Abstract:
:Progression of idiopathic dilated cardiomyopathy (IDCM) is marked with extensive left ventricular remodeling whose clinical manifestations and molecular basis are poorly understood. We aimed to evaluate the clinical potential of titin ligands in monitoring progression of cardiac remodeling associated with end-stage IDCM. Expression patterns of 8 mechanoptotic machinery-associated titin ligands (ANKRD1, ANKRD2, TRIM63, TRIM55, NBR1, MLP, FHL2, and TCAP) were quantitated in endomyocardial biopsies from 25 patients with advanced IDCM. When comparing NYHA disease stages, elevated ANKRD1 expression levels marked transition from NYHA < IV to NYHA IV. ANKRD1 expression levels closely correlated with systolic strain depression and short E wave deceleration time, as determined by echocardiography. On molecular level, myocardial ANKRD1 and serum adiponectin correlated with low BAX/BCL-2 ratios, indicative of antiapoptotic tissue propensity observed during the worsening of heart failure. ANKRD1 is a potential marker for cardiac remodeling and disease progression in IDCM. ANKRD1 expression correlated with reduced cardiac contractility and compliance. The association of ANKRD1 with antiapoptotic response suggests its role as myocyte survival factor during late stage heart disease, warranting further studies on ANKRD1 during end-stage heart failure.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Bogomolovas J,Brohm K,Čelutkienė J,Balčiūnaitė G,Bironaitė D,Bukelskienė V,Daunoravičus D,Witt CC,Fielitz J,Grabauskienė V,Labeit Sdoi
10.1155/2015/273936subject
Has Abstractpub_date
2015-01-01 00:00:00pages
273936eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6416941
更新日期:2019-06-11 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/8193821.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2017/6418529
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2013/783690.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/8693826
更新日期:2016-01-01 00:00:00
abstract::Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7902760
更新日期:2018-10-14 00:00:00
abstract::Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/145619
更新日期:2014-01-01 00:00:00
abstract::Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123601
更新日期:2020-09-05 00:00:00
abstract::Panax ginseng Meyer, a valuable medicinal plant, is severely threatened by rusty root, a condition that greatly affects its yield and quality. Studies investigating the relationship between soil microbial community composition and rusty roots are vital for the production of high-quality ginseng. Here, high-throughput ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8018525
更新日期:2020-01-15 00:00:00
abstract::A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solv...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/239838
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/3746232.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/1235429
更新日期:2016-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a lethal malignancy with poor prognosis and limited treatment options. Transarterial chemoembolization (TACE) using chemotherapy agents-doxorubicin and cisplatin-is an accepted treatment option for locally advanced hepatocellular carcinoma. In the current study, we analyzed the expres...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/649750
更新日期:2015-01-01 00:00:00
abstract::This study aimed to analyse the diversity of the Campylobacter jejuni population in broilers and to evaluate the major source of contamination in poultry meat. Eight rearing cycles over one year provided samples from three different broiler farms processed at the same slaughterhouse. A total of 707 C. jejuni were isol...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/859845
更新日期:2015-01-01 00:00:00
abstract:Background:Cardiogenic shock is associated with high mortality, despite new strategies for reperfusion therapy. Short-term circulatory support devices may provide adequate support for appropriate myocardial and organ perfusion. Objectives:This review is aimed at evaluating the impact on survival when using venoarteria...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6126534
更新日期:2020-04-19 00:00:00
abstract::We aimed to assess the prevalence of hospitalization for endometriosis in the general population in France and in each French region and to describe temporal trends, rehospitalization rates, and prevalence of the different types of endometriosis. The analyses were carried out on French hospital discharge data and cove...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3260952
更新日期:2016-01-01 00:00:00
abstract::To study the effect of intra-abdominal hypertension (IAH) on the frequency of pneumonia with an experimental study, thirteen Sprague-Dawley rats were included. Eight out of thirteen animals were randomly assigned to receive 10 ml of benzalkonium chloride 0.2% (megacolon group) and five animals received 10 ml NaCl 0.9%...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4601348
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1313586
更新日期:2016-01-01 00:00:00
abstract::A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimula...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7636290
更新日期:2020-01-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4598462
更新日期:2020-08-27 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/670949
更新日期:2015-01-01 00:00:00
abstract::Breast cancer is the leading cause of death in women worldwide. The search for novel compounds with antitumor activity, with less adverse effects and higher efficacy, and the development of methods to evaluate their toxicity is an area of intense research. In this study we implemented the preparation and culture of br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/618021
更新日期:2015-01-01 00:00:00
abstract:Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6762029
更新日期:2020-09-23 00:00:00
abstract::Hemoglobin, which widely exists in all vertebrates and in some invertebrates, is possibly a precursor of antimicrobial peptides (AMPs). However, AMPs in the hemoglobin of invertebrates have been rarely investigated. This study is the first to report the full-length cDNA, prokaryotic expression, and antimicrobial activ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5683026
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3627071
更新日期:2020-05-06 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/910812
更新日期:2014-01-01 00:00:00
abstract::Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects of emodin against SAP with SIRS. However, the exact mechanism unde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1736024
更新日期:2016-01-01 00:00:00
abstract::Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/183469
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/9853701
更新日期:2019-05-13 00:00:00
abstract::Mitochondria, the energy-generating organelles, play a role in numerous cellular functions including adenosine triphosphate (ATP) production, cellular homeostasis, and apoptosis. Maternal inheritance of mitochondria and mitochondrial DNA (mtDNA) is universally observed in humans and most animals. In general, high leve...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/981867
更新日期:2014-01-01 00:00:00
abstract::Photosystem II photochemistry and phycobiliprotein (PBP) genes of red algae Kappaphycus alvarezii, raw material of κ -carrageenan used in food and pharmaceutical industries, were analyzed in this study. Minimum saturating irradiance (I k) of this algal species was less than 115 μmol m(-2) s(-1). Its actual PSII effici...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/256549
更新日期:2013-01-01 00:00:00
abstract:Aims:To evaluate the effectiveness and safety of peritoneal dialysis (PD) in treating refractory congestive heart failure (RCHF) with cardiorenal syndrome (CRS). Methods:A total of 36 patients with RCHF were divided into type 2 CRS group (group A) and non-type 2 CRS group (group B) according to the patients' clinical ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/6529283
更新日期:2018-05-17 00:00:00
abstract::Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophyla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/807196
更新日期:2014-01-01 00:00:00