Abstract:
:Since the discovery of JAK2V617F tyrosine kinase-activating mutation, several genes have been found mutated in myeloproliferative neoplasms (MPNs). FLT3-ITD, NPM1, and DNMT3A mutations frequently occurred in AML patients and have been found conferred with myeloproliferative neoplasms in mouse model. Therefore, we sought to search for mutations in JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in 129 cases including 120 classic MPN cases and 9 MDS/MPN cases. JAK2V617F mutation was found in 60% of the 120 classic MPNs. However, none of the patients displayed FLT3-ITD and NPM1 mutations; only 2 patients harbored DNMT3A R882 mutation. Further studies including whole-genome sequence will be conducted to investigate the possible involvement of these genes in MPN.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wang M,He N,Tian T,Liu L,Yu S,Ma Ddoi
10.1155/2014/485645subject
Has Abstractpub_date
2014-01-01 00:00:00pages
485645eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process. In this work, we present the characterization of the bacterial commu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/242856
更新日期:2015-01-01 00:00:00
abstract::This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of struct...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/502093
更新日期:2014-01-01 00:00:00
abstract::The palmaris longus is considered a phylogenetic degenerate metacarpophalangeal joint flexor muscle in humans, a small vestigial forearm muscle; it is the most variable muscle in humans, showing variation in position, duplication, slips and could be reverted. It is frequently studied in papers about human anatomical v...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/178906
更新日期:2014-01-01 00:00:00
abstract:Purpose:Computer-aided diagnosis (CAD) can aid in improving diagnostic level; however, the main problem currently faced by CAD is that it cannot obtain sufficient labeled samples. To solve this problem, in this study, we adopt a generative adversarial network (GAN) approach and design a semisupervised learning algorith...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6425963
更新日期:2019-04-15 00:00:00
abstract::Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions be...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/4864195
更新日期:2016-01-01 00:00:00
abstract:Aim:This study aims to evaluate the accuracy of scanned images of 4 clinically used intraoral scanners (CS3600, i500, Trios3, Omnicam) when scanning the surface of full arch models with various kinds of orthodontic brackets in the presence of artificial saliva. Materials and Methods. Four study models were prepared; bo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2920804
更新日期:2020-02-27 00:00:00
abstract::The aim of this study was to find out the ideal cut-off level of phosphate for safe healing when deformity correction and concomitant lengthening are indicated in the two different skeletal maturity groups of patients with rickets. Thirty-nine hypophosphatemic rickets patients were selected for the study and were divi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569530
更新日期:2014-01-01 00:00:00
abstract::Primary cilia are organelles protruding from cell surface into environment that function in regulating cell cycle and modulating cilia-related signal. Primary ciliogenesis and autophagy play important roles in tumorigenesis. However, the functions and interactions between primary cilia and autophagy in hepatocellular ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5202750
更新日期:2019-10-02 00:00:00
abstract::CA-125 has been a valuable marker for the follow-up of ovarian cancer patients but it is not sensitive enough to be used as diagnostic marker. We had already used secretomic methods to identify proteins differentially secreted by serous ovarian cancer cells compared to healthy ovarian cells. Here, we evaluated the sec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/208017
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The PiCCO transpulmonary thermodilution technique provides two indices of cardiac systolic function, the cardiac function index (CFI) and the global ejection fraction (GEF). Both appear to be correlated with left ventricular ejection fraction (LVEF) measured by echocardiography in patients with circulatory...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/598029
更新日期:2014-01-01 00:00:00
abstract::Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/3176565
更新日期:2019-12-10 00:00:00
abstract:Background:Acute myocardial infarction (AMI) is regarded as an urgent clinical entity, and identification of differentially expressed genes, lncRNAs, and altered pathways shall provide new insight into the molecular mechanisms behind AMI. Materials and Methods:Microarray data was collected to identify key genes and ln...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1470867
更新日期:2020-10-06 00:00:00
abstract:Background:Waldenström macroglobulinemia (WM) is a rare, indolent B-cell lymphoma. Clinically, chromosome 6q deletion (6q del) including loss of the B lymphocyte-induced maturation protein 1 gene (BLIMP-1) is reported to be associated with poor prognosis. However, it remains unclear how the underlying biological mechan...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6728128
更新日期:2018-10-04 00:00:00
abstract:INTRODUCTION:The use of unlicensed food and herbal supplements to enhance sexual functions is drastically increasing. This phenomenon, combined with the availability of these products over the Internet, represents a challenge from a clinical and a public health perspective. METHODS:A comprehensive multilingual assessm...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841798
更新日期:2014-01-01 00:00:00
abstract:Purpose:We aimed to identify prognostic factors for survival and recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for patients with HCC and hepatitis C virus-related cirrhosis (HCV-cirrhosis). Methods:This retrospective cohort study followed all adult patients with HCV-cirrhosis who underw...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1487593
更新日期:2020-10-17 00:00:00
abstract::This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery. Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery. The concentra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/126984
更新日期:2015-01-01 00:00:00
abstract::New genomes are being sequenced at an increasingly rapid rate, far outpacing the rate at which manual gene annotation can be performed. Automated genome annotation is thus necessitated by this growth in genome projects; however, full-fledged annotation systems are usually home-grown and customized to a particular geno...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/502827
更新日期:2013-01-01 00:00:00
abstract::Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1069585
更新日期:2016-01-01 00:00:00
abstract::Hydrocephalus is a common neurological condition that can have traumatic ramifications and can be lethal without treatment. Nowadays, during therapy radiologists have to spend a vast amount of time assessing the volume of cerebrospinal fluid (CSF) by manual segmentation on Computed Tomography (CT) images. Further, som...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3059170
更新日期:2019-07-07 00:00:00
abstract::Tanshinone IIA (Tan IIA), an active phytochemical in the dried root of Salvia miltiorrhiza Bunge, has shown an antiproliferative activity on various human cancer cell lines including nasopharyngeal carcinoma cells. However, the effects of Tan IIA on human oral cancer cells are still unknown. This study aimed to invest...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版
doi:10.1155/2014/540516
更新日期:2014-01-01 00:00:00
abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2607928
更新日期:2018-06-14 00:00:00
abstract::Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/143109
更新日期:2015-01-01 00:00:00
abstract:Introduction:This study examines the utility of electroencephalography (EEG) in clinical decision making in acute ischemic stroke (AIS) patients in regards to the prescription of antiseizure medications. Methods:Patients were grouped as having positive EEG (+) for epileptiform activity or negative EEG (-). These studi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6250531
更新日期:2020-12-19 00:00:00
abstract:OBJECTIVES:Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. MATERIAL AND METHODS:In a population-based survey in Turkey demographics, height, weight, blood pre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/895401
更新日期:2014-01-01 00:00:00
abstract::In this paper, differences between multichannel EEG signals of artists and nonartists were analyzed during visual perception and mental imagery of some paintings and at resting condition using approximate entropy (ApEn). It was found that ApEn is significantly higher for artists during the visual perception and the me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/764382
更新日期:2014-01-01 00:00:00
abstract::We undertook an investigation to advance understanding of the host-range dynamics and biocontrol implications of Cochliobolus lunatus in the past decade. Potato (Solanum tuberosum L) farms were routinely surveyed for brown-to-black leaf spot disease caused by C. lunatus. A biphasic gene data set was assembled and data...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/378372
更新日期:2014-01-01 00:00:00
abstract::The goal of this study was to analyse perceptually and acoustically the voices of patients with Unilateral Vocal Fold Paralysis (UVFP) and compare them to the voices of normal subjects. These voices were analysed perceptually with the GRBAS scale and acoustically using the following parameters: mean fundamental freque...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/704121
更新日期:2015-01-01 00:00:00
abstract:Background:Left ventricular (LV) systolic dysfunction is common in septic shock. Global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE) is a useful marker of intrinsic left ventricular systolic function. However, the association between left ventricular GLS and outcome in septic patients i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7927353
更新日期:2020-10-21 00:00:00
abstract:PURPOSE:To quantitatively measure changes in cerebral perfusion in select regions of interest in the brain during urinary urgency in women with overactive bladder (OAB) using arterial spin labeling (ASL). METHODS:Twelve women with OAB and 10 controls underwent bladder filling and rated urinary urgency (scale 0-10). AS...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2759035
更新日期:2017-01-01 00:00:00
abstract::We study the interaction of 3T3 Swiss albino mouse fibroblasts with polymeric nanoparticles (NPs) and investigate cellular behaviour in terms of viability/cytotoxicity, cell cycle, NPs uptake, MAP kinase (ERK1/2), and focal adhesion kinase (FAK) activation. After incubation of NPs with cell culture media, western blot...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/539348
更新日期:2013-01-01 00:00:00