Somatostatin receptor-based molecular imaging and therapy for neuroendocrine tumors.

Abstract:

:Neuroendocrine tumors (NETs) are tumors originated from neuroendocrine cells in the body. The localization and the detection of the extent of NETs are important for diagnosis and treatment, which should be individualized according to the tumor type, burden, and symptoms. Molecular imaging of NETs with high sensitivity and specificity is achieved by nuclear medicine method using single photon-emitting and positron-emitting radiopharmaceuticals. Somatostatin receptor imaging (SRI) using SPECT or PET as a whole-body imaging technique has become a crucial part of the management of NETs. The radiotherapy with somatostatin analogues labeled with therapeutic beta emitters, such as lutetium-177 or yttrium-90, has been proved to be an option of therapy for patients with unresectable and metastasized NETs. Molecular imaging can deliver an important message to improve the outcome for patients with NETs by earlier diagnosis, better choice of the therapeutic method, and evaluation of the therapeutic response.

journal_name

Biomed Res Int

authors

Wang L,Tang K,Zhang Q,Li H,Wen Z,Zhang H,Zhang H

doi

10.1155/2013/102819

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

102819

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

杂志文章,评审
  • Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity.

    abstract::Chronic obesity is a known risk factor for metabolic syndrome. However, little is known about pathological changes in the small intestine associated with chronic obesity. This study investigated cellular and subcellular level changes in the small intestine of obese mice. In this study, a mouse model of obesity was est...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5251738

    authors: Nakadate K,Motojima K,Hirakawa T,Tanaka-Nakadate S

    更新日期:2016-01-01 00:00:00

  • Evaluation of alexithymia, somatosensory sensitivity, and health anxiety levels in patients with noncardiac chest pain.

    abstract:OBJECTIVE:Noncardiac chest pain (NCCP) is seen more frequently in young population and in these patients loss of function is evolving in social and professional areas. The aim of the study is to evaluate the levels of anxiety and somatic perception in patients with chest pain presenting to cardiology clinic. METHODS:F...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/896183

    authors: Zincir SB,Sunbul M,Sunbul EA,Dalkilic B,Cengiz F,Kivrak T,Durmus E

    更新日期:2014-01-01 00:00:00

  • Which Neighborhood Destinations Matter in the Asian Context? The Role of Destinations in Older Adults' Physical Activity and Sedentary Behaviors.

    abstract:Background:Neighborhood destinations play important roles in daily activity levels of older adults. However, little is known about how specific destinations are associated with these activities and/or sedentary behaviors, especially in Asia. This study investigated how neighborhood destinations were associated with phy...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8432934

    authors: Park JH,Park JH,Song S,Lai TF,Liao Y

    更新日期:2020-07-30 00:00:00

  • Degradation of diuron by Phanerochaete chrysosporium: role of ligninolytic enzymes and cytochrome P450.

    abstract::The white-rot fungus Phanerochaete chrysosporium was investigated for its capacity to degrade the herbicide diuron in liquid stationary cultures. The presence of diuron increased the production of lignin peroxidase in relation to control cultures but only barely affected the production of manganese peroxidase. The her...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/251354

    authors: Coelho-Moreira Jda S,Bracht A,de Souza AC,Oliveira RF,de Sá-Nakanishi AB,de Souza CG,Peralta RM

    更新日期:2013-01-01 00:00:00

  • Analysis of the Clinicopathological Characteristics and Risk Factors in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease.

    abstract:Objective:To investigate the clinicopathological characteristics and risk factors in patients with lung cancer and COPD. Materials and Methods:We retrospectively reviewed the clinical data of 282 patients with lung cancer, including 174 and 108 patients with and without COPD, respectively. Information on age, sex, smo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8398156

    authors: Miao JL,Cai JJ,Qin XF,Liu RJ

    更新日期:2018-02-14 00:00:00

  • Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn's Disease.

    abstract:BACKGROUND:We aimed to identify certain genes related to response to infliximab (IFX) and biomarkers to predict the IFX effect for Japanese Crohn's disease (CD) patients by performing an association study of single nucleotide polymorphisms (SNPs) in candidate genes in the interleukin- (IL-) 17 signaling pathway with re...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/416838

    authors: Urabe S,Isomoto H,Ishida T,Maeda K,Inamine T,Kondo S,Higuchi N,Sato K,Uehara R,Yajima H,Machida H,Chen CC,Fukuda Y,Takeshima F,Nakao K,Tsukamoto K

    更新日期:2015-01-01 00:00:00

  • Genetic Analysis of 25 Patients with 5α-Reductase Deficiency in Chinese Population.

    abstract:Background:A deficiency in steroid 5α-reductase type 2 is an autosomal recessive disorder. Affected individuals manifested ambiguous genitalia, which is caused by decreased dihydrotestosterone (DHT) synthesis in the fetus. Methods:We analyzed 25 patients with 5α-reductase deficiency in China. Seventeen of the 25 patie...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1789514

    authors: Han B,Cheng T,Zhu H,Yu J,Zhu WJ,Song HD,Yao H,Qiao J

    更新日期:2020-06-09 00:00:00

  • Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression.

    abstract::Progression of idiopathic dilated cardiomyopathy (IDCM) is marked with extensive left ventricular remodeling whose clinical manifestations and molecular basis are poorly understood. We aimed to evaluate the clinical potential of titin ligands in monitoring progression of cardiac remodeling associated with end-stage ID...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/273936

    authors: Bogomolovas J,Brohm K,Čelutkienė J,Balčiūnaitė G,Bironaitė D,Bukelskienė V,Daunoravičus D,Witt CC,Fielitz J,Grabauskienė V,Labeit S

    更新日期:2015-01-01 00:00:00

  • Image-Based Structural Modeling of the Cardiac Purkinje Network.

    abstract::The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the gene...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/621034

    authors: Liu BR,Cherry EM

    更新日期:2015-01-01 00:00:00

  • Inverse Kinematics for Upper Limb Compound Movement Estimation in Exoskeleton-Assisted Rehabilitation.

    abstract::Robot-Assisted Rehabilitation (RAR) is relevant for treating patients affected by nervous system injuries (e.g., stroke and spinal cord injury). The accurate estimation of the joint angles of the patient limbs in RAR is critical to assess the patient improvement. The economical prevalent method to estimate the patient...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2581924

    authors: Cortés C,de Los Reyes-Guzmán A,Scorza D,Bertelsen Á,Carrasco E,Gil-Agudo Á,Ruiz-Salguero O,Flórez J

    更新日期:2016-01-01 00:00:00

  • The significance of serum phosphate level on healing index and its relative effects in skeletally immature and mature patients with hypophosphatemic rickets.

    abstract::The aim of this study was to find out the ideal cut-off level of phosphate for safe healing when deformity correction and concomitant lengthening are indicated in the two different skeletal maturity groups of patients with rickets. Thirty-nine hypophosphatemic rickets patients were selected for the study and were divi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/569530

    authors: Song SH,Lee H,Jeong JM,Cho WI,Kim SE,Song HR

    更新日期:2014-01-01 00:00:00

  • New advances of preimplantation and prenatal genetic screening and noninvasive testing as a potential predictor of health status of babies.

    abstract::The current morphologically based selection of human embryos for transfer cannot detect chromosome aneuploidies. So far, only biopsy techniques have been able to screen for chromosomal aneuploidies in the in vitro fertilization (IVF) embryos. Preimplantation genetic diagnosis (PGD) or screening (PGS) involves the biop...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/306505

    authors: Milachich T

    更新日期:2014-01-01 00:00:00

  • Current Status and Prospects of Spontaneous Peritonitis in Patients with Cirrhosis.

    abstract::Spontaneous bacterial peritonitis (SBP) is a common cirrhotic ascites complication which exacerbates the patient's condition. SBP is caused by gram-negative bacilli and, to a lesser extent, gram-positive cocci. Hospital-acquired infections show higher levels of drug-resistant bacteria. Geographical location influences...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/3743962

    authors: Li YT,Huang JR,Peng ML

    更新日期:2020-07-06 00:00:00

  • Efficacy and safety of docetaxel plus oxaliplatin and capecitabine in the first line treatment of advanced gastric adenocarcinoma.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of docetaxel plus oxaliplatin and capecitabine (DOX) in the first line treatment of advanced gastric adenocarcinoma. METHODS:A total of 37 patients were enrolled into this study, and they received DOX regimen (docetaxel 75 mg/m² and oxaliplatin 130 mg/m² intravenous infusi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/971096

    authors: Liu Y,Ye Z,Xi W,Ma T,Shi M,Yang L,Zhu Z,Zhang J

    更新日期:2013-01-01 00:00:00

  • Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells.

    abstract:Background:Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formatio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6069390

    authors: Li T,Huang Y,Zhou W,Yan Q

    更新日期:2020-03-16 00:00:00

  • Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo.

    abstract::Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with bai...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5201790

    authors: Du H,Zhang S,He M,Ming K,Wang J,Yuan W,Qiao M,Wu Y,Wang D,Hu Y,Liu J

    更新日期:2019-04-04 00:00:00

  • Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma.

    abstract::There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma sam...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9807918

    authors: Zhou W,Zhang S,Li HB,Cai Z,Tang S,Chen LX,Lang JY,Chen Z,Chen XL

    更新日期:2020-09-02 00:00:00

  • Predictive factors affecting the short term and long term exodrift in patients with intermittent exotropia after bilateral rectus muscle recession and its effect on surgical outcome.

    abstract:PURPOSE:To determine the predictive factors that affect short term and long term postoperative drift in intermittent exotropia after bilateral lateral rectus recession and to evaluate its effect on surgical outcome. METHODS:Retrospective review of 203 patients with diagnosis of intermittent exotropia, who had surgical...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/482093

    authors: Yam JC,Chong GS,Wu PK,Wong US,Chan CW,Ko ST

    更新日期:2014-01-01 00:00:00

  • Effects of a pragmatic lifestyle intervention for reducing body mass in obese adults with obstructive sleep apnoea: a randomised controlled trial.

    abstract::This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The interventi...

    journal_title:BioMed research international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1155/2014/102164

    authors: Moss J,Tew GA,Copeland RJ,Stout M,Billings CG,Saxton JM,Winter EM,Bianchi SM

    更新日期:2014-01-01 00:00:00

  • Potential of RAS inhibition to improve metabolic bone disorders.

    abstract::Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic diso...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/932691

    authors: Gebru Y,Diao TY,Pan H,Mukwaya E,Zhang Y

    更新日期:2013-01-01 00:00:00

  • Bioinformatics Analysis of the Molecular Mechanism of Aging on Fracture Healing.

    abstract::Increasing age negatively affects different phases of bone fracture healing. The present study aimed to explore underlying mechanisms related to bone fracture repair in the elderly. GSE17825 public transcriptome data from the Gene Expression Omnibus database were used for analysis. First, raw data were normalized and ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7530653

    authors: Zhao SJ,Kong FQ,Fan J,Chen Y,Zhou S,Xue MX,Yin GY

    更新日期:2018-12-16 00:00:00

  • The Role of a Primary Arthroplasty in the Treatment of Proximal Tibia Fractures in Orthogeriatric Patients.

    abstract::The total knee arthroplasty (TKA) is the gold standard for patients with an advanced symptomatic gonarthrosis. However, there are very few publications dealing with the primary TKA for patients with a proximal tibia fracture. In our retrospective study we evaluated 30 patients treated with a TKA for a proximal tibia f...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6047876

    authors: Haufe T,Förch S,Müller P,Plath J,Mayr E

    更新日期:2016-01-01 00:00:00

  • Bone Healing Improvements Using Hyaluronic Acid and Hydroxyapatite/Beta-Tricalcium Phosphate in Combination: An Animal Study.

    abstract::The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslink...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8301624

    authors: Chang YL,Lo YJ,Feng SW,Huang YC,Tsai HY,Lin CT,Fan KH,Huang HM

    更新日期:2016-01-01 00:00:00

  • Quality and Brands of Amoxicillin Formulations in Nairobi, Kenya.

    abstract::Antibiotics are among the most counterfeited anti-infectious medicines in developing countries. Amoxicillin is one of the commonly prescribed, affordable, and easily accessible antibiotic in Kenya. It is a broad-spectrum antibiotic hence commonly used in chemotherapy. This study sought to determine the quality and ide...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7091278

    authors: Koech LC,Irungu BN,Ng'ang'a MM,Ondicho JM,Keter LK

    更新日期:2020-06-12 00:00:00

  • CD20+ B cell depletion in systemic autoimmune diseases: common mechanism of inhibition or disease-specific effect on humoral immunity?

    abstract::Autoimmunity remains a complex physiologic deviation, enabled and perpetuated by a variety of interplayers and pathways. Simplistic approaches, targeting either isolated end-effectors of more centrally placed interactors of these mechanisms, are continuously tried in an effort to comprehend and halt cascades with pote...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/973609

    authors: Pateinakis P,Pyrpasopoulou A

    更新日期:2014-01-01 00:00:00

  • Techniques and Methods for Testing the Postural Function in Healthy and Pathological Subjects.

    abstract::The different techniques and methods employed as well as the different quantitative and qualitative variables measured in order to objectify postural control are often chosen without taking into account the population studied, the objective of the postural test, and the environmental conditions. For these reasons, the...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/891390

    authors: Paillard T,Noé F

    更新日期:2015-01-01 00:00:00

  • Performance enhancement of a web-based picture archiving and communication system using commercial off-the-shelf server clusters.

    abstract::The rapid development of picture archiving and communication systems (PACSs) thoroughly changes the way of medical informatics communication and management. However, as the scale of a hospital's operations increases, the large amount of digital images transferred in the network inevitably decreases system efficiency. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/657417

    authors: Liu YL,Shih CT,Chang YJ,Chang SJ,Wu J

    更新日期:2014-01-01 00:00:00

  • Maintenance therapy with partially hydrolyzed guar gum in the conservative treatment of chronic anal fissure: results of a prospective, randomized study.

    abstract:PURPOSE:This study was designed to evaluate the role of maintenance therapy with partially hydrolyzed guar gum (PHGG) after topical application of glyceryl trinitrate (GTN) in the conservative treatment of chronic anal fissure (CAF). METHODS:From all the patients with CAF observed during the study period, 165 subjects...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/964942

    authors: Brillantino A,Iacobellis F,Izzo G,Di Martino N,Grassi R,Renzi A

    更新日期:2014-01-01 00:00:00

  • Improvement in hemodynamic responses to metaboreflex activation after one year of training in spinal cord injured humans.

    abstract::Spinal cord injured (SCI) individuals show an altered hemodynamic response to metaboreflex activation due to a reduced capacity to vasoconstrict the venous and arterial vessels below the level of the lesion. Exercise training was found to enhance circulating catecholamines and to improve cardiac preload and venous ton...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/893468

    authors: Milia R,Roberto S,Marongiu E,Olla S,Sanna I,Angius L,Bassareo P,Pinna M,Tocco F,Concu A,Crisafulli A

    更新日期:2014-01-01 00:00:00

  • Determining the Clinical Value and Critical Pathway of GTPBP4 in Lung Adenocarcinoma Using a Bioinformatics Strategy: A Study Based on Datasets from The Cancer Genome Atlas.

    abstract::Lung cancer is the leading cause of cancer-related death worldwide, and the most common histologic subtype is lung adenocarcinoma (LUAD). Due to the significant mortality and morbidity rates among patients with LUAD, the identification of novel biomarkers to guide diagnosis, prognosis, and therapy is urgent. Guanosine...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5171242

    authors: Zhang Z,Wang J,Mao J,Li F,Chen W,Wang W

    更新日期:2020-10-19 00:00:00