Assessment of Corneal Pachymetry Distribution and Morphologic Changes in Subclinical Keratoconus with Normal Biomechanics.

abstract：Purpose:To explore the effect of VEGF (vascular endothelial growth factor) on the vasculogenic mimicry (VM) formation of Choroidal Melanoma (CM) through PI3k signal pathway, to find novel targets for CM therapy. Methods:This research investigated the molecular mechanism of VEGF promoting VM formation of CM. First, we ...

journal_title：BioMed research international

authors： Xu X,Zong Y,Gao Y,Sun X,Zhao H,Luo W,Jia S

更新日期：2019-07-11 00:00:00

abstract：Objective:The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. Methods:Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retina...

journal_title：BioMed research international

authors： Solans Pérez de Larraya AM,Ortega Molina JM,Uberos Fernández J,González Ramírez AR,García Serrano JL

更新日期：2019-04-24 00:00:00

abstract：:Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...

journal_title：BioMed research international

authors： Ching XT,Lau YL,Fong MY,Nissapatorn V,Andiappan H

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the antitumor potential of iminoflavones in in vitro and in vivo anticancer models. Preliminary screening in various cancer cell lines revealed four potential iminoflavones out of which IMF-8 was taken based on its activity against colon cancer cells. This was further confi...

journal_title：BioMed research international

authors： Prasad VG,Kawade S,Jayashree BS,Reddy ND,Francis A,Nayak PG,Kishore A,Nandakumar K,Rao CM,Shenoy RR

更新日期：2014-01-01 00:00:00

abstract：:Hitherto, limited clinical impact has been achieved in the treatment of glioblastoma (GBMs). Although phytochemicals found in medicinal herbs can provide mankind with new therapeutic remedies, single agent intervention has failed to bring the expected outcome in clinical trials. Therefore, combinations of several agen...

journal_title：BioMed research international

authors： Elkady AI,Hussein RA,Abu-Zinadah OA

更新日期：2014-01-01 00:00:00

abstract：:The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and immunomodulation. Here we identified PROK2 as a critical mediator of neuropathic pain in the chronic constriction injury (CCI) of the sciatic nerve in mice and demonstrated that blocking the prokineticin rec...

journal_title：BioMed research international

authors： Lattanzi R,Maftei D,Marconi V,Florenzano F,Franchi S,Borsani E,Rodella LF,Balboni G,Salvadori S,Sacerdote P,Negri L

更新日期：2015-01-01 00:00:00

abstract：:The relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) has attracted wide attention. Studies have reported that ginsenoside Rb1 can improve human cognitive ability and glucose tolerance during the development of diabetes. The mechanism behind the improvement in cognitive ability and glucose toler...

journal_title：BioMed research international

authors： Yang R,Jiang X,He X,Liang D,Sun S,Zhou G

更新日期：2020-05-20 00:00:00

abstract：:Transcatheter treatment of children with congenital heart disease such as coarctation of the aorta and pulmonary artery stenosis currently involves the use of metal stents. While these provide good short term results, there are long term complications with their use. Children outgrow metal stents, obligating them to f...

journal_title：BioMed research international

authors： Alexy RD,Levi DS

更新日期：2013-01-01 00:00:00

abstract：:Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL...

journal_title：BioMed research international

authors： Li XJ,Mishra SK,Wu M,Zhang F,Zheng J

更新日期：2014-01-01 00:00:00

abstract：:Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen...

journal_title：BioMed research international

authors： Wu J,Xia S,Kalionis B,Wan W,Sun T

更新日期：2014-01-01 00:00:00

abstract：:Although multimodal therapies including surgery, chemotherapy, and radiotherapy have improved clinical outcomes of patients with bone and soft tissue sarcomas, the prognosis of patients has plateaued over these 20 years. Immunotherapies have shown the effectiveness for several types of advanced tumors. Immunotherapies...

journal_title：BioMed research international

authors： Uehara T,Fujiwara T,Takeda K,Kunisada T,Ozaki T,Udono H

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Thiopurine drugs are metabolized via S-methylation and catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low TPMT activity are at high risk of fatal bone marrow toxicity when standard doses of thiopurine drugs are administered. TPMT genotyping can predict TPMT activity and is not affec...

journal_title：BioMed research international

authors： Kim S,Lee HW,Lee W,Chun S,Min WK

更新日期：2013-01-01 00:00:00

abstract：:Chagas disease is caused by Trypanosoma cruzi infection. Besides the host-related factors, such as immune response and genetic background, the parasite, strain, and occurrences of reinfection episodes, may influence disease outcome. Our results demonstrate that both the primary infection and the reinfection with the C...

journal_title：BioMed research international

authors： Reis Machado J,Silva MV,Borges DC,da Silva CA,Ramirez LE,dos Reis MA,Castellano LR,Rodrigues V,Rodrigues DB

更新日期：2014-01-01 00:00:00

abstract：:Schwannomas are the commonest tumours of peripheral nerves. Despite the classical description that schwannomas are well encapsulated and can be completely enucleated during excision, a portion of them have fascicular involvement and could not be completely shelled out. A retrospective review for 8 patients was carried...

journal_title：BioMed research international

authors： Tang CY,Fung B,Fok M,Zhu J

更新日期：2013-01-01 00:00:00

abstract：:ADP-glucose pyrophosphorylase (AGPase) is the first rate limiting enzyme of starch biosynthesis pathway and has been exploited as the target for greater starch yield in several plants. The structure-function analysis and substrate binding specificity of AGPase have provided enormous potential for understanding the rol...

journal_title：BioMed research international

authors： Sarma K,Sen P,Barooah M,Choudhury MD,Roychoudhury S,Modi MK

更新日期：2014-01-01 00:00:00

abstract：:Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the secretome from the following informative cervical cell lines: SiHa (HPV16+), HeLa...

journal_title：BioMed research international

authors： Kontostathi G,Zoidakis J,Makridakis M,Lygirou V,Mermelekas G,Papadopoulos T,Vougas K,Vlamis-Gardikas A,Drakakis P,Loutradis D,Vlahou A,Anagnou NP,Pappa KI

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of docetaxel plus oxaliplatin and capecitabine (DOX) in the first line treatment of advanced gastric adenocarcinoma. METHODS:A total of 37 patients were enrolled into this study, and they received DOX regimen (docetaxel 75 mg/m² and oxaliplatin 130 mg/m² intravenous infusi...

journal_title：BioMed research international

authors： Liu Y,Ye Z,Xi W,Ma T,Shi M,Yang L,Zhu Z,Zhang J

更新日期：2013-01-01 00:00:00

abstract：:The palmaris longus is considered a phylogenetic degenerate metacarpophalangeal joint flexor muscle in humans, a small vestigial forearm muscle; it is the most variable muscle in humans, showing variation in position, duplication, slips and could be reverted. It is frequently studied in papers about human anatomical v...

journal_title：BioMed research international

authors： Aversi-Ferreira RA,Bretas RV,Maior RS,Davaasuren M,Paraguassú-Chaves CA,Nishijo H,Aversi-Ferreira TA

更新日期：2014-01-01 00:00:00

abstract：:The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects o...

journal_title：BioMed research international

authors： Pei K,Gui T,Kan D,Feng H,Jin Y,Yang Y,Zhang Q,Du Z,Gai Z,Wu J,Li Y

更新日期：2020-07-18 00:00:00

abstract：:The aim of this study was to develop a freeze-drying protocol facilitating successful processing of plant material containing the small surface antigen of hepatitis B virus (S-HBsAg) while preserving its VLP structure and immunogenicity. Freeze-drying of the antigen in lettuce leaf tissue, without any isolation or pur...

journal_title：BioMed research international

authors： Czyż M,Dembczyński R,Marecik R,Wojas-Turek J,Milczarek M,Pajtasz-Piasecka E,Wietrzyk J,Pniewski T

更新日期：2014-01-01 00:00:00

abstract：:Within-litter birth weight variation in multiparous animals has become a big issue due to high incidence of low birth weight neonates, which gives rise to high preweaning mortality and morbidity. Foetus with various birth weights is the outcome of diverse embryos competence which is affected by oocyte quality. Glucosa...

journal_title：BioMed research international

authors： Feng C,Yuan T,Wang S,Liu T,Tao S,Han D,Wang J

更新日期：2020-01-08 00:00:00

abstract：:New antimicrobial properties of products derived from Humulus lupulus L. such as antiadherent and antibiofilm activities were evaluated. The growth of gram-positive but not gram-negative bacteria was inhibited to different extents by these compounds. An extract of hop cones containing 51% xanthohumol was slightly less...

journal_title：BioMed research international

authors： Rozalski M,Micota B,Sadowska B,Stochmal A,Jedrejek D,Wieckowska-Szakiel M,Rozalska B

更新日期：2013-01-01 00:00:00

abstract：:The role of α-fetoprotein (AFP) in the surveillance and diagnosis of hepatocellular carcinoma (HCC) has been questioned in recent years due to its low sensitivity and specificity. In addition to AFP, several new serum biomarkers, such as lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) and des-gamma-carboxy...

journal_title：BioMed research international

authors： Wang X,Zhang Y,Yang N,He H,Tao X,Kou C,Jiang J

更新日期：2020-09-17 00:00:00

abstract：Objective:We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods. We combined two microarray profil...

journal_title：BioMed research international

authors： Wu K,Zhang C,Zhang C,Dai D

更新日期：2020-02-10 00:00:00

abstract：:The primary goal of this work was to study advantages of numerical methods used for the creation of continuous time Markov chain models (CTMC) of voltage gating of gap junction (GJ) channels composed of connexin protein. This task was accomplished by describing gating of GJs using the formalism of the stochastic autom...

journal_title：BioMed research international

authors： Snipas M,Pranevicius H,Pranevicius M,Pranevicius O,Paulauskas N,Bukauskas FF

更新日期：2015-01-01 00:00:00

abstract：:In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-international prognostic index (CLL-IPI), and the Barcelona-Brno biomarke...

journal_title：BioMed research international

authors： Muñoz-Novas C,Poza-Santaella M,González-Gascón Y Marín I,Hernández-Sánchez M,Rodríguez-Vicente AE,Infante MS,Heras C,Foncillas MÁ,Marín K,Hernández-Rivas JM,Hernández JÁ

更新日期：2018-03-15 00:00:00

abstract：:Although triacylglycerol, the major component for lipid storage, is essential for normal physiology, its excessive accumulation causes obesity in adipose tissue and is associated with organ dysfunction in nonadipose tissue. Here, we focused on the Drosophila model to develop therapeutics for preventing obesity. The br...

journal_title：BioMed research international

authors： Men TT,Thanh DN,Yamaguchi M,Suzuki T,Hattori G,Arii M,Huy NT,Kamei K

更新日期：2016-01-01 00:00:00

abstract：Objective:To investigate whether preventive administration of a proton pump inhibitor (PPI) can reduce the occurrence and development of traumatic granuloma (TG) following type IV-VI cordectomy. Methods:We retrospectively analyzed the status of postoperative granulomas in 37 patients who underwent type IV-VI cordectom...

journal_title：BioMed research international

authors： Jin X,Niu Y,Gu W,Wang J

更新日期：2020-08-10 00:00:00

abstract：:A bioenergetical analysis of swimming at intensities near competitive distances is inexistent. It was aimed to compare the transient VO2 kinetics responses and metabolic contributions whilst swimming at different velocities around VO2max. 12 trained male swimmers performed (i) an incremental protocol to determine the ...

journal_title：BioMed research international

authors： Sousa AC,Vilas-Boas JP,Fernandes RJ

更新日期：2014-01-01 00:00:00

abstract：:Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuri...

journal_title：BioMed research international

authors： Gao X,Zhang M,Feng W,Xu Z,Wang Y,Shi L,Zhang J

更新日期：2020-03-23 00:00:00