LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients.

Abstract:

:Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor development. In contrast, some reports indicate that tumors may induce immunosuppressive Treg cells to dampen immune reactivity, supporting tumor growth and progression. Thus, we aimed to analyze whether chronic inflammation or immunosuppression predominates at the systemic level in lung adenocarcinoma patients, and several cytokines and Th17 and Treg cells were studied. Higher proportions of IL-17-producing CD4(+) T-cells were found in smoking control subjects and in lung adenocarcinoma patients compared to nonsmoking control subjects. In addition, lung adenocarcinoma patients increased both plasma concentrations of IL-2, IL-4, IL-6, and IL-10, and proportions of Latency Associated Peptide (LAP) TGF-β subset of CD4(+)CD25(+)CD127(-) Treg cells, which overexpressed LAP TGF-β. This knowledge may lead to the development of immunotherapies that could inhibit the suppressor activity mediated by the LAP TGF-β subset of CD4(+)CD25(+)CD127(-) Treg cells to promote reactivity of immune cells against lung adenocarcinoma cells.

journal_name

Biomed Res Int

authors

Islas-Vazquez L,Prado-Garcia H,Aguilar-Cazares D,Meneses-Flores M,Galicia-Velasco M,Romero-Garcia S,Camacho-Mendoza C,Lopez-Gonzalez JS

doi

10.1155/2015/430943

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

430943

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice.

    abstract::Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment. Given the association of diabetes, insulin treatment, an...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9472939

    authors: Arboatti AS,Lambertucci F,Sedlmeier MG,Pisani G,Monti J,Álvarez ML,Francés DEA,Ronco MT,Carnovale CE

    更新日期:2018-04-23 00:00:00

  • MYD88 L265P mutations are correlated with 6q deletion in Korean patients with Waldenström macroglobulinemia.

    abstract::Waldenström macroglobulinemia (WM) is a malignant lymphoplasma-proliferative disorder with IgM monoclonal gammopathy. A recent whole-genome study identified MYD88 L265P as the key mutation in WM. We investigated MYD88 mutations in conjunction with cytogenetic study in 22 consecutive Korean WM patients. Conventional G-...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/363540

    authors: Kim JA,Im K,Park SN,Kwon J,Choi Q,Hwang SM,Sekiguchi N,Yoon SS,Lee DS,Kim SY

    更新日期:2014-01-01 00:00:00

  • Accuracy on Scanned Images of Full Arch Models with Orthodontic Brackets by Various Intraoral Scanners in the Presence of Artificial Saliva.

    abstract:Aim:This study aims to evaluate the accuracy of scanned images of 4 clinically used intraoral scanners (CS3600, i500, Trios3, Omnicam) when scanning the surface of full arch models with various kinds of orthodontic brackets in the presence of artificial saliva. Materials and Methods. Four study models were prepared; bo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2920804

    authors: Song J,Kim M

    更新日期:2020-02-27 00:00:00

  • Deep Response in Multiple Myeloma: A Critical Review.

    abstract::Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/832049

    authors: Fulciniti M,Munshi NC,Martinez-Lopez J

    更新日期:2015-01-01 00:00:00

  • A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis.

    abstract::Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature. In this review, the author offers a 3-step pathway of pathogenesis for syndactyly. The first step is initiated either by the overactivation of the WNT canonical pathway or the...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9652649

    authors: Al-Qattan MM

    更新日期:2019-09-15 00:00:00

  • The pilot study of fibrin with temporomandibular joint derived synovial stem cells in repairing TMJ disc perforation.

    abstract::TMJ disc related diseases are difficult to be cured due to the poor repair ability of the disc. TMJ-SDSCs were ideal cell sources for cartilage tissue engineering which have been widely used in hyaline cartilage regeneration. Fibrin gel has been demonstrated as a potential scaffold for neocartilage formation. The aim ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/454021

    authors: Wu Y,Gong Z,Li J,Meng Q,Fang W,Long X

    更新日期:2014-01-01 00:00:00

  • Low-Abundance Dietzia Inhabiting a Water-Flooding Oil Reservoir and the Application Potential for Oil Recovery.

    abstract::With the development of molecular ecology, increasing low-abundance microbial populations were detected in oil reservoirs. However, our knowledge about the oil recovery potential of these populations is lacking. In this study, the oil recovery potential of low-abundance Dietzia that accounts for less than 0.5% in micr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2193453

    authors: Gao P,Wang H,Li G,Ma T

    更新日期:2019-10-02 00:00:00

  • CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens.

    abstract::Individuals with X-HIGM syndrome fail to express functional CD40 ligand; consequently they cannot mount effective protective antibody responses against pathogenic bacteria. We evaluated, compared, and characterized the humoral immune response of wild type (WT) and C57-CD40L deficient (C57-CD40L(-/-)) mice infected wit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/679850

    authors: Lopez-Saucedo C,Bernal-Reynaga R,Zayas-Jahuey J,Galindo-Gomez S,Shibayama M,Garcia-Galvez C,Estrada-Parra S,Estrada-Garcia T

    更新日期:2015-01-01 00:00:00

  • UnderstAID, an ICT Platform to Help Informal Caregivers of People with Dementia: A Pilot Randomized Controlled Study.

    abstract::Information and communications technology (ICT) could support ambient assisted living (AAL) based interventions to provide support to informal caregivers of people with dementia, especially when they need to cope with their feelings of overburden or isolation. An e-learning platform (understAID application) was tested...

    journal_title:BioMed research international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1155/2016/5726465

    authors: Núñez-Naveira L,Alonso-Búa B,de Labra C,Gregersen R,Maibom K,Mojs E,Krawczyk-Wasielewska A,Millán-Calenti JC

    更新日期:2016-01-01 00:00:00

  • Corrigendum to "Effect of Short-Term Stimulation with Interleukin-1β and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts".

    abstract::[This corrects the article DOI: 10.1155/2015/714230.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2016/9325260

    authors: Voss JO,Loebel C,Bara JJ,Fuessinger MA,Duttenhoefer F,Alini M,Stoddart MJ

    更新日期:2016-01-01 00:00:00

  • Metabolomic Profiling of Human Spermatozoa in Idiopathic Asthenozoospermia Patients Using Gas Chromatography-Mass Spectrometry.

    abstract::The purpose of this study was to describe the first metabolic profile of human sperm cells through the application of an untargeted platform based on gas chromatography-mass spectrometry (GC-MS). Sperm cell samples from patients diagnosed with idiopathic asthenozoospermia (n = 30) and healthy subjects (n = 30) were an...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8327506

    authors: Zhao K,Zhang J,Xu Z,Xu Y,Xu A,Chen W,Miao C,Liu S,Wang Z,Jia R

    更新日期:2018-02-28 00:00:00

  • Potent anti-inflammatory activity of carbohydrate polymer with oxide of zinc.

    abstract::Pebisut is a biological adhesive composed of naturally occurring carbohydrates combined with zinc oxide (ZnO) initially used as a coadjutant for healing of anastomoses. Likewise some works demonstrated that carbohydrate complexes exerts anti-inflammatory activity and it is widely known that ZnO modulate inflammation. ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/712312

    authors: Moreno-Eutimio MA,Nieto-Velázquez NG,Espinosa-Monroy L,Torres-Ramos Y,Montoya-Estrada A,Cueto J,Hicks JJ,Acosta-Altamirano G

    更新日期:2014-01-01 00:00:00

  • Optimized periocular template selection for human recognition.

    abstract::A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/481431

    authors: Bakshi S,Sa PK,Majhi B

    更新日期:2013-01-01 00:00:00

  • Resveratrol ameliorates motor neuron degeneration and improves survival in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

    abstract::Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...

    journal_title:BioMed research international

    pub_type: 杂志文章,收录出版

    doi:10.1155/2014/483501

    authors: Song L,Chen L,Zhang X,Li J,Le W

    更新日期:2014-01-01 00:00:00

  • Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events.

    abstract::Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions be...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/4864195

    authors: Feller L,Khammissa RA,Thomadakis G,Fourie J,Lemmer J

    更新日期:2016-01-01 00:00:00

  • The Use and Effectiveness of Triple Multiplex System for Coding Region Single Nucleotide Polymorphism in Mitochondrial DNA Typing of Archaeologically Obtained Human Skeletons from Premodern Joseon Tombs of Korea.

    abstract::Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions SNPs could be also...

    journal_title:BioMed research international

    pub_type: 历史文章,杂志文章

    doi:10.1155/2015/850648

    authors: Oh CS,Lee SD,Kim YS,Shin DH

    更新日期:2015-01-01 00:00:00

  • Automated Ventricular System Segmentation in Paediatric Patients Treated for Hydrocephalus Using Deep Learning Methods.

    abstract::Hydrocephalus is a common neurological condition that can have traumatic ramifications and can be lethal without treatment. Nowadays, during therapy radiologists have to spend a vast amount of time assessing the volume of cerebrospinal fluid (CSF) by manual segmentation on Computed Tomography (CT) images. Further, som...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3059170

    authors: Klimont M,Flieger M,Rzeszutek J,Stachera J,Zakrzewska A,Jończyk-Potoczna K

    更新日期:2019-07-07 00:00:00

  • Association between Serum Ferritin and Contrast-Induced Nephropathy in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

    abstract::Background and Aims. CIN is a major and serious complication following PCI in patients with ACS. It is unclear whether a higher serum ferritin level is associated with an increased risk of CIN in high-risk patients. Thus, we conducted this study to assess the predictive value of SF for the risk of CIN after PCI. Metho...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5420345

    authors: Zhu B,Hou J,Gong Y,Yan G,Wang Q,Wang D,Qiao Y,Chen Y,Tang C

    更新日期:2016-01-01 00:00:00

  • Whole Body Vibration Retards Progression of Atherosclerosis via Insulin-Like Growth Factor 1 in Apolipoprotein E-Deficient Mice.

    abstract::Whole body vibration (WBV) has a marked impact on lipid metabolism and the endocrine system, which is related to the progression of atherosclerosis (AS). To investigate the effects of WBV, we measured the atherosclerotic plaque area of apolipoprotein E-knockout (ApoE-/-) AS mice, which were trained by WBV (15 Hz, 30 m...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4934861

    authors: Wu H,Zhang Y,Yang X,Li X,Shao Z,Zhou Z,Li Y,Pan S,Liu C

    更新日期:2018-03-07 00:00:00

  • Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot.

    abstract:Objective:The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at p...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6383906

    authors: Cui M,Gao Y,Zhao Y,Pang H,Chen L,Wang Z,Zhao L,Li M

    更新日期:2020-06-21 00:00:00

  • Circadian Variation of Migraine Attack Onset: A Review of Clinical Studies.

    abstract::Several studies suggested that migraine attack onset shows a circadian variation; however, there has not been an overview and synthesis of these findings. A PubMed search with keywords "migraine" AND "circadian" resulted in ten studies directly investigating this topic. Results of these studies mostly show that migrai...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/4616417

    authors: Baksa D,Gecse K,Kumar S,Toth Z,Gal Z,Gonda X,Juhasz G

    更新日期:2019-08-25 00:00:00

  • Endoscopic Management of Foreign Bodies in the Upper Gastrointestinal Tract of Adults.

    abstract:BACKGROUND:Foreign object ingestion and food bolus impaction are a common clinical problem. We report our clinical experiences in endoscopic management for adults, foreign body ingestion, and food bolus impaction. METHOD:A retrospective chart review study was conducted on adult patients with foreign body ingestion and...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/658602

    authors: Yao CC,Wu IT,Lu LS,Lin SC,Liang CM,Kuo YH,Yang SC,Wu CK,Wang HM,Kuo CH,Chiou SS,Wu KL,Chiu YC,Chuah SK,Tai WC

    更新日期:2015-01-01 00:00:00

  • Acetylated hyaluronic acid: enhanced bioavailability and biological studies.

    abstract::Hyaluronic acid (HA), a macropolysaccharidic component of the extracellular matrix, is common to most species and it is found in many sites of the human body, including skin and soft tissue. Not only does HA play a variety of roles in physiologic and in pathologic events, but it also has been extensively employed in c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/921549

    authors: Saturnino C,Sinicropi MS,Parisi OI,Iacopetta D,Popolo A,Marzocco S,Autore G,Caruso A,Cappello AR,Longo P,Puoci F

    更新日期:2014-01-01 00:00:00

  • Analysis of the time and location of the silicone oil emulsification by spectral-domain optical coherence tomography after silicone oil tamponade.

    abstract:PURPOSE:To estimate localization and the period up to the appearance of small hyperreflective round-shaped droplets using spectral-domain optical coherence tomography (SD-OCT) after pars plana vitrectomy with silicone oil tamponade. METHODS:A retrospective observational study included 24 patients who had undergone par...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/372045

    authors: Odrobina D,Laudańska-Olszewska I

    更新日期:2014-01-01 00:00:00

  • A Prediction Model for Membrane Proteins Using Moments Based Features.

    abstract::The most expedient unit of the human body is its cell. Encapsulated within the cell are many infinitesimal entities and molecules which are protected by a cell membrane. The proteins that are associated with this lipid based bilayer cell membrane are known as membrane proteins and are considered to play a significant ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8370132

    authors: Butt AH,Khan SA,Jamil H,Rasool N,Khan YD

    更新日期:2016-01-01 00:00:00

  • Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertility.

    abstract::Mitochondria, the energy-generating organelles, play a role in numerous cellular functions including adenosine triphosphate (ATP) production, cellular homeostasis, and apoptosis. Maternal inheritance of mitochondria and mitochondrial DNA (mtDNA) is universally observed in humans and most animals. In general, high leve...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/981867

    authors: Song WH,Ballard JW,Yi YJ,Sutovsky P

    更新日期:2014-01-01 00:00:00

  • Electrical Bioimpedance Spectroscopy on Acute Unilateral Stroke Patients: Initial Observations regarding Differences between Sides.

    abstract:PURPOSE:Electrical Bioimpedance Cerebral Monitoring is assessment in real time of health of brain tissue through study of passive dielectric properties of brain. During the last two decades theory and technology have been developed in parallel with animal experiments aiming to confirm feasibility of using bioimpedance-...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/613247

    authors: Seoane F,Reza Atefi S,Tomner J,Kostulas K,Lindecrantz K

    更新日期:2015-01-01 00:00:00

  • The Preoperative CT-Scan Can Help to Predict Postoperative Complications after Pancreatoduodenectomy.

    abstract::After pancreatoduodenectomy, complication rates are up to 40%. To predict the risk of developing postoperative pancreatic fistula or severe complications, various factors were evaluated. 110 consecutive patients undergoing pancreatoduodenectomy at our institute between January 2012 and September 2014 with complete CT ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/824525

    authors: Schröder FF,de Graaff F,Bouman DE,Brusse-Keizer M,Slump KH,Klaase JM

    更新日期:2015-01-01 00:00:00

  • The Construct and Measurement of Perceived Risk of Nonremunerated Blood Donation: Evidence from the Chinese Public.

    abstract::The perceived risk of nonremunerated blood donation (NRBD) is one of the most important factors which hinder the Chinese public from donating blood. To understand deeply and measure scientifically the public's perceived risk of NRBD, in this paper the qualitative and quantitative methods were used to explore the const...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/302043

    authors: Chen L,Ma Z

    更新日期:2015-01-01 00:00:00

  • Occupational allergic diseases in kitchen and health care workers: an underestimated health issue.

    abstract:OBJECTIVE:This study evaluated the frequencies of allergic symptoms and rate of upper respiratory infections during the past year in the general population, kitchen workers (KW) and health care workers (HCW). METHODS:The European Community Respiratory Health Survey (ECRHS) was used to inquire retrospectively about ast...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/285420

    authors: Bilge U,Unluoglu I,Son N,Keskin A,Korkut Y,Unalacak M

    更新日期:2013-01-01 00:00:00