Abstract:
:Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can be used as an alternative to embryonic stem cells. Stem cells from the apical papilla (SCAPs) are a novel population of MSCs residing in the apical papilla of immature permanent teeth. SCAPs present the characteristics of expression of MSCs markers, self-renewal, proliferation, migration, differentiation, and immunosuppression, which support the application of SCAPs in stem cell-based therapy, including the immunotherapy and the regeneration of dental tissues, bone, neural, and vascular tissues. In view of these properties and therapeutic potential, SCAPs can be considered as promising candidates for stem cell-based therapy. Thus the aim of our review was to summarize the current knowledge of SCAPs considering isolation, characterization, and multilineage differentiation. The prospects for their use in stem cell-based therapy were also discussed.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kang J,Fan W,Deng Q,He H,Huang Fdoi
10.1155/2019/6104738subject
Has Abstractpub_date
2019-01-29 00:00:00pages
6104738eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章,评审abstract::Despite significant advances in the study of the molecular mechanisms altered in the development and progression of neurodegenerative diseases (NDs), the etiology is still enigmatic and the distinctions between diseases are not always entirely clear. We present an efficient computational method based on protein-protei...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/686505
更新日期:2014-01-01 00:00:00
abstract::We review the recent literature concerning the efficiency of antimicrobial photodynamic inactivation toward various microbial species in planktonic and biofilm cultures. The review is mainly focused on biofilm-growing microrganisms because this form of growth poses a threat to chronically infected or immunocompromised...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/150653
更新日期:2013-01-01 00:00:00
abstract::The future development of shrimp farming needs to improve its ecoefficiency. The purpose of this study was to evaluate water quality, flows, and nitrogen balance and production parameters on a farm with interconnected pond design to improve the efficiency of the semi-intensive culture of Litopenaeus vannamei ponds. Th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/873748
更新日期:2015-01-01 00:00:00
abstract::Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide. In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note. In the present study, we investigated the impact of the gender on the development of experimental CKD in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2159739
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Recovery of walking outdoors after hip fracture is important for equal participation in the community. The causes of poor recovery are not fully understood. This study investigates recovery of walking outdoors and associated determinants after hip fracture. METHODS:A prospective follow-up study, among clinical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/289549
更新日期:2014-01-01 00:00:00
abstract::CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4093435
更新日期:2018-03-29 00:00:00
abstract::The treatment of traumatic low-degree vertebral compression fracture remains in a wide range between functional treatment, bracing, vertebroplasty, kyphoplasty, and even surgical fixation. The objective was to assess the innovation of instrumented kyphoplasty and to report the early and mid-term functional and radiolo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1386510
更新日期:2019-12-10 00:00:00
abstract:Background:Physical activity has been found to maintain and improve cognitive function and consequently improve health-related quality of life (HRQoL). The relationships between different types of physical activities, cognitive function, and HRQoL have not been studied sufficiently and compared in different age and gen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8856284
更新日期:2020-12-18 00:00:00
abstract::This study is aimed at determining how oral squamous cell carcinoma (OSCC) regulates the angiogenesis of HUVECs through miR-210-3p expression and exploring the relationship among miR-210-3p, its target protein, and the possible mechanism of angiogenesis regulation. miR-210-3p expression was detected in OSCC tissues an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2125656
更新日期:2020-07-08 00:00:00
abstract::The objective and quantitative analysis of longitudinal single photon emission computed tomography (SPECT) images are significant for the treatment monitoring of brain disorders. Therefore, a computer aided analysis (CAA) method is introduced to extract a change-rate map (CRM) as a parametric image for quantifying the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1962181
更新日期:2017-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2019/5879089.]. ...
journal_title:BioMed research international
pub_type: 撤回出版物
doi:10.1155/2020/5014928
更新日期:2020-08-26 00:00:00
abstract::Objective. To confirm that physical activity program improves the symptoms of dementia and the most effective physical activity was selected to help establish exercise programs. Methods. Three databases, PubMed, Science Direct, and Willey online, were used to collect articles. The databases were published between Janu...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2016/2920146
更新日期:2016-01-01 00:00:00
abstract::Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose- or hand-poking, subjects l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/927685
更新日期:2014-01-01 00:00:00
abstract::This study investigated how the posture of the thumb while performing common pinch movements and the levels of pinch force applied by the thumb affect the arthrokinematics of the trapeziometacarpal joint in vivo. Fifteen subjects performed the pinch tasks at the distal phalange (DP), proximal interphalangeal (PIP) joi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/157295
更新日期:2014-01-01 00:00:00
abstract::Giardia duodenalis, is often seen as an opportunistic pathogen and one of the major food and waterborne parasites. Some insights of Giardia infestation in a diarrhoea-prone population were investigated in the present study. Our primary goal was to understand the interaction of this parasite with other pathogens during...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/786480
更新日期:2014-01-01 00:00:00
abstract::Background. The aim of this study was to assess the effects of low concentrations of H2O2 on angiogenesis of human umbilical vein endothelial cells (HUVECs) in vitro and explore the underlying mechanisms. Methods. HUVECs were cultured and stimulated with different concentrations of H2O2. Flow cytometric analysis was u...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6895730
更新日期:2017-01-01 00:00:00
abstract::Adult orthodontics may confront problems related to the bonding performance of orthodontic brackets to new generation restorative materials used for crown or laminate restorations. The aim of the present study was to investigate the shear bond strength of ceramic brackets to two new generation CAD/CAM interpenetrating...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1871598
更新日期:2018-05-30 00:00:00
abstract::Diesel exhaust and its particles (DEP) have been under scrutiny for health effects in humans. In the development of these effects inflammation is regarded as a key process. Overall, in vitro studies report similar DEP-induced changes in markers of inflammation, including cytokines and chemokines, as studies in vivo. I...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/685142
更新日期:2013-01-01 00:00:00
abstract::The Toll-Like receptor 4 (TLR4) plays an important role in immunity, tissue repair, and regeneration. The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/318686
更新日期:2013-01-01 00:00:00
abstract::Background. Surgical treatment of proximal humeral fractures (PHF) in osteoporotic bone of elderly patients is challenging. The aim of this retrospective study was to evaluate the clinical and radiological outcome after percutaneous reduction and internal fixation of osteoporotic PHF in geriatric patients using the se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6451849
更新日期:2016-01-01 00:00:00
abstract::Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs. The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit. Seven female rabbits were used in t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/140327
更新日期:2013-01-01 00:00:00
abstract::Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects. Ten patients with unilater...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6560234
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The genome-wide association studies (GWAS) have been successful during the last few years. A key challenge is that the interpretation of the results is not straightforward, especially for transacting SNPs. Integration of transcriptome data into GWAS may provide clues elucidating the mechanisms by which a gen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/493019
更新日期:2013-01-01 00:00:00
abstract::Since the discovery of JAK2V617F tyrosine kinase-activating mutation, several genes have been found mutated in myeloproliferative neoplasms (MPNs). FLT3-ITD, NPM1, and DNMT3A mutations frequently occurred in AML patients and have been found conferred with myeloproliferative neoplasms in mouse model. Therefore, we soug...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/485645
更新日期:2014-01-01 00:00:00
abstract::Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy placental function is the proper development of its vascular network. Poor vascularization of the placenta can lead to fetal growth restriction, preeclampsia, and in so...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/814543
更新日期:2015-01-01 00:00:00
abstract::Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability fac...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/180468
更新日期:2014-01-01 00:00:00
abstract::Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/549785
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/673018
更新日期:2015-01-01 00:00:00
abstract::Background. The survival rates of in-hospital cardiac arrests (IHCAs) are reportedly low at night, but the difference between the survival rates of cardiac origin and noncardiac origin IHCAs occurring at night remains unclear. Methods. Outcomes of IHCAs during different shifts (night, day, and evening) were compared a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4626027
更新日期:2016-01-01 00:00:00
abstract::We applied a metabolomic approach to monitor the modifications occurring in goat vitreous humor (VH) metabolite composition at different times (0, 6, 12, 18, and 24 hours) after death. The (1)H-NMR analysis of the VH samples was performed for the simultaneous determination of several metabolites (i.e., the metabolite ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/627201
更新日期:2015-01-01 00:00:00