Abstract:
:Substitution rates strongly depend on their nucleotide context. One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates. Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutagenesis, and cancer development. Recently several other hypermutable motifs were identified in the human genome. There is an increased frequency of T > C mutations in the second position of the words ATTG and ATAG and an increased frequency of A > C mutations in the first position of the word ACAA. For a better understanding of evolution, it is of interest whether these mutation regularities are human specific or present in other vertebrates, as their presence might affect the validity of currently used substitution models and molecular clocks. A comprehensive analysis of mutagenesis in 4 bp mutation contexts requires a vast amount of mutation data. Such data may be derived from the comparisons of individual genomes or from single nucleotide polymorphism (SNP) databases. Using this approach, we performed a systematical comparison of mutation regularities within 2-4 bp contexts in Mus musculus and Homo sapiens and uncovered that even closely related organisms may have notable differences in context-dependent mutation regularities.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Medvedeva SA,Panchin AY,Alexeevski AV,Spirin SA,Panchin YVdoi
10.1155/2013/989410subject
Has Abstractpub_date
2013-01-01 00:00:00pages
989410eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
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journal_title:BioMed research international
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更新日期:2018-09-24 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:BioMed research international
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pub_type: 杂志文章
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更新日期:2018-08-13 00:00:00
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
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