Abstract:
:Enzymes play important roles in most of the biological processes. Although only a small fraction of residues are directly involved in catalytic reactions, these catalytic residues are the most crucial parts in enzymes. The study of the fundamental and unique features of catalytic residues benefits the understanding of enzyme functions and catalytic mechanisms. In this work, we analyze the structural context of catalytic residues based on theoretical and experimental structure flexibility. The results show that catalytic residues have distinct structural features and context. Their neighboring residues, whether sequence or structure neighbors within specific range, are usually structurally more rigid than those of noncatalytic residues. The structural context feature is combined with support vector machine to identify catalytic residues from enzyme structure. The prediction results are better or comparable to those of recent structure-based prediction methods.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chien YT,Huang SWdoi
10.1155/2013/802945subject
Has Abstractpub_date
2013-01-01 00:00:00pages
802945eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract:Background:The aim of this study was to assess changes in skin microbiota of wrestlers during training sessions and to determine the sensitivity of hemolytic bacterial isolates to antiseptics. Methods:The main skin bacterial isolates obtained from the skin of 15 wrestlers were identified by cultivation method, with th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9843781
更新日期:2019-01-10 00:00:00
abstract:Purpose:Computer-aided diagnosis (CAD) can aid in improving diagnostic level; however, the main problem currently faced by CAD is that it cannot obtain sufficient labeled samples. To solve this problem, in this study, we adopt a generative adversarial network (GAN) approach and design a semisupervised learning algorith...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6425963
更新日期:2019-04-15 00:00:00
abstract:Background:The tumor volume of high-grade glioma (HGG) after surgery is usually determined by contrast-enhanced MRI (CE-MRI), but the clinical target volume remains controversial. Functional magnetic resonance imaging (multimodality MRI) techniques such as magnetic resonance perfusion-weighted imaging (PWI) and diffusi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8718097
更新日期:2020-08-10 00:00:00
abstract::Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/318364
更新日期:2015-01-01 00:00:00
abstract::GABAergic inhibition and particularly perisomatic inhibition play a crucial role in controlling the firing properties of large principal cell populations. Furthermore, GABAergic network is a key element in the therapy attempting to reduce epileptic activity. Here, we present a review showing the synaptic changes of pe...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7154295
更新日期:2017-01-01 00:00:00
abstract:Background:The aim of this article is to present a short review of noninvasive, nonpharmacological treatment methods used in somatic illnesses that fall under the umbrella of approach called behavioral medicine. Methods:The narrative review method was applied in the study. Science paper databases, including PubMed, ha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/5076516
更新日期:2020-11-03 00:00:00
abstract::Transcatheter treatment of children with congenital heart disease such as coarctation of the aorta and pulmonary artery stenosis currently involves the use of metal stents. While these provide good short term results, there are long term complications with their use. Children outgrow metal stents, obligating them to f...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/137985
更新日期:2013-01-01 00:00:00
abstract::A number of statistical methods for detecting gene-gene interactions have been developed in genetic association studies with binary traits. However, many phenotype measures are intrinsically quantitative and categorizing continuous traits may not always be straightforward and meaningful. Association of gene-gene inter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/523641
更新日期:2015-01-01 00:00:00
abstract::The number of RNA-Seq studies has grown in recent years. The design of RNA-Seq studies varies from very simple (e.g., two-condition case-control) to very complicated (e.g., time series involving multiple samples at each time point with separate drug treatments). Most of these publically available RNA-Seq studies are d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/318064
更新日期:2015-01-01 00:00:00
abstract::The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can mod...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/271276
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to develop a freeze-drying protocol facilitating successful processing of plant material containing the small surface antigen of hepatitis B virus (S-HBsAg) while preserving its VLP structure and immunogenicity. Freeze-drying of the antigen in lettuce leaf tissue, without any isolation or pur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/485689
更新日期:2014-01-01 00:00:00
abstract::Background and Objective. Although minimally invasive surgical treatment of acute epidural hematoma attracts increasing attention, no generalized indications for the surgery have been adopted. This study aimed to evaluate the effects of minimally invasive surgery in acute epidural hematoma with various hematoma volume...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6507350
更新日期:2016-01-01 00:00:00
abstract::This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ). JSJ presented high polyphenol content and steroids. HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract. In rat, JSJ induc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4827461
更新日期:2018-10-08 00:00:00
abstract::Coronary artery disease complicates only 0.01% of all pregnancies. For this reason, more exhaustive data on the management of such cases is lacking. Even guidelines on management of cardiovascular disease in pregnant women are scarce focusing mainly on acute myocardial infarction. This is a complex issue involving tho...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/957027
更新日期:2013-01-01 00:00:00
abstract::Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ in functions. The purpose of this study is to investigate the evolutionary impacts on diversity functions of PPAR members and the regulatory differences on gene expression patterns. 63...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/613910
更新日期:2015-01-01 00:00:00
abstract:Background:The purpose of this study was to examine the physical activity patterns and health-related fitness levels of adolescents within the Juvenile Justice System. Methods:Participants included 68 adolescents (Mean age = 17.1 ± 1.0 years) in two secure Juvenile Justice correctional facilities in the Western USA. M...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9710714
更新日期:2018-07-15 00:00:00
abstract::Adult neuronal cells which can regenerate have been reported. The present study investigated whether acupuncture enhances neuronal regeneration in ischemic stroke rats. We established an ischemic stroke rat model by occluding the cerebral blood flow of the right middle cerebral artery for 15 minutes and then allowing ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3178014
更新日期:2017-01-01 00:00:00
abstract::Lung cancer is one of the leading triggers for cancer death worldwide. In this study, the relationship of the aberrantly methylated and differentially expressed genes in lung adenocarcinoma (LUAD) with cancer prognosis was investigated, and 5 feature genes were identified eventually. Specifically, we firstly downloade...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1807089
更新日期:2020-09-25 00:00:00
abstract:OBJECT:Video-assisted thoracoscopic sympathectomy is a safe, effective, and minimally invasive procedure for primary hyperhidrosis. This study aims to evaluate long-term results and patients' quality of life and investigate potential variables responsible for compensatory sweating after one-stage bilateral single-port ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/348017
更新日期:2013-01-01 00:00:00
abstract:Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2748219
更新日期:2020-01-10 00:00:00
abstract::Liver cell culture within three-dimensional structures provides an improved culture system for various applications in basic research, pharmacological screening, and implantable or extracorporeal liver support. Biodegradable calcium-based scaffolds in such systems could enhance liver cell functionality by providing en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6040146
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2351037
更新日期:2017-01-01 00:00:00
abstract::Mild cognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/920902
更新日期:2014-01-01 00:00:00
abstract::Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world. DM is seen associated with obesity and diabetic retinopathy (DR). In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6068437
更新日期:2016-01-01 00:00:00
abstract::Gastric cancer (GC) is one of the most common and fatal malignancies worldwide. MicroRNAs (miRNAs) play a critical role in tumor initiation, proliferation, and metastasis of gastric cancer. miR193b has been identified as a tumor suppressor in a variety of tumor types; however, its role in gastric cancer is yet to be d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2863236
更新日期:2020-05-25 00:00:00
abstract::Diabetes mellitus is a major health problem that affects a patient's life quality throughout the world due to its worst complications. It was recognized that chronic hyperglycemia with oxidative stress was the major cause of male infertility. Echinacea purpurea ethanol extract (EE) contains phenolic acid and isobutyla...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4237354
更新日期:2018-08-30 00:00:00
abstract::Atypical chemokine receptors (ACKRs) are a subclass of G protein-coupled receptors characterized by promiscuity of ligand binding and an obvious inability to signal after ligand binding. Although some discoveries regarding this family in Homo sapiens and other species have been reported in some studies, the evolution ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9065181
更新日期:2018-09-24 00:00:00
abstract::A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimula...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7636290
更新日期:2020-01-13 00:00:00
abstract::Neuroendocrine tumors (NETs) are tumors originated from neuroendocrine cells in the body. The localization and the detection of the extent of NETs are important for diagnosis and treatment, which should be individualized according to the tumor type, burden, and symptoms. Molecular imaging of NETs with high sensitivity...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/102819
更新日期:2013-01-01 00:00:00
abstract::This study aimed to compare within-subject blood pressure (BP) variabilities from different measurement techniques. Cuff pressures from three repeated BP measurements were obtained from 30 normotensive and 30 hypertensive subjects. Automatic BPs were determined from the pulses with normalised peak amplitude larger tha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5201069
更新日期:2017-01-01 00:00:00