Abstract:
:28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15.6 to 31.3 μg/mL against 55 S. aureus isolates (43 MRSA and 12 MSSA isolates). The active compound also displayed MBC values between 250 and 500 μg/mL against 58 S. aureus isolates (45 MRSA and 13 MSSA isolates) implying that MFM 501 has a bacteriostatic rather than bactericidal effect against both MRSA and MSSA isolates. In addition, MFM 501 showed no apparent cytotoxicity activity towards three normal cell lines (WRL-68, Vero, and 3T3) with IC50 values of >625 µg/mL. Selectivity index (SI) of MFM 501 gave a value of >10 suggesting that MFM 501 is significant and suitable for further in vivo investigations. These results suggested that synthetically derived intermediate compounds based on natural products may play an important role in the discovery of new anti-infective agents against MRSA.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Johari SA,Mohtar M,Mohammad SA,Sahdan R,Shaameri Z,Hamzah AS,Mohammat MFdoi
10.1155/2015/823829subject
Has Abstractpub_date
2015-01-01 00:00:00pages
823829eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
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