Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors.

abstract：Background:Splenectomy can improve liver function and survival in patients with autoimmune hepatitis (AIH) and liver cirrhosis. We investigated the underlying mechanism in a mouse model of concanavalin A- (ConA-) induced liver fibrosis. Methods:We used ConA to induce immune liver fibrosis in BALB/c mice. Splenectomy w...

journal_title：BioMed research international

authors： Wang Y,Guo X,Jiao G,Luo L,Zhou L,Zhang J,Wang B

更新日期：2019-01-06 00:00:00

abstract：:A novel methylamine-selective amperometric bienzyme biosensor based on recombinant primary amine oxidase isolated from the recombinant yeast strain Saccharomyces cerevisiae and commercial horseradish peroxidase is described. Two amine oxidase preparations were used: free enzyme (AMO) and covalently immobilized on the ...

journal_title：BioMed research international

authors： Stasyuk NY,Smutok OV,Zakalskiy AE,Zakalska OM,Gonchar MV

更新日期：2014-01-01 00:00:00

abstract：:The research was performed on male Wistar rats based on assumptions that new microelement preparations containing metal nanoparticles and their agglomerates had potential. Morphological and functional changes in tissues in the injection site and dynamics of chemical element metabolism (25 indicators) in body were asse...

journal_title：BioMed research international

authors： Sizova E,Miroshnikov S,Yausheva E,Polyakova V

更新日期：2015-01-01 00:00:00

abstract：:Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...

journal_title：BioMed research international

authors： Marasco R,Rolli E,Fusi M,Cherif A,Abou-Hadid A,El-Bahairy U,Borin S,Sorlini C,Daffonchio D

更新日期：2013-01-01 00:00:00

abstract：:Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentratio...

journal_title：BioMed research international

authors： Maurer-Ertl W,Pranckh-Matzke D,Friesenbichler J,Bratschitsch G,Holzer LA,Maier M,Leithner A

更新日期：2017-01-01 00:00:00

abstract：:Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease (CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the physiological significance of stenotic lesions. A noninvasive "one-stop-...

journal_title：BioMed research international

authors： Xu L,Sun Z,Fan Z

更新日期：2015-01-01 00:00:00

abstract：:Studies pertaining to trans fatty acids (TFA), which have been implicated in development of chronic diseases, are more relevant in developing countries where nutrition transition is changing traditional habits and practices. Measuring TFA is an arduous task because of the need for fat biopsies. This study identifies a...

journal_title：BioMed research international

authors： Abraham RA,Bahl VK,Parshad R,Seenu V,Roy A,Golandaz S,Dorairaj P,Ramakrishnan L

更新日期：2013-01-01 00:00:00

abstract：:Scaffolds play an important role in tissue engineering and their structure and biocompatibility have great influence on cell behaviors. In this study, poly(l-lactide-co-ε-caprolactone) (PLCL) scaffolds were printed by a 3D printing technology, low-temperature deposition manufacturing (LDM), and then PLCL scaffolds wer...

journal_title：BioMed research international

authors： He Y,Liu W,Guan L,Chen J,Duan L,Jia Z,Huang J,Li W,Liu J,Xiong J,Liu L,Wang D

更新日期：2018-02-28 00:00:00

abstract：:Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...

journal_title：BioMed research international

authors： Amaya-Amaya J,Montoya-Sánchez L,Rojas-Villarraga A

更新日期：2014-01-01 00:00:00

abstract：Objective:To investigate the prevalence of infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) among ICU admission patients in central China and develop a reliable prediction model. Methods:Five hundred and seven consecutive ICU admission patients with Klebsiella pneumoniae (KP) infection were enrolled...

journal_title：BioMed research international

authors： Li Y,Shen H,Zhu C,Yu Y

更新日期：2019-03-27 00:00:00

abstract：Background:The incidence of osteoporotic fractures is increasing. In this study, we explored the activities of Wnt/β-catenin signaling in bone tissues with iron accumulation. Methods:We established rat bipedal walking models (RBWM), and a portion of our RBWM rats were intraperitoneally injected with ferric ammonium ci...

journal_title：BioMed research international

authors： Xu W,Yu R,Zhu X,Li Z,Jia J,Li D,Chen Y,Zhang X

更新日期：2020-05-24 00:00:00

abstract：:We evaluated single nucleotide polymorphism (SNP) detection via a target-capture, C-probe ligation, and RAM assay in a single-blind comparison to clinical samples that had been tested with FDA-cleared tests for up to 4 different vascular disease-related SNPs. In the RAM assay circulizable linear probes (C- or padlock ...

journal_title：BioMed research international

authors： Smith JH,Cui M,Zhang DY,Beals TP,Ye F

更新日期：2014-01-01 00:00:00

abstract：:Background. Stenotrophomonas maltophilia bacteremia (SMB) is the most perilous situation as compared to other types of S. maltophilia infection. The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China. Methods. ...

journal_title：BioMed research international

authors： Chen Y,Suo J,Du M,Chen L,Liu Y,Wang L,Liang Z

更新日期：2019-12-09 00:00:00

abstract：:Acetabular fractures involving predominantly the anterior column associated with a disruption of the quadrilateral surface can be treated with instrumentation implementing the stabilization of the quadrilateral surface. The recently introduced suprapectineal quadrilateral buttress plate is specifically designed to pre...

journal_title：BioMed research international

authors： Egli RJ,Keel MJB,Cullmann JL,Bastian JD

更新日期：2017-01-01 00:00:00

abstract：:Targeted drug delivery using folate receptors is one of the most interesting chemotherapeutic research areas over the past few years. A novel folate targeted copolymer was synthesized using dextran stearate coupled to folic acid. FT-IR and NMR spectroscopy were used to confirm successful conjugation. Micelles prepared...

journal_title：BioMed research international

authors： Varshosaz J,Hassanzadeh F,Sadeghi-Aliabadi H,Firozian F

更新日期：2014-01-01 00:00:00

abstract：:Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction protocol could be ef...

journal_title：BioMed research international

authors： Caruso C,Bramé B,Bagnasco D,Cocconcelli A,Ortolani V,Pravettoni V,Scarpa S,Zisa G,Passalacqua G,Colantuono S

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Novel prognostic markers are needed so newly diagnosed breast cancer patients do not undergo any unnecessary therapy. Various microarray gene expression datasets based studies have generated gene signatures to predict the prognosis outcomes, while ignoring the large amount of information contained in establi...

journal_title：BioMed research international

authors： Saini A,Hou J,Zhou W

更新日期：2014-01-01 00:00:00

abstract：:Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to discriminate presynapti...

journal_title：BioMed research international

authors： Tang H,Yang Y,Zhang C,Chen R,Huang P,Duan C,Zou P

更新日期：2017-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide. In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note. In the present study, we investigated the impact of the gender on the development of experimental CKD in...

journal_title：BioMed research international

authors： Fanelli C,Dellê H,Cavaglieri RC,Dominguez WV,Noronha IL

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:This study investigated whether the 1 : 2 ω-3/ω-6 ratio may reduce proinflammatory response in human alveolar cells (A549) exposed to an ex vivo inflammatory stimulus (bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients). Methods. We exposed A549 cells to the BALF colle...

journal_title：BioMed research international

authors： Cotogni P,Trombetta A,Muzio G,Maggiora M,Canuto RA

更新日期：2015-01-01 00:00:00

abstract：:Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway involves a complex interaction among adhesion molecules, cytokines, proteolytic enzymes, stromal cells, and hematopoietic cells. The identification of new mechanisms that regulate the traffick...

journal_title：BioMed research international

authors： Alvarez P,Carrillo E,Vélez C,Hita-Contreras F,Martínez-Amat A,Rodríguez-Serrano F,Boulaiz H,Ortiz R,Melguizo C,Prados J,Aránega A

更新日期：2013-01-01 00:00:00

abstract：Background:Since the dawn of human history, foodborne diseases have been a problem for all societies, and it is an increasing public health issue worldwide. The objective of this study is to examine knowledge, practice, and attitude in food safety among college students in the city Gondar, northwest Ethiopia. Methods:...

journal_title：BioMed research international

authors： Azanaw J,Dagne H,Andualem Z,Adane T

更新日期：2021-01-12 00:00:00

abstract：:This study documented the population dynamics of Biomphalaria and associated natural infections with digenetic trematodes, along the shores of Lake Albert and Lake Victoria, recording local physicochemical factors. Over a two-and-a-half-year study period with monthly sampling, physicochemical factors were measured at ...

journal_title：BioMed research international

authors： Rowel C,Fred B,Betson M,Sousa-Figueiredo JC,Kabatereine NB,Stothard JR

更新日期：2015-01-01 00:00:00

abstract：:Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R ...

journal_title：BioMed research international

authors： Song L,Gao LN,Wang J,Thapa S,Li Y,Zhong XB,Zhao HW,Xiang XR,Zhang FG,Ji P

更新日期：2018-01-11 00:00:00

abstract：:The use of supplemental oxygen in uncomplicated cesarean deliveries under spinal anesthesia has been thoroughly investigated during recent decades. The aim of this study was to determine the benefits for both mother and infant of administering supplemental, low-dose oxygen via a nasal cannula versus having no suppleme...

journal_title：BioMed research international

authors： Siriussawakul A,Triyasunant N,Nimmannit A,Ngerncham S,Hirunkanokpan P,Luang-Aram S,Pechpaisit N,Wangdee A,Ruangvutilert P

更新日期：2014-01-01 00:00:00

abstract：:Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions between diseases are not always entirely clear. We present an efficient computational method based on protein-protei...

journal_title：BioMed research international

authors： Nguyen TP,Caberlotto L,Morine MJ,Priami C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-M...

journal_title：BioMed research international

authors： Sklavos MM,Spracklen CN,Saftlas AF,Pinto LA

更新日期：2014-01-01 00:00:00

abstract：:Cystic echinococcosis is a serious zoonotic disease caused by Echinococcus granulosus species complex. The current study is the first attempt to determine the level of infection in domestic livestock and to explore the CE-related knowledge and awareness among livestock farmers in different districts of Khyber Pakhtunk...

journal_title：BioMed research international

authors： Haleem S,Niaz S,Qureshi NA,Ullah R,Alsaid MS,Alqahtani AS,Shahat AA

更新日期：2018-09-12 00:00:00

abstract：INTRODUCTION:Frail older people are often unable to undertake high-intensity exercise programmes. Chair-based exercises (CBEs) are used as an alternative, for which health benefits are uncertain. OBJECTIVE:To examine the effects of CBE programmes for frail older people through a systematic review of existing literatur...

journal_title：BioMed research international

authors： Anthony K,Robinson K,Logan P,Gordon AL,Harwood RH,Masud T

更新日期：2013-01-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a major cause of nonrelapse mortality after allo-HSCT. A conditioning regimen plays a pivotal role in the development of aGVHD. To provide a platform for studying aGVHD and evaluating t...

journal_title：BioMed research international

authors： He X,Ye Y,Xu X,Wang J,Huang Y,Weng G,Zhang M,Guo K

更新日期：2016-01-01 00:00:00