Abstract:
:The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the field of dermatological products. Recent studies have shown the influence of the rheological features of a vehicle on the release of drugs and active compounds from the formulation. In this context, the aim of this study was to evaluate the influence of the rheological features of two different emulsion formulations on the release of alpha-lipoic acid. Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging. The rheological and mechanical behavior and the in vitro release profile were assayed. The results showed that rheological features, such as viscosity, thixotropy, and compliance, strongly influenced the release of ALA from the emulsion and that the presence of a hydrophilic polymer in one of the emulsions was an important factor affecting the rheology and, therefore, the release of ALA.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Isaac VL,Chiari-Andréo BG,Marto JM,Moraes JD,Leone BA,Corrêa MA,Ribeiro HMdoi
10.1155/2015/818656subject
Has Abstractpub_date
2015-01-01 00:00:00pages
818656eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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doi:10.1155/2014/549785
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2018/4916497
更新日期:2018-09-27 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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abstract::[This corrects the article DOI: 10.1155/2017/8094152.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章,随机对照试验
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