How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective.

abstract：:A novel methylamine-selective amperometric bienzyme biosensor based on recombinant primary amine oxidase isolated from the recombinant yeast strain Saccharomyces cerevisiae and commercial horseradish peroxidase is described. Two amine oxidase preparations were used: free enzyme (AMO) and covalently immobilized on the ...

journal_title：BioMed research international

authors： Stasyuk NY,Smutok OV,Zakalskiy AE,Zakalska OM,Gonchar MV

更新日期：2014-01-01 00:00:00

abstract：:The crude ethanolic extract from aerial parts of Pothomorphe umbellata L. (Piperaceae) and fractions obtained by partitions sequentially among water-methanol, methylene chloride, and ethyl acetate, as well as the major constituent, 4-nerolidylcatechol, were, respectively, evaluated and evidenced for antioxidant and cy...

journal_title：BioMed research international

authors： Lopes AP,Bagatela BS,Rosa PC,Nanayakkara DN,Tavares Carvalho JC,Maistro EL,Bastos JK,Perazzo FF

更新日期：2013-01-01 00:00:00

abstract：:Mixed-phase TiO2 nanocomposite thin films consisting of anatase and rutile prepared on commercially pure Ti sheets via the electrochemical anodization and annealing treatments were investigated in terms of their photocatalytic activity for antibacterial use around dental implants. The resulting films were characterize...

journal_title：BioMed research international

authors： Yeniyol S,Mutlu I,He Z,Yüksel B,Boylan RJ,Ürgen M,Karabuda ZC,Basegmez C,Ricci JL

更新日期：2015-01-01 00:00:00

abstract：:Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...

journal_title：BioMed research international

authors： Coyle KM,Boudreau JE,Marcato P

更新日期：2017-01-01 00:00:00

abstract：:Aerobic granulation of activated sludge was successfully achieved in a full-scale sequencing batch reactor (SBR) with 50,000 m(3) d(-1) for treating a town's wastewater. After operation for 337 days, in this full-scale SBR, aerobic granules with an average SVI30 of 47.1 mL g(-1), diameter of 0.5 mm, and settling veloc...

journal_title：BioMed research international

authors： Li J,Ding LB,Cai A,Huang GX,Horn H

更新日期：2014-01-01 00:00:00

abstract：:Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors, and calcium sensitizers, which have been successively discovered and applied in clinical practice. However, there are only a few new drugs available in this field, and the selection is very limited. Digitalis, catecholamines, and...

journal_title：BioMed research international

authors： Pan J,Yang YM,Zhu JY,Lu YQ

更新日期：2019-09-19 00:00:00

abstract：:Interactions between proteins and drugs, which can lead to formation of stable drug-protein complexes, have important implications on several processes related to human health. These interactions can affect, for instance, free concentration, biological activity, and metabolism of the drugs in the blood stream. Here, w...

journal_title：BioMed research international

authors： Gorza FD,Pedro GC,Trescher TF,da Silva RJ,Silva JR,de Souza NC

更新日期：2014-01-01 00:00:00

abstract：Background:Many studies, comparing the health associated risks of electronic cigarettes with conventional cigarettes focus mainly on the common chemical compounds found between them. Aim:Review chemical compounds found exclusively in electronic cigarettes and describe their toxic effects, focusing on electronic-cigare...

journal_title：BioMed research international

authors： Armendáriz-Castillo I,Guerrero S,Vera-Guapi A,Cevallos-Vilatuña T,García-Cárdenas JM,Guevara-Ramírez P,López-Cortés A,Pérez-Villa A,Yumiceba V,Zambrano AK,Leone PE,Paz-Y-Miño C

更新日期：2019-12-19 00:00:00

abstract：:Alzheimer's disease affects millions of people worldwide and incidence is expected to rise as the population ages, but no effective therapies exist despite decades of research and more than 20 known disease markers. Research has shown that Alzheimer's disease's missing heritability remains extensive with an estimated ...

journal_title：BioMed research international

authors： Ebbert MT,Ridge PG,Kauwe JS

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the influence of gene-gene and gene-environment interactions on the risk of developing asbestosis. The study comprised 262 cases with asbestosis and 265 controls with no asbestos-related disease previously studied for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS polymorphisms. Data on cumul...

journal_title：BioMed research international

authors： Franko A,Dolžan V,Arnerić N,Dodič-Fikfak M

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to develop a freeze-drying protocol facilitating successful processing of plant material containing the small surface antigen of hepatitis B virus (S-HBsAg) while preserving its VLP structure and immunogenicity. Freeze-drying of the antigen in lettuce leaf tissue, without any isolation or pur...

journal_title：BioMed research international

authors： Czyż M,Dembczyński R,Marecik R,Wojas-Turek J,Milczarek M,Pajtasz-Piasecka E,Wietrzyk J,Pniewski T

更新日期：2014-01-01 00:00:00

abstract：:Lung cancer is a leading cause of death worldwide. Currently, in differential diagnosis of lung cancer, accurate classification of cancer types (adenocarcinoma, squamous cell carcinoma, and small cell carcinoma) is required. However, improving the accuracy and stability of diagnosis is challenging. In this study, we d...

journal_title：BioMed research international

authors： Teramoto A,Tsukamoto T,Kiriyama Y,Fujita H

更新日期：2017-01-01 00:00:00

abstract：:Objective. Our objective is to develop a computerized scheme for liver tumor segmentation in MR images. Materials and Methods. Our proposed scheme consists of four main stages. Firstly, the region of interest (ROI) image which contains the liver tumor region in the T1-weighted MR image series was extracted by using se...

journal_title：BioMed research international

authors： Le TN,Bao PT,Huynh HT

更新日期：2016-01-01 00:00:00

abstract：:Psoriasis is one of the most prevalent immune mediated skin diseases worldwide. Despite the large prevalence in both men and women, the pathogenesis of this disease has not yet been fully clarified. Nowadays, it is believed that psoriasis is most likely a T helper Th1/Th17 induced inflammatory disease. Stressful life ...

journal_title：BioMed research international

authors： Ceovic R,Mance M,Bukvic Mokos Z,Svetec M,Kostovic K,Stulhofer Buzina D

更新日期：2013-01-01 00:00:00

abstract：:Periodontitis is an inflammatory disease involving complex interactions between oral microorganisms and the host immune response. Understanding the structure of the microbiota community associated with periodontitis is essential for improving classifications and diagnoses of various types of periodontal diseases and w...

journal_title：BioMed research international

authors： Chen WP,Chang SH,Tang CY,Liou ML,Tsai SJ,Lin YL

更新日期：2018-11-15 00:00:00

abstract：:The efficiency of oat bran and barley bran in lowering the induced hyperlipidemia and hypercholesterolemia in blood of male Albino rats (Rattus rattus) was studied. Twenty rats were divided into four groups each consisted of five rats and fed the specified test diets for eight weeks. The first group (G1) is the negati...

journal_title：BioMed research international

authors： El Rabey HA,Al-Seeni MN,Amer HM

更新日期：2013-01-01 00:00:00

abstract：Background:The incidence of osteoporotic fractures is increasing. In this study, we explored the activities of Wnt/β-catenin signaling in bone tissues with iron accumulation. Methods:We established rat bipedal walking models (RBWM), and a portion of our RBWM rats were intraperitoneally injected with ferric ammonium ci...

journal_title：BioMed research international

authors： Xu W,Yu R,Zhu X,Li Z,Jia J,Li D,Chen Y,Zhang X

更新日期：2020-05-24 00:00:00

abstract：:Tyrosine kinase inhibitors (TKI) belong to a new class of molecular multitargeted anticancer therapy which targets different growth factor receptors and hence attenuates cancer cell survival and growth. Since their introduction as adjunct treatment for renal cell carcinoma and gastrointestinal stromal tumors (GIST), a...

journal_title：BioMed research international

authors： Ahmadieh H,Salti I

更新日期：2013-01-01 00:00:00

abstract：Background and Aims:The present study aimed to develop a simple and sensitive method for quantitative determination of monocrotaline (MCT) in mouse blood employing ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS) using rhynchophylline as an internal standard. Me...

journal_title：BioMed research international

authors： Chen L,Zhang B,Liu J,Fan Z,Weng Z,Geng P,Wang X,Lin G

更新日期：2018-08-13 00:00:00

abstract：:Apc-mutated Pirc rats, spontaneously developing intestinal tumours, are resistant to 1,2-dimethylhydrazine- (DMH-) induced colon apoptosis. To understand this phenomenon, we analyzed the expression of genotoxic stress-related genes Mgmt, Gsta1, and Gstp1 in the colon of wt and Pirc rats in basal conditions and 24 h af...

journal_title：BioMed research international

authors： Femia AP,Luceri C,Lodovici M,Crucitta S,Caderni G

更新日期：2016-01-01 00:00:00

abstract：:Purpose. Analysis of early vascular and nerve complications of supracondylar humerus fractures in children. Material and Methods. 220 children hospitalized in the Pediatric Trauma-Orthopedic Department in the years 2004-2014. The group consisted of 143 males and 77 females. Results. Acute neurovascular complications o...

journal_title：BioMed research international

authors： Tomaszewski R,Wozowicz A,Wysocka-Wojakiewicz P

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high-incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin-embedded esophageal tissues and 152 paraffin-embedd...

journal_title：BioMed research international

authors： Zheng Y,Fan Y,Zeng Y,Liu S,Gao L

更新日期：2020-12-02 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/6935123.]. ...

journal_title：BioMed research international

authors： Pruimboom L,Ruiz-Núñez B,Raison CL,Muskiet FAJ,Freese J

更新日期：2017-01-01 00:00:00

abstract：:Freshly ejaculated spermatozoa are incapable or poorly capable of fertilizing an oocyte. The fertilization aptness of spermatozoa depends on the appropriate and time-dependent acquisition of hyperactivation, chemotaxis, capacitation, and the acrosome reaction, where calcium (Ca(2+)) is extensively involved in almost e...

journal_title：BioMed research international

authors： Rahman MS,Kwon WS,Pang MG

更新日期：2014-01-01 00:00:00

abstract：:Feed efficiency (FE) is an important trait affecting costs in swine industry. Investigation on FE-related genes in different tissues is valuable for molecular breeding. Hypothalamus is a convergent and integrated centre for multiple nutrient-related signals. The present study identified 363 differentially expressed (D...

journal_title：BioMed research international

authors： Hou Y,Hu M,Zhou H,Li C,Li X,Liu X,Zhao Y,Zhao S

更新日期：2018-12-26 00:00:00

abstract：BACKGROUND:It is well established that the Mediterranean and Arab populations are at high risk for thalassemias in general and for alpha-thalassemia in particular. Yet, reports on alpha-thalassemia in Lebanon are still lacking. In this study, we aim at assessing the incidence of alpha-thalassemia in the Lebanese popula...

journal_title：BioMed research international

authors： Farra C,Daher R,Badra R,el Rafei R,Bejjany R,Charafeddine L,Yunis K

更新日期：2015-01-01 00:00:00

abstract：:Cancer related fatigue (CRF) is a common and debilitating symptom that can influence quality of life (QoL) in cancer patients. The increase in survival times stresses for a better understanding of how CRF affects patients' QoL. This was a cross-sectional descriptive study with 148 randomly recruited prostate cancer pa...

journal_title：BioMed research international

authors： Charalambous A,Kouta C

更新日期：2016-01-01 00:00:00

abstract：:During hundreds of years of medication, it is believed that the steamed Panax notoginseng (SPN) can enrich and regulate the blood, replenish the body, and improve the health. The aim of this study was to optimize the steaming conditions of SPN which are related to the hematopoietic effect. In the study, network pharma...

journal_title：BioMed research international

authors： Zhou S,Jiang N,Zhang M,Xiao X,Liu Z,Xu X,Gao Q,Lv W

更新日期：2020-07-26 00:00:00

abstract：:Alterations in muscle protein turnover of the unaffected side of stroke patients could contribute to physical disability. We investigated whether hypercatabolic activity occurred in unaffected arm muscle and whether supplemented essential amino acids (EAAs) could limit muscle hypercatabolism (MH). Thirty-eight dysphag...

journal_title：BioMed research international

authors： Aquilani R,Boselli M,D'Antona G,Baiardi P,Boschi F,Viglio S,Iadarola P,Pasini E,Barbieri A,Dossena M,Bongiorno AI,Verri M

更新日期：2014-01-01 00:00:00

abstract：:Mammalian protection against leishmanial infection depends on the development of an effective immune response. Zoonotic visceral leishmaniasis (ZVL) patients are usually unable to mount an effective immune response against the parasite and indeed appear to be severely immunosuppressed. This suppression has strong nons...

journal_title：BioMed research international

authors： Soares NM,de Souza JN,Leal TF,Reis EAG,Miranda MS,Dos Santos WLC,Teixeira MCA

更新日期：2017-01-01 00:00:00