Abstract:
:Growing evidence indicates that immune-related biomarkers play an important role in tumor processes. This study investigates immune-related gene expression and its prognostic value in lung squamous cell carcinoma (LUSC). A cohort of 493 samples of patients with LUSC was collected and analyzed from data generated by the TCGA Research Network and ImmPort database. The R coxph package was employed to mine significant immune-related genes using univariate analysis. Lasso and stepwise regression analyses were used to construct the LUSC prognosis prediction model, and clusterProfiler was used for gene functional annotation and enrichment analysis. The Kaplan-Meier analysis and ROC were used to evaluate the model efficiency in predicting and classifying LUSC case prognoses. We identified 14 immune-related genes to incorporate into our prognosis model. The patients were divided into two subgroups (Risk-H and Risk-L) according to their risk score values. Compared to Risk-L patients, Risk-H patients showed significantly improved overall survival (OS) in both training and testing sets. Functional annotation indicated that the 14 identified genes were mainly enriched in several immune-related pathways. Our results also revealed that a risk score value was correlated with various signaling pathways, such as the JAK-STA signaling pathway. Establishment of a nomogram for clinical application demonstrated that our immune-related model exhibited good predictive prognostic performance. Our predictive prognosis model based on immune signatures has potential clinical implications for assessing the overall survival and precise treatment for patients with LUSC.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yan Y,Zhang M,Xu S,Xu Sdoi
10.1155/2020/5024942subject
Has Abstractpub_date
2020-06-27 00:00:00pages
5024942eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1155/2016/1952947
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2014/210560
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doi:10.1155/2016/4575024
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pub_type: 杂志文章,评审
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doi:10.1155/2017/8402035
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/864946
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6847685
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pub_type: 杂志文章
doi:10.1155/2018/6820160
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/289549
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2019-03-07 00:00:00
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00