Abstract:
:The aim of this study is to investigate the changes in QT, QTc, and Tp-e intervals and Tp-e/QT ratio on surface electrocardiogram (ECG) signals during anaesthesia induction using propofol or sevoflurane after preoperative cefuroxime infusion. Some 120 cases of gynaecological patients are randomly divided into propofol (P) and sevoflurane (S) groups (n=60). After cefuroxime (1.5 g) was infused in the two groups of patients, propofol target controlled infusion (TCI) was conducted in the P group for 5 min to realise a plasma concentration of 4 μg/ml while patients in the S group inhaled anaesthesia by infusing 1.3 MAC sevoflurane for 6 min. The 12-lead ECGs were separately collected before infusing cefuroxime (T1), after infusing cefuroxime (T2), and after infusing propofol or sevoflurane (T3) to measure QT and Tp-e intervals, calculate QTc and Tp-e/QT, and record MAP and HR. Finally, we demonstrated that QT, QTc, and Tp-e intervals and Tp-e/QT ratio had no change (P > 0.05) after cefuroxime infusion in the two groups of patients compared with that before infusing antibiotics. Moreover, after conducting preoperative cefuroxime infusion, using propofol and sevoflurane had no influence on Tp-e interval, but sevoflurane can significantly prolong QT and QTc intervals (P < 0.05).
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Liu Y,Gao H,Wang G,An L,Yi J,Fu X,Wen C,Wang Zdoi
10.1155/2019/8978906subject
Has Abstractpub_date
2019-01-02 00:00:00pages
8978906eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/845032
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/127548
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2019/6897187
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