Evaluation of the Combined Application of AFP, AFP-L3%, and DCP for Hepatocellular Carcinoma Diagnosis: A Meta-analysis.

Abstract:

:The role of α-fetoprotein (AFP) in the surveillance and diagnosis of hepatocellular carcinoma (HCC) has been questioned in recent years due to its low sensitivity and specificity. In addition to AFP, several new serum biomarkers, such as lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) and des-gamma-carboxy prothrombin (DCP), have also been identified as useful HCC serological markers. However, the exact diagnostic value of the combinations of these biomarkers for detecting HCC in patients with liver disease remains unclear. Thus, we performed the current meta-analysis to assess performance of AFP+AFP-L3%+DCP for diagnosing HCC. Studies were systematically searched in PubMed, Embase, the Cochrane Library, CNKI, and WanFang Data databases. After full-text evaluation, 13 studies from 11 articles focusing on the combination of the three serum biomarkers for HCC detection were enrolled. Random-effects models were used due to the presence of heterogeneity. The pooled sensitivity and specificity for AFP+AFP-L3%+DCP were 88% and 79%, respectively. The area under the summary receiver operating characteristic (sROC) curve was 0.91, and the diagnostic odds ratio (DOR) was 28.33 (95% CI 16.78-47.83). Subgroup analysis showed that the pooled sensitivity and specificity of AFP+AFP-L3%+DCP in the diagnosis of HCC versus cirrhosis patients were 0.81 and 0.82, respectively. In conclusion, the combination of AFP, AFP-L3%, and DCP may prove to be useful in the diagnosis and screening of HCC.

journal_name

Biomed Res Int

authors

Wang X,Zhang Y,Yang N,He H,Tao X,Kou C,Jiang J

doi

10.1155/2020/5087643

subject

Has Abstract

pub_date

2020-09-17 00:00:00

pages

5087643

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • Multiparametric MRI and Computational Modelling in the Assessment of Human Articular Cartilage Properties: A Comprehensive Approach.

    abstract::Quantitative magnetic resonance imaging (qMRI) is a promising approach to detect early cartilage degeneration. However, there is no consensus on which cartilage component contributes to the tissue's qMRI signal properties. T1, T1ρ, and T2⁎ maps of cartilage samples (n = 8) were generated on a clinical 3.0-T MRI system...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9460456

    authors: Thüring J,Linka K,Itskov M,Knobe M,Hitpaß L,Kuhl C,Truhn D,Nebelung S

    更新日期:2018-05-15 00:00:00

  • Clinical evaluation of CyberKnife in the treatment of vestibular schwannomas.

    abstract:OBJECTIVE:This study assessed the posttreatment tumor control and auditory function of vestibular schwannoma (VS) patients after CyberKnife (CK) and analyzed the possible prognostic factors of hearing loss. METHODS:We retrospectively studied 117 VS patients, with Gardner-Robertson (GR) classification grades I to IV, w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/297093

    authors: Tsai JT,Lin JW,Lin CM,Chen YH,Ma HI,Jen YM,Chen YH,Ju DT

    更新日期:2013-01-01 00:00:00

  • The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma.

    abstract::Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer. Inducible nitric oxide synthase (iNOS) and p53 are associated with a variety of human cancers, but their expression and interaction in OSCC have not been fully explored. In this study, we investigated the expression of iNOS and p53 in OSCC ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/637853

    authors: Yang L,Wang Y,Guo L,Wang L,Chen W,Shi B

    更新日期:2015-01-01 00:00:00

  • Corticospinal reorganization after locomotor training in a person with motor incomplete paraplegia.

    abstract::Activity-dependent plasticity as a result of reorganization of neural circuits is a fundamental characteristic of the central nervous system that occurs simultaneously in multiple sites. In this study, we established the effects of subthreshold transcranial magnetic stimulation (TMS) over the primary motor cortex regi...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/516427

    authors: Hajela N,Mummidisetty CK,Smith AC,Knikou M

    更新日期:2013-01-01 00:00:00

  • Protective Effect of Zuojin Fang on Lung Injury Induced by Sepsis through Downregulating the JAK1/STAT3 Signaling Pathway.

    abstract::Lung injury was the common and serious complication of sepsis, a systemic inflammatory response syndrome caused by severe infections. Chinese medicine had unique advantages in attenuating inflammatory response, such as Zuojinfang (ZJF). ZJF was a classical compound herb formula composed of Coptidis Rhizoma and Euodiae...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2021/1419631

    authors: Yin J,Yu Z,Hou C,Peng Y,Xiao J,Jiang J

    更新日期:2021-01-06 00:00:00

  • Comparison of Immune Checkpoint Inhibitors between Older and Younger Patients with Advanced or Metastatic Lung Cancer: A Systematic Review and Meta-Analysis.

    abstract:Objectives:Despite the fact that it is widely acknowledged that immune checkpoint inhibitors (ICIs) rely on the presence of immune response to take their antitumor effect, little is known whether there is an influence exerted on the efficacy of ICIs based on patients' age. We performed a systematic review and meta-anal...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2019/9853701

    authors: Zhang L,Sun L,Yu J,Shan F,Zhang K,Pang X,Ma C,Zhang Y,Shen M,Ma S,Ruan S

    更新日期:2019-05-13 00:00:00

  • Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate.

    abstract::The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvova...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3714329

    authors: Kenechukwu FC,Attama AA,Ibezim EC,Nnamani PO,Umeyor CE,Uronnachi EM,Momoh MA,Akpa PA,Ozioko AC

    更新日期:2018-06-06 00:00:00

  • Assessment of Mycobacterium bovis deleted in p27-p55 virulence operon as candidate vaccine against tuberculosis in animal models.

    abstract::A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models. The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs using M. bovis or M. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/951978

    authors: Bianco MV,Clark S,Blanco FC,Garbaccio S,García E,Cataldi AA,Williams A,Bigi F

    更新日期:2014-01-01 00:00:00

  • Anti-Candida properties of urauchimycins from actinobacteria associated with trachymyrmex ants.

    abstract::After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/835081

    authors: Mendes TD,Borges WS,Rodrigues A,Solomon SE,Vieira PC,Duarte MC,Pagnocca FC

    更新日期:2013-01-01 00:00:00

  • Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine.

    abstract::Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9620870

    authors: Coyle KM,Boudreau JE,Marcato P

    更新日期:2017-01-01 00:00:00

  • The Effects of County Public Hospital Reform on the Consumption and Costs of Antibiotics: Evidence from a Quasinatural Experiment in Jiangsu, China.

    abstract:Background:Overuse of antibiotics is a major driver for rapid spread of antimicrobial resistance worldwide, particularly common in China. The close linkage between hospital revenue and sales of drugs has become the key incentive for overprescription of antibiotics. Since 2009, the Chinese government implemented a serie...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9262170

    authors: Wang Y,Zhu Y,Liu X,Xu X,Fang W,Li X

    更新日期:2020-10-22 00:00:00

  • Strain diversity of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Afar pastoral region of Ethiopia.

    abstract::Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance. This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tubercul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/238532

    authors: Belay M,Ameni G,Bjune G,Couvin D,Rastogi N,Abebe F

    更新日期:2014-01-01 00:00:00

  • Assessment of the Relationship between Y-Balance Test and Stabilometric Parameters in Youth Footballers.

    abstract:Objectives:The purpose of the study was to evaluate the correlation between dynamic test results obtained on a stabilometric platform and the results achieved on the Y-balance test (Y-BT). Method:The study group consisted of 52 adolescent athletes, aged 14 to 17 years. Each participant was evaluated in the scope of th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6968473

    authors: Sikora D,Pałac M,Myśliwiec A,Wolny T,Linek P

    更新日期:2020-11-12 00:00:00

  • Robust Individual-Cell/Object Tracking via PCANet Deep Network in Biomedicine and Computer Vision.

    abstract::Tracking individual-cell/object over time is important in understanding drug treatment effects on cancer cells and video surveillance. A fundamental problem of individual-cell/object tracking is to simultaneously address the cell/object appearance variations caused by intrinsic and extrinsic factors. In this paper, in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8182416

    authors: Zhong B,Pan S,Wang C,Wang T,Du J,Chen D,Cao L

    更新日期:2016-01-01 00:00:00

  • Postoperative Renal Outcomes of Patients Receiving Percutaneous Nephrolithotomy versus Pyelolithotomy: A Population-Based Cohort Study.

    abstract::The aim of this population-based cohort study was to explore postoperative renal outcomes of patients receiving pyelolithotomy versus percutaneous nephrolithotomy (PCNL). Data were retrieved from the Taiwan National Health Insurance Research Database. During the period from Jan 1, 1998, to Dec 31, 2012, there were 254...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8582901

    authors: Chen FT,Liu FC,Cheng CW,Lin JR,Yu HP

    更新日期:2018-05-02 00:00:00

  • The Hearing Outcomes of Cochlear Implantation in Waardenburg Syndrome.

    abstract::Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genet...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2854736

    authors: Koyama H,Kashio A,Sakata A,Tsutsumiuchi K,Matsumoto Y,Karino S,Kakigi A,Iwasaki S,Yamasoba T

    更新日期:2016-01-01 00:00:00

  • Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis.

    abstract::Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects of emodin against SAP with SIRS. However, the exact mechanism unde...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1736024

    authors: Wang GJ,Wang Y,Teng YS,Sun FL,Xiang H,Liu JJ,Xia SL,Zhang GX,Chen HL,Shang D

    更新日期:2016-01-01 00:00:00

  • Autophagy in hepatic fibrosis.

    abstract::Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged o...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/436242

    authors: Song Y,Zhao Y,Wang F,Tao L,Xiao J,Yang C

    更新日期:2014-01-01 00:00:00

  • The usefulness of impedance cardiography for predicting beneficial effects of cardiac rehabilitation in patients with heart failure.

    abstract:AIM:Cardiac rehabilitation (CR) is an important part of heart failure (HF) treatment. The aim of this paper was to evaluate if thoracic fluid content (TFC) measured by impedance cardiography (ICG) is a useful parameter for predicting the outcome of CR. METHODS:Fifty HF patients underwent clinical and noninvasive haemo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/595369

    authors: Gielerak G,Krzesiński P,Piotrowicz E,Piotrowicz R

    更新日期:2013-01-01 00:00:00

  • Endowing iPSC-Derived MSCs with Angiogenic and Keratinogenic Differentiation Potential: A Promising Cell Source for Skin Tissue Engineering.

    abstract::Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based therapy for skin regeneration. Aiming to establish human iPSCs as a potential cell source for skin tissue engineering, we expect to obtain an epidermal-like cell line with angiogenic and keratinogenic differentiation potential ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8459503

    authors: Lin W,Chen M,Hu C,Qin S,Chu C,Xiang L,Man Y,Qu Y

    更新日期:2018-09-13 00:00:00

  • Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo.

    abstract::Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with bai...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5201790

    authors: Du H,Zhang S,He M,Ming K,Wang J,Yuan W,Qiao M,Wu Y,Wang D,Hu Y,Liu J

    更新日期:2019-04-04 00:00:00

  • Comparative analysis of context-dependent mutagenesis using human and mouse models.

    abstract::Substitution rates strongly depend on their nucleotide context. One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates. Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutag...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/989410

    authors: Medvedeva SA,Panchin AY,Alexeevski AV,Spirin SA,Panchin YV

    更新日期:2013-01-01 00:00:00

  • Diverse Reductive Dehalogenases Are Associated with Clostridiales-Enriched Microcosms Dechlorinating 1,2-Dichloroethane.

    abstract::The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process. In this work, we present the characterization of the bacterial commu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/242856

    authors: Merlino G,Balloi A,Marzorati M,Mapelli F,Rizzi A,Lavazza D,de Ferra F,Carpani G,Daffonchio D

    更新日期:2015-01-01 00:00:00

  • Does off-pump coronary artery bypass grafting negatively impact long-term survival and freedom from reintervention?

    abstract::Recently published evidence has raised concerns about worse late mortality and increasing need for reintervention after off-pump coronary artery bypass grafting. We undertook this study to assess the impact of off-pump coronary artery bypass grafting on survival and freedom from reintervention at 10 years. From Januar...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/602871

    authors: Raja SG,Husain M,Popescu FL,Chudasama D,Daley S,Amrani M

    更新日期:2013-01-01 00:00:00

  • Microarray Based Functional Analysis of Myricetin and Proteomic Study on Its Anti-Inflammatory Property.

    abstract::Myricetin has been reported as a promising chemopreventive compound with multiple biofunctions. To evaluate its influence on gene expressions in genome-wide set and further investigate its anti-inflammatory property, the present study performed Gene Ontology and Ingenuity Pathway Analysis (IPA) to describe the basic g...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3746326

    authors: Li T,Zhu J,Deng F,Wu W,Zheng Z,Lv C,Li Y,Xiang W,Lu X,Qin S

    更新日期:2019-03-07 00:00:00

  • Novel 3'-Processing Integrase Activity Assay by Real-Time PCR for Screening and Identification of HIV-1 Integrase Inhibitors.

    abstract::The 3'-end processing (3'P) of each viral long terminal repeat (LTR) during human immunodeficiency virus type-1 (HIV-1) integration is a vital step in the HIV life cycle. Blocking the 3'P using 3'P inhibitor has recently become an attractive strategy for HIV-1 therapeutic intervention. Recently, we have developed a no...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/853891

    authors: Sakkhachornphop S,Thongkum W,Tayapiwatana C

    更新日期:2015-01-01 00:00:00

  • Enhancing Ecoefficiency in Shrimp Farming through Interconnected Ponds.

    abstract::The future development of shrimp farming needs to improve its ecoefficiency. The purpose of this study was to evaluate water quality, flows, and nitrogen balance and production parameters on a farm with interconnected pond design to improve the efficiency of the semi-intensive culture of Litopenaeus vannamei ponds. Th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/873748

    authors: Barraza-Guardado RH,Arreola-Lizárraga JA,Miranda-Baeza A,Juárez-García M,Juvera-Hoyos A,Casillas-Hernández R

    更新日期:2015-01-01 00:00:00

  • Duodenal Atresia: Open versus MIS Repair-Analysis of Our Experience over the Last 12 Years.

    abstract::Objective. Duodenal atresia (DA) routinely has been corrected by laparotomy and duodenoduodenostomy with excellent long-term results. We revisited the patients with DA treated in the last 12 years (2004-2016) comparing the open and the minimally invasive surgical (MIS) approach. Methods. We divided our cohort of patie...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4585360

    authors: Chiarenza SF,Bucci V,Conighi ML,Zolpi E,Costa L,Fasoli L,Bleve C

    更新日期:2017-01-01 00:00:00

  • Side-by-side comparison of the biological characteristics of human umbilical cord and adipose tissue-derived mesenchymal stem cells.

    abstract::Both human adipose tissue-derived mesenchymal stem cells (ASCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been explored as attractive mesenchymal stem cells (MSCs) sources, but very few parallel comparative studies of these two cell types have been made. We designed a side-by-side comparative st...

    journal_title:BioMed research international

    pub_type: 杂志文章,收录出版

    doi:10.1155/2013/438243

    authors: Hu L,Hu J,Zhao J,Liu J,Ouyang W,Yang C,Gong N,Du L,Khanal A,Chen L

    更新日期:2013-01-01 00:00:00

  • Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?

    abstract:BACKGROUND:An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2016/7963972

    authors: Pongpit J,Porntharukchareon S,Kaewduang P,Promson K,Stitchantrakul W,Petraksa S,Thakkinstian A,Kositchaiwat C,Rajatanavin N,Sobhonslidsuk A

    更新日期:2016-01-01 00:00:00