Abstract:
:The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical staging between January 2009 and December 2011, were prospectively enrolled. Myometrial invasion was evaluated by subjective assessment using ultrasound (<50% or ≥50%) and calculated as deepest invasion/normal myometrium ratio (Gordon's ratio) and as tumor/uterine anteroposterior diameter ratio (Karlsson's ratio). Histological assessment from hysterectomy was considered the gold standard. Altogether 210 patients were prospectively included. Subjective assessment and two objective ratios were found to be statistically significant predictors of the myometrial invasion (AUC = 0.65, p value < 0.001). Subjective assessment was confirmed as the most reliable method to assess myometrial invasion (79.3% sensitivity, 73.2% specificity, and 75.7% overall accuracy). Deepest invasion/normal myometrium (Gordon's) ratio (cut-off 0.5) reached 69.6% sensitivity, 65.9% specificity, and 67.3% overall accuracy. Tumor/uterine anteroposterior diameter (Karlsson's) ratio with the same cut-off reached 56.3% sensitivity, 76.4% specificity, and 68.1% overall accuracy. The subjective ultrasound evaluation of myometrial invasion performed better than objective methods in nearly all measures but showed statistically significantly better outcomes only in case of sensitivity.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Frühauf F,Zikan M,Semeradova I,Dundr P,Nemejcova K,Dusek L,Cibula D,Fischerova Ddoi
10.1155/2017/1318203subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1318203eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract:Background:Glucagon-like peptide 1 (GLP-1) hormone is an incretin hormone that is secreted in the ileum and plays a role in the pancreas to increase insulin secretion, stimulate proliferation, and prevent pancreatic β-cell apoptosis. Currently, diabetes mellitus (DM) treatment based on GLP-1 work is being developed, fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8724824
更新日期:2019-11-11 00:00:00
abstract::Purpose. Kawasaki disease (KD) is a systemic vasculitis and is a leading cause of coronary artery lesions (CALs) in childhood. Our previous study has shown higher levels of serum Resistin in KD patients with coronary aneurysm. This study aimed at examining the association of Resistin with inflammatory cytokine express...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3296437
更新日期:2016-01-01 00:00:00
abstract::Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3706581
更新日期:2019-11-20 00:00:00
abstract::Colorectal cancer, a malignant neoplasm that occurs in the colorectal mucosa, is one of the most common types of gastrointestinal cancer. Colorectal cancer has been studied extensively, but the molecular mechanisms of this malignancy have not been characterized. This study identified and verified core genes associated...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8082697
更新日期:2020-05-08 00:00:00
abstract:OBJECTIVE:The serotonin (5-HT) pathway was shown to play a role in pulmonary hypertension (PH), but its functions in right ventricular failure (RVF) remain poorly understood. The aim of the current study was to investigate the effects of Terguride (5-HT2A and 2B receptor antagonist) or SB204741 (5-HT2B receptor antagon...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/438403
更新日期:2015-01-01 00:00:00
abstract::Microalgae are a promising source of omega-3. The purpose of this study was to extract lipid with a relatively high content of eicosapentaenoic acid (EPA) from Nannochloropsis gaditana using subcritical water extraction (SWE). The effects of different temperatures (156.1-273.9°C), extraction times (6.6-23.4 minutes), ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8273581
更新日期:2018-12-27 00:00:00
abstract::The aim of the present study was to analyze the relationship between the sum of the four limbs' pulse pressure (Sum-PP) and brachial-ankle pulse wave velocity (baPWV) and atherosclerosis risk factors and evaluate the feasibility of Sum-PP in diagnosing atherosclerosis systemically. For the purpose, a cross-sectional s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/434516
更新日期:2015-01-01 00:00:00
abstract::In vivo confocal microscopy (IVCM) of the living human cornea offers the ability to perform repeated imaging without tissue damage. Studies using corneal IVCM have led to significant contributions to scientific and clinical knowledge of the living cornea in health and pathological states. Recently the application of c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/951081
更新日期:2015-01-01 00:00:00
abstract:Aim:To address the impact of noncavity-distorting intramural fibroids on the efficacy of in vitro fertilization-embryo transfer (IVF-ET) outcomes. Methods:The PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure were searched systematically. A meta-analysis was performed based ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/8924703
更新日期:2018-09-04 00:00:00
abstract::Fermenticin HV6b is a class IIa antimicrobial peptide produced by Lactobacillus fermentum HV6b MTCC 10770 isolated from human vaginal ecosystem. It shows growth inhibition of a wide range of opportunistic pathogens of humans, for example, Bacteroides, Gardnerella vaginalis, Mobiluncus, Staphylococci, and Streptococci,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/168438
更新日期:2013-01-01 00:00:00
abstract:Background:Comparison of single-level open and minimally invasive transforaminal lumbar interbody fusions (O-TLIF and MI-TLIF) of a single surgeon and presentation of his MI-TLIF learning curve in a retrospective observational cohort study. Methods:27 MI-TLIF and 31 O-TLIF patients, performed between 03/01/2013 and 03...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3798537
更新日期:2020-01-25 00:00:00
abstract::We have analyzed anatomic variations in the pectoralis major and pectoralis minor muscles of common chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) and compared them to anatomic variations in these muscles in humans (Homo sapiens). We have macroscopically dissected these muscles in six adult Pan troglodytes, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9404508
更新日期:2018-01-21 00:00:00
abstract:OBJECTIVE:Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with eccentric versus traditio...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/398960
更新日期:2014-01-01 00:00:00
abstract:Objectives:The aim of this study was to evaluate the influence of ferule and the post type on the fracture strength and stress distribution in premolars. Materials and Methods:Forty human mandibular premolars were decoronated, allocated in four groups, and restored as follows: CPC-NF: cast post-and-core and absence of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2196519
更新日期:2019-01-03 00:00:00
abstract::Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detriment...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/864946
更新日期:2015-01-01 00:00:00
abstract::Both human adipose tissue-derived mesenchymal stem cells (ASCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been explored as attractive mesenchymal stem cells (MSCs) sources, but very few parallel comparative studies of these two cell types have been made. We designed a side-by-side comparative st...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版
doi:10.1155/2013/438243
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI). METHODS:Forty patients with SAP and 20 with UAP/n-ST...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/401357
更新日期:2015-01-01 00:00:00
abstract:Background:Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data regarding the functional role of DCLK1 in breast cancer metastasis. In the present study, we s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1061979
更新日期:2019-05-15 00:00:00
abstract::We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming. Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/613078
更新日期:2014-01-01 00:00:00
abstract::Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO antibody (monoclonal 72D9)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/984041
更新日期:2013-01-01 00:00:00
abstract::Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine. However, little is known regarding the sedative and hypnotic effects of PRPCA. In the present study, we examined th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6198067
更新日期:2019-04-28 00:00:00
abstract:Background:It is unclear whether computer navigation can improve the accuracy and reliability of targeted lower limb alignment correction following open-wedge high tibial osteotomy (HTO). This meta-analysis was designed to compare the accuracy and reliability of limb alignment correction between computer navigated and ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2017/3803457
更新日期:2017-01-01 00:00:00
abstract::Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/981841
更新日期:2015-01-01 00:00:00
abstract::Objectives. Osteopontin (OPN) is overexpressed in breast cancers, while its clinical and prognostic significance remained unclear. This study aimed to assess the prognostic value of OPN, especially its splice variants, in breast cancers. Methods. Data were extracted from eligible studies concerning the OPN and OPN-c e...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2016/7310694
更新日期:2016-01-01 00:00:00
abstract:Background:Thyroid cancer is the most common endocrine malignancy, with a recent global increase of 20% in age-related incidence. Ultrasonography and ultrasonography-guided fine-needle aspiration biopsy (FNAB) are the most widely used diagnostic tests for thyroid nodules; however, it is estimated that up to 25% of thyr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/6752141
更新日期:2021-01-12 00:00:00
abstract::Saponins are a group of naturally occurring plant glycosides with the features of their strong foam-forming properties and multibiological effects such as antitumor activity. Though Misaponin B, one of the triterpenoid saponins from Madhuca longifolia, is known to have spermicidal and antioxidant activity, the other b...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5925094
更新日期:2020-02-07 00:00:00
abstract::A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial. The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4848652
更新日期:2018-08-13 00:00:00
abstract::Purslane, a fleshy herbaceous plant, plays a pivotal role in various preventive and therapeutic purposes. To date, no report has documented the consequence of salt stress on metabolite accumulation in purslane. Herein, we proposed an insight into the metabolic and physiological traits of purslane under saline stress e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4827045
更新日期:2020-06-17 00:00:00
abstract::There is a need to scientifically validate the claim that wild species of medicinal plants are more potent than the cultivated plants. Thus, this study evaluated the phytochemical and antioxidant properties of wild and cultivated Alepidea amatymbica. Acetone, methanol, and water extracts of the rhizome of wild and cul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5808624
更新日期:2020-04-13 00:00:00
abstract::WNT proteins are involved in embryonic development, sex determination, stem cell recruitment, angiogenesis, and cancer. They take part in morphological changes in the endometrium during development, regulate processes of endometrial proliferation and differentiation. This review presents current knowledge about implic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/854056
更新日期:2015-01-01 00:00:00