CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens.

Abstract:

:Individuals with X-HIGM syndrome fail to express functional CD40 ligand; consequently they cannot mount effective protective antibody responses against pathogenic bacteria. We evaluated, compared, and characterized the humoral immune response of wild type (WT) and C57-CD40L deficient (C57-CD40L(-/-)) mice infected with Citrobacter rodentium. Basal serum isotype levels were similar for IgM and IgG3 among mice, while total IgG and IgG2b concentrations were significantly lower in C57-CD40L(-/-) mice compared with WT. Essentially IgG1 and IgG2c levels were detectable only in WT mice. C57-CD40L(-/-) animals, orally inoculated with 2 × 10(9) CFU, presented several clinical manifestations since the second week of infection and eventually died. In contrast at this time point no clinical manifestations were observed among C57-CD40L(-/-) mice infected with 1 × 10(7) CFU. Infection was subclinical in WT mice inoculated with either bacterial dose. The serum samples from infected mice (1 × 10(7) CFU), collected at day 14 after infection, had similar C. rodentium-specific IgM titres. Although C57-CD40L(-/-) animals had lower IgG and IgG2b titres than WT mice, C57-CD40L(-/-) mice sera displayed complement-mediated bactericidal activity against C. rodentium. C. rodentium-infected C57-CD40L(-/-) mice are capable of producing antibodies that are protective. C57-CD40L(-/-) mouse is a useful surrogate model of X-HIGM syndrome for studying immune responses elicited against pathogens.

journal_name

Biomed Res Int

authors

Lopez-Saucedo C,Bernal-Reynaga R,Zayas-Jahuey J,Galindo-Gomez S,Shibayama M,Garcia-Galvez C,Estrada-Parra S,Estrada-Garcia T

doi

10.1155/2015/679850

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

679850

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Basic Fibroblast Growth Factor Ameliorates Endothelial Dysfunction in Radiation-Induced Bladder Injury.

    abstract::This study was designed to explore the effect of basic fibroblast growth factor (bFGF) on radiation-induced endothelial dysfunction and histological changes in the urinary bladder. bFGF was administrated to human umbilical vein cells (HUVEC) or urinary bladder immediately after radiation. Reduced expression of thrombo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/967680

    authors: Zhang S,Qiu X,Zhang Y,Fu K,Zhao X,Wu J,Hu Y,Zhu W,Guo H

    更新日期:2015-01-01 00:00:00

  • Intake of Meals Containing High Levels of Carbohydrates or High Levels of Unsaturated Fatty Acids Induces Postprandial Dysmetabolism in Young Overweight/Obese Men.

    abstract::Postprandial metabolic response depends on the meals' components and can be different in normal weight and obese people. However, there are some discrepancies between various reports. The aim of this study was to determine the metabolic response after intake of standardised meals with various fat and carbohydrate cont...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/147196

    authors: Adamska E,Ostrowska L,Gościk J,Waszczeniuk M,Krętowski A,Górska M

    更新日期:2015-01-01 00:00:00

  • Controversial indications for sentinel lymph node biopsy in breast cancer patients.

    abstract::Sentinel lymph node biopsy (SLNB) emerged in the 1990s as a new technique in the surgical management of the axilla for patients with early breast cancer, resulting in lower complication rates and better quality of life than axillary lymph node dissection (ALND). Today SLNB is firmly established in the armamentarium of...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/405949

    authors: Assi H,Sbaity E,Abdelsalam M,Shamseddine A

    更新日期:2015-01-01 00:00:00

  • Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells.

    abstract::Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/421746

    authors: Florencio-Silva R,Sasso GR,Sasso-Cerri E,Simões MJ,Cerri PS

    更新日期:2015-01-01 00:00:00

  • The Epidemiological, Morphological, and Clinical Aspects of the Cervical Ribs in Humans.

    abstract::A familiarity with the anatomy of some types of bone anomalies is necessary for clinicians involved in many medical areas. The aim of this paper is to review the newest literature concerning the morphology, embryology, clinical image, and therapeutic methods of the cervical ribs in the humans. The incidence of cervica...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/8034613

    authors: Spadliński Ł,Cecot T,Majos A,Stefańczyk L,Pietruszewska W,Wysiadecki G,Topol M,Polguj M

    更新日期:2016-01-01 00:00:00

  • ASPic-GeneID: a lightweight pipeline for gene prediction and alternative isoforms detection.

    abstract::New genomes are being sequenced at an increasingly rapid rate, far outpacing the rate at which manual gene annotation can be performed. Automated genome annotation is thus necessitated by this growth in genome projects; however, full-fledged annotation systems are usually home-grown and customized to a particular geno...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/502827

    authors: Alioto T,Picardi E,Guigó R,Pesole G

    更新日期:2013-01-01 00:00:00

  • Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity.

    abstract::Chronic obesity is a known risk factor for metabolic syndrome. However, little is known about pathological changes in the small intestine associated with chronic obesity. This study investigated cellular and subcellular level changes in the small intestine of obese mice. In this study, a mouse model of obesity was est...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5251738

    authors: Nakadate K,Motojima K,Hirakawa T,Tanaka-Nakadate S

    更新日期:2016-01-01 00:00:00

  • Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats.

    abstract::Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg bod...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/8428304

    authors: Ekanayake CP,Thammitiyagodage MG,Padumadasa S,Seneviratne B,Padumadasa C,Abeysekera AM

    更新日期:2019-12-03 00:00:00

  • Integron-Mediated Antibiotic Resistance in Acinetobacter baumannii Isolated from Intensive Care Unit Patients, Babol, North of Iran.

    abstract:BACKGROUND:We investigated the integron types and their relation with antibiotic resistance among A. baumannii isolates collected from intensive care unit patients, Babol, north of Iran. METHODS:In this cross-sectional study, a total of 73 bronchoalveolar lavage samples were obtained from patients in ICU. Susceptibili...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/7157923

    authors: Deylam Salehi M,Ferdosi-Shahandashti E,Yahyapour Y,Khafri S,Pournajaf A,Rajabnia R

    更新日期:2017-01-01 00:00:00

  • Effects of Physical Activity Programs on the Improvement of Dementia Symptom: A Meta-Analysis.

    abstract::Objective. To confirm that physical activity program improves the symptoms of dementia and the most effective physical activity was selected to help establish exercise programs. Methods. Three databases, PubMed, Science Direct, and Willey online, were used to collect articles. The databases were published between Janu...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2016/2920146

    authors: Lee HS,Park SW,Park YJ

    更新日期:2016-01-01 00:00:00

  • Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins.

    abstract::Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/520464

    authors: Dias MI,Barreira JC,Calhelha RC,Queiroz MJ,Oliveira MB,Soković M,Ferreira IC

    更新日期:2014-01-01 00:00:00

  • Comparison of National Institutes of Health-Chronic Prostatitis Symptom Index with International Index of Erectile Function 5 in Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Large Cross-Sectional Study in China.

    abstract::The purpose of the study is to evaluate the relationship between NIH-CPSI and IIEF-5 in Chinese men with CP/CPPS. A large cross-sectional and multicenter survey was conducted from July 2012 to January 2014. Men were recruited from urology clinics which were located at the five cities in China. All men participated in ...

    journal_title:BioMed research international

    pub_type: 杂志文章,多中心研究

    doi:10.1155/2015/560239

    authors: Gao J,Gao P,Hao Z,Zhou Z,Liu J,Li H,Xing J,Zhou Z,Deng C,Deng L,Wei Q,Zhang X,Zhou J,Fan S,Tai S,Yang C,Shi K,Huang Y,Ye Z,Liang C

    更新日期:2015-01-01 00:00:00

  • Whether Keratectasia Area Shown in Corneal Topography Is Appropriate for Evaluating the Effect of Corneal Cross-Linking for Keratoconus: A 12-Month Follow-Up Study.

    abstract:Purpose:To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods:A retrospective analysis was conducted in 34 eyes from 24 progressive...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1762537

    authors: Wang J,Li Z,Zhang H,Gao N,Mu G

    更新日期:2019-04-03 00:00:00

  • Transforaminal Percutaneous Endoscopic Lumbar Decompression by Using Rigid Bendable Burr for Lumbar Lateral Recess Stenosis: Technique and Clinical Outcome.

    abstract:Background:Open laminectomy has been regarded as the standard surgical procedure for lumbar lateral recess stenosis during the last decades. Although percutaneous endoscopic lumbar decompression has led to successful results comparable with open decompression, its application in LSS with is still challenging and techni...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2601232

    authors: Tang S,Jin S,Liao X,Huang K,Luo J,Zhu T

    更新日期:2018-11-26 00:00:00

  • Enhanced oral bioavailability of efavirenz by solid lipid nanoparticles: in vitro drug release and pharmacokinetics studies.

    abstract::Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/363404

    authors: Gaur PK,Mishra S,Bajpai M,Mishra A

    更新日期:2014-01-01 00:00:00

  • Assessment of respiration-induced motion and its impact on treatment outcome for lung cancer.

    abstract::This study presented the analysis of free-breathing lung tumor motion characteristics using GE 4DCT and Varian RPM systems. Tumor respiratory movement was found to be associated with GTV size, the superior-inferior tumor location in the lung, and the attachment degree to rigid structure (e.g., chest wall, vertebrae, o...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/872739

    authors: Wang Y,Bao Y,Zhang L,Fan W,He H,Sun ZW,Hu X,Huang SM,Chen M,Deng XW

    更新日期:2013-01-01 00:00:00

  • hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers.

    abstract::Because of their high incidence and mortality solid cancers are a major health problem worldwide. Although several new biomarkers and potential targets for therapy have been identified through biomolecular research in the last years, the effects on patients' outcome are still unsatisfactory. Increasing evidence indica...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/896432

    authors: Lastraioli E,Lottini T,Bencini L,Bernini M,Arcangeli A

    更新日期:2015-01-01 00:00:00

  • Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators.

    abstract::The role of non-steroidal anti-inflammatory drugs in inflammatory bowel disease is controversial, as they have been implicated in disease aggravation. Different from other cyclooxygenase inhibitors, acetylsalicylic acid (ASA) enhances the formation of anti-inflammatory and proresolution lipoxins derived from arachidon...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/748160

    authors: Köhnke T,Gomolka B,Bilal S,Zhou X,Sun Y,Rothe M,Baumgart DC,Weylandt KH

    更新日期:2013-01-01 00:00:00

  • Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications.

    abstract::Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6956794

    authors: Mellor LF,Huebner P,Cai S,Mohiti-Asli M,Taylor MA,Spang J,Shirwaiker RA,Loboa EG

    更新日期:2017-01-01 00:00:00

  • The Influence of Diabetes Mellitus on Patients Undergoing Primary Total Lower Extremity Arthroplasty: A Systematic Review and Meta-Analysis.

    abstract:Background:Diabetes mellitus (DM) is a common disease that has an adverse impact on most orthopedic surgeries, and its prevalence has gradually increased in recent years. We aim to investigate the influence of DM on comorbidities and complications of patients undergoing primary total lower extremity arthroplasty. Meth...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/6661691

    authors: Qin W,Huang X,Yang H,Shen M

    更新日期:2020-12-15 00:00:00

  • Incidence and Predictors of Catheterization-Related Cerebral Infarction on Diffusion-Weighted Magnetic Resonance Imaging.

    abstract::Introduction. The aim of this study was to examine the incidence and risk factors of catheterization-related CI in the contemporary era, using diffusion-weighted magnetic resonance imaging. Methods. We retrospectively analyzed consecutive 84 patients who underwent MRI (magnetic resonance imaging) after 2.81 ± 2.4 days...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6052125

    authors: Morita Y,Kato T,Okano M,Suu K,Kimura M,Minamino-Muta E,Nakane E,Izumi T,Miyamoto S,Haruna T,Ueyama K,Inoko M

    更新日期:2016-01-01 00:00:00

  • Abdominal Wall Reconstruction after Flap Surgery and the Effect on the Immune System.

    abstract:Background:The aim of our study was to investigate the impact of abdominal wall reconstruction surgery on tissue anatomy and to explore how flap surgery influences the patient's immune status. Methods:Experimental abdominal wall defects were created in 8 Sus scrofa (swine) animal models. The animals were divided into ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2421585

    authors: Popa F,Georgescu AV

    更新日期:2017-01-01 00:00:00

  • ADC Benchmark Range for Correct Diagnosis of Primary and Recurrent Middle Ear Cholesteatoma.

    abstract:Objectives:Magnetic resonance imaging (MRI) and in particular diffusion-weighted imaging (DWI) have been broadly proven to be the reference imaging method to discriminate between cholesteatoma and noncholesteatomatous middle ear lesions, especially when high tissue specificity is required. The aim of this study is to d...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7945482

    authors: Russo C,Elefante A,Di Lullo AM,Carotenuto B,D'Amico A,Cavaliere M,Iengo M,Brunetti A

    更新日期:2018-04-24 00:00:00

  • Effects of Combined Use of Ultrasonic Bone Scalpel and Hemostatic Matrix on Perioperative Blood Loss and Surgical Duration in Degenerative Thoracolumbar Spine Surgery.

    abstract::How to decrease intraoperative bleeding, shorten surgical time, and increase safety in spinal surgery is an important issue. Ultrasonic bone removers and FloSeal have been proven to increase safety, reduce the surgical duration, and decrease intraoperative bleeding in skull base surgery. Therefore, we aimed to compare...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6286258

    authors: Chen HT,Hsu CC,Lu ML,Chen SH,Chen JM,Wu RW

    更新日期:2019-05-19 00:00:00

  • A nonthoracotomy myocardial infarction model in an ovine using autologous platelets.

    abstract:OBJECTIVE:There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the pathophysiology of MI. METHODS:Mepacrine stained autologous platelets from male ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/938047

    authors: Spata T,Bobek D,Whitson BA,Parthasarathy S,Mohler PJ,Higgins RS,Kilic A

    更新日期:2013-01-01 00:00:00

  • Biological Activities of Tetrodotoxin-Producing Enterococcus faecium AD1 Isolated from Puffer Fishes.

    abstract::Puffer fishes were collected from the central sea in Vietnam from spring to summer season. The eggs were incubated in MRS broth that was used to test the toxicity in mice and isolate the lactic acid bacteria community that could produce tetrodotoxin (TTX). Thin layer chromatography (TLC) and high performance lipid chr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/973235

    authors: Nguyen TH,Nguyen HN,Nghe DV,Nguyen KH

    更新日期:2015-01-01 00:00:00

  • Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy.

    abstract::Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving su...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3656574

    authors: Yang DS,Lee JA,Yoon WS,Lee NK,Park YJ,Lee S,Kim CY,Son GS

    更新日期:2016-01-01 00:00:00

  • Combined High Resistin and EGFR Expression Predicts a Poor Prognosis in Breast Cancer.

    abstract::Elevated levels of resistin and epidermal growth factor receptor (EGFR) facilitate the development of breast cancer, although there are no reports of any correlation between these proteins. This study analyzed 392 human breast cancer tissue specimens and 42 samples of adjacent normal tissue. Rates of positive and stro...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8835398

    authors: Zeng Y,Tang CH,Wang Y,Lu HJ,Huang BF,Wang Q,Shao JK,Jin LL,Wang CQ,Teng LS

    更新日期:2020-11-28 00:00:00

  • Identification and Progression of Heart Disease Risk Factors in Diabetic Patients from Longitudinal Electronic Health Records.

    abstract::Heart disease is the leading cause of death worldwide. Therefore, assessing the risk of its occurrence is a crucial step in predicting serious cardiac events. Identifying heart disease risk factors and tracking their progression is a preliminary step in heart disease risk assessment. A large number of studies have rep...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/636371

    authors: Jonnagaddala J,Liaw ST,Ray P,Kumar M,Dai HJ,Hsu CY

    更新日期:2015-01-01 00:00:00

  • Analytical Validation of a New Enzymatic and Automatable Method for d-Xylose Measurement in Human Urine Samples.

    abstract::Hypolactasia, or intestinal lactase deficiency, affects more than half of the world population. Currently, xylose quantification in urine after gaxilose oral administration for the noninvasive diagnosis of hypolactasia is performed with the hand-operated nonautomatable phloroglucinol reaction. This work demonstrates t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8421418

    authors: Sánchez-Moreno I,Monsalve-Hernando C,Godino A,Illa L,Gaspar MJ,Muñoz GM,Díaz A,Martín JL,García-Junceda E,Fernández-Mayoralas A,Hermida C

    更新日期:2017-01-01 00:00:00