Abstract:
:Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Rowdhwal SSS,Chen Jdoi
10.1155/2018/1750368subject
Has Abstractpub_date
2018-02-22 00:00:00pages
1750368eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章,评审abstract::The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/261745
更新日期:2014-01-01 00:00:00
abstract::Alterations in pancreatic milieu to adapt to physiological shifts occurring in conditions of obesity and metabolic syndrome (MS) have been documented, though mechanisms leading to such a state have remained elusive so far. The data presented here tries to look at the gravity of metabolic insult during the early and pr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/617569
更新日期:2013-01-01 00:00:00
abstract::Seeking new biomarkers for epithelial ovarian cancer, the fifth most common cause of death from all cancers in women and the leading cause of death from gynaecological malignancies, we performed a meta-analysis of three independent studies and compared the results in regard to clinicopathological parameters. This anal...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2013/238284
更新日期:2013-01-01 00:00:00
abstract::Targeted drug delivery using folate receptors is one of the most interesting chemotherapeutic research areas over the past few years. A novel folate targeted copolymer was synthesized using dextran stearate coupled to folic acid. FT-IR and NMR spectroscopy were used to confirm successful conjugation. Micelles prepared...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/708593
更新日期:2014-01-01 00:00:00
abstract::A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial. The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4848652
更新日期:2018-08-13 00:00:00
abstract::Aim. The aim of the study was to compare the incidence of "de novo" overactive bladder (OAB) after sling surgeries and Burch procedure and to analyze the effect of the preoperative bladder volume on the incidence of this condition. Methods. This prospective trial included 290 female patients with stress urinary incont...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9515242
更新日期:2019-02-12 00:00:00
abstract::The research was performed on male Wistar rats based on assumptions that new microelement preparations containing metal nanoparticles and their agglomerates had potential. Morphological and functional changes in tissues in the injection site and dynamics of chemical element metabolism (25 indicators) in body were asse...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243173
更新日期:2015-01-01 00:00:00
abstract::We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraper...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/526367
更新日期:2013-01-01 00:00:00
abstract::This study aimed at clarifying the mechanism and role of survivin in hypoxia-induced multidrug resistance (MDR) of laryngeal carcinoma cells. Human laryngeal cancer cells were incubated under hypoxia or normoxia. The expression of survivin was silenced by performing RNA interference. Additionally, by Western blot and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5696801
更新日期:2019-04-24 00:00:00
abstract:Purpose:Osteosarcoma is one of the most common primary malignant, aggressive bone neoplasms. However, the mechanisms of osteosarcoma proliferation, migration, and invasion are not well understood. To explore the possible mechanism of osteosarcoma progression, we used a public database for gene analysis to identify the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4068521
更新日期:2019-11-30 00:00:00
abstract::Giardia duodenalis, is often seen as an opportunistic pathogen and one of the major food and waterborne parasites. Some insights of Giardia infestation in a diarrhoea-prone population were investigated in the present study. Our primary goal was to understand the interaction of this parasite with other pathogens during...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/786480
更新日期:2014-01-01 00:00:00
abstract:Background:Although sleeve gastrectomy results in good weight loss and metabolic improvements, it is an irreversible procedure. Therefore, we attempted to assess the possibility of creating a sleeved stomach without resection. Material and Methods. A total of 22 male Sprague-Dawley rats with type 2 diabetes were random...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9024923
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:Osteopontin (OPN), a multifunctional glycoprotein secreted from a wide variety of cells after inflammatory stimulation, is well accepted to contribute to the development of allergic diseases. However, the influence of histamine H1 receptor antagonists (antihistamines) on OPN functions is not well understood....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/735835
更新日期:2013-01-01 00:00:00
abstract::Neuroendocrine tumors (NETs) are tumors originated from neuroendocrine cells in the body. The localization and the detection of the extent of NETs are important for diagnosis and treatment, which should be individualized according to the tumor type, burden, and symptoms. Molecular imaging of NETs with high sensitivity...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/102819
更新日期:2013-01-01 00:00:00
abstract::Obesity or maternal overnutrition during pregnancy and lactation might have long-term consequences in offspring health. Fetal programming is characterized by adaptive responses to specific environmental conditions during early life stages. Programming alters gene expression through epigenetic modifications leading to ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/8061389
更新日期:2018-06-20 00:00:00
abstract::The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslink...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8301624
更新日期:2016-01-01 00:00:00
abstract::Contrast-induced nephropathy (CIN) remains a leading cause of iatrogenic acute kidney injury, as the usage of contrast media for imaging and intravascular intervention keeps expanding. Diabetes is an important predisposing factor for CIN, particularly in patients with renal functional impairment. Renal hypoxia, combin...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/123589
更新日期:2013-01-01 00:00:00
abstract:Background:Many studies, comparing the health associated risks of electronic cigarettes with conventional cigarettes focus mainly on the common chemical compounds found between them. Aim:Review chemical compounds found exclusively in electronic cigarettes and describe their toxic effects, focusing on electronic-cigare...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/1386710
更新日期:2019-12-19 00:00:00
abstract:Aim:To investigate the effect of fecal microbiota transplantation on visceral hypersensitivity compared with Bifidobacterium longum. Methods:Mice visceral hypersensitivity was induced by Trichinella spiralis. After 8 weeks, they were divided into three groups (controls, Bifidobacterium longum, and fecal microbiota tra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3860743
更新日期:2018-01-30 00:00:00
abstract::Persistent catecholamine-resistant shock in children causes severe morbidity and mortality. We aimed to analyze the association between hemodynamics and serum lactate at different time points and 28-day mortality in children with persistent catecholamine-resistant shock. Methods. Twenty-six children with persistent ca...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1341326
更新日期:2020-06-19 00:00:00
abstract:AIM:Gastrointestinal mucositis is a frequent complication of antineoplastic chemotherapy, but the effects of chemotherapy on mucosal defense mechanisms remain poorly understood. We studied the effects of cisplatin on mucin, one of the principal defense factors of the gastrointestinal mucosa, and evaluated the efficacy ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276186
更新日期:2013-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldeh...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/2025636
更新日期:2019-06-24 00:00:00
abstract::This study presented the analysis of free-breathing lung tumor motion characteristics using GE 4DCT and Varian RPM systems. Tumor respiratory movement was found to be associated with GTV size, the superior-inferior tumor location in the lung, and the attachment degree to rigid structure (e.g., chest wall, vertebrae, o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/872739
更新日期:2013-01-01 00:00:00
abstract::Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/720514
更新日期:2013-01-01 00:00:00
abstract::Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8751384
更新日期:2017-01-01 00:00:00
abstract::Nowadays, several screening strategies are available to prevent cervical cancer, but inadequate resources, sociocultural barriers, and sampling issues impede their success in low-income countries. To overcome these issues, this study aimed to evaluate the performance of human papillomavirus (HPV) testing from dried ur...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/283036
更新日期:2015-01-01 00:00:00
abstract::We identified a nitidine- (NTD-) accumulating organelle and evaluated the net cytotoxicity of accumulated NTD. To evaluate tumor cell selectivity of the drug, we evaluated its selective cytotoxicity against 39 human cancer cell lines (JFCR39 panel), and the profile was compared with those of known anticancer drugs. Or...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2130594
更新日期:2017-01-01 00:00:00
abstract:Result:In the denture wearers, HHV8 DNA was detected in 11 cases. Two of the controls amplified HHV8 DNA. Fisher's exact test demonstrates a significant difference between virus infection and using removable dentures (p = 0.015). Conclusion:Our findings suggested that HHV8 detection could be associated with use of den...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9358947
更新日期:2020-04-15 00:00:00
abstract:Background:Salinity is one of the major abiotic constraints that hinder health and quality of crops. Conversely, halotolerant plant growth-promoting rhizospheric (PGPR) bacteria are considered biologically safe for alleviating salinity stress. Results:We isolated halotolerant PGPR strains from the rhizospheric soil of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9530963
更新日期:2019-10-20 00:00:00
abstract::The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the gene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/621034
更新日期:2015-01-01 00:00:00