowa P,Gąsior M

更新日期：2016-01-01 00:00:00

abstract：:The success rate of oral implants is lower in type 2 diabetes mellitus (T2DM) patients than in nondiabetic subjects; functional impairment of bone marrow-derived mesenchymal stem cells (BMSCs) is an important underlying cause. Many factors in the blood can act on BMSCs to regulate their biological functions and influe...

journal_title：BioMed research international

authors： Liang C,Sun R,Xu Y,Geng W,Li J

更新日期：2020-06-07 00:00:00

abstract：PURPOSE:To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. METHODS:89 patients (124 eyes) with established myopia ra...

journal_title：BioMed research international

authors： Zivkovic M,Jaksic V,Giarmoukakis A,Grentzelos M,Zlatanovic M,Zlatanovic G,Miljkovic A,Jovanovic S,Stamenkovic M,Kymionis G

更新日期：2017-01-01 00:00:00

abstract：:Immunomodulatory agents have been proposed as therapeutic candidates to improve outcomes in sepsis. Transferon™, a dialyzable leukocyte extract (DLE), has been supported in Mexico as an immunomodulatory adjuvant in anti-infectious therapy. Here we present a retrospective study describing the experience of a referral p...

journal_title：BioMed research international

authors： Castrejón Vázquez MI,Reséndiz-Albor AA,Ynga-Durand MA,Arciniega Martínez IM,Orellana-Villazon VI,García López CA,Laue Noguera ML,Vargas Camaño ME

更新日期：2019-06-23 00:00:00

abstract：:The ultrasound imaging is one of the most common schemes to detect diseases in the clinical practice. There are many advantages of ultrasound imaging such as safety, convenience, and low cost. However, reading ultrasound imaging is not easy. To support the diagnosis of clinicians and reduce the load of doctors, many u...

journal_title：BioMed research international

authors： Huang Q,Zhang F,Li X

更新日期：2018-03-04 00:00:00

abstract：:Puffer fishes were collected from the central sea in Vietnam from spring to summer season. The eggs were incubated in MRS broth that was used to test the toxicity in mice and isolate the lactic acid bacteria community that could produce tetrodotoxin (TTX). Thin layer chromatography (TLC) and high performance lipid chr...

journal_title：BioMed research international

authors： Nguyen TH,Nguyen HN,Nghe DV,Nguyen KH

更新日期：2015-01-01 00:00:00

abstract：:Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...

journal_title：BioMed research international

authors： Lee H,Kong SY,Sohn JY,Shim H,Youn HS,Lee S,Kim HJ,Eom HS

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Inflammation in dental pulp cells (DPCs) initiated by Lipopolysaccharide (LPS) results in dental pulp necrosis. So far, whether there is a common system regulating inflammation response and tissue regeneration remains unknown. miR-146a is closely related to inflammation. Basic fibroblast growth factor (bFG...

journal_title：BioMed research international

authors： Liu L,Shu S,Cheung GS,Wei X

更新日期：2016-01-01 00:00:00

abstract：:The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from two urothelial cell lines (RT4 and UROtsa cells). Hypotonic Kreb...

journal_title：BioMed research international

authors： Mansfield KJ,Hughes JR

更新日期：2014-01-01 00:00:00