Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview.

Abstract:

:Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo.

journal_name

Biomed Res Int

authors

Rowdhwal SSS,Chen J

doi

10.1155/2018/1750368

subject

Has Abstract

pub_date

2018-02-22 00:00:00

pages

1750368

eissn

2314-6133

issn

2314-6141

journal_volume

2018

pub_type

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