Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats.

abstract：:Hosts' innate defense systems are upregulated by antimicrobial peptide elicitors (APEs). Our aim was to investigate the effects of hyperthermia, ultraviolet A rays (UVA), and ultraviolet C rays (UVC) as well as glucose and ascorbic acid (AA) on the regulation of human β-defensin 1 (DEFB1), cathelicidin (CAMP), and int...

journal_title：BioMed research international

authors： Cruz Díaz LA,Flores Miramontes MG,Chávez Hurtado P,Allen K,Gonzalez Ávila M,Prado Montes de Oca E

更新日期：2015-01-01 00:00:00

abstract：:New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel. Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in several tumor model syst...

journal_title：BioMed research international

authors： Zeng J,Harris TJ,Lim M,Drake CG,Tran PT

更新日期：2013-01-01 00:00:00

abstract：Objective:Epidemiological studies have shown a correlation between periodontal disease (PD) and age-related macular degeneration (AMD). However, the results have been inconsistent, and no relevant meta-analysis has been performed on this topic. Hence, we performed a meta-analysis to evaluate whether the two diseases ar...

journal_title：BioMed research international

authors： Lv X,Li W,Fang Z,Xue X,Pan C

更新日期：2020-09-28 00:00:00

abstract：:Viscosupplementation with hyaluronic acid is safe and effective in the management of osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English...

journal_title：BioMed research international

authors： Abate M,Schiavone C,Salini V

更新日期：2014-01-01 00:00:00

abstract：:Significant positive effects, particularly on psychological state in patients who completed the follow-up pulmonary rehabilitation programs, are indicated by a large number of studies. Yet, a remarkable proportion of selected patients drop out from these programs. In this study, we investigated existing differences on...

journal_title：BioMed research international

authors： Tselebis A,Kosmas E,Bratis D,Pachi A,Ilias I,Harikiopoulou M,Theodorakopoulou E,Velentzas K,Dumitru S,Moussas G,Siafakas N,Tzanakis N

更新日期：2014-01-01 00:00:00

abstract：:Mitochondria, the energy-generating organelles, play a role in numerous cellular functions including adenosine triphosphate (ATP) production, cellular homeostasis, and apoptosis. Maternal inheritance of mitochondria and mitochondrial DNA (mtDNA) is universally observed in humans and most animals. In general, high leve...

journal_title：BioMed research international

authors： Song WH,Ballard JW,Yi YJ,Sutovsky P

更新日期：2014-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This stu...

journal_title：BioMed research international

authors： Zhao Z,Lu J,Jia X,Chao W,Han Y,Jia J,Li K

更新日期：2014-01-01 00:00:00

abstract：:Heart disease is the leading cause of death worldwide. Therefore, assessing the risk of its occurrence is a crucial step in predicting serious cardiac events. Identifying heart disease risk factors and tracking their progression is a preliminary step in heart disease risk assessment. A large number of studies have rep...

journal_title：BioMed research international

authors： Jonnagaddala J,Liaw ST,Ray P,Kumar M,Dai HJ,Hsu CY

更新日期：2015-01-01 00:00:00

abstract：:Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulation of the amyloid-β peptide 1-42 (Aβ42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas of the brain and, more recently reported, in the visual cortex. Recently, Aβ42 peptid...

journal_title：BioMed research international

authors： Hernández-Zimbrón LF,Perez-Hernández M,Torres-Romero A,Gorostieta-Salas E,Gonzalez-Salinas R,Gulias-Cañizo R,Quiroz-Mercado H,Zenteno E

更新日期：2017-01-01 00:00:00

abstract：:The etiology of nephrotic syndrome is complex and ranges from primary glomerulonephritis to secondary forms. Patients with nephrotic syndrome often need immunosuppressive treatment with its side effects and may progress to end stage renal disease. This review focuses on recent advances in the treatment of primary caus...

journal_title：BioMed research international

authors： Königshausen E,Sellin L

更新日期：2017-01-01 00:00:00

abstract：:GABAergic inhibition and particularly perisomatic inhibition play a crucial role in controlling the firing properties of large principal cell populations. Furthermore, GABAergic network is a key element in the therapy attempting to reduce epileptic activity. Here, we present a review showing the synaptic changes of pe...

journal_title：BioMed research international

authors： Wittner L,Maglóczky Z

更新日期：2017-01-01 00:00:00

abstract：:Therapeutic approach for Alzheimer's disease (AD) is still deficient. To find active compounds from herbal medicine is of interest in the alleviation of AD symptoms. This study aimed to investigate the protective effects of Tanshinone IIA (TIIA) on memory performance and synaptic plasticity in a transgenic AD model at...

journal_title：BioMed research international

authors： Li F,Han G,Wu K

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2018/2109865.]. ...

journal_title：BioMed research international

authors： You J,Chen W,Chen J,Zheng Q,Dong J,Zhu Y

更新日期：2019-12-13 00:00:00

abstract：OBJECTIVE:Firstly, to, through instrumentation with the iPhone4 smartphone, measure and describe variability of tridimensional acceleration, angular velocity, and displacement of the trunk in the turn transition during the ten-meter Extended Timed-Get-up-and-Go test in two groups of frail and physically active elderly ...

journal_title：BioMed research international

authors： Galán-Mercant A,Cuesta-Vargas AI

更新日期：2013-01-01 00:00:00

abstract：:One of the most important tasks of a living organism is to maintain its genetic integrity with respect to stress. Endoplasmic reticulum (ER) has a crucial role in sensing cellular homeostasis by controlling metabolism, proteostasis, and several signaling processes. ER stressors can induce autophagy-dependent survival;...

journal_title：BioMed research international

authors： Holczer M,Márton M,Kurucz A,Bánhegyi G,Kapuy O

更新日期：2015-01-01 00:00:00

abstract：:Angiogenesis is essential for tumor growth and metastasis. Over the last decades, a substantial progress has been achieved in defining different patterns of tumor microcirculation. Sprouting angiogenesis, the oldest model of microcirculation, is the de novo vessel formation from preexisting blood vessels. Vessel split...

journal_title：BioMed research international

authors： Alameddine RS,Hamieh L,Shamseddine A

更新日期：2014-01-01 00:00:00

abstract：:Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death ...

journal_title：BioMed research international

authors： Piccirillo G,Moscucci F,Persi A,Di Barba D,Pappadà MA,Rossi P,Quaglione R,Nguyen BL,Barillà F,Casenghi M,Magrì D

更新日期：2014-01-01 00:00:00

abstract：Background:Identification of potential molecular targets of acute myocardial infarction is crucial to our comprehensive understanding of the disease mechanism. However, studies of gene coexpression analysis via jointing multiple microarray data of acute myocardial infarction still remain restricted. Methods:Microarray...

journal_title：BioMed research international

authors： Li Y,He XN,Li C,Gong L,Liu M

更新日期：2019-02-11 00:00:00

abstract：:It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer's d...

journal_title：BioMed research international

authors： Yu B,Zhang B,Zhou WB,Wang QW,Yuan P,Yang YQ,Kong J

更新日期：2015-01-01 00:00:00

abstract：:Different opinions exist on the relationship between the C-reactive protein-to-albumin ratio (CAR) and the prognosis of colon cancer. This study is aimed at evaluating the relationship between CAR and prognosis of stage II-III colon cancer and establishing a clinical prognosis model. Patients were randomised to a trai...

journal_title：BioMed research international

authors： Xu Y,Liang F,Chen Y,Wang Z,Zhong H,Tang W

更新日期：2020-11-22 00:00:00

abstract：Objective:Hepatitis B virus (HBV) causes inflammation of the liver and is the leading cause of both liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Serine protease inhibitor Kazal type 1 (SPINK1) is an acute-phase response protein that is overexpressed in liver cancer tissue. This study investigated the clinic...

journal_title：BioMed research international

authors： Zhu C,Han H,Li J,Xu L,Liu F,Wu K,Liu X

更新日期：2019-05-22 00:00:00

abstract：:Extra-intestinal E. coli are emerging as a global threat due to their diffusion as opportunistic pathogens and, above all, to their wide set of antibiotic resistance determinants. There are still many gaps in our knowledge of their origin and spread pathways, although food animals have been adjudicated vehicles for pa...

journal_title：BioMed research international

authors： Caruso G,Giammanco A,Cardamone C,Oliveri G,Mascarella C,Capra G,Fasciana T

更新日期：2018-11-18 00:00:00

abstract：:Triple-negative breast cancer (TNBC) has a significant clinical relevance of being associated with a shorter median time to relapse and death and does not respond to endocrine therapy or other available targeted agents. Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be as...

journal_title：BioMed research international

authors： Collina F,Di Bonito M,Li Bergolis V,De Laurentiis M,Vitagliano C,Cerrone M,Nuzzo F,Cantile M,Botti G

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? METHODS AND MATERIALS:Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and exami...

journal_title：BioMed research international

authors： Sasaki S,Sasaki Y,Kunimura T,Sekizawa A,Kojima Y,Iino K

更新日期：2015-01-01 00:00:00

abstract：:We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on con...

journal_title：BioMed research international

authors： Subash S,Essa MM,Al-Asmi A,Al-Adawi S,Vaishnav R

更新日期：2014-01-01 00:00:00

abstract：:The early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI) is very important for treatment research and patient care purposes. Few biomarkers are currently considered in clinical settings, and their use is still optional. The objective of this work was to determine whether multimodal and nonpr...

journal_title：BioMed research international

authors： Martínez-Torteya A,Treviño V,Tamez-Peña JG

更新日期：2015-01-01 00:00:00

abstract：:Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can b...

journal_title：BioMed research international

authors： Kang J,Fan W,Deng Q,He H,Huang F

更新日期：2019-01-29 00:00:00

abstract：:Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose- or hand-poking, subjects l...

journal_title：BioMed research international

authors： Zoratto F,Sinclair E,Manciocco A,Vitale A,Laviola G,Adriani W

更新日期：2014-01-01 00:00:00

abstract：Background:Left ventricular (LV) systolic dysfunction is common in septic shock. Global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE) is a useful marker of intrinsic left ventricular systolic function. However, the association between left ventricular GLS and outcome in septic patients i...

journal_title：BioMed research international

authors： Hai PD,Binh NT,Hien NVQ,Hoang NH,Hoan VN,Son PN,Hoa LTV

更新日期：2020-10-21 00:00:00

abstract：:The aim of this study was to investigate the influence of a topically administered hygienic preparation containing a 3% ethanolic extract of Brazilian green propolis (EEP-B) on oral microflora spectrum changes in a group of patients who underwent common oral surgery procedures. Two gel samples were compared: the teste...

journal_title：BioMed research international

authors： Morawiec T,Mertas A,Wojtyczka RD,Niedzielska I,Dziedzic A,Bubiłek-Bogacz A,Sender J,Wróbel J,Tanasiewicz M,Wesołowski P,Król W

更新日期：2015-01-01 00:00:00