Neuronal Signal Transduction-Involved Genes in Pig Hypothalamus Affect Feed Efficiency as Revealed by Transcriptome Analysis.

Abstract:

:Feed efficiency (FE) is an important trait affecting costs in swine industry. Investigation on FE-related genes in different tissues is valuable for molecular breeding. Hypothalamus is a convergent and integrated centre for multiple nutrient-related signals. The present study identified 363 differentially expressed (DE) genes and 14 DE lincRNAs in the hypothalamus of high- and low-FE Yorkshire pigs. Furthermore, 983 significantly correlated DE gene-lincRNA pairs were identified through weighted correlation network analysis (WGCNA) and Pearson correlation analysis. These DE genes were primarily enriched in the neuronal signal transduction process containing the upregulated genes of VIPR1, CCR1, CCR5, LEPR, INSR, ADRA1A, CCKAR, and ADORA3 and the downregulated genes of GRM1, GRM4, GRM5, and VIPR2, which were located in the cell membrane. These signal receptors were mainly connected to downstream Jak-STAT signaling that involved the increased genes (JAK2, STAT3, and POMC) and mTOR signaling pathway, including the decreased genes (CAMKK2, AMPK, and MTOR). STAT3 and AMPK genes also played a role in two major hypothalamic neurons of POMC and NPY/AGRP. A total of eight DE lincRNAs also participated in the potential network. In conclusion, neuronal signaling transduction-involved genes and lincRNAs were related to FE variation in pig hypothalamus.

journal_name

Biomed Res Int

authors

Hou Y,Hu M,Zhou H,Li C,Li X,Liu X,Zhao Y,Zhao S

doi

10.1155/2018/5862571

subject

Has Abstract

pub_date

2018-12-26 00:00:00

pages

5862571

eissn

2314-6133

issn

2314-6141

journal_volume

2018

pub_type

杂志文章
  • Socioeconomic Impact on the Prevalence of Cardiovascular Risk Factors in Wallonia, Belgium: A Population-Based Study.

    abstract::Background. Monitoring the epidemiology of cardiovascular risk factors (CRFs) and their determinants is important to develop appropriate recommendations to prevent cardiovascular diseases in specific risk groups. The NESCaV study was designed to collect standardized data to estimate the prevalence of CRFs in relation ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/580849

    authors: Streel S,Donneau AF,Hoge A,Majerus S,Kolh P,Chapelle JP,Albert A,Guillaume M

    更新日期:2015-01-01 00:00:00

  • Monounsaturated fatty acids are substrates for aldehyde generation in tellurite-exposed Escherichia coli.

    abstract::Reactive oxygen species (ROS) damage macromolecules and cellular components in nearly all kinds of cells and often generate toxic intracellular byproducts. In this work, aldehyde generation derived from the Escherichia coli membrane oxidation as well as membrane fatty acid profiles, protein oxidation, and bacterial re...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/563756

    authors: Pradenas GA,Díaz-Vásquez WA,Pérez-Donoso JM,Vásquez CC

    更新日期:2013-01-01 00:00:00

  • Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism.

    abstract::Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve reg...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/949624

    authors: Roussel E,Drolet MC,Walsh-Wilkinson E,Dhahri W,Lachance D,Gascon S,Sarrhini O,Rousseau JA,Lecomte R,Couet J,Arsenault M

    更新日期:2015-01-01 00:00:00

  • Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have bee...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/837157

    authors: Jia Q,Deng Y,Qing H

    更新日期:2014-01-01 00:00:00

  • Second-Generation Bioethanol from Coconut Husk.

    abstract::Coconut palm (Cocos nucifera) is an important commercial crop in many tropical countries, but its industry generates large amounts of residue. One way to address this problem is to use this residue, coconut husk, to produce second-generation (2G) ethanol. The aim of this review is to describe the methods that have bee...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/4916497

    authors: Bolivar-Telleria M,Turbay C,Favarato L,Carneiro T,de Biasi RS,Fernandes AAR,Santos AMC,Fernandes PMB

    更新日期:2018-09-27 00:00:00

  • Shock absorbing function study on denucleated intervertebral disc with or without hydrogel injection through static and dynamic biomechanical tests in vitro.

    abstract::Hydrogel injection has been recently proposed as a novel therapy for disc degenerative diseases, with the potential to restore the spine motion and the intervertebral disc height. However, it remains unknown whether the new technique could also maintain the shock absorbing property of the treated intervertebral disc. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/461724

    authors: Zhou Z,Gao M,Wei F,Liang J,Deng W,Dai X,Zhou G,Zou X

    更新日期:2014-01-01 00:00:00

  • Labeling of Chromosomes in Cell Development and the Appearance of Monozygotic Twins.

    abstract::Understanding the mechanism behind the structure of the internal cellular clock can lead to advances in the knowledge of origins of pairs of monozygotic twins and higher order multiples as well as other biological phenomena. To gain insight into this mechanism, we analyze possible cell labeling schemes that model an o...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/628092

    authors: Jim C,Berkovich S

    更新日期:2015-01-01 00:00:00

  • Atypical enteropathogenic Escherichia coli strains form biofilm on abiotic surfaces regardless of their adherence pattern on cultured epithelial cells.

    abstract::The aim of this study was to determine the capacity of biofilm formation of atypical enteropathogenic Escherichia coli (aEPEC) strains on abiotic and biotic surfaces. Ninety-one aEPEC strains, isolated from feces of children with diarrhea, were analyzed by the crystal violet (CV) assay on an abiotic surface after 24 h...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/845147

    authors: Culler HF,Mota CM,Abe CM,Elias WP,Sircili MP,Franzolin MR

    更新日期:2014-01-01 00:00:00

  • Surface modifications of dental ceramic implants with different glass solder matrices: in vitro analyses with human primary osteoblasts and epithelial cells.

    abstract::Ceramic materials show excellent esthetic behavior, along with an absence of hypersensitivity, making them a possible alternative implant material in dental surgery. However, their surface properties enable only limited osseointegration compared to titanium implants. Within this study, a novel surface coating techniqu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/742180

    authors: Markhoff J,Mick E,Mitrovic A,Pasold J,Wegner K,Bader R

    更新日期:2014-01-01 00:00:00

  • LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients.

    abstract::Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor developm...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/430943

    authors: Islas-Vazquez L,Prado-Garcia H,Aguilar-Cazares D,Meneses-Flores M,Galicia-Velasco M,Romero-Garcia S,Camacho-Mendoza C,Lopez-Gonzalez JS

    更新日期:2015-01-01 00:00:00

  • A pipeline with multiplex reverse transcription polymerase chain reaction and microarray for screening of chromosomal translocations in leukemia.

    abstract::Chromosome rearrangements and fusion genes present major portion of leukemogenesis and contribute to leukemic subtypes. It is practical and helpful to detect the fusion genes in clinic diagnosis of leukemia. Present application of reverse transcription polymerase chain reaction (RT-PCR) method to detect the fusion gen...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/135086

    authors: Xiong FF,Li BS,Zhang CX,Xiong H,Shen SH,Zhang QH

    更新日期:2013-01-01 00:00:00

  • Improving Physical Fitness of Children with Intellectual and Developmental Disabilities through an Adapted Rhythmic Gymnastics Program in China.

    abstract:Background:Health-related physical fitness is vital for children with intellectual and developmental disabilities (IDD) to gain healthier lives. The adapted rhythmic gymnastics (ARG) program was designed for children with IDD and is aimed at testing the effects of the exercise program on children's physical fitness. M...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2345607

    authors: Xu C,Yao M,Kang M,Duan G

    更新日期:2020-08-10 00:00:00

  • Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection.

    abstract::Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB). The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore,...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2017/9679843

    authors: Xu T,Sun M,Wang H

    更新日期:2017-01-01 00:00:00

  • Identification of age-related macular degeneration related genes by applying shortest path algorithm in protein-protein interaction network.

    abstract::This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The gene...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/523415

    authors: Zhang J,Jiang M,Yuan F,Feng KY,Cai YD,Xu X,Chen L

    更新日期:2013-01-01 00:00:00

  • Bridging the gap between statistical and biological epistasis in Alzheimer's disease.

    abstract::Alzheimer's disease affects millions of people worldwide and incidence is expected to rise as the population ages, but no effective therapies exist despite decades of research and more than 20 known disease markers. Research has shown that Alzheimer's disease's missing heritability remains extensive with an estimated ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/870123

    authors: Ebbert MT,Ridge PG,Kauwe JS

    更新日期:2015-01-01 00:00:00

  • Neem (Azadirachta indica A. Juss) Oil to Tackle Enteropathogenic Escherichia coli.

    abstract::Neem (Azadirachta indica A. Juss) oil (NO) was assayed against forty-eight isolates of Escherichia coli by standardised disc diffusion test and microdilution test. By molecular biology characterization, fourteen isolates resulted in diarrheagenic E. coli with sixteen primer pairs that specifically amplify unique seque...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/343610

    authors: Del Serrone P,Toniolo C,Nicoletti M

    更新日期:2015-01-01 00:00:00

  • Lactulose Hydrogen Breath Test Result Is Associated with Age and Gender.

    abstract::Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to la...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1064029

    authors: Newberry C,Tierney A,Pickett-Blakely O

    更新日期:2016-01-01 00:00:00

  • Transcriptional Regulation of lncRNA Genes by Histone Modification in Alzheimer's Disease.

    abstract::Increasing studies have revealed that long noncoding RNAs (lncRNAs) are not transcriptional noise but play important roles in the regulation of a wide range of biological processes, and the dysregulation of lncRNA genes is associated with disease development. Alzheimer's disease (AD) is a chronic neurodegenerative dis...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3164238

    authors: Wan G,Zhou W,Hu Y,Ma R,Jin S,Liu G,Jiang Q

    更新日期:2016-01-01 00:00:00

  • High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy.

    abstract:BACKGROUND:Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population. Hence, the Ameri...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/351831

    authors: Han C,Li C,Mao J,Wang W,Xie X,Zhou W,Li C,Xu B,Bi L,Meng T,Du J,Zhang S,Gao Z,Zhang X,Yang L,Fan C,Teng W,Shan Z

    更新日期:2015-01-01 00:00:00

  • Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head.

    abstract:Background:Osteonecrosis of the femoral head (ONFH) is a challenge for surgeons and is still without effective treatment method. This study is aimed at evaluating the combined pharmacotherapy with alendronate and desferoxamine for preventing glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) and evaluatin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3120458

    authors: Sheng H,Lao Y,Zhang S,Ding W,Lu D,Xu B

    更新日期:2020-09-21 00:00:00

  • Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy.

    abstract::Liver regeneration after partial hepatectomy (PH) is a highly orchestrated biological process in which synchronized hepatocyte proliferation is induced after massive liver mass loss. Hepatocyte proliferation could be regulated by multiple signals, such as miRNAs and autophagy, but underlying mechanism remains unclear....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3817057

    authors: Lu T,Hao J,Shen C,Gu G,Zhang J,Xu N

    更新日期:2018-07-31 00:00:00

  • A comprehensive review of contemporary role of local treatment of the primary tumor and/or the metastases in metastatic prostate cancer.

    abstract::To provide an overview of the currently available literature regarding local control of primary tumor and oligometastases in metastatic prostate cancer and salvage lymph node dissection of clinical lymph node relapse after curative treatment of prostate cancer. Evidence Acquisition. A systematic literature search was ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/501213

    authors: Aoun F,Peltier A,van Velthoven R

    更新日期:2014-01-01 00:00:00

  • Factors Influencing Administration, Recognition, and Compliance of Medicine among Community Residents from Jilin Province, China: A Questionnaire Study.

    abstract:Introduction:To identify and analyze factors that influence administration, recognition, and compliance of medicine among community residents in Jilin Province, China. Methods:A survey was carried out among 2417 community residents in Jilin Province, China, to study their administration (CRA), recognition (CRR), and c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8730212

    authors: Song YQ,Zhang WR,Zhang SX,Wang TH,Jiang Z,Meng CF,Zhang TZ,Xin QZ,Cao KJ,Zhang Y,Sun Y

    更新日期:2020-07-18 00:00:00

  • In vitro inhibitory and cytotoxic activity of MFM 501, a novel codonopsinine derivative, against Methicillin-Resistant Staphylococcus aureus clinical isolates.

    abstract::28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/823829

    authors: Johari SA,Mohtar M,Mohammad SA,Sahdan R,Shaameri Z,Hamzah AS,Mohammat MF

    更新日期:2015-01-01 00:00:00

  • Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents.

    abstract:Objective:Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods:In this retrospe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8052143

    authors: Zhao Q,Zhang M,Chu Y,Ji B,Pan H,Sun H,Ban B

    更新日期:2020-08-13 00:00:00

  • Effects of ACEIs and ARBs on the Residual Renal Function in Peritoneal Dialysis Patients: A Meta-Analysis of Randomized Controlled Trials.

    abstract:Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/6762029

    authors: Ding L,Yang J,Li L,Yang Y

    更新日期:2020-09-23 00:00:00

  • Effects of Raloxifene on the Proliferation and Apoptosis of Human Aortic Valve Interstitial Cells.

    abstract::We aimed to explore the effects of raloxifene (RAL) on the proliferation and apoptosis of human aortic valve interstitial cells (AVICs). Different concentrations of RAL were used to act on AVICs. MTS kit is used to test the effects of different concentrations of RAL on the proliferation of AVICs. Cell cycle and apopto...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5473204

    authors: Fu Z,Luo B,Li M,Peng B,Wang Z

    更新日期:2016-01-01 00:00:00

  • The Diagnostic Accuracy of Ultrasound in Assessment of Myometrial Invasion in Endometrial Cancer: Subjective Assessment versus Objective Techniques.

    abstract::The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/1318203

    authors: Frühauf F,Zikan M,Semeradova I,Dundr P,Nemejcova K,Dusek L,Cibula D,Fischerova D

    更新日期:2017-01-01 00:00:00

  • Pathogenesis of renal failure in multiple myeloma: any role of contrast media?

    abstract::The spectrum of kidney disease-associated monoclonal immunoglobulin and plasma cell malignancies is remarkably broad and encompasses nearly all nephropathologic entities. Multiple myeloma with kidney impairment at presentation is a medical emergency since the recovery of kidney function is associated with survival ben...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/167125

    authors: Mussap M,Merlini G

    更新日期:2014-01-01 00:00:00

  • Misleading Westerns: Common Quantification Mistakes in Western Blot Densitometry and Proposed Corrective Measures.

    abstract::Densitometry data generated for Western blots are commonly used to compare protein abundance between samples. In the last decade, it has become apparent that assumptions underpinning these comparisons are often violated in studies reporting Western blot data in the literature. These violations can lead to erroneous in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5214821

    authors: Butler TAJ,Paul JW,Chan EC,Smith R,Tolosa JM

    更新日期:2019-01-21 00:00:00