Abstract:
:Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL interactions have been identified in yeast, only a few have been known in human. There is a pressing need to systematically discover and understand SL interactions specific to human cancer. In this paper, we present Syn-Lethality, the first integrative knowledge base of SL that is dedicated to human cancer. It integrates experimentally discovered and verified human SL gene pairs into a network, associated with annotations of gene function, pathway, and molecular mechanisms. It also includes yeast SL genes from high-throughput screenings which are mapped to orthologous human genes. Such an integrative knowledge base, organized as a relational database with user interface for searching and network visualization, will greatly expedite the discovery of novel anticancer drug targets based on synthetic lethality interactions. The database can be downloaded as a stand-alone Java application.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Li XJ,Mishra SK,Wu M,Zhang F,Zheng Jdoi
10.1155/2014/196034subject
Has Abstractpub_date
2014-01-01 00:00:00pages
196034eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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journal_title:BioMed research international
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1155/2013/276174
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/4848652
更新日期:2018-08-13 00:00:00
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pub_type: 杂志文章
doi:10.1155/2013/140327
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/5207031
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pub_type: 杂志文章,评审
doi:10.1155/2013/462179
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3860743
更新日期:2018-01-30 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/457473
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9568351
更新日期:2018-05-23 00:00:00
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