Abstract:
OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS:Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study. From these, all patients ≤60 years (n = 71) were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5). Forty age- and sex-matched controls were included. The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5. RESULTS:There was no significant difference in the level of Lp-PLA2 between patients with RA and controls (p > 0.05). In simple linear regression models among patients with RA, Lp-PLA2 at T0 was significantly associated with intima media thickness (IMT) at T0 and T5, flow mediated dilation (FMD) at T0 and T5, ever smoking, male sex, HDL-cholesterol (inversely), non-HDL-cholesterol, SCORE, Reynolds Risk Score, and Larsen score (p < 0.05). CONCLUSION. In this cohort of patients with early RA, the concentration of Lp-PLA2 was associated with both subclinical atherosclerosis and disease severity.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Södergren A,Karp K,Bengtsson C,Möller B,Rantapää-Dahlqvist S,Wållberg-Jonsson Sdoi
10.1155/2015/673018subject
Has Abstractpub_date
2015-01-01 00:00:00pages
673018eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Falls are an important health concern among older adults due to age-related changes in the body. Having a medical history of chronic health condition may pose even higher risk of falling. Only few studies have assessed a number of chronic health conditions as risk factor for falls over a large nationally representativ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5146378
更新日期:2017-01-01 00:00:00
abstract:Aim:The aim of this study is to assess the awareness of biomedical waste management in dental students of various dental colleges of Nepal. Methodology:A structured pretested questionnaire was used among 434 (323 males and 111 females) undergraduate dental students of five different dental colleges of Nepal. First par...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1742326
更新日期:2018-12-09 00:00:00
abstract::The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections, are reported to have low bioavailability pertaining to high first-pass metabolism, high protein binding, and enzymatic metabolism. They also show low permeability across blood brain barrier. The CNS is reported to be the most...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5984014
更新日期:2017-01-01 00:00:00
abstract::Tryptophan (Trp) plays an essential role in pig behavior and growth performances. However, little is known about Trp's effects on tight junction barrier and intestinal health in weaned pigs. In the present study, twenty-four (24) weaned pigs were randomly assigned to one of the three treatments with 8 piglets/treatmen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2912418
更新日期:2016-01-01 00:00:00
abstract::Malignant melanoma is characterized by its bad prognosis for aggressiveness, drug resistance, and early metastasis. Isorhamnetin (3'-methoxy-3,4',5,7-tetrahydroxyflavone; IH) is a natural flavonoid that has been investigated for its antitumor effects in breast cancer, colon cancer, and gastric cancer through inducing ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1057943
更新日期:2020-05-05 00:00:00
abstract::Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/790842
更新日期:2013-01-01 00:00:00
abstract::The insula is believed to be associated with touch-evoked effects. In this work, functional MRI was applied to investigate the network model of insula function when 20 normal subjects received tactile stimulation over segregated areas. Data analysis was performed with SPM8 and Conn toolbox. Activations in the contrala...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/734326
更新日期:2013-01-01 00:00:00
abstract::Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when canc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/470253
更新日期:2014-01-01 00:00:00
abstract::This study aimed to analyse the diversity of the Campylobacter jejuni population in broilers and to evaluate the major source of contamination in poultry meat. Eight rearing cycles over one year provided samples from three different broiler farms processed at the same slaughterhouse. A total of 707 C. jejuni were isol...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/859845
更新日期:2015-01-01 00:00:00
abstract::To provide an overview of the currently available literature regarding local control of primary tumor and oligometastases in metastatic prostate cancer and salvage lymph node dissection of clinical lymph node relapse after curative treatment of prostate cancer. Evidence Acquisition. A systematic literature search was ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/501213
更新日期:2014-01-01 00:00:00
abstract:Objectives:Childhood malnutrition is major health concern in many low- and middle-income countries, including Vietnam. It was a major risk factor for child mortality and adult ill-health. Malnutrition could increase the risk of serious infections; conversely current diseases also had a negative impact on the growth of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6921312
更新日期:2019-02-05 00:00:00
abstract:BACKGROUND AND AIM:Chemokine/receptor axis is a predominant actor of clinical disorders. They are key factors of pathogenesis of almost all clinical situations including asthma. Correspondingly, CXCL12 is involved in the immune responses. Therefore, this study was designed to explore the association between gene polymo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/759361
更新日期:2013-01-01 00:00:00
abstract::The aim of the study was to comparatively evaluate the fracture strength and mode of root canal treated teeth restored with resin composites with and without posts. The lingual cusps of root canal treated first upper premolars (n = 10/group) were removed down to cervical enamel and restored with the following: group A...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9054301
更新日期:2018-08-14 00:00:00
abstract::There is an emerging body of evidence that chemoresistance and minimal residual disease result from selective resistance of a cell subpopulation from the original tumor that is molecularly and phenotypically distinct. These cells are called "cancer stem cells" (CSCs). In this review, we analyze the potential targeting...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/859871
更新日期:2014-01-01 00:00:00
abstract::X-ray radiation resistance associated 1 (XRRA1) has been found to regulate the response of human tumor and normal cells to X-radiation (XR). Although XRRA1 overexpression is known to be involved in cancer cell response to XR, there are no reports about whether the expression of XRRA1 in tumors can adjust radioresistan...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5718968
更新日期:2017-01-01 00:00:00
abstract::Enzymes play important roles in most of the biological processes. Although only a small fraction of residues are directly involved in catalytic reactions, these catalytic residues are the most crucial parts in enzymes. The study of the fundamental and unique features of catalytic residues benefits the understanding of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/802945
更新日期:2013-01-01 00:00:00
abstract::The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5280514
更新日期:2019-03-28 00:00:00
abstract::CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4093435
更新日期:2018-03-29 00:00:00
abstract::Neonatal hyperbilirubinemia is a common problem with potentiality to cause irreversible brain damage. Reduction of serum bilirubin level is essential to minimize such damage. Compact fluorescent tubes, halogen bulbs, fiber optic blankets, and LEDs are commonly used light sources for phototherapy with varying efficacie...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/6274719
更新日期:2019-04-11 00:00:00
abstract:Objectives:The aim of this study was to evaluate the influence of ferule and the post type on the fracture strength and stress distribution in premolars. Materials and Methods:Forty human mandibular premolars were decoronated, allocated in four groups, and restored as follows: CPC-NF: cast post-and-core and absence of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2196519
更新日期:2019-01-03 00:00:00
abstract::Diabetes has become the third most serious threat to human health, after cancer and cardiovascular disease. Notably, Lactobacillus brevis is the most common species of LAB that produces γ-aminobutyric acid (GABA). The aim of this study is to clarify the effect of time, strain types, antibiotic concentrations, differen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7356173
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND AND PURPOSE:Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based 18F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs. MATERIALS AND METHODS:We retrospectively...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8132676
更新日期:2017-01-01 00:00:00
abstract::Mild cognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/920902
更新日期:2014-01-01 00:00:00
abstract::Kawasaki disease (KD) is an acute systemic vasculitis of childhood with prolonged fever, and the diagnosis of KD is mainly based on clinical criteria, which is prone to misdiagnosis with other febrile infectious (FI) diseases. Currently, there remain no effective molecular markers for KD diagnosis. In this study, we a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6539398
更新日期:2020-04-26 00:00:00
abstract:PURPOSE:To evaluate the role of nutritional factors, serum lipids, and lipoproteins in late age-related macular degeneration (late AMD). METHODS:Intake of red meat, fruit, fish, vegetables, and alcohol, smoking status, and body mass index (BMI) were ascertained questionnaire-based in 1147 late AMD cases and 1773 contr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/413150
更新日期:2014-01-01 00:00:00
abstract::The role of α-fetoprotein (AFP) in the surveillance and diagnosis of hepatocellular carcinoma (HCC) has been questioned in recent years due to its low sensitivity and specificity. In addition to AFP, several new serum biomarkers, such as lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) and des-gamma-carboxy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5087643
更新日期:2020-09-17 00:00:00
abstract::Extra-intestinal E. coli are emerging as a global threat due to their diffusion as opportunistic pathogens and, above all, to their wide set of antibiotic resistance determinants. There are still many gaps in our knowledge of their origin and spread pathways, although food animals have been adjudicated vehicles for pa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8714975
更新日期:2018-11-18 00:00:00
abstract::The aim of this study was to evaluate a novel composite material for tracheal reconstruction in an ovine model. A polymer containing various forms of carbon fibers (roving, woven, and nonwoven fabric) impregnated with polysulfone (PSU) was used to create cylindrical tracheal implants, 3 cm in length and 2.5 cm in diam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2610637
更新日期:2018-10-17 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/2643862.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2017/5782619
更新日期:2017-01-01 00:00:00
abstract::Early Infantile Epileptic Encephalopathy (known as Ohtahara Syndrome) is one of the most severe and earliest forms of epilepsy, characterized by early seizures onset. It affects newborns and children between two and six years old. Among the genes that have been associated with early infantile epileptic encephalopathy,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4872101
更新日期:2019-12-17 00:00:00