CD20+ B cell depletion in systemic autoimmune diseases: common mechanism of inhibition or disease-specific effect on humoral immunity?

Abstract:

:Autoimmunity remains a complex physiologic deviation, enabled and perpetuated by a variety of interplayers and pathways. Simplistic approaches, targeting either isolated end-effectors of more centrally placed interactors of these mechanisms, are continuously tried in an effort to comprehend and halt cascades with potential disabling and deleterious effects in the affected individuals. This review focuses on theoretical and clinically proved effects of rituximab-induced CD20+ B cell depletion on different systemic autoimmune diseases and extrapolates on pathogenetic mechanisms that may account for different interindividual or interdisease responses.

journal_name

Biomed Res Int

authors

Pateinakis P,Pyrpasopoulou A

doi

10.1155/2014/973609

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

973609

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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